Sparse neural networks visualize paired transcriptomic and electrophysiological data.
problem Efficiently analyzing and visualizing paired multivariate neuroscientific data.
method Sparse deep neural networks with a two-dimensional bottleneck and group lasso penalty.
result Biologically interpretable two-dimensional visualizations of paired data.
VIND infers smooth nonlinear dynamics from electrophysiology data.
problem Analyzing smooth, nonlinear time series data from neuroscience experiments.
method Variational Inference for Nonlinear Dynamics (VIND) with structured approximate posterior and fixed-point iteration.
result VIND reconstructs 5D latent space variables similar to Hodgkin-Huxley models, and excels in predicting future neural activity.
Machine learning enhances cardiac arrhythmia treatment through predictive modelling.
problem Improving catheter ablation success rates for treating atrial fibrillation.
method Combining machine learning and predictive modelling with cardiac electrophysiology data.
result Enhanced accuracy in predicting and inferring parameters of cardiac models.
Model reconstructs missing EKG data more accurately than baseline.
problem Reconstruct missing EKG data with high accuracy.
method Developed a probabilistic model of cardiac electrophysiology and EKG measurement process.
result Model outperforms baseline in reconstructing missing EKG data.
Improved Schizophrenia diagnosis using brain signal features with limited observations.
problem Ambulatory diagnoses of neuronal diseases with limited brain signal data.
method Pairwise distance learning approach using Siamese neural network and cosine contrastive loss.
result Improved accuracy and sensitivity in Schizophrenia diagnosis (+10pp).
The paper highlights the importance of model discrepancy in cardiac simulations.
problem Uncertainty in model structure and equations affects predictions.
method The authors use Gaussian processes and autoregressive-moving-average models to account for model discrepancy.
result Different methods to account for model discrepancy have advantages and shortcomings.
This study shows how EEG can be used to generate fMRI data.
problem Mapping fMRI from EEG signals.
method Deep learning approaches (Autoencoders, GANs, Pairwise Learning).
result Feasibility of EEG to fMRI brain image mappings.
Proposes a nonparametric approach for inferring spike train filters.
problem Modeling neuron information encoding from electrophysiological recordings.
method Gaussian process framework for joint inference of filters and hyperparameters.
result Automatic learning of filter temporal span and stimulus/history filters.
Researchers use operator learning to predict cardiac activation and repolarization times.
problem Computational demands and need for clear, interpretable information in cardiac electrophysiology.
method Exploiting Fourier Neural Operators (FNO) and Kernel Operator Learning (KOL) to learn operator mappings.
result Both FNO and KOL approaches are computationally efficient and robust to hyperparameters.
Neural memory networks improve seizure type classification.
problem Automating the classification of seizure type for clinical and research purposes.
method Introduced a novel approach using neural memory networks (NMNs) enhanced with external memory modules and trainable neural plasticity.
result Achieved a state-of-the-art weighted F1 score of 0.945 for seizure type classification.
Bayesian optimization on cardiac models using a graph convolutional VAE.
problem Optimizing tissue properties in cardiac models with spatially varying properties.
method Graph convolutional VAE for generative modeling of non-Euclidean data.
result Effective optimization of cardiac tissue properties using a novel generative model.
Novel method embeds generative model into Bayesian optimization for HD cardiac model parameter estimation.
problem High-dimensional optimization of patient-specific cardiac model parameters with limited data.
method Embeds a generative variational auto-encoder into the objective function of Bayesian optimization.
result Improves accuracy of parameter estimation with more than 10x gain in efficiency.
This paper improves parameter estimation in cardiac models using Gaussian process-based MH sampling.
problem Uncertainty in estimating patient-specific model parameters from sparse and noisy clinical data.
method Integrates surrogate modeling into Metropolis-Hastings sampling to improve computational efficiency and accuracy.
result Significant gain in computational efficiency without compromising accuracy, and insights into tissue heterogeneity.
New classifier uses lower fidelity models to speed up expensive simulations.
problem Expensive computational models limit machine learning applications.
method Autoregressive model with Gaussian process priors, active learning, and sparse approximation.
result Median computational cost reduction of 23% for target accuracy of 90%.
This paper compares spike sorting techniques for rat brain neuronal activity.
problem Improving the accuracy of spike sorting for neuronal activity analysis.
method Three-step spike sorting process: detection, feature extraction, and clustering. Various methods are compared.
result Kernel PCA outperforms in feature extraction, leading to better spike sorting results.
We consider the problem of locating a point-source heart arrhythmia using data from a standard diagnostic procedure, where a reference catheter is placed in the heart, and arrival times from a second diagnostic catheter are recorded as the diagnostic catheter moves around within the heart. We model this situation as a …
Method extracts time-localized clusters to explain deep learning models in ECG analysis.
problem Limited understanding of deep learning models in ECG analysis.
method Extracts time-localized clusters from model's internal representations.
result Enhances trust in AI-driven diagnostics and reveals clinically relevant patterns.
Deep convolutional neural networks (CNNs) have demonstrated impressive performance on visual object classification tasks. In addition, it is a useful model for predication of neuronal responses recorded in visual system. However, there is still no clear understanding of what CNNs learn in terms of visual neuronal circu…
LISBET automates social behavior analysis using machine learning.
problem Manual annotation of social behaviors is time-consuming, biased, and misses subtle interactions.
method Self-supervised learning on body tracking data.
result Automated detection and segmentation of social interactions.
hyperSBINN improves drug cardiosafety assessment by efficiently modeling cardiac action potentials.
problem Complexity and limited data in modeling cardiac effects of drugs.
method Combining meta-learning with SBINNs to solve parameterized cardiac action potential models.
result hyperSBINN outperforms traditional solvers in speed and accuracy for predicting APD90 values.
Estimates neural representation dimensionality from small sample sizes.
problem Estimating neural representation dimensionality from limited data.
method Proposed a bias-corrected estimator for participation ratio of eigenvalues.
result The estimator is more accurate with finite samples and noise.
HNPE uses auxiliary data to estimate parameters in uncertain models.
problem Uncertain models with identical observations.
method Exploits global parameters from auxiliary data to estimate parameters.
result Validated on a motivating example and applied to neuroscience.
The increasing size and complexity of scientific data could dramatically enhance discovery and prediction for basic scientific applications. Realizing this potential, however, requires novel statistical analysis methods that are both interpretable and predictive. We introduce Union of Intersections (UoI), a flexible, m…
A method uses autoencoders to align multi-modal neuron data.
problem Inconsistent cell type definitions across different data modalities.
method Coupled training of autoencoders for cross-modal alignment.
result Representations learned by coupled autoencoders can identify single-modality sampled cell types.
Develops a method to interpret deep learning models by identifying key features.
problem Revealing the decision-making process of blackbox models from raw data to predictions.
method Adversarial attacks to localize discriminative features with statistical guarantees.
result Locally identified features are both biologically plausible and statistically significant.
GAME improves matrix completion by considering subgroup-specific latent structures.
problem Heterogeneous data with overlapping categories, smoothing away subgroup-specific variation.
method Group-Aware Matrix Estimation (GAME) with overlapping nuclear-norm penalties.
result GAME outperforms global low-rank estimators in structured missingness regimes.
New method handles indirect mediators in CMA for complex scenarios.
problem Handling indirect and multi-dimensional mediators in causal mediation analysis.
method Identifiable Variational Autoencoder (iVAE) architecture for multi-dimensional, indirectly observed mediators.
result Accurate estimation of direct and mediated effects in synthetic and semi-synthetic experiments.
New estimator corrects bias in CKA for sparsely sampled neurons.
problem Bias in CKA for sparsely sampled neurons.
method Novel estimator that corrects for input and feature sampling.
result Reliable model-to-brain alignment with sparsely sampled neurons.
Framework for reconstructing nonlinear systems from multi-modal time series data.
problem Reconstructing nonlinear dynamical systems from multi-modal time series data.
method Dynamic interpretable recurrent neural networks coupled with generalized linear models for multi-modal data integration.
result Framework efficiently compensates for noisy or missing information in one data channel using other channels.
Transfer learning improves EEG signal classification with less data.
problem Limited data for EEG signal classification.
method Transfer learning applied to deep learning models for EEG analysis.
result Outperformed top results in BCI competition IV by 33%.
G-FuNK learns solutions for nonlinear PDEs on multiple domains and parameters.
problem Predicting time-dependent dynamics of complex systems governed by nonlinear PDEs with varying parameters and domains.
method Graph Fourier Neural Kernels combining domain-adapted and transferable components for non-diffusive and diffusive terms.
result G-FuNK achieves low relative errors on unseen domains and fiber fields, significantly accelerating predictions.
Method detects batch heterogeneity in genomic data.
problem Batch effects confound genomic diagnostics.
method Bayesian model evidence clustering.
result Detects batch effects without known labels.
SOS-VAE improves generative models for scientific applications by correcting decoder bias.
problem Bias in generative parameters due to supervised learning in VAEs.
method Develops SOS-VAE framework to influence decoder for predictive latent representation.
result Ensures reliable generative parameters for scientific applications.
Identifies learning rules from neural network observables.
problem Determine the underlying plasticity rules governing learning in biological systems.
method Simulated idealized neuroscience experiments with artificial neural networks to generate a dataset of learning trajectories. Used linear and non-linear classifiers to identify learning rules from aggregate statistics of weights, activations, and activity changes.
result Different classes of learning rules can be separated solely on the basis of aggregate statistics of the weights, activations, or instantaneous layer-wise activity changes.
New method creates indistinguishable but misclassified ECG signals.
problem Adversarial examples fool deep neural networks in ECG classification.
method Developed a technique to generate smoothed adversarial examples for single-lead ECG.
result Adversarial examples are not unique and can be collated and perturbed.