FRESH combines patient-level and aggregate-level data for better clinical decision making.
problem Combining patient-level and aggregate-level data for clinical decision making.
method FRESH method that re-calibrates a patient-level model to match specified aggregate statistics.
result Unified data-efficient model for clinical decision making.
CEDAR efficiently analyzes distributed EHR data without sharing patient-level info.
problem Analyzing patient-level data from multiple EHRs databases without sharing raw data.
method Tackles by turning problem into missing data, incorporating posterior samples.
result Improves efficiency and privacy of parameter estimates in sparse regressions.
Proposes a framework for personalized treatment recommendations using observational data.
problem Estimating patient-level treatment effects from observational data.
method Integrates existing methods for learning patient-level causal models.
result Improves patient outcomes in heart failure patients with acute kidney injury.
Bayesian CNN improves MRI stroke diagnosis accuracy and uncertainty quantification.
problem Uncertainty quantification in automated image analysis for medical decision-making.
method Bayesian Convolutional Neural Network (CNN) with aggregation methods for patient-level diagnoses.
result Bayesian CNN achieved 95.33% accuracy on 511 patients, 2% higher than non-Bayesian.
New model captures patient-level EHR data efficiently.
problem Irregular EHR code timing and lack of temporal structure.
method Latent factor point process model with Fourier-Eigen embedding.
result Efficiently captures subgroup-specific temporal patterns.
CAT framework improves AI medical screening fairness and reliability.
problem Imbalanced data, varying performance across cohorts, and patient-level inconsistencies in traditional metrics.
method CAT framework introduces patient-level assessment, entropy-based distribution weighting, and cohort-weighted sensitivity and specificity.
result Enhanced predictive reliability, fairness, and interpretability of AI-driven medical screening models.
Tensor factorization models offer an effective approach to convert massive electronic health records into meaningful clinical concepts (phenotypes) for data analysis. These models need a large amount of diverse samples to avoid population bias. An open challenge is how to derive phenotypes jointly across multiple hospi…
A new model improves homogeneity in burn patient reimbursement.
problem Incomplete homogeneity checks for burn patients using LOS as a proxy.
method Cost-sensitive decision tree model considering patient-level cost and severity of burn.
result Identified groups with increased homogeneity compared to current HRG groups.
With continuous glucose monitoring (CGM), data-driven models on blood glucose prediction have been shown to be effective in related work. However, such (CGM) systems are not always available, e.g., for a patient at home. In this work, we conduct a study on 9 patients and examine the online predictability of data-driven…
A new method boosts survival analysis by stratifying patients and removing noise covariates.
problem Weak detection of treatment differences in randomized clinical trials due to patient heterogeneity.
method 5-Step Stratified Testing and Amalgamation Routine (5-STAR) using elastic net Cox regression and conditional inference trees.
result The 5-STAR routine significantly improves power in detecting treatment effects compared to traditional methods.
Computational Drug Repositioning (CDR) is the task of discovering potential new indications for existing drugs by mining large-scale heterogeneous drug-related data sources. Leveraging the patient-level temporal ordering information between numeric physiological measurements and various drug prescriptions provided in E…
A conjecturing machine uncovers feature relationships in data.
problem Discovering nonlinear and boolean relationships among features.
method Proposes a conjecturing machine that suggests feature relationships using bounds and expressions.
result Reveals true underlying relationships in datasets.
Objective: The advent of Electronic Medical Records (EMR) with large electronic imaging databases along with advances in deep neural networks with machine learning has provided a unique opportunity to achieve milestones in automated image analysis. Optical coherence tomography (OCT) is the most commonly obtained imagin…
Study finds that only a fraction of data is needed for accurate patient-level prediction models.
problem Developing predictive models for patient-level outcomes using large observational data.
method Empirical assessment of sample size effects on model performance and complexity using learning curves.
result A median reduction of 9.5% to 78.5% in the number of observations and 8.6% to 68.3% in the number of predictors can be achieved with adequate sample size.
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a rapid motor decline, leading to respiratory failure and subsequently to death. In this context, researchers have sought for models to automatically predict disease progression to assisted ventilation in ALS patients. However, the clin…
Computational models that forecast the progression of Alzheimer's disease at the patient level are extremely useful tools for identifying high risk cohorts for early intervention and treatment planning. The state-of-the-art work in this area proposes models that forecast by using latent representations extracted from t…
Malaria is a life-threatening disease affecting millions. Microscopy-based assessment of thin blood films is a standard method to (i) determine malaria species and (ii) quantitate high-parasitemia infections. Full automation of malaria microscopy by machine learning (ML) is a challenging task because field-prepared sli…
Framework detects brain tumors robustly from MRI images.
problem Low clinical incidence of brain tumor cases makes diagnosis challenging.
method YOLOv8n for detection, DeiT for classification, PTP metric for evaluation.
result F1-score of 0.92 achieved with reduced computational resources.
Kernel method optimizes personalized dose rules for patients.
problem Finding optimal individualized dose rules for patients.
method Kernel assisted learning method for estimating optimal dose rules.
result The method identifies the optimal individualized dose rule and produces favorable outcomes.
MCU-Net combines U-Net and Monte Carlo Dropout for uncertainty in medical image segmentation.
problem Lack of uncertainty representation in deep learning methods for patient-centered healthcare decisions.
method MCU-Net framework using U-Net and Monte Carlo Dropout with four uncertainty metrics.
result MCU-Net maximizes automated performance and refers truly uncertain cases.
The widespread digitization of patient data via electronic health records (EHRs) has created an unprecedented opportunity to use machine learning algorithms to better predict disease risk at the patient level. Although predictive models have previously been constructed for a few important diseases, such as breast cance…
Proposes statistical inference for dependency knowledge graphs from EHR data.
problem Statistical uncertainty in linking entities in EHR data.
method Dynamic log-linear topic model with singular value decomposition.
result Established asymptotic normality for sparse graph edge recovery.
Deep learning ensembles improve COVID-19 detection from chest X-rays.
problem Detecting COVID-19 from chest X-rays using machine learning.
method Custom CNN and ImageNet models, transfer learning, iterative pruning, ensemble learning.
result 99.01% accuracy in detecting COVID-19 from chest X-rays.
Proposes a method to correct for covariate shift in meta-analysis of randomized trials.
problem Invalidation of standard IPD meta-analysis due to covariate shift across studies.
method Placebo-anchored transport framework that treats source-trial outcomes as proxy signals and target-trial placebo outcomes as gold labels.
result Yields target-identified effect estimates in connected targets and a principled screen--then--transport procedure in disconnected targets.
While deep learning has shown promise in the domain of disease classification from medical images, models based on state-of-the-art convolutional neural network architectures often exhibit performance loss due to dataset shift. Models trained using data from one hospital system achieve high predictive performance when …
In recent times, machine learning (ML) and artificial intelligence (AI) based systems have evolved and scaled across different industries such as finance, retail, insurance, energy utilities, etc. Among other things, they have been used to predict patterns of customer behavior, to generate pricing models, and to predic…
Background. Real-world data show that approximately 50% of psoriasis patients treated with a biologic agent will discontinue the drug because of loss of efficacy. History of previous therapy with another biologic, female sex and obesity were identified as predictors of drug discontinuations, but their individual predic…
Bayesian model forecasts hospital resource use during pandemic.
problem Modeling constrained hospital resources during pandemic.
method Approximate Bayesian Computation for an ACED-HMM.
result Mechanistic approach provides competitive probabilistic forecasts.
New diagnostics detect variability in individual risk estimates from machine learning models in healthcare.
problem Variability in individual risk estimates from machine learning models in healthcare, leading to unreliable treatment decisions.
method Proposed evaluation framework using empirical prediction interval width and empirical decision flip rate diagnostics.
result Randomness in optimization and initialization can lead to substantial individual-level variability in risk estimates, affecting clinical decisions.
Machine learning models outperform traditional actuarial methods in predicting health insurance costs.
problem Improving accuracy in health insurance pricing to identify concession opportunities.
method Developed and evaluated two machine learning models at the patient and employer-group levels.
result Machine learning models outperformed traditional actuarial models by 20% in predicting costs.
Digital twins improve single-arm trials by providing robust treatment effect estimates.
problem Lack of control arms in single-arm trials limits their gold-standard evidence.
method Outcome-model-based synthetic controls using machine learning models trained on historical data.
result Digital twins offer more robust treatment effect estimates and principled corrections.
Bayesian model enhances phenotype discovery in asthma EHRs.
problem Lack of interpretability in unsupervised learning phenotyping of EHR data.
method Operationalized a Bayesian latent class framework with clinical knowledge priors.
result Identified an asthma sub-phenotype with elevated eosinophil levels and allergy markers.
TRACER improves interpretability in high stakes analytics.
problem Interpreting complex models in high stakes applications.
method TRACER framework with TITV model for healthcare analytics.
result TRACER facilitates both accurate and interpretable analytics.
Bayesian meta-learning improves health prediction models across similar diseases.
problem Inter- and intra-task variability in healthcare predictions due to disease heterogeneity and patient differences.
method Bayesian meta-learning approach that models task similarity to mitigate negative transfer and improve generalizability.
result Significant generalizability improvements in stroke prediction tasks using electronic health record data.
MLHO predicts COVID-19 adverse outcomes using past medical records.
problem Predicting adverse outcomes after COVID-19 infection.
method Iterative feature and algorithm selection, sequential representation mining.
result Mean AUC ROC of 0.91 for mortality prediction.
Analyzes COVID-19 data to predict mortality, forecast spread, and optimize resource allocation.
problem Challenges in patient triage, treatment, and care management during the pandemic.
method Integrated four-step approach combining descriptive, predictive, and prescriptive analytics.
result Optimized resource allocation and informed policy decisions.
A benchmark evaluates ioUS-to-MR synthesis methods for brain tumor surgery.
problem Difficult interpretation of ioUS images for brain tumor surgery.
method Six generators trained under four inference regimes and two targets on public data.
result SynDiff-2.5D best preserved downstream segmentation (U_Dice=0.55).