Proposes guidelines for developing medical AI products.
problem Lack of clear pathways for regulating medical AI.
method Statistical risk perspective and deep understanding of machine learning methodologies.
result Enhanced development of medical AI products and regulations.
The medical field stands to see significant benefits from the recent advances in deep learning. Knowing the uncertainty in the decision made by any machine learning algorithm is of utmost importance for medical practitioners. This study demonstrates the utility of using Bayesian LSTMs for classification of medical time…
Paper shows how to quantify uncertainty in medical ML models.
problem Uncertainty in opaque ML models can lead to safety risks in medical applications.
method Introduces Uncertainty Wrapper to quantify uncertainty transparently.
result Demonstrates practical utility of Uncertainty Wrapper in flow cytometry.
This chapter introduces reproducibility in machine learning for medical imaging.
problem Lack of reproducibility in machine learning for medical imaging.
method Distinguishes and defines types of reproducibility, outlines requirements, and discusses utility.
result Discussion on benefits and a plea for a non-dogmatic approach to reproducibility.
Proposes a new method for medical diagnosis using network-based representation learning.
problem Improving medical diagnosis accuracy through better data representation.
method Heterogeneous network-based model and modified metapath2vec algorithm for learning latent node representations.
result Significant performance boost in symptom/disease classification and disease prediction tasks.
Paper detects bias in AI medical models using CART.
problem Ensuring fairness in AI medical decision support systems.
method Uses Classification and Regression Trees (CART) algorithm to identify bias.
result Validated the CART approach in both synthetic and real-world data.
Teaches reproducible research to medical students and postgrads.
problem Lack of reproducibility in medical research practices.
method Designed and delivered a lecture series on reproducible research.
result Encountered practical obstacles in reproducing a published analysis.
Deep learning predicts ICU mortality with enhanced interpretability.
problem Improving mortality prediction accuracy and clinician trust in AI.
method Trained a deep learning model on MIMIC-III to interpret nursing notes.
result Model reaches ROC of 0.8629, outperforming SAPS-II.
The study evaluates AI model performance measures for medical use.
problem Selecting appropriate performance measures for AI models in medical practice.
method Assessed 32 performance measures across five domains for binary outcomes.
result 17 measures are both proper and reflect decision-analytic performance.
Paper tackles medical image diagnosis with unsupervised domain adaptation.
problem Limited labeled samples and label noise in medical images.
method Collaborative Unsupervised Domain Adaptation (UDA) algorithm.
result Empirical results show superiority of the proposed method.
DiffDenoise preserves fine structures in medical images using conditional diffusion models.
problem Medical image denoising often results in loss of fine structures.
method Conditional diffusion model with stabilized reverse sampling and supervised training.
result DiffDenoise outperforms state-of-the-art methods in medical image denoising.
Laboratory testing and medication prescription are two of the most important routines in daily clinical practice. Developing an artificial intelligence system that can automatically make lab test imputations and medication recommendations can save costs on potentially redundant lab tests and inform physicians of a more…
COMPASS improves uncertainty quantification for medical segmentation metrics.
problem Uncertainty quantification for medical segmentation metrics is crucial for clinical decision-making.
method COMPASS leverages deep neural network inductive biases to generate efficient, metric-based conformal prediction intervals.
result COMPASS produces significantly tighter intervals than traditional conformal prediction methods on medical image segmentation tasks.
Paper detects biases in medical imaging ML models using counterfactual analysis.
problem Bias in medical imaging ML models negatively impacts generalization performance.
method Counterfactual invariance framework combining conditional latent diffusion models and statistical hypothesis testing.
result The method identifies and quantifies biases without direct access to counterfactual data.
The computer-aided analysis of medical scans is a longstanding goal in the medical imaging field. Currently, deep learning has became a dominant methodology for supporting pathologists and radiologist. Deep learning algorithms have been successfully applied to digital pathology and radiology, nevertheless, there are st…
Is it true that patients with similar conditions get similar diagnoses? In this paper we show NLP methods and a unique corpus of documents to validate this claim. We (1) introduce a method for representation of medical visits based on free-text descriptions recorded by doctors, (2) introduce a new method for clustering…
Prediction models can harm patients even when accurate, leading to self-fulfilling prophecies.
problem Prediction models can lead to harmful decisions that worsen patient outcomes.
method Formal characterization of harmful prediction models and analysis of their impact.
result Well-calibrated models are ineffective for decision-making as they do not change the data distribution.
This paper benchmarks OoDD methods for medical imaging.
problem Medical models trained for one domain may fail on images from a different domain.
method Defined 3 categories of OoD examples and benchmarked methods in 3 medical imaging domains.
result Simple binary classifier on feature representation yields best accuracy and AUPRC.
Enhances uncertainty estimation in medical image segmentation.
problem Frequency-related noise in medical imaging leads to biased uncertainty estimates.
method Extends MC-Dropout to the frequency domain for better uncertainty estimation.
result MC-Frequency Dropout improves calibration and uncertainty in semantic segmentation.
Stability in clinical prediction models is crucial for transferability between studies, yet has received little attention. The problem is paramount in high dimensional data which invites sparse models with feature selection capability. We introduce an effective method to stabilize sparse Cox model of time-to-events usi…
The discovery of adversarial examples has raised concerns about the practical deployment of deep learning systems. In this paper, we demonstrate that adversarial examples are capable of manipulating deep learning systems across three clinical domains. For each of our representative medical deep learning classifiers, bo…
Foundation models alter medical data science workflow, challenging veridical data science principles.
problem Foundation models disrupt traditional data science practices in medicine.
method Critically examined the medical foundation model lifecycle and its deviation from veridical data science principles.
result Foundation models challenge veridical data science principles of predictability, computability, and stability.
This paper uses neural networks to accurately model competing risks in survival analysis.
problem Ignoring competing risks leads to biased survival estimation in machine learning models.
method The paper introduces constrained monotonic neural networks to model each competing survival distribution.
result The method ensures exact likelihood maximization with reduced computational cost.
Study clusters Kenyan medical insurance companies based on financial performance and reporting consistency.
problem Identifying financial health and reporting consistency in Kenyan medical insurance companies.
method Advanced clustering techniques (KMeans, DTW) on financial ratios and time series data.
result Four distinct clusters identified, each representing different financial performance and reporting consistency combinations.
Paper proposes a human-algorithm approach to reduce medical device recall risk and workload.
problem High recall rate and regulatory workload in FDA's 510(k) pathway.
method Developed machine learning models to estimate recall risk and proposed a data-driven clearance policy.
result Conservative evaluation of policy shows a 32.9% improvement in recall rate and 40.5% reduction in workload.
Causal inference deals with identifying which random variables "cause" or control other random variables. Recent advances on the topic of causal inference based on tools from statistical estimation and machine learning have resulted in practical algorithms for causal inference. Causal inference has the potential to hav…
New method explains survival analysis models using median-SHAP.
problem Need for explainable AI in medical applications, especially for survival analysis.
method Introduces median-SHAP for explaining survival analysis models.
result Conventionally used mean anchor point can lead to misleading interpretations; median-SHAP provides a better approach.
In this work we explored building automatic speech recognition models for transcribing doctor patient conversation. We collected a large scale dataset of clinical conversations (14,000 hr), designed the task to represent the real word scenario, and explored several alignment approaches to iteratively improve data qua…
Deep neural networks have been proved efficient for medical image denoising. Current training methods require both noisy and clean images. However, clean images cannot be acquired for many practical medical applications due to naturally noisy signal, such as dynamic imaging, spectral computed tomography, arterial spin …
In this work, we investigate unsupervised representation learning on medical time series, which bears the promise of leveraging copious amounts of existing unlabeled data in order to eventually assist clinical decision making. By evaluating on the prediction of clinically relevant outcomes, we show that in a practical …
A new method relaxes Boolean Matrix Factorization to make it more efficient.
problem High computational cost of solving NP-hard combinatorial optimization problems in Boolean Matrix Factorization.
method Proposes a proximal gradient algorithm using an elastic-binary regularizer to relax BMF.
result Demonstrates improved runtime and better recall, loss, and interpretability on real-world data.
Paper tackles missing data in medical records using advanced optimization.
problem Missing data in medical records hinders machine learning applications.
method Applied multi-level stochastic optimization for imputation.
result The method significantly outperforms current approaches and reduces error up to 75%.
Machine learning detects NASH patients from medical claims data.
problem Detecting undiagnosed NASH patients for screening and management.
method Gradient-boosted decision trees trained on administrative medical claims data.
result Model precision for NASH detection is significantly higher than NASH incidence.
GANs help create realistic synthetic health data, boosting medical research.
problem Challenges in creating realistic synthetic health data due to private patient data.
method Generative Adversarial Networks (GANs) to learn and produce synthetic health data.
result GANs can produce realistic synthetic health data, overcoming challenges in OHD.
New DAM method improves AUC scores in medical image classification.
problem Maximizing AUC in large-scale medical image classification.
method Proposes AUC margin loss for robust optimization, conducts extensive empirical studies.
result Improves performance on four medical image classification tasks, achieving 1st place on Stanford CheXpert.
We have recently seen many successful applications of recurrent neural networks (RNNs) on electronic medical records (EMRs), which contain histories of patients' diagnoses, medications, and other various events, in order to predict the current and future states of patients. Despite the strong performance of RNNs, it is…
The Intensive Care Unit (ICU) is a hospital department where machine learning has the potential to provide valuable assistance in clinical decision making. Classical machine learning models usually only provide point-estimates and no uncertainty of predictions. In practice, uncertain predictions should be presented to …
Study uses multi-task Bayesian optimization to speed up SVM hyperparameter tuning for nodules diagnosis.
problem Redundant and time-consuming hyperparameter tuning for SVM classifiers in medical imaging.
method Employed multi-task Bayesian optimization to accelerate hyperparameter search.
result Multi-task Bayesian optimization significantly accelerates hyperparameter search.
New method combines multiple datasets to estimate ATE with valid confidence intervals.
problem Combining multiple observational datasets to estimate ATE with valid confidence intervals.
method Prediction-powered inferences to shrink CIs and provide valid CIs.
result Valid confidence intervals for ATE from multiple datasets.
Machine-learned diagnosis models have shown promise as medical aides but are trained under a closed-set assumption, i.e. that models will only encounter conditions on which they have been trained. However, it is practically infeasible to obtain sufficient training data for every human condition, and once deployed such …
FEET protocol evaluates foundation models across three scenarios.
problem Lack of standardized evaluation protocols for foundation models.
method Structured evaluation protocol across three use cases: frozen, few-shot, and fine-tuned embeddings.
result Demonstrates comprehensive assessment of foundation models' effectiveness.
Improves medication name inference for telemedicine and conversational agents.
problem Challenges in mapping user-friendly medication names to standardized ones.
method Entity-boosted two-tower neural network for ranking SMN to DMP.
result State-of-the-art results achieved with improved attention-based ranking.
The treatment effects of medications play a key role in guiding medical prescriptions. They are usually assessed with randomized controlled trials (RCTs), which are expensive. Recently, large-scale electronic health records (EHRs) have become available, opening up new opportunities for more cost-effective assessments. …
Zero-Shot Learning helps learn new concepts without examples, useful for COVID-19 diagnosis.
problem Learning new concepts without examples, especially in medical imaging.
method Uses existing knowledge and auxiliary information to predict unknown concepts.
result Effective in diagnosing COVID-19 from chest X-rays.
Estimates causal effects from patient trajectories using DeepACE model.
problem Estimating causal effects from observational data in medical practice.
method DeepACE model using iterative G-computation formula and sequential targeting procedure.
result DeepACE achieves state-of-the-art performance in estimating time-varying ACEs.
Data is one of the essential ingredients to power deep learning research. Small datasets, especially specific to medical institutes, bring challenges to deep learning training stage. This work aims to develop a practical deep multimodal that can classify patients into abnormal and normal categories accurately as well a…
Two large medical dialogue datasets for improving healthcare.
problem Improving healthcare through better dialogue systems.
method Building two large-scale medical dialogue datasets: MedDialog-EN and MedDialog-CN.
result The datasets are the largest medical dialogue datasets to date.
Underspecified ML models can behave unpredictably in real-world use.
problem ML models can fail in real-world deployment due to ambiguous predictors.
method Identified underspecification as the cause, showing it affects various ML domains.
result Underspecified models can behave differently in deployment domains.