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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,695 papers · 148 categories

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0111 · Dec 202019922001200920172026
2 results for “pleiotropy”
A statistical framework for GWAS of high dimensional phenotypes using summary statistics, with application to metabolite GWASstat.ME

Develops methods for GWAS of high dimensional phenotypes using summary statistics.

problem Lack of methods to model pleiotropy in multi-phenotype GWAS.
method Bayesian inference model using summary statistics, fast computation, and biologically informed priors.
result Demonstrates utility in metabolite GWAS with interpretable pathway-level inference.
GWASsummary statisticspleiotropyBayesian inferencemetabolite
2023-03-17abs ↗pdf ↗
Inferring the Direction of a Causal Link and Estimating Its Effect via a Bayesian Mendelian Randomization Approachstat.ME

BayesMR estimates causal effects and directionality from genetic data.

problem Challenges in finding good genetic instruments and estimating causal effects.
method Bayesian Mendelian randomization approach that accounts for pleiotropy and reverse causation.
result BayesMR provides a posterior distribution over causal effects and uncertainty.
Bayesian statisticsMendelian randomizationgenetic instrumentspleiotropyreverse causation
2020-12-18abs ↗pdf ↗