Deep models improve GWAS by identifying genetic interactions.
problem Missing non-linear interaction effects in GWAS.
method Gradient-based DeepLIFT technique to interpret deep models.
result Known and novel genetic risk factors identified.
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48 results for “genetic factors”
Sparse GFA identifies disease factors in FTD subgroups.
problem Heterogeneity in neurological disorders hinders understanding and treatment.
method Sparse Group Factor Analysis (GFA) with regularised horseshoe priors.
result Identified latent disease factors differentially expressed in FTD subgroups.
Genome-wide association studies (GWAS) have achieved great success in the genetic study of Alzheimer's disease (AD). Collaborative imaging genetics studies across different research institutions show the effectiveness of detecting genetic risk factors. However, the high dimensionality of GWAS data poses significant cha…
This study introduces a new GAS blending ensemble model for Bitcoin price prediction.
problem Predicting Bitcoin price fluctuations in the cryptocurrency market.
method Integrates advanced ensemble learning methods, feature selection algorithms, and sentiment analysis.
result The GAS model demonstrates excellent performance in daily Bitcoin trend prediction.
Enhances genetic programming for stock alpha discovery with warm start and structural constraints.
problem Overwhelming search space and computational burden in traditional genetic programming for alpha factor discovery.
method Proposes a new GP framework with warm start and structural constraints to enhance search performance and interpretability.
result Superior out-of-sample prediction results and higher portfolio returns compared to benchmarks.
New models capture complex genetic causes of diseases.
problem Capturing causal relationships between genetic factors and diseases.
method Implicit causal models combining neural architectures and Bayesian inference.
result Significantly outperformed existing genetics methods.
New method groups genetic data into coherent topics for disease insights.
problem Analyzing large, multi-dimensional genetic data sets.
method Conditional Hierarchical Bayesian Tucker Decomposition for genetic data analysis.
result Our models are more coherent than baseline models.
Bayesian method identifies multi-way interactions among predictors.
problem Identifying meaningful interactions among multiple variables.
method Factorization mechanism and Gibbs sampling for posterior inference.
result Posterior consistency of the regression model.
DL/FBF improves GPSR solutions by selecting compact, generalising expressions.
problem Overfitting and structural bloat in symbolic regression with genetic programming.
method Description length (DL) and fractional Bayes factor (FBF) criteria for selecting compact, generalising expressions.
result DL/FBF post-selection improves test performance compared to AIC/BIC baseline.
Extracting Epistatic Interactions in Type 2 Diabetes Genome-Wide Data Using Stacked Autoencodercs.LG
Deep learning detects genetic interactions in type 2 diabetes.
problem Detecting genetic interactions in complex diseases like type 2 diabetes.
method Stacked Autoencoder for non-linear epistatic interactions.
result Deep learning can uncover missing heritability in complex diseases.
ADNN uses prior knowledge to construct financial features.
problem Feature construction in financial trading.
method Tailored neural network structure with domain knowledge.
result ADNN constructs more informative features than genetic programming.
Method controls extrapolation in prediction profiles for statistical and machine learning models.
problem Avoiding invalid predictions due to extrapolation in prediction profiles.
method Genetic algorithm optimization over constrained factor regions.
result Optimal factor settings without constraint are often invalid and extrapolated.
Genome-wide association studies (GWAS) offer new opportunities to identify genetic risk factors for Alzheimer's disease (AD). Recently, collaborative efforts across different institutions emerged that enhance the power of many existing techniques on individual institution data. However, a major barrier to collaborative…
Covariance-Insured Screeningstat.ML
Method screens weakly associated predictors in high-dimensional data.
problem Identifying weakly associated predictors in ultrahigh-dimensional data.
method Covariance-insured screening methodology.
result Validates the method through simulations and real data studies.
BayesMR estimates causal effects and directionality from genetic data.
problem Challenges in finding good genetic instruments and estimating causal effects.
method Bayesian Mendelian randomization approach that accounts for pleiotropy and reverse causation.
result BayesMR provides a posterior distribution over causal effects and uncertainty.
Linear Mixed Models (LMMs) are important tools in statistical genetics. When used for feature selection, they allow to find a sparse set of genetic traits that best predict a continuous phenotype of interest, while simultaneously correcting for various confounding factors such as age, ethnicity and population structure…
Genetic Programming constructs features for physics experiments, improving classification accuracy.
problem Lack of interpretable feature construction for experimental physics.
method Combining Genetic Programming with dimensional consistency constraints.
result Constructed features improve classification accuracy by a significant margin.
A new model identifies genetic risk factors using gene-level priors.
problem Identifying genetic risk factors from nucleotide-level genetic variants.
method Sparse Group Lasso with Group-level Graph structure (SGLGG) model.
result SGLGG effectively identifies phenotype-associated risk SNPs.
ENN method uses expectile regression for genetic data analysis of complex diseases.
problem Discover additional genetic variants contributing to complex diseases.
method Developed an expectile neural network (ENN) method integrating expectile regression and neural networks.
result ENN method outperforms existing expectile regression in discovering genetic variants predisposing to sub-populations.
Semi-supervised GAN creates synthetic genetic data for disease prediction.
problem Expensive and time-consuming to build large labeled genetic databases.
method Semi-supervised Genetic Generative Adversarial Network (gGAN).
result Model achieved satisfactory results with real genetic data.
BoGA combines evolutionary search with Bayesian optimization for efficient protein design.
problem Designing novel proteins with specific characteristics is challenging due to sequence space complexity.
method BoGA integrates a genetic algorithm with Bayesian optimization to efficiently explore sequence space.
result BoGA accelerates discovery of high-confidence binders for diverse protein design objectives.
Efficiently infers graph edges from genetic similarity data in landscape genetics.
problem Inferring unknown graph edges from genetic similarity data in a heterogeneous landscape.
method Developed an efficient first-order optimization method to solve the inverse landscape genetics problem.
result Our method provides fast and reliable convergence, significantly outperforming existing heuristics.
Paper uses machine learning to analyze stock market anomalies, predicting drift direction and portfolio performance.
problem Capturing dynamics of Post-Earnings-Announcement Drift (PEAD) using machine learning.
method Uses Extreme Gradient Boosting (XGBoost) with genetic algorithm optimization to analyze PEAD dynamics.
result Demonstrates how PEAD dynamics are influenced by different factors across sectors and quarters.
System identifies health risks using semantic and machine learning.
problem Identifying risk factors associated with health conditions in subpopulations.
method Developed a combined semantic and machine learning system using a health risk ontology and knowledge graph.
result Dynamic discovery of risk factors and their subpopulations.
Method distinguishes genetic correlations from causation in GWAS.
problem Identifying causal relationships among genetically correlated traits.
method Mixed fourth moments to quantify causal relationships.
result Identified 30 putative genetically causal relationships across 52 traits.
Proposes a hybrid deep learning network for better heart failure survival prediction.
problem Improving survival prediction in heart failure patients.
method Joint analysis of cardiac motion features and clinical risk factors using a hybrid deep learning network.
result Optimal integration of clinical risk factors into deep prediction networks.
Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding task, especially in the presence of gene-gene interactions. A non-parametric Bayesian approach in the form o…
GPO uses genetic algorithms for deep policy optimization in reinforcement learning.
problem Catastrophic consequence of parameter crossovers in neural networks for deep reinforcement learning.
method GPO uses imitation learning for policy crossover in the state space and applies policy gradient methods for mutation.
result GPO achieves superior performance and comparable sample efficiency compared to state-of-the-art policy gradient methods.
Paper proposes NNAFC for automatic financial factor construction.
problem Manual factor construction is time-consuming and prone to bias.
method NNAFC uses neural networks to automatically construct diversified financial factors.
result NNAFC outperforms GP in constructing more informative and diversified factors.
Novel tests for genetic independence in high-dimensional data.
problem Testing independence in genetics studies with many variables.
method Defining premetric structures on genetic data support spaces.
result Solid theoretical framework and computationally-efficient implementations.
Improved genetic programming by optimizing mutation operators for continuous program search.
problem Small syntactic mutations in genetic programming can lead to unpredictable behavioral shifts.
method Learned a compact trading-strategy DSL, created a block-factorized embedding, and designed geometry-compiled mutation operators.
result Geometry-compiled mutation operators discover strong strategies using fewer evaluations and achieve higher Sharpe ratios.
Deep Genetic Networkcs.LG
Introduces Deep Genetic Network for optimizing neural network hyperparameters.
problem Optimizing neural network hyperparameters is a tedious and time-consuming task.
method Uses genetic algorithms within a deep neural network architecture to optimize hyperparameters during training.
result Deep Genetic Network successfully optimizes hyperparameters in various types of neural network layers.
This paper optimizes portfolio rebalancing under uncertain security returns using meta-heuristic algorithms.
problem Optimizing portfolio rebalancing under uncertain security returns with transaction costs.
method Meta-heuristic algorithms (genetic algorithm) for solving the portfolio rebalancing problem.
result Meta-heuristic algorithms provide better results than global optimization solvers for portfolio rebalancing under uncertainty.
GeNet classifies metagenomic sequences with less memory and comparable recall to state-of-the-art methods.
problem Classifying metagenomic sequences from raw DNA sequences.
method Exploits hierarchical structure between labels for training, using deep representations.
result GeNet achieves competitive precision and good recall with less memory requirements.
AlphaForge mines and dynamically combines alpha factors for better investment performance.
problem Inconsistency and inflexibility of fixed factor weights in alpha factor mining.
method Generative-predictive neural network for factor generation and dynamic weight adjustment.
result Demonstrated superior performance in formulaic alpha factor mining and portfolio returns.
Stein-Encoder isolates genetic signals in multi-modal biomedical data.
problem Integration of high-dimensional genomic data with clinical data obscures genetic predictive impact.
method White-box supervised framework using Stein's method and residualization.
result Stein-Encoder improves predictive accuracy and reveals specific biological mechanisms.
New method uses DNN for genetic variant identification, controlling randomness and improving interpretability.
problem Challenges in interpreting deep neural networks for genetic variant identification.
method Interpretable neural network model with controlled variable selection using ensembling, knockoffs, and de-randomization.
result The proposed method leads to more discoveries compared to conventional methods.
Novel method prioritizes genetic variants in nonlinear models.
problem Variable selection in nonlinear and nonparametric regression.
method Developed RATE measure for summarizing variable importance.
result RATE explains improved predictive accuracy of nonlinear models.
Genetic sequence data are well described by hidden Markov models (HMMs) in which latent states correspond to clusters of similar mutation patterns. Theory from statistical genetics suggests that these HMMs are nonhomogeneous (their transition probabilities vary along the chromosome) and have large support for self tran…
G2Ns combine genetic genes with neural networks for reinforcement learning.
problem Improving sample efficiency and performance in reinforcement learning.
method Genetic-Gated Networks (G2Ns) that integrate binary genetic genes with neural network hidden layers.
result G2Ns achieve significant improvements in sample efficiency and performance in reinforcement learning.
A Consolidated Volatility Prediction with Back Propagation Neural Network and Genetic Algorithmq-fin.CP
Paper uses AI to predict stock market volatility with neural networks and genetic algorithms.
problem Traditional methods for predicting stock market volatility have high errors.
method Back-propagation neural network and genetic algorithm integrated model.
result The model predicts future volatility with low errors and high accuracy.
A multilevel model combines genetic and imaging data for AD diagnosis.
problem Classification from multimodal genetic and brain imaging data with unbalanced contributions.
method Multilevel model with structured penalties for joint effects between modalities.
result The model reveals relationships between genes, brain regions, and disease status.
Predict genetic inheritance patterns using hypergraphs and latent models.
problem Diagnosing inherited diseases requires identifying family genetic patterns.
method Represent family trees as hypergraphs, use latent state space models for causal inference.
result Allows for explainable predictions of patient genotypes based on relatives' phenotypes.
In plant and animal breeding studies a distinction is made between the genetic value (additive + epistatic genetic effects) and the breeding value (additive genetic effects) of an individual since it is expected that some of the epistatic genetic effects will be lost due to recombination. In this paper, we argue that t…
Ensemble GP improves genetic programming by achieving better results with smaller models.
problem Improving genetic programming for binary classification problems.
method Ensemble GP uses an evolved population structure, fitness evaluation, and genetic operators inspired by ensemble learning methods.
result Ensemble GP outperformed standard GP on eight binary classification problems, achieving better results with smaller models.
Historical review of genetic algorithms for the TSP shows three distinct phases.
problem Optimizing routes for the Traveling Salesman Problem using genetic algorithms.
method Meta-data analysis of publications over time.
result Three distinct phases in the development of genetic algorithms for TSP identified.
Proposes new genetic algorithm rule for market competition.
problem Market competition genetic algorithm rules.
method Econophysics kinetic market model as an evolutionary algorithm.
result New replacement rule for genetic algorithms.
This paper compares Grid Search, Random Search, and Genetic Algorithm for NAS.
problem Hyperparameter optimization for neural architecture search.
method Comparison of Grid Search, Random Search, and Genetic Algorithm.
result Genetic Algorithm outperforms Grid Search and Random Search in terms of accuracy and execution time.