The opioid epidemic in the United States claims over 40,000 lives per year, and it is estimated that well over two million Americans have an opioid use disorder. Over-prescription and misuse of prescription opioids play an important role in the epidemic. Individuals who are prescribed opioids, and who are diagnosed wit…
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48 results for “opioid use disorder”
Identifying Risk of Opioid Use Disorder for Patients Taking Opioid Medications with Deep Learningcs.LG
Deep learning predicts opioid use disorder risk in patients.
problem Identifying patients at high risk of opioid use disorder.
method Applied LSTM models to analyze electronic health records of opioid users.
result LSTM model outperformed other methods with F1 score of 0.8023 and AUCROC of 0.9369.
Computational chemists typically assay drug candidates by virtually screening compounds against crystal structures of a protein despite the fact that some targets, like the Opioid Receptor and other members of the GPCR family, traverse many non-crystallographic states. We discover new conformational states of …
Opioid overdose is a growing public health crisis in the United States. This crisis, recognized as "opioid epidemic," has widespread societal consequences including the degradation of health, and the increase in crime rates and family problems. To improve the overdose surveillance and to identify the areas in need of p…
Enhanced framework selects features for unbiased causal inference.
problem Unbiased estimation of causal quantities in causal inference.
method Three-stage computational framework balancing treatment and non-treatment variables.
result Significantly reduces bias and variance in estimating causal quantities.
The dearth of prescribing guidelines for physicians is one key driver of the current opioid epidemic in the United States. In this work, we analyze medical and pharmaceutical claims data to draw insights on characteristics of patients who are more prone to adverse outcomes after an initial synthetic opioid prescription…
Opioid addiction is a severe public health threat in the U.S, causing massive deaths and many social problems. Accurate relapse prediction is of practical importance for recovering patients since relapse prediction promotes timely relapse preventions that help patients stay clean. In this paper, we introduce a Generati…
Paper proposes a machine learning-based method for estimating mediation effects.
problem Challenges in estimating mediation effects with multiple, continuous mediators.
method Developed a one-step estimation algorithm using machine learning and Riesz learning.
result Proposed method can estimate mediation effects from just two statistical estimands.
Model predicts drug overdose hotspots using EMS and toxicology data.
problem Predicting drug overdose hotspots to focus limited services.
method Spatial-temporal point process model integrating EMS and toxicology data.
result Model improves prediction accuracy by integrating heterogeneous data.
Study uses interviews to automatically detect BD and BPD with good accuracy.
problem Challenges in distinguishing BD and BPD from clinical interviews.
method Developed a multi-modal dataset and used a linear classifier with selected features from interviews.
result Different sets of features characterize BD and BPD, providing insights into their differences.
A signature-based machine learning model for bipolar disorder and borderline personality disorderstat.ML
Mobile technologies offer opportunities for higher resolution monitoring of health conditions. This opportunity seems of particular promise in psychiatry where diagnoses often rely on retrospective and subjective recall of mood states. However, getting actionable information from these rather complex time series is cha…
ED-Filter improves eating disorder classification on Twitter.
problem High dimensionality and extensive feature sets in Twitter data for ED classification.
method Informed branch and bound search technique with hybrid greedy-based deep learning.
result Significant improvements in classification accuracy and efficiency.
Study on a pinning model with random walk increments, showing convergence to a critical disordered pinning measure.
problem Understanding the critical behavior of a disordered pinning model.
method Analyzing a disordered pinning model induced by a random walk with specific moment conditions, showing convergence to a limiting measure.
result Convergence of point-to-point partition functions to the critical disordered pinning measure in the critical window.
Automated detection of voice disorders with computational methods is a recent research area in the medical domain since it requires a rigorous endoscopy for the accurate diagnosis. Efficient screening methods are required for the diagnosis of voice disorders so as to provide timely medical facilities in minimal resourc…
Glottal Closure Instants Detection From Pathological Acoustic Speech Signal Using Deep Learningcs.SD
In this paper, we propose a classification based glottal closure instants (GCI) detection from pathological acoustic speech signal, which finds many applications in vocal disorder analysis. Till date, GCI for pathological disorder is extracted from laryngeal (glottal source) signal recorded from Electroglottograph, a d…
As a mental disorder progresses, it may affect brain structure, but brain function expressed in brain dynamics is affected much earlier. Capturing the moment when brain dynamics express the disorder is crucial for early diagnosis. The traditional approach to this problem via training classifiers either proceeds from ha…
The study predicts how discussions in mental disorder Reddit communities affect users' emotional states.
problem Improving mental health conditions through social support analysis.
method Text embedding techniques and RNNs for predicting emotional tone shifts.
result Users' emotional states can improve due to social support, as evidenced by positive comments following negative posts.
Vocal disorders have affected several patients all over the world. Due to the inherent difficulty of diagnosing vocal disorders without sophisticated equipment and trained personnel, a number of patients remain undiagnosed. To alleviate the monetary cost of diagnosis, there has been a recent growth in the use of data a…
Whole MILC learns brain disorder dynamics from unlabeled data.
problem Learning spatio-temporal brain disorder dynamics from unlabeled data.
method Self-supervised pre-training of whole MILC on unlabeled healthy control data.
result Whole MILC outperforms existing methods and provides diagnostic insights.
Deep-learning model detects ASD from MRI data with high accuracy.
problem Challenges in diagnosing ASD due to subjective behavioral assessments and informant biases.
method Integrates deep-learning and SVM techniques to classify ASD brain scans.
result Highly accurate classification of ASD brain scans from neurotypical scans.
Matrix Reordering for Noisy Disordered Matrices: Optimality and Computationally Efficient Algorithmsmath.ST
New algorithm optimizes matrix reordering for noisy disordered matrices.
problem Optimizing matrix reordering for noisy disordered matrices in single-cell biology and metagenomics.
method Proposed a polynomial-time adaptive sorting algorithm to improve upon spectral seriation.
result Our algorithm achieves superior performance compared to existing methods in real datasets.
Model predicts cannabis use disorder risk for adolescents and young adults.
problem Predicting cannabis use disorder progression in adolescents and young adults.
method Bayesian machine learning model trained on longitudinal data.
result Model provides personalized risk assessment with AUC of 0.68-0.75 and E/O ratio of 0.95-1.
Accurate diagnosis of psychiatric disorders plays a critical role in improving the quality of life for patients and potentially supports the development of new treatments. Many studies have been conducted on machine learning techniques that seek brain imaging data for specific biomarkers of disorders. These studies hav…
Key features of mental illnesses are reflected in speech. Our research focuses on designing a multimodal deep learning structure that automatically extracts salient features from recorded speech samples for predicting various mental disorders including depression, bipolar, and schizophrenia. We adopt a variety of pre-t…
We construct 1-parameter families of non-periodic embedded minimal surfaces of infinite genus in , where denotes a flat 2-tori. Each of our families converges to a foliation of by . These surfaces then lift to minimal surfaces in that are periodic in hori…
Investigates stochastic networks on disordered lattices, converging to Brownian web in 2D.
problem Stochastic networks on disordered lattices.
method Directed spanning forests on randomly perturbed lattices.
result DSF converges to Brownian web in 2D under diffusive scaling.
Entropy and Economicsq-fin.GN
Entropy helps explain disorder in both macro and micro systems.
problem Connecting macro and micro systems with entropy analysis.
method Analyzing entropy from both macroscopic and microscopic perspectives.
result Entropy measures disorder in both macroscopic and microscopic systems.
Towards automated symptoms assessment in mental healthphysics.med-ph
Activity and motion analysis has the potential to be used as a diagnostic tool for mental disorders. However, to-date, little work has been performed in turning stratification measures of activity into useful symptom markers. The research presented in this thesis has focused on the identification of objective activity …
ASD-DiagNet: A hybrid learning approach for detection of Autism Spectrum Disorder using fMRI datacs.LG
Mental disorders such as Autism Spectrum Disorders (ASD) are heterogeneous disorders that are notoriously difficult to diagnose, especially in children. The current psychiatric diagnostic process is based purely on the behavioural observation of symptomology (DSM-5/ICD-10) and may be prone to over-prescribing of drugs …
This thesis explores emergent intelligence in disordered systems like spin glasses and neural networks.
problem Understanding the principles behind emergent intelligent behaviors in disordered systems.
method Statistical physics approach to charting learning mechanisms and dynamics.
result Uncovering relationships between learning mechanisms and physical dynamics.
Machine learning improves ASD diagnosis accuracy.
problem Early detection and treatment of ASD.
method Machine learning, specifically SMO-SVM and Relief Attributes.
result SMO-SVM classifier outperforms other algorithms in ASD detection.
Transfer entropy shows abnormal brain connectivity in depression.
problem Abnormal brain connectivity in depression.
method Transfer entropy analysis on EEG recordings.
result Aberrated dynamics and direction of information between brain centers in depression.
PR-GNN identifies salient brain regions for ASD biomarkers.
problem Identifying brain regions associated with neurological disorders.
method Pooling Regularized Graph Neural Network (PR-GNN) with novel salient region selection.
result PR-GNN outperforms baseline methods in ASD classification accuracy.
Deep learning methods are increasingly being used with neuroimaging data like structural and function magnetic resonance imaging (MRI) to predict the diagnosis of neuropsychiatric and neurological disorders. For psychiatric disorders in particular, it is believed that one of the most promising modality is the resting-s…
The analysis of comorbidity is an open and complex research field in the branch of psychiatry, where clinical experience and several studies suggest that the relation among the psychiatric disorders may have etiological and treatment implications. In this paper, we are interested in applying latent feature modeling to …
Autism Spectrum Disorder (ASD) is a developmental disorder that often impairs a child's normal development of the brain. According to CDC, it is estimated that 1 in 6 children in the US suffer from development disorders, and 1 in 68 children in the US suffer from ASD. This condition has a negative impact on a person's …
Deep learning aids in autism diagnosis and rehabilitation using neuroimaging data.
problem Challenges in automated detection and rehabilitation of ASD using neuroimaging data.
method Deep learning techniques applied to neuroimaging data for ASD diagnosis and rehabilitation.
result Deep learning improves accuracy in ASD diagnosis and rehabilitation.
Identifying anomalous patterns in real-world data is essential for understanding where, when, and how systems deviate from their expected dynamics. Yet methods that separately consider the anomalousness of each individual data point have low detection power for subtle, emerging irregularities. Additionally, recent dete…
Ordered phase and non-equilibrium fluctuation in stock marketcond-mat.stat-mech
We analyze the statistics of daily price change of stock market in the framework of a statistical physics model for the collective fluctuation of stock portfolio. In this model the time series of price changes are coded into the sequences of up and down spins, and the Hamiltonian of the system is expressed by spin-spin…
Broken ergodicity and memory in the minority gamecond-mat.dis-nn
We study the dynamics of the `batch' minority game with market-impact correction using generating functional techniques to carry out the quenched disorder average. We find that the assumption of weak long-term memory, which one usually makes in order to calculate ergodic stationary states, breaks down when the persiste…
Deep learning improves MRI analysis of MSK disorders.
problem Accurate and rapid analysis of musculoskeletal disorders from MRI scans.
method Convolutional neural networks (CNN) for automatic classification of knee abnormalities.
result Multi-view deep learning showed promising performance in classifying MSK abnormalities.
Cost-effective models detect depression from speech.
problem Detecting depression from speech with limited resources.
method Comparison of conventional and deep acoustic features for depression prediction.
result Conventional acoustic features perform as well as deep representations at lower cost.
Convolutional neural networks (CNNs) can be applied to graph similarity matching, in which case they are called graph CNNs. Graph CNNs are attracting increasing attention due to their effectiveness and efficiency. However, the existing convolution approaches focus only on regular data forms and require the transfer of …
New cooperative dynamics enhances retrieval performance in neural networks.
problem Understanding emergent computational capabilities in disordered systems.
method Leveraging statistical mechanics, extended neural network architecture for hetero-associative memory.
result Layers trained with less informative datasets develop retrieval regions of the same amplitude, leading to optimal performance.
Paper proposes a smart neck-band for detecting neck postures using integrated kinematic and kinetic data.
problem Improper neck postures lead to musculoskeletal disorders requiring therapy and rehabilitation.
method Integrated use of kinematic and kinetic data with machine learning algorithms.
result 100% accuracy in predicting neck postures using the proposed platform.
Study integrates causal inference and temporal complexity measures to analyze mental health symptoms.
problem Examining how individual symptom trajectories reveal diagnostic patterns in mental disorders.
method Causal inference, graph analysis, temporal complexity measures, machine learning.
result 91% accuracy in diagnosing symptom dynamics, highlighting disorder-specific causal mechanisms.
Reliable diagnosis of depressive disorder is essential for both optimal treatment and prevention of fatal outcomes. In this study, we aimed to elucidate the effectiveness of two non-linear measures, Higuchi Fractal Dimension (HFD) and Sample Entropy (SampEn), in detecting depressive disorders when applied on EEG. HFD a…
Electroencephalography (EEG) is a method to record the electrical signals in the brain. Recognizing the EEG patterns in the sleeping brain gives insights into the understanding of sleeping disorders. The dataset under consideration contains EEG data points associated with various physiological conditions. This study at…