Paper uses genome Markov structure for outlier detection and read classification.
arXiv research
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Metagenomic studies have increasingly utilized sequencing technologies in order to analyze DNA fragments found in environmental samples.One important step in this analysis is the taxonomic classification of the DNA fragments. Conventional read classification methods require large databases and vast amounts of memory to…
We introduce GeNet, a method for shotgun metagenomic classification from raw DNA sequences that exploits the known hierarchical structure between labels for training. We provide a comparison with state-of-the-art methods Kraken and Centrifuge on datasets obtained from several sequencing technologies, in which dataset s…
Metagenomics characterizes the taxonomic diversity of microbial communities by sequencing DNA directly from an environmental sample. One of the main challenges in metagenomics data analysis is the binning step, where each sequenced read is assigned to a taxonomic clade. Due to the large volume of metagenomics datasets,…
New algorithm estimates intrinsic dimension of discrete datasets.
New algorithm optimizes matrix reordering for noisy disordered matrices.
Study examines how classifier performance is affected by training data quality.
The tremendous boost in the next generation sequencing and in the omics technologies makes it possible to characterize human gut microbiome (the collective genomes of the microbial community that reside in our gastrointestinal tract). While some of these microorganisms are considered as essential regulators of our immu…
Convolutional Neural Networks (CNNs) are a popular deep learning architecture widely applied in different domains, in particular in classifying over images, for which the concept of convolution with a filter comes naturally. Unfortunately, the requirement of a distance (or, at least, of a neighbourhood function) in the…
A critical decision point when training predictors using multiple studies is whether studies should be combined or treated separately. We compare two multi-study prediction approaches in the presence of potential heterogeneity in predictor-outcome relationships across datasets: 1) merging all of the datasets and traini…
This paper addresses measurement errors in high-dimensional compositional data using a log-contrast model calibration approach.
We introduce a new method for estimating the support size of an unknown distribution which provably matches the performance bounds of the state-of-the-art techniques in the area and outperforms them in practice. In particular, we present both theoretical and computer simulation results that illustrate the utility and p…
Pipeline integrates cross-sectional and longitudinal multi-omics data for IBD research.
DeepLINK-T uses deep learning and knockoffs for time series data.