BayesMR estimates causal effects and directionality from genetic data.
problem Challenges in finding good genetic instruments and estimating causal effects.
method Bayesian Mendelian randomization approach that accounts for pleiotropy and reverse causation.
result BayesMR provides a posterior distribution over causal effects and uncertainty.
This research develops an evolutionary approach to discover non-Gaussian stochastic dynamical systems.
problem Discovering explicit governing equations of stochastic dynamical systems with Lévy noise from data.
method ESSR approach using genetic programming, sparse regression, and nonlocal Kramers-Moyal formulas.
result The approach effectively extracts non-Gaussian stochastic dynamical systems from sample path data.
Ivy combines weak IV candidates to estimate causal effects robustly.
problem Estimating causal effects from observational data using weak or invalid IV candidates.
method Ivy synthesizes multiple weak IV candidates into a robust summary.
result Ivy produces more reliable causal effect estimates compared to allele scores.
We propose a Genetic Programming architecture for the generation of foreign exchange trading strategies. The system's principal features are the evolution of free-form strategies which do not rely on any prior models and the utilization of price series from multiple instruments as input data. This latter feature consti…
ENN method uses expectile regression for genetic data analysis of complex diseases.
problem Discover additional genetic variants contributing to complex diseases.
method Developed an expectile neural network (ENN) method integrating expectile regression and neural networks.
result ENN method outperforms existing expectile regression in discovering genetic variants predisposing to sub-populations.
Semi-supervised GAN creates synthetic genetic data for disease prediction.
problem Expensive and time-consuming to build large labeled genetic databases.
method Semi-supervised Genetic Generative Adversarial Network (gGAN).
result Model achieved satisfactory results with real genetic data.
Efficiently infers graph edges from genetic similarity data in landscape genetics.
problem Inferring unknown graph edges from genetic similarity data in a heterogeneous landscape.
method Developed an efficient first-order optimization method to solve the inverse landscape genetics problem.
result Our method provides fast and reliable convergence, significantly outperforming existing heuristics.
Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding task, especially in the presence of gene-gene interactions. A non-parametric Bayesian approach in the form o…
Genome-wide association studies (GWAS) have emerged as a rich source of genetic clues into disease biology, and they have revealed strong genetic correlations among many diseases and traits. Some of these genetic correlations may reflect causal relationships. We developed a method to quantify causal relationships betwe…
Novel tests for genetic independence in high-dimensional data.
problem Testing independence in genetics studies with many variables.
method Defining premetric structures on genetic data support spaces.
result Solid theoretical framework and computationally-efficient implementations.
Estimates long-term effects using past experiments as instruments with many weak instruments.
problem Estimating long-term causal effects with limited short-term outcomes and many weak instruments.
method Nonparametric instrumental variable inference with many weak instruments, using past experiments as instruments.
result Automatic debiased machine learning estimators for linear functionals of the structural function and its minimum-norm projection are efficient in the many-weak-instruments regime.
Deep models improve GWAS by identifying genetic interactions.
problem Missing non-linear interaction effects in GWAS.
method Gradient-based DeepLIFT technique to interpret deep models.
result Known and novel genetic risk factors identified.
We introduce GeNet, a method for shotgun metagenomic classification from raw DNA sequences that exploits the known hierarchical structure between labels for training. We provide a comparison with state-of-the-art methods Kraken and Centrifuge on datasets obtained from several sequencing technologies, in which dataset s…
ZNet learns instrumental representations from covariates for causal inference.
problem Lack of valid instruments in observational studies.
method Representation learning approach that constructs instrumental representations from observed covariates.
result ZNet enables IV-based estimation without explicit instruments.
Genetic algorithms have been widely used in many practical optimization problems. Inspired by natural selection, operators, including mutation, crossover and selection, provide effective heuristics for search and black-box optimization. However, they have not been shown useful for deep reinforcement learning, possibly …
New method uses DNN for genetic variant identification, controlling randomness and improving interpretability.
problem Challenges in interpreting deep neural networks for genetic variant identification.
method Interpretable neural network model with controlled variable selection using ensembling, knockoffs, and de-randomization.
result The proposed method leads to more discoveries compared to conventional methods.
TSCI estimates treatment effects using machine learning and data-adaptive methods for invalid instruments.
problem Estimating treatment effects with invalid instruments.
method Two-stage algorithm: first stage uses machine learning for nonlinearities, second stage selects and projects out instrument violations.
result Effective treatment effect estimation even with invalid instruments.
Researchers develop methods for causal inference with imperfect instrumental variables.
problem Quantifying cause and effect relationships with imperfect instrumental variables.
method Established a quantitative relationship between violations of instrumental inequalities and minimal measurement dependence, providing adapted inequalities valid in the presence of relaxed measurement dependence.
result Adapted inequalities for average causal effect in instrumental scenarios with binary outcomes, addressing violations of instrumental inequalities.
Genetic sequence data are well described by hidden Markov models (HMMs) in which latent states correspond to clusters of similar mutation patterns. Theory from statistical genetics suggests that these HMMs are nonhomogeneous (their transition probabilities vary along the chromosome) and have large support for self tran…
Optimizing a neural network's performance is a tedious and time taking process, this iterative process does not have any defined solution which can work for all the problems. Optimization can be roughly categorized into - Architecture and Hyperparameter optimization. Many algorithms have been devised to address this pr…
Paper proposes CIV estimator for categorical instruments in small sample settings.
problem Estimation with categorical instruments in settings with few observations per category.
method CIV estimator leveraging regularization assumption for latent categorical variable.
result CIV estimator is asymptotically normal, efficient, and semiparametrically efficient under homoskedasticity.
Paper uses AI to predict stock market volatility with neural networks and genetic algorithms.
problem Traditional methods for predicting stock market volatility have high errors.
method Back-propagation neural network and genetic algorithm integrated model.
result The model predicts future volatility with low errors and high accuracy.
In plant and animal breeding studies a distinction is made between the genetic value (additive + epistatic genetic effects) and the breeding value (additive genetic effects) of an individual since it is expected that some of the epistatic genetic effects will be lost due to recombination. In this paper, we argue that t…
A genetic algorithm improves multivariate kernel density estimation.
problem Efficiently estimating multivariate kernel density functions.
method Genetic algorithm applied to subsamples of the original data.
result The genetic algorithm-based estimator performs better than traditional methods.
This paper improves dynamic hedging accuracy using genetic programming to forecast implied volatilities.
problem Improving the accuracy of dynamic hedging using implied volatilities.
method The paper uses genetic programming to forecast implied volatilities and tests the performance of these forecasts in dynamic hedging strategies.
result Genetic programming-generated implied volatilities improve hedging accuracy compared to static training methods.
For every group genetic code with finite number of generating and at most with one defining relation we introduce the braid group of this genetic code. This construction includes the braid group of Euclidean plane, the braid groups of closed orientable surfaces, B type groups of Artin-Brieskorn, and allow us to study a…
New method uses few instruments to estimate complex causal effects.
problem Estimating causal effects with limited instruments in high-dimensional settings.
method Sequentially selects and combines instruments to estimate the treatment effect.
result Can reliably recover the treatment effect's projection onto the instrumented subspace.
Gradient GA uses gradient information to improve molecular design.
problem Random walk exploration limits genetic algorithms' quality and speed in molecular design.
method Gradient GA incorporates gradient information from the objective function into genetic algorithms, using a differentiable neural network and Discrete Langevin Proposal.
result Significantly improves convergence speed and solution quality over traditional genetic algorithms.
Proposes Genetic Thompson Sampling for multi-armed bandits, improving performance in nonstationary settings.
problem Improving sequential decision making tasks of online learning agents using multi-armed bandits.
method Integrates genetic principles into Thompson Sampling for multi-armed bandits.
result Significantly outperforms baselines in nonstationary settings.
EvoNUDGE uses graph neural networks to improve genetic programming performance.
problem Efficiency in evolutionary computation for problem solving.
method Graph neural network to elicit additional knowledge from symbolic regression problems.
result EvoNUDGE significantly outperforms conventional and neural genetic programming methods.
Paper develops a new estimator for panel data with endogenous treatments, improving causal inference.
problem Challenges in causal inference for static panel data with endogenous treatments and confounding variables.
method Develops Double Machine Learning (DML) estimator for static panel models with endogenous treatments (panel IV DML). Introduces weak-identification diagnostics.
result Panel IV DML estimator improves estimation accuracy and delivers more reliable inference under weak identification.
DFIV uses deep neural nets to learn nonlinear features in IV regression.
problem Learning causal relationships from observational data with nonlinear interactions.
method DFIV trains deep neural nets to define nonlinear features on instruments and treatments, alternating training to compose stages 1 and 2.
result DFIV outperforms state-of-the-art methods on IV benchmarks and off-policy policy evaluation.
As the amount and complexity of genetic information increases it is necessary that we explore some efficient ways of handling these data. This study takes the "divide and conquer" approach for analyzing high dimensional genomic data. Our aims include reducing the dimensionality of the problem that has to be dealt one a…
Genome-wide association studies (GWAS) have achieved great success in the genetic study of Alzheimer's disease (AD). Collaborative imaging genetics studies across different research institutions show the effectiveness of detecting genetic risk factors. However, the high dimensionality of GWAS data poses significant cha…
Learning a causal effect from observational data is not straightforward, as this is not possible without further assumptions. If hidden common causes between treatment X and outcome Y cannot be blocked by other measurements, one possibility is to use an instrumental variable. In principle, it is possible under some…
GEGL uses genetic experts to improve deep learning for molecular design.
problem Designing molecules with desired properties using deep learning.
method Genetic expert-guided learning (GEGL) framework for training DNN.
result Significantly improves molecular design, achieving high scores on benchmarks.
We study the problem of semi-supervised singing voice separation, in which the training data contains a set of samples of mixed music (singing and instrumental) and an unmatched set of instrumental music. Our solution employs a single mapping function g, which, applied to a mixed sample, recovers the underlying instrum…
Valid causal inference with invalid instruments using majority or modal valid relationships.
problem Estimating causal effects in the presence of unobserved confounding and invalid instruments.
method Ensemble of instrumental variable estimators to estimate the modal prediction, achieving accurate estimates of conditional average treatment effects.
result Valid causal inference can be achieved with a majority or modal valid instrument-response relationship.
Genetic algorithms optimize neural networks for cosmological data analysis.
problem Inaccurate results from neural networks due to poor hyperparameter selection.
method Used genetic algorithms to optimize hyperparameters of neural networks.
result Genetic algorithms improve neural network performance in cosmological data analysis.
Technical analysis is used to discover investment opportunities. To test this hypothesis we propose an hybrid system using machine learning techniques together with genetic algorithms. Using technical analysis there are more ways to represent a currency exchange time series than the ones it is possible to test computat…
Bayesian nonparametric machine learning improves instrumental variable inference.
problem Estimating causal effects with nonlinear relationships.
method Bayesian Additive Regression Trees (BART) for estimating functions and Dirichlet Process mixtures for error terms.
result Dramatic improvements in inference with nonlinear data, no manual tuning required.
In this paper, we learn disentangled representations of timbre and pitch for musical instrument sounds. We adapt a framework based on variational autoencoders with Gaussian mixture latent distributions. Specifically, we use two separate encoders to learn distinct latent spaces for timbre and pitch, which form Gaussian …
Gradient boosting enhances existing Mendelian models for genetic disease risk prediction.
problem Improving existing Mendelian models for genetic disease risk prediction.
method Combining gradient boosting with existing Mendelian models.
result Improved model outperforms both original and gradient boosting-only models.
Study investigates how preprocessing, feature selection, and model selection affect performance on imbalanced genetic data.
problem Challenges in using machine learning on imbalanced genetic datasets.
method Comparative analysis of data preprocessing, feature selection techniques, and machine learning models on imbalanced genetic data.
result Class-imbalanced target variables and skewed predictors have little to no impact on classification performance.
In this paper, we propose a framework for automatic classification of patients from multimodal genetic and brain imaging data by optimally combining them. Additive models with unadapted penalties (such as the classical group lasso penalty or L1-multiple kernel learning) treat all modalities in the same manner and ca…
Proposes TSCI method to infer causal effects with weak or invalid instruments using machine learning.
problem Causal inference with weak or invalid instrumental variables.
method Two-stage curvature identification (TSCI) using machine learning.
result Asymptotically unbiased and Gaussian estimator for causal effects.
The paper uses graph learning to detect valid instruments in high-dimensional data for house pricing.
problem Endogeneity bias and invalid instrument validation in high-dimensional data.
method Merge variable selection algorithms and probabilistic graphs to estimate house prices and causal structure.
result Efficient data-driven instrument selection and invalid instrument purge in high-dimensional data.
Enhances genetic programming for stock alpha discovery with warm start and structural constraints.
problem Overwhelming search space and computational burden in traditional genetic programming for alpha factor discovery.
method Proposes a new GP framework with warm start and structural constraints to enhance search performance and interpretability.
result Superior out-of-sample prediction results and higher portfolio returns compared to benchmarks.