Deep neural networks map brain lesions to deficits for better brain function understanding.
arXiv research
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We develop a topological model of site-specific recombination that applies to substrates which are the connected sum of two torus links of the form . Then we use our model to prove that all knots and links that can be produced by site-specific recombination on such substrates are contained in one of two…
GNNs improve brain activity forecasting in fMRI studies.
A new method approximates deep neural networks using Kalman Filters.
We develop a model characterizing all possible knots and links arising from recombination starting with a twist knot substrate, extending previous work of Buck and Flapan. We show that all knot or link products fall into three well-understood families of knots and links, and prove that given a positive integer , the…
Site-specific recombination on supercoiled circular DNA molecules can yield a variety of knots and catenanes. Twist knots are some of the most common conformations of these products and they can act as substrates for further rounds of site-specific recombination. They are also one of the simplest families of knots and …
We develop a topological model of knots and links arising from a single (or multiple processive) round(s) of recombination starting with an unknot, unlink, or (2,m)-torus knot or link substrate. We show that all knotted or linked products fall into a single family, and prove that the size of this family grows linearly …
A new hierarchy quantifies agency in systems based on information processing.
Graphs predict reaction conditions for organic chemistry.
The implementation of artificial neural networks in hardware substrates is a major interdisciplinary enterprise. Well suited candidates for physical implementations must combine nonlinear neurons with dedicated and efficient hardware solutions for both connectivity and training. Reservoir computing addresses the proble…
We establish that equally-spaced smectic configurations enjoy an infinite-dimensional conformal symmetry and show that there is a natural map between them and null hypersurfaces in maximally-symmetric spacetimes. By choosing the appropriate conformal factor it is possible to restore additional symmetries of focal struc…
A neural atlas simplifies 3D geometry simulation by avoiding meshing.
This thesis explores emergent intelligence in disordered systems like spin glasses and neural networks.
New Heintze-Karcher inequality helps understand droplet shapes.
The study learns neural update rules by remembering past experiences.
Multiplicative stochasticity such as Dropout improves the robustness and generalizability of deep neural networks. Here, we further demonstrate that always-on multiplicative stochasticity combined with simple threshold neurons are sufficient operations for deep neural networks. We call such models Neural Sampling Machi…
Adapts MBDOE for real-time parameter estimation in complex systems.
We explore the use of graph neural networks (GNNs) to model spatial processes in which there is no a priori graphical structure. Similar to finite element analysis, we assign nodes of a GNN to spatial locations and use a computational process defined on the graph to model the relationship between an initial function de…
AgensFlow learns multi-agent coordination policies from experience.
MEGAN models chemical reactions as graph edits, improving synthesis planning.
Site-specific recombination is an enzymatic process where two sites of precise sequence and orientation along a circle come together, are cleaved, and the ends are recombined. Site-specific recombination on a knotted substrate produces another knot or a two-component link depending on the relative orientation of the si…
We consider a disk-shaped thin elastic sheet bonded to a compliant sphere. (Our sheet can slip along the sphere; the bonding controls only its normal displacement.) If the bonding is stiff (but not too stiff), the geometry of the sphere makes the sheet wrinkle to avoid azimuthal compression. The total energy of this sy…
Cognitive brain imaging is accumulating datasets about the neural substrate of many different mental processes. Yet, most studies are based on few subjects and have low statistical power. Analyzing data across studies could bring more statistical power; yet the current brain-imaging analytic framework cannot be used at…
Financial asset markets are sociotechnical systems whose constituent agents are subject to evolutionary pressure as unprofitable agents exit the marketplace and more profitable agents continue to trade assets. Using a population of evolving zero-intelligence agents and a frequent batch auction price-discovery mechanism…
Enhances disease progression modeling using LLMs for complex brain connectivity.
An increasing body of evidence suggests that the trial-to-trial variability of spiking activity in the brain is not mere noise, but rather the reflection of a sampling-based encoding scheme for probabilistic computing. Since the precise statistical properties of neural activity are important in this context, many model…
GeomHerd predicts herding behavior before market prices move, using Ricci curvature of agent interaction graphs.
Study predicts social relationships using triadic influence from social networks.
Novel graph network learns hierarchical network structure.
A framework compares image representations based on local geometry.
We present a principled framework to address resource allocation for realizing boosting algorithms on substrates with communication or computation noise. Boosting classifiers (e.g., AdaBoost) make a final decision via a weighted vote from the outputs of many base classifiers (weak classifiers). Suppose that the base cl…
How do we assign value to economic transactions? To answer this question, we must consider whether the value of objects is inherent, is a product of social interaction, or involves other mechanisms. Economic theory predicts that there is an optimal price for any market transaction, and can be observed during auctions o…
We show that some pieces of cylinders bounded by two parallel straight-lines bifurcate in a family of periodic non-rotational surfaces with constant mean curvature and with the same boundary conditions. These cylinders are initial interfaces in a problem of microscale range modeling the morphologies that adopt a liquid…
METRO predicts reactions using minimal templates, reducing computational overhead and achieving state-of-the-art results.
How spiking networks are able to perform probabilistic inference is an intriguing question, not only for understanding information processing in the brain, but also for transferring these computational principles to neuromorphic silicon circuits. A number of computationally powerful spiking network models have been pro…
The Conant-Ashby theorem is verified for hypergraph observers, leading to unique learning rules.
For a biological agent operating under environmental pressure, energy consumption and reaction times are of critical importance. Similarly, engineered systems are optimized for short time-to-solution and low energy-to-solution characteristics. At the level of neuronal implementation, this implies achieving the desired …
Functional brain networks exhibit dynamics on the sub-second temporal scale and are often assumed to embody the physiological substrate of cognitive processes. Here we analyse the temporal and spatial dynamics of these states, as measured by EEG, with a hidden Markov model and compare this approach to classical EEG mic…
BNNs enhance reservoir computing by acting as generalization filters.
Instrumented data enables causal scientific machine learning
GPMI method interpolates uncertain atrial conduction velocity on non-Euclidean manifolds.
Method improves microbial biomass yield estimation from noisy data.
Quantum systems with scrambling improve temporal information processing, but scaling requires exponential overhead.
The paper models financial order books using geometric shears and directional liquidity.
The episodic, irregular and asynchronous nature of medical data render them difficult substrates for standard machine learning algorithms. We would like to abstract away this difficulty for the class of time-stamped categorical variables (or events) by modeling them as a renewal process and inferring a probability dens…
Agent-to-agent finance aims to manage payments and trust for AI agents.
Transformers mimic Bayesian reasoning in controlled settings, revealing geometric mechanisms.
Quantum ELMs use a quantum reservoir to learn from data, with limits on expressivity and scalability.