Proposes methods for learning optimal dynamic treatment regimes robust to unconfoundedness violations.
problem Estimating optimal dynamic treatment regimes using historical observational data when unconfoundedness is violated.
method Utilizes proximal causal inference framework to propose three nonparametric identification methods, a (K+1)-robust method, and establish a semiparametric efficiency bound.
result Establishes the (K+1)-robust method for learning optimal dynamic treatment regimes, validating its efficiency and multiple robustness through numerical experiments.
The paper develops methods to estimate optimal treatment sequences under policy constraints.
problem Estimating the best sequence of treatments over multiple stages for individuals.
method Empirical welfare maximization approach, solving treatment assignment sequentially or simultaneously.
result Established convergence rates and upper bounds for estimation methods.
Paper proposes robust methods for estimating optimal treatment rules with censored survival data.
problem Estimating optimal treatment rules for censored survival data.
method Developed two robust criteria and a sampling-based difference-of-convex algorithm for learning optimal treatment rules.
result Proposed methods show improved performance compared to existing methods in simulations and real data.
Method uses semi-supervised learning to estimate optimal treatment regimes from medical records.
problem Estimating optimal treatment regimes from electronic medical records.
method Imputation-based semi-supervised method using unlabeled data.
result Proposed method yields more efficient estimators of optimal treatment regimes.
Bayesian model ranks treatments in multi-response experiments.
problem Identifying the best treatment among competing ideal properties.
method Bayesian approach with Markov Chain Monte Carlo algorithm.
result Reliable inference of treatment ranks in practice.
Optimal adaptive experiment for choosing best treatment with binary outcomes.
problem Choosing the best treatment from binary options in an adaptive experiment.
method Adaptive experiment with two phases: treatment allocation and choice. Neyman allocation method used.
result Neyman allocation is minimax and Bayes optimal, matching lower bounds for regret.
A new method improves efficiency in finding optimal personalized treatment rules.
problem Heteroscedasticity and misspecified treatment-free effect models affect optimal ITR estimation.
method E-Learning framework that accounts for covariate-treatment dependent variance of residuals.
result E-Learning framework improves efficiency of optimal ITR estimation.
Optimizes treatment allocation in networks considering indirect effects.
problem Finding optimal treatment allocation in network settings with interference.
method OTAPI: Optimizing Treatment Allocation in the Presence of Interference, integrating causal estimators into IM algorithms.
result OTAPI outperforms classic IM and UM approaches on synthetic and semi-synthetic datasets.
Develops methods for near-optimal personalized treatment recommendations.
problem Assigning optimal treatments to patients based on individual characteristics.
method Outcome weighted learning framework to estimate near-optimal alternative individualized treatment recommendations (A-ITR).
result Consistency of proposed methods and upper bound for risk between optimal and estimated recommendations.
A novel framework synthesizes treatment data across sites using optimal transport.
problem Estimating treatment effects across different sites with varying conditions.
method Distributional causal inference, Optimal Transport for alignment of control group distributions.
result Synthetic treatment group data aligns with true target distribution under general conditions.
Method learns optimal treatment sequences from observational data.
problem Optimal dynamic treatment regimes for public policies and medical interventions.
method Doubly robust classification-based approach via backward induction.
result Achieves optimal convergence rate of n^(-1/2) for welfare regret.
In treatment allocation problems the individuals to be treated often arrive sequentially. We study a problem in which the policy maker is not only interested in the expected cumulative welfare but is also concerned about the uncertainty/risk of the treatment outcomes. At the outset, the total number of treatment assign…
Framework integrates mental disorder measurements for personalized treatment.
problem Optimizing treatment for mental disorders with latent mental states and heterogeneity.
method Measurement theory and multi-layer neural network for complex treatment effects.
result Learned treatment policies outperform alternatives on heterogeneous treatment effects.
Optimal treatment regime uses proxy variables to improve decision-making.
problem Insufficient covariates in observational data lead to confounding issues.
method Proximal causal inference framework and outcome/treatment confounding bridges.
result The proposed optimal treatment regime outperforms existing ones.
LI-ITR combines flexible ML with interpretable approximations for personalized treatment rules.
problem Combining flexibility and interpretability in personalized treatment rules.
method Uses variational autoencoders and a mixture of interpretable experts.
result Accurately recovers true local coefficients and optimal treatment strategies.
Paper proves optimality of doubly robust estimators for treatment effects.
problem Estimating treatment effects in causal inference.
method Structure-agnostic framework of statistical lower bounds, using non-parametric regression and classification oracles.
result Doubly robust estimators are statistically optimal for ATE and ATT.
Develops methods to learn optimal treatment regimes using causal tree methods.
problem Lack of methods for estimating treatment effects and handling complex patient data.
method Causal tree and causal forest methods for estimating heterogeneous treatment effects.
result Outperforms state-of-the-art baselines in cumulative regret and percentage of optimal decisions.
New methods optimize personalized treatment assignment in trials with many arms.
problem Poor performance of standard methods in trials with many treatment arms.
method Regularized and clustered joint assignment forest algorithm.
result Gains in predicting arm-wise outcomes and utility gains from personalization.
Optimal treatment regimes (OTR) are individualised treatment assignment strategies that identify a medical treatment as optimal given all background information available on the individual. We discuss Bayes optimal treatment regimes estimated using a loss function defined on the bivariate distribution of dichotomous po…
Q-learning adapted to find near-equivalent treatment strategies.
problem Finding optimal treatment sequences in dynamic treatment regimes.
method Introducing a worst-value tolerance criterion to find sets of near-equivalent policies.
result Constructs families of near-equivalent treatment strategies.
Optimizes treatment duration to maximize quality-adjusted lifetime.
problem Balancing risks and benefits in clinical decision making.
method Proposes a weighted estimating equation to adjust for confounding and informative censoring, and a nonparametric estimator for mean counterfactual quality-adjusted lifetime.
result Shows the optimal time for percutaneous endoscopic gastrostomy insertion in ALS patients.
Study optimal and equitable encouragement policies for treatment adherence.
problem Optimal treatment adherence policies in the presence of human non-adherence.
method Covariate-conditional no-direct-effect model of encouragement; tractable policy characterizations under constraints.
result Induced treatment take-up is the fairness target, not recommendation rates.
New method evaluates personalized treatment in critical care, robust to death.
problem Truncation by death in critical care makes traditional DTR evaluation ineffective.
method Principal stratification-based approach, focusing on always-survivor value function, with a semiparametrically efficient, multiply robust estimator.
result Demonstrates robustness and efficiency of the method for personalized treatment optimization.
The paper addresses treatment recommendation problems by optimizing distributional characteristics.
problem Optimizing treatment recommendations based on distributional targets.
method Characterizes the problem's difficulty and proposes near-optimal policies.
result Characterizes the difficulty of the problem and proposes near-regret optimal policies.
Proposes ESCFR to estimate treatment effects from biased data.
problem Treatment selection bias in observational data.
method Stochastic optimal transport with relaxed mass-preserving and proximal factual outcome regularizers.
result Significantly better performance in estimating treatment effects.
EHR-MPC optimizes sepsis treatment using digital twins and inference-time control.
problem Optimal sepsis treatment policies are contested and difficult to adapt during inference.
method EHR-MPC decouples learning patient dynamics from treatment optimization, enabling inference-time control over learned digital twins.
result EHR-MPC achieves comparable off-policy performance and improved simulation performance compared to RL baselines.
Proposes a new method for dynamic treatment regimes that improves sample efficiency and stability.
problem Challenges in estimating optimal treatments for individuals with dynamic decision-making stages.
method Focuses on prioritizing alignment between observed and optimal treatment trajectories across decision stages.
result Improves sample efficiency and stability of IPWE-based methods by relaxing the alignment requirement.
Efficiently find near-optimal medical treatments with less trial and error.
problem Finding effective medical treatments through trial and error.
method Formalizes the problem, uses a causal inference framework, and proposes model-based dynamic programming and greedy algorithms.
result Our methods compare favorably to model-free reinforcement learning, offering a more transparent trade-off between search time and treatment efficacy.
A new algorithm learns optimal personalized treatment plans online with low regret.
problem Learning optimal dynamic treatment regimes in an online setting.
method Developed a novel algorithm balancing exploration and exploitation for rate-optimal regret.
result Guaranteed rate-optimal regret for linear transition and reward models.
The paper proposes a new policy for optimal treatment allocation based on quantile treatment effects.
problem Optimal treatment allocation policies that target distributional welfare, especially when individuals are heterogeneous.
method The approach involves allocating treatments based on the conditional quantile of individual treatment effects (QoTE), considering both prudent and negligent policymakers.
result The proposed minimax policies are robust to model uncertainty and can be generalized to various settings.
We propose a new procedure for inference on optimal treatment regimes in the model-free setting, which does not require to specify an outcome regression model. Existing model-free estimators for optimal treatment regimes are usually not suitable for the purpose of inference, because they either have nonstandard asympto…
Paper optimizes experimental design for estimating treatment effect.
problem Estimating treatment effect with heterogeneous subjects and treatments.
method Adaptive experimental design incorporating bandit learning.
result Demonstrates optimality of proposed adaptive experiment framework.
CAPITAL algorithm identifies optimal patient subgroups for better treatment.
problem Identify maximum number of patients benefiting from better treatment.
method Constrained Policy Tree Search (CAPITAL) algorithm to find optimal subgroup selection rule (SSR).
result Maximizes the number of patients with enhanced treatment effects.
Proposes a new method to estimate continuous treatment policies and match treatments effectively.
problem Current methods struggle with continuous treatment policies and complex matching.
method Formulates treatment effectiveness as a parametrizable model, using deep learning for optimization.
result Significant improvement in treatment effectiveness and matching efficiency.
There is a fast-growing literature on estimating optimal treatment regimes based on randomized trials or observational studies under a key identifying condition of no unmeasured confounding. Because confounding by unmeasured factors cannot generally be ruled out with certainty in observational studies or randomized tri…
Optimizes balanced treatment assignment for experiments.
problem Balancing treatment groups in experiments for optimal results.
method Optimization of a two-sample test, using minimum spanning tree test.
result Optimal assignment algorithm with polynomial time complexity.
Many scientific questions require estimating the effects of continuous treatments. Outcome modeling and weighted regression based on the generalized propensity score are the most commonly used methods to evaluate continuous effects. However, these techniques may be sensitive to model misspecification, extreme weights o…
SAFER improves personalized treatment recommendations for dynamic clinical contexts.
problem Personalized treatment optimization in evolving clinical contexts with safety concerns.
method Integrates structured EHR and clinical notes, uses conformal prediction for safe recommendations.
result SAFER outperforms state-of-the-art baselines in recommendation metrics and mortality rates.
The paper develops deep learning models for personalized treatment rules in survival analysis.
problem Deriving optimal treatment rules for bivariate survival outcomes in randomized trials.
method Adaptive prediction-powered learning using deep neural networks and stochastic policies.
result Maximizes joint survival probability beyond fixed time points (t1,t2). Enhances credit card limit adjustments by considering treatment uncertainty and prediction criteria.
problem Optimal treatment selection under multitreatment scenarios.
method Proposes a comprehensive methodology incorporating conditional value-at-risk and prediction criterion for continuous outcomes.
result Significantly improved policy performance in credit card limit adjustments.
The vision for precision medicine is to use individual patient characteristics to inform a personalized treatment plan that leads to the best healthcare possible for each patient. Mobile technologies have an important role to play in this vision as they offer a means to monitor a patient's health status in real-time an…
Optimal biomarker combinations for treatment-selection can be derived by minimizing total burden to the population caused by the targeted disease and its treatment. However, when multiple biomarkers are present, including all in the model can be expensive and hurt model performance. To remedy this, we consider feature …
Neural network feature optimization for causal inference.
problem Estimating heterogeneous treatment effects from data.
method Genetic algorithm optimization of intermediate neural network layers for feature representations.
result Retains useful features for outcome prediction even if related to treatment assignment.
The estimation of optimal treatment regimes is of considerable interest to precision medicine. In this work, we propose a causal k-nearest neighbor method to estimate the optimal treatment regime. The method roots in the framework of causal inference, and estimates the causal treatment effects within the nearest neig…
The complexity of human cancer often results in significant heterogeneity in response to treatment. Precision medicine offers potential to improve patient outcomes by leveraging this heterogeneity. Individualized treatment rules (ITRs) formalize precision medicine as maps from the patient covariate space into the space…
We study the problem of policy evaluation and learning from batched contextual bandit data when treatments are continuous, going beyond previous work on discrete treatments. Previous work for discrete treatment/action spaces focuses on inverse probability weighting (IPW) and doubly robust (DR) methods that use a reject…
Study compares methods for treatment assignment, finding A-learner best for playlist generation.
problem Treatment assignment in various applications.
method Three classes of algorithms: O-learner, E-learner, A-learner.
result Optimizing for outcomes or causal effects does not lead to optimal treatment assignments.
Proposes a new decision rule for continuous treatments.
problem Developing personalized treatment recommendations for continuous treatments.
method Jump interval-learning method to estimate conditional mean of outcomes.
result Optimal interval-valued decision rule (I2DR) for continuous treatments.