Study investigates how machine learning models degrade over time, leading to patient safety issues.
problem Overtime degradation of machine learning models in clinical settings.
method Used MIMIC-IV dataset to train models replicating commercial approaches, observing and analyzing degradation over a decade.
result An RNN model built on Epic features degrades from 0.729 AUC to 0.525 AUC over a decade, highlighting technical and clinical drift as root causes.
SDF-Bayes finds safe drug combinations safely, balancing optimism and caution.
problem Finding safe drug combinations in clinical trials with multiple drugs and patient heterogeneity.
method SDF-Bayes uses Bayesian statistics to choose the most likely MTD while ensuring safety constraints.
result SDF-Bayes outperforms existing methods in both accuracy and safety for drug combination trials.
C3T-Budget optimizes drug efficacy in dose-finding trials with budget and safety constraints.
problem Heterogeneous patient populations and budget constraints make dose-finding clinical trials challenging.
method Contextual constrained clinical trial algorithm that maximizes drug efficacy while learning subgroup responses.
result Demonstrates efficient budget usage and balanced learning-treatment trade-off in simulated trials.
Proposes a framework for personalized treatment recommendations using observational data.
problem Estimating patient-level treatment effects from observational data.
method Integrates existing methods for learning patient-level causal models.
result Improves patient outcomes in heart failure patients with acute kidney injury.
Paper proposes a fast method to detect changes in audiometric function.
problem Detecting changes in psychometric function estimation quickly and accurately.
method Bayesian active differential selection for pure-tone audiogram testing.
result Fewer tones can detect changes in audiometric function with high confidence.
SEEDA optimizes dose allocation in clinical trials to balance efficacy and safety.
problem Complex relationships between efficacy and toxicity in new drug trials.
method Adaptive clinical trial methodology that maximizes cumulative efficacy while ensuring safety constraints.
result SEEDA outperforms existing methods in finding optimal doses with higher success rates and fewer patients.
Recent progress in deep learning is revolutionizing the healthcare domain including providing solutions to medication recommendations, especially recommending medication combination for patients with complex health conditions. Existing approaches either do not customize based on patient health history, or ignore existi…
We develop a prediction-based prescriptive model for learning optimal personalized treatments for patients based on their Electronic Health Records (EHRs). Our approach consists of: (i) predicting future outcomes under each possible therapy using a robustified nonlinear model, and (ii) adopting a randomized prescriptiv…
Paper shows Cox model optimisation leaks patient data in distributed learning.
problem Risk of patient data leakage in distributed learning models.
method Optimisation of Cox survival model using federated learning.
result Optimisation process can leak patient data, necessitating new validation methods.
A framework identifies worst-case decision points in safety-critical scenarios, improving risk assessment by 10 hours.
problem Identifying worst-case outcomes in safety-critical decision-making under uncertainty.
method Explicitly estimating distributions of expected return to identify dead-ends, tuning based on risk tolerance.
result Significantly improves risk assessment, providing indications 10 hours earlier and increasing detection by 20%.
Study assesses weakly-supervised methods for rare outcomes in medical records.
problem Identifying patients with specific medical conditions using electronic health records.
method Compared three methods (PheNorm, MAP, and sureLDA) in simulations with varying outcomes and silver labels.
result No single method consistently outperformed others, but sureLDA often did well.
New methods use RL and DA to improve dosing precision and reduce side effects.
problem Improving precision and safety of anticancer drug dosing.
method Bayesian data assimilation and reinforcement learning.
result Significantly reduces incidence of severe side effects.
New method combines multiple datasets to estimate ATE with valid confidence intervals.
problem Combining multiple observational datasets to estimate ATE with valid confidence intervals.
method Prediction-powered inferences to shrink CIs and provide valid CIs.
result Valid confidence intervals for ATE from multiple datasets.
New method calibrates neural network uncertainty for medical images.
problem Uncalibrated probabilistic outputs from deep neural networks in medical diagnosis.
method Functional space variational inference for Bayesian neural networks.
result Better calibrated uncertainty estimates at lower computational cost.
Machine learning promises to revolutionize clinical decision making and diagnosis. In medical diagnosis a doctor aims to explain a patient's symptoms by determining the diseases \emph{causing} them. However, existing diagnostic algorithms are purely associative, identifying diseases that are strongly correlated with a …
Interventional cancer clinical trials are generally too restrictive, and some patients are often excluded on the basis of comorbidity, past or concomitant treatments, or the fact that they are over a certain age. The efficacy and safety of new treatments for patients with these characteristics are, therefore, not defin…
CSP improves time-series forecasting without training, outperforming DeepNPTS in speed and accuracy.
problem Improving probabilistic time-series forecasting without training.
method Mixing empirical and residual draws around a seasonal naive forecast.
result CSP significantly outperforms DeepNPTS on CRPS, normalized mean quantile loss, and coverage metrics.
Study improves forecasting of ED crowding using advanced ML models.
problem Improving forecasting of emergency department crowding.
method Advanced machine learning models (N-BEATS, LightGBM, DeepAR) using multivariable input data.
result N-BEATS and LightGBM outperform benchmarks in forecasting ED occupancy.
RLVR maintains safety while improving reasoning capabilities in LLMs.
problem Safety-capability tradeoff in fine-tuning LLMs.
method Reinforcement Learning with Verifiable Rewards (RLVR) and theoretical analysis.
result RLVR can enhance reasoning while maintaining safety guardrails.
The paper reviews machine learning safety techniques for autonomous vehicles.
problem Challenges in machine learning safety for autonomous vehicles.
method Organizes practical safety techniques to complement engineering safety.
result Enhances dependability and safety of machine learning algorithms in autonomous vehicles.
Research tackles safety of deep learning in safety-critical tasks.
problem Safety concerns of deep learning in perception tasks for autonomous agents.
method Technical enumeration and discussions on safety concerns and mitigation methods.
result Need for more mitigation methods to ensure safety of deep learning.
Causal ML predicts treatment outcomes, aiding personalized medicine.
problem Predicting individualized treatment effects for personalized medicine.
method Flexible, data-driven methods using causal inference with clinical trial and real-world data.
result Causal ML allows for estimating individualized treatment effects.
The paper discusses safety assessment for AI systems, focusing on machine learning models.
problem Safety assessment of AI systems, especially machine learning models, in safety-related applications.
method Analyzed AI models as statistical models and proposed a new budget allocation for AI safety.
result Safety assessment of AI systems requires a new approach focusing on the model used, not just the system.
Fine-tuning LLMs improves capability but harms safety, study finds.
problem Balancing capability and safety in LLM fine-tuning.
method Theoretical framework and numerical experiments for two safety-aware fine-tuning strategies.
result Characterization of fundamental limits of safety-capability trade-off in LLM fine-tuning.
RAGuard improves safety in LLMs for offshore wind maintenance.
problem Conventional LLMs fail with specialised or unexpected scenarios in offshore wind maintenance.
method Integrates safety-critical documents alongside technical manuals in RAG framework.
result RAGuard increases safety recall from almost 0% to over 50% while maintaining technical recall above 60%.
Survey of algorithms for testing AI-driven CPS safety.
problem Testing AI-driven CPS for safety in complex environments.
method Survey of applied algorithms for safety validation.
result Survey of existing tools and techniques for safety validation.
Safe imitation learning with a safety layer for flexible training.
problem Flexible yet safe imitation learning for complex tasks.
method Theory and modular method with a safety layer for continuous policy, adversarial training, and worst-case safety guarantees.
result Robustness advantage of safety layer during training compared to test time.
This paper formalizes AI safety using hypothesis testing in GenAI.
problem Ensuring safety of generative AI tools that create realistic content.
method Formalization of computational safety through hypothesis testing and signal processing.
result Demonstrates how AI safety can be assessed quantitatively using mathematical frameworks.
Objective: A median of 14.4% of patient undergone at least one adverse event during surgery and a third of them are preventable. The occurrence of adverse events forces surgeons to implement corrective strategies and, thus, deviate from the standard surgical process. Therefore, it is clear that the automatic identifica…
A new algorithm for identifying the best arm in linear feedback with safety constraints.
problem Identifying the best arm in linear feedback with safety constraints.
method A gap-based algorithm that ensures safety while minimizing sample complexity.
result The algorithm achieves meaningful sample complexity while ensuring safety.
Safety filter for unknown discrete-time systems with learned models and noise covariance.
problem Ensuring safety for unknown discrete-time linear systems with Gaussian noise.
method Develops a learning-based safety filter using empirical model and noise covariance, optimizing control actions to stay within safety constraints.
result Minimally modifies nominal control actions to ensure safety with high probability, tightening constraints as more data is collected.
Proposes a framework to assess model robustness to dataset shifts.
problem Evaluating model robustness to changes in setting or population.
method Derives a debiased estimator for analyzing performance on worst-case distributions.
result Demonstrates the estimator can account for realistic shifts in complex distributions.
SafeML monitors ML systems for safety and security risks.
problem Ensuring safety and explainability of ML systems in safety-critical domains.
method Statistical difference measures of ECDF to detect distributional shifts.
result Approach can detect invalid application contexts of ML components.
Paper defines and quantifies safety risks in deep neural networks.
problem Safety concerns in deep neural networks applied to critical sectors.
method Defines safety property, computes maximum safe radius, identifies new risk class, develops algorithm.
result Method achieves competitive performance in safety quantification.
Study best arm identification with safety constraints in bandit problems.
problem Real-world decision-making with safety constraints.
method Analyzed linear and monotonic reward and safety constraints, proposed algorithms.
result Guaranteed safe learning in both linear and general reward/safety constraint settings.
Failures are challenging for learning to control physical systems since they risk damage, time-consuming resets, and often provide little gradient information. Adding safety constraints to exploration typically requires a lot of prior knowledge and domain expertise. We present a safety measure which implicitly captures…
Safe reinforcement learning tackles safety constraints with linear approximations.
problem Ensuring safety in reinforcement learning without violating constraints.
method Modeling safety as a linear cost function, developing SLUCB-QVI and RSLUCB-QVI algorithms for MDPs with linear function approximation.
result Achieved a nearly optimal regret bound for safe reinforcement learning, matching state-of-the-art unsafe algorithms.
Enhances safety of 3D object detection neural networks.
problem Ensuring robustness and safety of 3D object detection systems.
method Symbolic error propagation, specialized loss function, safety-aware non-max-inclusion algorithm.
result Improved safety and robustness of 3D object detection neural networks.
Each year, around 6 million car accidents occur in the U.S. on average. Road safety features (e.g., concrete barriers, metal crash barriers, rumble strips) play an important role in preventing or mitigating vehicle crashes. Accurate maps of road safety features is an important component of safety management systems for…
CARL safely adapts RL agents for safety-critical tasks.
problem Safety hazards in RL for safety-critical tasks.
method CARL combines model-based RL and cautious adaptation.
result CARL achieves higher rewards with fewer failures in safety-critical tasks.
A novel approach for safe offline RL using latent safety constraints.
problem Balancing safety constraints and reward maximization in offline RL.
method Conditional Variational Autoencoders for latent safety modeling, Constrained Reward-Return Maximization.
result Our approach maintains safety compliance while optimizing rewards, outperforming existing methods.
New method improves safety analytics by addressing imbalanced data issues.
problem Imbalanced safety datasets lead to inaccurate predictions and management problems.
method Extended accident triangle theory and three oversampling methods.
result Robust improvements in machine learning algorithms for safety analytics.
LLM safety alignment explained as divergence estimation.
problem Aligning large language models to avoid harmful outputs.
method Presented a theoretical framework showing alignment methods as divergence estimators.
result KLDO method improves safety alignment using compliance-refusal datasets.
Machine learning algorithms increasingly influence our decisions and interact with us in all parts of our daily lives. Therefore, just as we consider the safety of power plants, highways, and a variety of other engineered socio-technical systems, we must also take into account the safety of systems involving machine le…
Safe Bayesian Optimization algorithms are improved to ensure safety in real-world applications.
problem Ensuring safety in Bayesian Optimization algorithms for real-world applications.
method Investigated and improved three safety-related issues of SafeOpt-type algorithms: frequentist uncertainty bounds, RKHS norm assumptions, and discrete search spaces.
result Introduced Real-{eta}-SafeOpt, Lipschitz-only Safe Bayesian Optimization (LoSBO), and Lipschitz-only GP-UCB (LoS-GP-UCB) algorithms that retain safety guarantees and superior performance.
Study examines uncertainty in adversarially trained models and proposes improved AT methods.
problem Uncertainty quantification in adversarially trained models for safety-critical applications.
method Investigates conformal prediction (CP) for adversarial attacks, proposes Beta-weighting loss with entropy minimization for improved prediction set size (PSS).
result Proposed AT-UR method improves CP efficiency and prediction set size.
Improved forecasting of suicide attempts using LSGPs for patients with little data.
problem Challenges in predicting suicide attempts due to their rarity and patient heterogeneity.
method Introduced Latent Similarity Gaussian Processes (LSGPs) to capture patient heterogeneity.
result LSGPs outperform baseline models, even without kernel-design, and offer new insights into patient similarity.
Researchers introduce a method to assess the safety of interpretable machine learning models.
problem Ensuring safety in machine learning models that are easy to understand.
method Introduce maximum deviation as an optimization problem to find the largest deviation from a safe reference model.
result Interpretability helps in assessing the safety of machine learning models.