A new method for virtual drug screening detects top treatments.
problem Understanding model performance in virtual drug screening tasks.
method Regression Enrichment Surfaces (RES) method.
result RES detects more top-performing treatments than existing methods.
Heteroskedasticity biases uplift model rankings, leading to inefficient treatment allocation.
problem Bias in uplift model rankings due to heteroskedasticity.
method Theoretical analysis and simulation on real-world data.
result Heteroskedasticity can cause individuals with high treatment effects to be ranked at the bottom, leading to inefficient treatment allocation.
The paper compares methods for estimating individual treatment effects.
problem Estimating the optimal treatment effect for each individual.
method Comparison of machine learning methods for individual treatment effect estimation.
result Combination of Logistic Regression and Difference Score method, as well as Uplift Random Forest method, provides the best prediction accuracy.
In personalised decision making, evidence is required to determine whether an action (treatment) is suitable for an individual. Such evidence can be obtained by modelling treatment effect heterogeneity in subgroups. The existing interpretable modelling methods take a top-down approach to search for subgroups with heter…
Proposes a deep learning framework for estimating counterfactual outcomes.
problem Challenges in estimating individual outcomes under different treatments.
method Deep variational Bayesian framework integrating factual and similar subjects' outcomes.
result Rigorously integrates individual features and similar subjects' responses for counterfactual outcomes.
Optimizes treatment allocation in networks considering indirect effects.
problem Finding optimal treatment allocation in network settings with interference.
method OTAPI: Optimizing Treatment Allocation in the Presence of Interference, integrating causal estimators into IM algorithms.
result OTAPI outperforms classic IM and UM approaches on synthetic and semi-synthetic datasets.
Q-Learner estimates ratio-based treatment effects without imposing parametric structures.
problem Estimating treatment effects as ratios in non-linear settings.
method Decomposes ratio-CATE into two classification tasks, using doubly robust augmentations.
result Q-Learner outperforms other methods in low-conversion and observational data settings.
The paper develops a method to optimize individualized treatment rules for cost-effectiveness.
problem Developing cost-effective individualized treatment rules for healthcare policy.
method Using conditional random forest and net-monetary-benefit (NMB) to estimate optimal CE-ITR.
result The approach optimizes healthcare resource allocation by maximizing health gains and minimizing costs.
WEINCE improves contrastive learning by correcting softmax biases.
problem Softmax in InfoNCE can lead to misaligned statistical assumptions in contrastive learning.
method WEINCE uses anchor-wise online batch statistics to blend softmax logits with an endpoint shortfall correction.
result WEINCE yields consistent improvements in frozen-feature evaluation across five vision benchmarks.
Multivariate techniques based on engineered features have found wide adoption in the identification of jets resulting from hadronic top decays at the Large Hadron Collider (LHC). Recent Deep Learning developments in this area include the treatment of the calorimeter activation as an image or supplying a list of jet con…
Many computational models were proposed to extract temporal patterns from clinical time series for each patient and among patient group for predictive healthcare. However, the common relations among patients (e.g., share the same doctor) were rarely considered. In this paper, we represent patients and clinicians relati…
Abstract: Rational decomposition of homeomorphism spaces for manifolds.
problem Constructing rational homotopy pullback decompositions for homeomorphism spaces.
method Rational homotopy pullback decomposition, nullhomotopy of stabilisation maps, tensor products of truncated operads.
result Rational section of the stabilisation map for homeomorphisms of R^d.
Unified model optimizes experiment performance and reduces duration.
problem Balancing reward maximization and experiment termination.
method Unified model that considers both within-experiment and post-experiment outcomes.
result Familiar algorithms can optimize a broad class of objectives with proper parameter adjustment.
A new method corrects for bias in selecting the best candidate.
problem Bias in selecting the best candidate leads to invalid conclusions.
method Zoom correction, flexible for parametric and nonparametric settings.
result Valid inference on the winner is possible, even with selection bias.
This paper introduces a novel low-cost device prototype for the automatic diagnosis of diseases, utilizing inputted symptoms and personal background. The engineering goal is to solve the problem of limited healthcare access with a single device. Diagnosing diseases automatically is an immense challenge, owing to their …
New algorithms find all ε-good arms in stochastic bandits.
problem Finding all arms with means above a specified threshold in stochastic bandits.
method Two algorithms introduced to identify all ε-good arms.
result Demonstrated great empirical performance on large datasets.
Dr.S recommends cancer drugs based on genomic data.
problem Personalizing cancer treatments using genomic information.
method Machine learning to identify optimal drug-gene associations.
result Developed a Drug Recommendation System (Dr.S) for cancer cell lines.
A statistical description and model of individual healthcare expenditures in the US has been developed for measuring value in healthcare. We find evidence that healthcare expenditures are quantifiable as an infusion-diffusion process, which can be thought of intuitively as a steady change in the intensity of treatment …
Paper analyzes trade-offs in top-k classification accuracies and proposes a new loss function.
problem CE loss does not always optimize top-k prediction, especially with complex data.
method Introduces a novel top-k transition loss to improve top-k accuracy.
result Our loss function improves top-k accuracy, especially for k > 10.
Spectral feature learning improves IV regression for causal effect estimation.
problem Estimating causal effects in the presence of hidden confounders.
method Two-stage least squares estimator based on spectral features.
result Performance of the method depends on strong spectral alignment and slow eigenvalue decay.
TyXe enables flexible Bayesian neural networks in Pytorch.
problem Uncertainty estimation in neural networks.
method Separates architecture, prior, inference, and likelihood specification; modular choices for priors, guides, and inference techniques.
result Minimal modifications to existing code for Bayesian neural networks.
Top/O's first two k-invariants are zero.
problem Understanding the structure of Top/O.
method Analyzing the first two k-invariants.
result The first two k-invariants of Top/O vanish.
GraphITE estimates individual effects of graph-structured treatments.
problem Estimating individual effects of complex treatment structures.
method Graph neural networks and Hilbert-Schmidt Independence Criterion regularization.
result GraphITE outperforms baselines in estimating treatment effects for large numbers of treatments.
M3E2 neural network estimates multiple treatment effects.
problem Estimating effects of multiple treatments simultaneously.
method Multi-task learning neural network model for multiple treatments, continuous and binary.
result M3E2 outperforms baselines in synthetic datasets.
Class ambiguity is typical in image classification problems with a large number of classes. When classes are difficult to discriminate, it makes sense to allow k guesses and evaluate classifiers based on the top-k error instead of the standard zero-one loss. We propose top-k multiclass SVM as a direct method to optimiz…
The top-k error is often employed to evaluate performance for challenging classification tasks in computer vision as it is designed to compensate for ambiguity in ground truth labels. This practical success motivates our theoretical analysis of consistent top-k classification. Surprisingly, it is not rigorously und…
Proposes a new method to estimate continuous treatment policies and match treatments effectively.
problem Current methods struggle with continuous treatment policies and complex matching.
method Formulates treatment effectiveness as a parametrizable model, using deep learning for optimization.
result Significant improvement in treatment effectiveness and matching efficiency.
Paper introduces a new loss function for deep imbalanced classification.
problem Class ambiguity and imbalance in large datasets.
method Stochastic top-K hinge loss based on smoothed top-K operator.
result Our loss function significantly outperforms other baseline loss functions in imbalanced datasets.
Framework generates personalized insulin treatment strategies using deep models.
problem Developing optimal personalized treatment strategies for diabetes patients.
method Combines deep generative time series models with decision theory.
result Demonstrated improved personalized insulin treatment strategies for diabetes patients.
Unified model for prediction and deferral selects top-k entities efficiently.
problem Efficiently selecting top-k entities for deferral in machine learning.
method One-stage Top-k Learning-to-Defer framework with a convex surrogate. result Unified model achieves superior accuracy-cost trade-offs.
Develops deep jump learning for continuous treatment OPE.
problem Estimating mean outcomes under new treatment rules using historical data from different rules.
method Adaptive deep discretization of continuous treatment space using deep learning and multi-scale change point detection.
result Validated method through theoretical results, simulations, and real application to Warfarin Dosing.
Work on making classifiers robust against adversarial attacks for top-k predictions.
problem Vulnerability of classifiers to adversarial perturbations, especially for top-k predictions.
method Randomized smoothing to turn any classifier into a robust one, using Gaussian noise.
result Derives a tight robustness in ℓ2 norm for top-k predictions, achieving 62.8% certified top-5 accuracy on ImageNet.
Proposes top-label calibration and M2B framework for multiclass to binary calibration.
problem Multiclass calibration and interpretation issues.
method Top-label calibration and M2B reduction framework.
result M2B + HB achieves lower calibration error than other methods.
Method controls treatment risk in learning beneficial allocations.
problem Learning beneficial treatment allocations with risk control in precision medicine.
method Proposes a certifiable learning method that controls treatment risk with finite samples in the partially identified setting.
result Illustrates method using both simulated and real data.
Optimal adaptive experiment for choosing best treatment with binary outcomes.
problem Choosing the best treatment from binary options in an adaptive experiment.
method Adaptive experiment with two phases: treatment allocation and choice. Neyman allocation method used.
result Neyman allocation is minimax and Bayes optimal, matching lower bounds for regret.
Proposes a fusion method for many treatment groups in ITRs.
problem Challenges in handling many treatment groups with data sparsity and covariate imbalance.
method Calibration-weighted treatment fusion procedure that balances covariates and fuses similar treatments.
result Ensures robust treatment group recovery and policy value compared to existing methods.
Dynamic treatment effects estimated over time using covariate balancing.
problem Estimating treatment effects in panel data with dynamic treatments.
method Dynamic covariate balancing with potential local projections.
result Established inferential guarantees for the proposed method.
A new method learns outcome-aware spectral features for causal effect estimation.
problem Estimation of causal effects in the presence of hidden confounders.
method Augmented Spectral Feature Learning framework that minimizes a contrastive loss derived from an augmented operator incorporating outcome information.
result Our method remains effective even under spectral misalignment.
In order to push the performance on realistic computer vision tasks, the number of classes in modern benchmark datasets has significantly increased in recent years. This increase in the number of classes comes along with increased ambiguity between the class labels, raising the question if top-1 error is the right perf…
CRN model estimates treatment effects over time using adversarial balancing.
problem Estimating treatment effects over time in medical settings.
method Adversarial domain balancing to remove time-varying confounders.
result CRN achieves lower error in estimating counterfactuals and treatment timing.
Estimates heterogeneous treatment effects in panel data with a new method.
problem Estimating heterogeneous treatment effects in panel data with general treatment patterns.
method Partition observations into clusters with similar treatment effects using a regression tree, then estimate average treatment effects for each cluster.
result Our method achieves superior accuracy compared to alternative approaches.
In treatment allocation problems the individuals to be treated often arrive sequentially. We study a problem in which the policy maker is not only interested in the expected cumulative welfare but is also concerned about the uncertainty/risk of the treatment outcomes. At the outset, the total number of treatment assign…
NICE model estimates causal effects for image treatments.
problem Challenges in causal effect estimation for multi-dimensional treatments.
method Proposes NICE model for image treatments, incorporating rich multidimensional information.
result NICE significantly outperforms existing models in estimating causal effects for image treatments.
Smoothed top-k operator improves model training efficiency.
problem Discontinuous top-k operation makes models untrainable end-to-end.
method SOFT top-k operator approximates top-k as EOT solution.
result Improved performance in k-nearest neighbors and beam search.
XTNet estimates complex cross-treatment effects in multi-category, multi-valued settings.
problem Challenges in estimating causal effects for multi-category, multi-valued treatments.
method Dynamic Neural Masking for capturing treatment interactions without restrictive assumptions.
result XTNet consistently outperforms state-of-the-art baselines in multi-category, multi-valued treatment effect estimation.
Personalized medicine aims at identifying best treatments for a patient with given characteristics. It has been shown in the literature that these methods can lead to great improvements in medicine compared to traditional methods prescribing the same treatment to all patients. Subgroup identification is a branch of per…
The paper proposes a method to precisely decompose confounders and estimate treatment effects.
problem Estimating treatment effects from observational data with confounder identification and balancing.
method Learning decomposed representations to identify and balance confounders and non-confounders.
result The method achieves more precise treatment effect estimation than existing methods.
RATE metrics evaluate treatment prioritization rules, subsuming existing methods.
problem Comparing and testing the quality of treatment prioritization rules.
method Rank-weighted average treatment effect (RATE) metrics.
result RATE metrics enable asymptotically exact inference in various study settings.