The paper improves patient targeting in pharmaceutical sales by predicting treatment delays.
problem Improving accuracy in predicting treatment delays for patients.
method A time-sensitive targeting framework using a time series model with extracted features and look-forward periods.
result Improved accuracy in predicting treatment delays for patients.
In rare disease physician targeting, a major challenge is how to identify physicians who are treating diagnosed or underdiagnosed rare diseases patients. Rare diseases have extremely low incidence rate. For a specified rare disease, only a small number of patients are affected and a fractional of physicians are involve…
Traditional medicine typically applies one-size-fits-all treatment for the entire patient population whereas precision medicine develops tailored treatment schemes for different patient subgroups. The fact that some factors may be more significant for a specific patient subgroup motivates clinicians and medical researc…
FalconBC improves patient-specific cardiovascular modeling by estimating boundary conditions efficiently.
problem Efficiently estimating boundary conditions in patient-specific cardiovascular models, especially in open-loop models and anatomies with lesions.
method A general amortized inference framework based on probabilistic flow that treats clinical targets and anatomies as conditioning variables.
result Demonstrated on two patient-specific models, FalconBC improves efficiency and accuracy in estimating boundary conditions.
Model predicts missed doses and targets TB patients more effectively.
problem Improving adherence to TB treatment using digital data.
method Deep learning model trained on 17k TB patients' adherence data.
result Model predicts 21% more patients at risk of missing doses.
Deep learning predicts response to HER2-targeted breast cancer therapy.
problem Predicting response to HER2-targeted neoadjuvant chemotherapy.
method Developed and validated a deep learning approach using pre-treatment dynamic breast MRI.
result Deep learning model achieved strong performance in predicting pathological complete response.
Objective: Predict patient-specific vitals deemed medically acceptable for discharge from a pediatric intensive care unit (ICU). Design: The means of each patient's hr, sbp and dbp measurements between their medical and physical discharge from the ICU were computed as a proxy for their physiologically acceptable state …
In this paper, we introduce the use of a personalized Gaussian Process model (pGP) to predict the key metrics of Alzheimer's Disease progression (MMSE, ADAS-Cog13, CDRSB and CS) based on each patient's previous visits. We start by learning a population-level model using multi-modal data from previously seen patients us…
Proposes a framework for personalized treatment recommendations using observational data.
problem Estimating patient-level treatment effects from observational data.
method Integrates existing methods for learning patient-level causal models.
result Improves patient outcomes in heart failure patients with acute kidney injury.
MetaPred uses meta-learning to improve clinical risk prediction from limited EHR data.
problem Clinical risk prediction from sparse patient EHR data.
method Meta-learning approach to train a meta-learner from related tasks, then fine-tune for target risk prediction.
result MetaPred achieves better performance for target risk prediction with limited data.
Bedside monitors in Intensive Care Units (ICUs) frequently sound incorrectly, slowing response times and desensitising nurses to alarms (Chambrin, 2001), causing true alarms to be missed (Hug et al., 2011). We compare sliding window predictors with recurrent predictors to classify patient state-of-health from ICU multi…
SurvFM-RMST converts survival outcomes into pseudo-observation targets for tabular models.
problem Right-censored follow-up prevents direct use of survival labels in tabular patient data.
method SurvFM-RMST framework that converts survival outcomes into jackknife pseudo-observation targets for restricted mean survival time.
result SurvFM-RMST accurately recovered restricted event-free time in simulations and outperformed naive targets in static datasets.
We present a personalized and reliable prediction model for healthcare, which can provide individually tailored medical services such as diagnosis, disease treatment, and prevention. Our proposed framework targets at making personalized and reliable predictions from time-series data, such as Electronic Health Records (…
T-LSTM autoencoder improves chronic kidney disease patient representation.
problem Improving latent representations from irregularly sampled clinical data.
method Time-Aware Long Short-Term Memory Autoencoder.
result Significant improvements in learnt representations on synthetic and real datasets.
New DTI model using self-attention molecule representation outperforms state-of-the-art.
problem Predicting drug-target interactions to reduce costs and improve personalized medicine.
method Proposes a new molecule representation using self-attention and a new DTI model.
result Our DTI model outperforms state-of-the-art by up to 4.9% points in precision-recall.
Model identifies key problems in HIV patients' records.
problem Complex and time-consuming task of identifying patient problems from electronic health records.
method Unsupervised phenotyping approach that jointly learns phenotypes from structured and unstructured data.
result Learned phenotypes and their relatedness are clinically valid and surpass existing methods.
A novel framework synthesizes treatment data across sites using optimal transport.
problem Estimating treatment effects across different sites with varying conditions.
method Distributional causal inference, Optimal Transport for alignment of control group distributions.
result Synthetic treatment group data aligns with true target distribution under general conditions.
FRESH combines patient-level and aggregate-level data for better clinical decision making.
problem Combining patient-level and aggregate-level data for clinical decision making.
method FRESH method that re-calibrates a patient-level model to match specified aggregate statistics.
result Unified data-efficient model for clinical decision making.
SepVAE separates patient-specific patterns from healthy ones using contrastive VAE.
problem Separating patient-specific patterns from healthy ones in medical datasets.
method SepVAE uses a contrastive VAE with disentangling and classification losses to differentiate between common and salient features.
result SepVAE outperforms previous methods in three medical applications and a CelebA dataset.
Models predict patients at risk of uncontrolled hypertension.
problem Identifying patients at risk of uncontrolled hypertension.
method Developed machine learning models (logistic regression and recurrent neural networks) using EHR data.
result Best model achieved AUROC of 0.719, outperforming baseline.
Participants enrolled into randomized controlled trials (RCTs) often do not reflect real-world populations. Previous research in how best to translate RCT results to target populations has focused on weighting RCT data to look like the target data. Simulation work, however, has suggested that an outcome model approach …
Estimates causal effects from patient trajectories using DeepACE model.
problem Estimating causal effects from observational data in medical practice.
method DeepACE model using iterative G-computation formula and sequential targeting procedure.
result DeepACE achieves state-of-the-art performance in estimating time-varying ACEs.
Improves survival analysis across multiple domains with machine learning.
problem Adapting survival analysis to new or rare illness types with limited labeled data.
method Introduces a new survival metric and discrepancy measure for censored data, enabling domain adaptation.
result Superb performance on target domains, better treatment recommendations, and interpretable weight matrix.
We aim to create a framework for transfer learning using latent factor models to learn the dependence structure between a larger source dataset and a target dataset. The methodology is motivated by our goal of building a risk-assessment model for surgery patients, using both institutional and national surgical outcomes…
Method uses random forest with distance covariance for transfer learning in healthcare.
problem Transfer learning in random forests with sparse differences between source and target.
method Distance covariance-based feature weights in residual random forest.
result Upper bound on mean square error rate for transfer learning in RF.
CAPITAL algorithm identifies optimal patient subgroups for better treatment.
problem Identify maximum number of patients benefiting from better treatment.
method Constrained Policy Tree Search (CAPITAL) algorithm to find optimal subgroup selection rule (SSR).
result Maximizes the number of patients with enhanced treatment effects.
RATE metrics evaluate treatment prioritization rules, subsuming existing methods.
problem Comparing and testing the quality of treatment prioritization rules.
method Rank-weighted average treatment effect (RATE) metrics.
result RATE metrics enable asymptotically exact inference in various study settings.
Study predicts which patients will benefit from digital health interventions.
problem Unclear targeting of patients for digital care management programs.
method Analyzed claims data, combined with sociodemographic and app-generated data. Created two models: cost prediction and impactability classification.
result Random forest model accurately categorized patients as impactable or not, achieving 71.9% accuracy.
This Perspective provides examples of current and future applications of deep learning in pharmacogenomics, including: (1) identification of novel regulatory variants located in noncoding domains and their function as applied to pharmacoepigenomics; (2) patient stratification from medical records; and (3) prediction of…
Trans-GLMC tackles source heterogeneity in transfer learning for structured clusters.
problem Source heterogeneity makes it hard to use multiple related auxiliary sources effectively.
method Trans-GLMC constructs clusters of sources, then combines global fusion, within-cluster refinement, and target debiasing.
result Improves facility-specific prediction and identifies interpretable communities of hospitals with mutual transferability.
Optimizes personalized medicine prediction by individual tuning.
problem Predicting individual drug responses using genomic information.
method Introduces a new ridge estimator and tuning parameter calibration scheme.
result Optimal in terms of oracle inequalities, fast, and highly effective.
Unified framework for response-adaptive targeting in multi-treatment experiments
problem Improving ethical and statistical efficiency in multi-treatment clinical trials
method Response-adaptive targeting strategies
result Unified framework for α-Rebalancing Targeting Strategies (αRTS) The use of drug combinations, termed polypharmacy, is common to treat patients with complex diseases and co-existing conditions. However, a major consequence of polypharmacy is a much higher risk of adverse side effects for the patient. Polypharmacy side effects emerge because of drug-drug interactions, in which activi…
Strong baseline for medical imaging domain adaptation.
problem Improving generalization in medical imaging across different datasets.
method Training on diverse chest X-ray datasets.
result Empirical demonstration of model generalization to out-of-sample domains.
The study uses transfer learning to compare surgical outcomes across racial/ethnic subgroups.
problem Difficulty in comparing surgical outcomes due to racial/ethnic and geographic differences.
method Causal inference framework and transfer learning to incorporate data from multiple populations.
result Racial and ethnic differences in surgical outcomes are found, with non-Hispanic Black patients experiencing wide variability.
Proposes a method to correct for covariate shift in meta-analysis of randomized trials.
problem Invalidation of standard IPD meta-analysis due to covariate shift across studies.
method Placebo-anchored transport framework that treats source-trial outcomes as proxy signals and target-trial placebo outcomes as gold labels.
result Yields target-identified effect estimates in connected targets and a principled screen--then--transport procedure in disconnected targets.
Paper proposes a fast method to detect changes in audiometric function.
problem Detecting changes in psychometric function estimation quickly and accurately.
method Bayesian active differential selection for pure-tone audiogram testing.
result Fewer tones can detect changes in audiometric function with high confidence.
Random shuffle method boosts HF dataset size 10-21 times.
problem Narrow dataset cardinality in HF clinical studies.
method Random shuffle method to enhance dataset size.
result Enhanced HF dataset size 10-21 times.
New method estimates optimal personalized treatment rules from mixed data sources.
problem Combining RCT and observational data for personalized treatment rules.
method Doubly robust estimator for value function, maximizing within pre-specified ITR class.
result Consistent and asymptotically normal optimal value estimator with N−1/3 rate of convergence. Proposes a method to improve treatment policies in data-scarce clinical settings.
problem Improving treatment policies in data-scarce clinical settings with unobserved confounding.
method Uses a causal mechanism to model the underlying generative process and augments counterfactual trajectories with source domain priors.
result Significantly improves treatment policy performance in a simulated sepsis treatment task.
Objective: Anemia is a frequent comorbidity in hemodialysis patients that can be successfully treated by administering erythropoiesis-stimulating agents (ESAs). ESAs dosing is currently based on clinical protocols that often do not account for the high inter- and intra-individual variability in the patient's response. …
Study describes severe dengue ICU patients in Brazil, 2012-2024.
problem Characterize severe dengue ICU patients and identify risk factors.
method Prospective study, descriptive statistics, logistic regression, machine learning.
result Advanced age, comorbidities, leukocytes, and platelets are significant risk factors for complications.
Study estimates treatment effect on survival outcomes using targeted maximum likelihood estimation.
problem Estimating treatment effect on time-to-event outcomes in clinical settings.
method Divided into three phases: estimation, feature selection, and targeted maximum likelihood estimation.
result Method performs well in high sample size or event rate conditions.
HOLMES improves real-time model serving for ICU patients, balancing accuracy and speed.
problem Real-time model serving is crucial in ICU due to urgency and cost.
method Online model ensemble serving framework for healthcare applications.
result HOLMES achieves high accuracy and sub-second latency for model ensemble serving.
Improved forecasting of suicide attempts using LSGPs for patients with little data.
problem Challenges in predicting suicide attempts due to their rarity and patient heterogeneity.
method Introduced Latent Similarity Gaussian Processes (LSGPs) to capture patient heterogeneity.
result LSGPs outperform baseline models, even without kernel-design, and offer new insights into patient similarity.
New method targets relative risk heterogeneity in clinical trials.
problem Identifying treatment effects across subgroups with absolute risk differences.
method Modified causal forests using a novel node-splitting procedure based on relative risk.
result Relative risk causal forests can capture heterogeneity not detected by absolute risk methods.
The paper proposes a method to predict the performance of data-driven algorithms using surrogate models.
problem Improving the performance prediction of data-driven knowledge discovery algorithms.
method Surrogate-assisted performance prediction using evolutionary modeling of clinical pathways.
result The proposed approach provides interpretable prediction of algorithm performance and quality.
Efficiently fine-tunes patient-independent seizure detection models with tensor kernel machine.
problem Improving seizure detection accuracy for wearable devices.
method Transfer learning with tensor kernel machine using canonical polyadic decomposition.
result Patient fine-tuned model achieves high performance with smaller model size.