New algorithm detects interactions for better individual trait prediction.
problem Tackles the challenge of making accurate individual trait predictions using interactions.
method Extends model-based MDR (MB-MDR) to detect and utilize interactions.
result Outperforms other algorithms in detecting and utilizing interactions for better prediction.
BayesMR estimates causal effects and directionality from genetic data.
problem Challenges in finding good genetic instruments and estimating causal effects.
method Bayesian Mendelian randomization approach that accounts for pleiotropy and reverse causation.
result BayesMR provides a posterior distribution over causal effects and uncertainty.
Paper proposes a hybrid AI method to optimize pandemic actions.
problem Optimizing government actions to balance public health and economy.
method Combines Deep Q-Learning and Genetic Algorithms for optimal sequences of actions.
result Deep Q-Learning outperforms Genetic Algorithms in optimizing action sequences.
Paper proposes inference method for high-dimensional censored quantile regression.
problem Identifying heterogeneous effects of high-dimensional genetic biomarkers on survival outcomes.
method Combines low-dimensional model estimates based on multi-sample splittings and variable selection.
result Proposed estimator is consistent and asymptotically follows a Gaussian process.
ESOP uses Bayesian optimization to find optimal lock-down schedules.
problem Finding optimal lock-down schedules balancing health and economy.
method Bayesian optimization interacting with epidemiological models.
result ESOP schedules balance public health and economic impacts.
The study examines methods to correct measurement error in nutritional epidemiology studies.
problem Measurement error in nutritional studies leads to biased and underconfident estimates.
method The article reviews various bias-correction models for exposure variables in nutritional epidemiology.
result Bias-correction methods are essential for accurate inference in nutritional studies.
SVI and GP surrogates improve calibration of ABMs in epidemiology.
problem Calibrating stochastic ABMs in epidemiology is computationally expensive.
method Stein Variational Inference (SVI) with Gaussian process (GP) surrogates.
result SVI maintains comparable predictive accuracy and calibration effectiveness to MCMC.
Count data, for example the number of observed cases of a disease in a city, often arise in the fields of healthcare analytics and epidemiology. In this paper, we consider performing regression on multivariate data in which our outcome is a count. Specifically, we derive log-likelihood functions for finite mixtures of …
Machine learning aids epidemiologists in analyzing big data.
problem Handling large, complex data in epidemiology.
method Explains principles and methods of supervised and unsupervised learning.
result Develops strategies for model evaluation and hyperparameter optimization.
ARF synthesizes epidemiological data to match original findings.
problem Synthetic data quality and privacy in epidemiology.
method Adversarial Random Forests (ARF) for efficient data synthesis.
result ARF-generated synthetic data consistently matches original epidemiological findings.
Efficiently calibrates epidemiological models using Bayesian optimization.
problem Calibration of complex epidemiological models is computationally expensive and challenging.
method Graybox Bayesian optimization scheme leveraging Gaussian processes and functional structure of compartmental models.
result Proposed methods achieve efficient calibration and improved performance compared to existing schemes.
Automates infectious disease policy-making via inference in epidemiological models.
problem Improving policy-making for infectious diseases during pandemics.
method Performing inference in existing epidemiological models using a probabilistic programming language.
result Automated inference leads to better disease progression outcomes and policy prescriptions.
A framework detects nonlinear and interaction effects in epidemiological data with uncertainty quantification.
problem Lack of reliable inference for ML-discovered nonlinearities and interactions in epidemiological data.
method Combines Bayesian sparse regression, tree ensembles, and Shapley values.
result Valid uncertainty quantification for feature effects at the individual level.
Paper introduces a method to interpret complex epidemiology simulators.
problem Difficult interpretation of stochastic epidemiology simulators.
method Hijacking internal random number generators with probabilistic programming.
result Restores trust between policymakers and simulators by providing insights.
Unified Bayesian-AI framework improves epidemiological risk prediction and uncertainty quantification.
problem Lack of calibrated uncertainty in machine learning models for epidemiology.
method Combines Bayesian prediction with Bayesian hyperparameter optimization using logistic regression and Gaussian-process Bayesian optimization.
result Unified Bayesian-AI framework provides reliable coverage and improved calibration, enhancing epidemiological decision making.
TOO optimizes stochastic epidemiological models by finding both parameter settings and random seeds.
problem Calibrating stochastic epidemiological models to match empirical observations.
method Gaussian process surrogates and Thompson sampling for optimization.
result Produces actual trajectories consistent with ground truth.
Bayesian network modelling is a well adapted approach to study messy and highly correlated datasets which are very common in, e.g., systems epidemiology. A popular approach to learn a Bayesian network from an observational datasets is to identify the maximum a posteriori network in a search-and-score approach. Many sco…
ENN method uses expectile regression for genetic data analysis of complex diseases.
problem Discover additional genetic variants contributing to complex diseases.
method Developed an expectile neural network (ENN) method integrating expectile regression and neural networks.
result ENN method outperforms existing expectile regression in discovering genetic variants predisposing to sub-populations.
Semi-supervised GAN creates synthetic genetic data for disease prediction.
problem Expensive and time-consuming to build large labeled genetic databases.
method Semi-supervised Genetic Generative Adversarial Network (gGAN).
result Model achieved satisfactory results with real genetic data.
Efficiently infers graph edges from genetic similarity data in landscape genetics.
problem Inferring unknown graph edges from genetic similarity data in a heterogeneous landscape.
method Developed an efficient first-order optimization method to solve the inverse landscape genetics problem.
result Our method provides fast and reliable convergence, significantly outperforming existing heuristics.
TMLE improves unbiased estimation in public health studies.
problem Improving unbiased estimation in observational studies.
method Targeted Maximum Likelihood Estimation (TMLE) integrates machine learning and statistical theory.
result TMLE has been adopted by researchers worldwide, especially outside the US.
Study uses epidemiological models to analyze financial contagion risks.
problem Analyzing and controlling contagion risks in the global financial network.
method Formulated an optimal control problem based on infection spread models.
result The approach effectively describes the world economy's financial contagion.
Method distinguishes genetic correlations from causation in GWAS.
problem Identifying causal relationships among genetically correlated traits.
method Mixed fourth moments to quantify causal relationships.
result Identified 30 putative genetically causal relationships across 52 traits.
Novel method for estimating SIRD model parameters and forecasting COVID-19 deaths in Poland.
problem Estimating epidemiological parameters for SARS-CoV-2 spread in Poland.
method Modified SIRD model, GPU architecture for computation.
result Effectiveness of short-term forecasts (up to 2 weeks) and stability of the method.
Epidemiological model updates infection rates in China, US, Italy.
problem Evaluate policy interventions for mitigating the 2019-nCov pandemic.
method Custom SITR model with variational data assimilation for real-time updates.
result Model robust to initial conditions, infers infection numbers and parameters.
Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding task, especially in the presence of gene-gene interactions. A non-parametric Bayesian approach in the form o…
Novel tests for genetic independence in high-dimensional data.
problem Testing independence in genetics studies with many variables.
method Defining premetric structures on genetic data support spaces.
result Solid theoretical framework and computationally-efficient implementations.
Introduces Deep Genetic Network for optimizing neural network hyperparameters.
problem Optimizing neural network hyperparameters is a tedious and time-consuming task.
method Uses genetic algorithms within a deep neural network architecture to optimize hyperparameters during training.
result Deep Genetic Network successfully optimizes hyperparameters in various types of neural network layers.
Ivy combines weak IV candidates to estimate causal effects robustly.
problem Estimating causal effects from observational data using weak or invalid IV candidates.
method Ivy synthesizes multiple weak IV candidates into a robust summary.
result Ivy produces more reliable causal effect estimates compared to allele scores.
Deep models improve GWAS by identifying genetic interactions.
problem Missing non-linear interaction effects in GWAS.
method Gradient-based DeepLIFT technique to interpret deep models.
result Known and novel genetic risk factors identified.
GeNet classifies metagenomic sequences with less memory and comparable recall to state-of-the-art methods.
problem Classifying metagenomic sequences from raw DNA sequences.
method Exploits hierarchical structure between labels for training, using deep representations.
result GeNet achieves competitive precision and good recall with less memory requirements.
Simulation-based inference aids in predicting disease dynamics for health policy.
problem Predicting disease dynamics to inform public health interventions.
method Simulation-based inference using machine learning.
result Potential for efficient interpretable Bayesian inference in epidemiological models.
Genetic algorithms have been widely used in many practical optimization problems. Inspired by natural selection, operators, including mutation, crossover and selection, provide effective heuristics for search and black-box optimization. However, they have not been shown useful for deep reinforcement learning, possibly …
New method uses DNN for genetic variant identification, controlling randomness and improving interpretability.
problem Challenges in interpreting deep neural networks for genetic variant identification.
method Interpretable neural network model with controlled variable selection using ensembling, knockoffs, and de-randomization.
result The proposed method leads to more discoveries compared to conventional methods.
Genetic sequence data are well described by hidden Markov models (HMMs) in which latent states correspond to clusters of similar mutation patterns. Theory from statistical genetics suggests that these HMMs are nonhomogeneous (their transition probabilities vary along the chromosome) and have large support for self tran…
G2Ns combine genetic genes with neural networks for reinforcement learning.
problem Improving sample efficiency and performance in reinforcement learning.
method Genetic-Gated Networks (G2Ns) that integrate binary genetic genes with neural network hidden layers.
result G2Ns achieve significant improvements in sample efficiency and performance in reinforcement learning.
Paper uses AI to predict stock market volatility with neural networks and genetic algorithms.
problem Traditional methods for predicting stock market volatility have high errors.
method Back-propagation neural network and genetic algorithm integrated model.
result The model predicts future volatility with low errors and high accuracy.
Predict genetic inheritance patterns using hypergraphs and latent models.
problem Diagnosing inherited diseases requires identifying family genetic patterns.
method Represent family trees as hypergraphs, use latent state space models for causal inference.
result Allows for explainable predictions of patient genotypes based on relatives' phenotypes.
In plant and animal breeding studies a distinction is made between the genetic value (additive + epistatic genetic effects) and the breeding value (additive genetic effects) of an individual since it is expected that some of the epistatic genetic effects will be lost due to recombination. In this paper, we argue that t…
Ensemble GP improves genetic programming by achieving better results with smaller models.
problem Improving genetic programming for binary classification problems.
method Ensemble GP uses an evolved population structure, fitness evaluation, and genetic operators inspired by ensemble learning methods.
result Ensemble GP outperformed standard GP on eight binary classification problems, achieving better results with smaller models.
Historical review of genetic algorithms for the TSP shows three distinct phases.
problem Optimizing routes for the Traveling Salesman Problem using genetic algorithms.
method Meta-data analysis of publications over time.
result Three distinct phases in the development of genetic algorithms for TSP identified.
Proposes new genetic algorithm rule for market competition.
problem Market competition genetic algorithm rules.
method Econophysics kinetic market model as an evolutionary algorithm.
result New replacement rule for genetic algorithms.
This paper compares Grid Search, Random Search, and Genetic Algorithm for NAS.
problem Hyperparameter optimization for neural architecture search.
method Comparison of Grid Search, Random Search, and Genetic Algorithm.
result Genetic Algorithm outperforms Grid Search and Random Search in terms of accuracy and execution time.
A genetic algorithm improves multivariate kernel density estimation.
problem Efficiently estimating multivariate kernel density functions.
method Genetic algorithm applied to subsamples of the original data.
result The genetic algorithm-based estimator performs better than traditional methods.
New method groups genetic data into coherent topics for disease insights.
problem Analyzing large, multi-dimensional genetic data sets.
method Conditional Hierarchical Bayesian Tucker Decomposition for genetic data analysis.
result Our models are more coherent than baseline models.
This paper improves dynamic hedging accuracy using genetic programming to forecast implied volatilities.
problem Improving the accuracy of dynamic hedging using implied volatilities.
method The paper uses genetic programming to forecast implied volatilities and tests the performance of these forecasts in dynamic hedging strategies.
result Genetic programming-generated implied volatilities improve hedging accuracy compared to static training methods.
For every group genetic code with finite number of generating and at most with one defining relation we introduce the braid group of this genetic code. This construction includes the braid group of Euclidean plane, the braid groups of closed orientable surfaces, B type groups of Artin-Brieskorn, and allow us to study a…
Gradient GA uses gradient information to improve molecular design.
problem Random walk exploration limits genetic algorithms' quality and speed in molecular design.
method Gradient GA incorporates gradient information from the objective function into genetic algorithms, using a differentiable neural network and Discrete Langevin Proposal.
result Significantly improves convergence speed and solution quality over traditional genetic algorithms.