Algorithm segments glandular structures in colon histology images for cancer grading.
problem Manual gland segmentation is time-consuming and risky for patients.
method Local intensity and texture features, Random Forest classifier, multilevel approach.
result Fast, accurate automatic gland segmentation for clinical use.
Context-aware CNN improves cancer grading accuracy.
problem Grading colorectal cancer histology images accurately.
method Proposes a context-aware neural network for 1,792x1,792 pixel images.
result Outperforms traditional methods by 3.61%.
CNN-based prostate cancer grading improves accuracy and efficiency.
problem Manual Gleason grading by pathologists is time-consuming and prone to errors.
method Patch-Based Image Reconstruction (PBIR), Distribution Correction (DC), Quadratic Weighted Mean Square Error (QWMSE).
result Achieved superior expert-level performance (0.8885 quadratic-weighted kappa coefficient).
Federated learning improves CRC grading accuracy and privacy.
problem Inter-observer variability and data privacy in CRC grading.
method Multi-scale federated learning framework integrating ResNetRS50.
result Framework achieves 83.5% accuracy, outperforming centralized models.
In order to investigate the breast cancer prediction problem on the aging population with the grades of DCIS, we conduct a tree augmented naive Bayesian network experiment trained and tested on a large clinical dataset including consecutive diagnostic mammography examinations, consequent biopsy outcomes and related can…
Paper proposes clustering model for ICC based on histologic patterns.
problem Challenges in grading rare cancers like ICC due to small sample sizes and difficulty in extracting patterns.
method Unsupervised deep convolutional autoencoder clustering model trained on 246 ICC digitized slides.
result Three clusters significantly associated with recurrence-free survival in Cox-proportional hazard models.
The medical research facilitates to acquire a diverse type of data from the same individual for particular cancer. Recent studies show that utilizing such diverse data results in more accurate predictions. The major challenge faced is how to utilize such diverse data sets in an effective way. In this paper, we introduc…
The analysis of cancer genomic data has long suffered "the curse of dimensionality". Sample sizes for most cancer genomic studies are a few hundreds at most while there are tens of thousands of genomic features studied. Various methods have been proposed to leverage prior biological knowledge, such as pathways, to more…
A new algorithm improves medical image grading accuracy.
problem Improving automatic grading of medical images for disease severity or risk score.
method Sparse range-constrained learning (SRCL) algorithm integrating sparse representation and grading.
result Improves accuracy in cup-to-disc ratio computation and cataract grading.
Proposes RCVs for explaining deep neural network predictions in medical images.
problem Need for explainable predictions in medical applications.
method Uses continuous concept measures as RCVs in neural network activation space.
result Nuclei texture is a relevant concept in breast cancer grading.
Deep object detection improves mitotic nucleus detection in breast cancer biopsies.
problem Challenges in automated mitotic nucleus detection in breast cancer histopathological images.
method Adapted Mask R-CNN for deep object detection, initially selects candidate regions with maximum recall, refines them with multi-object loss function.
result Improved discrimination ability (F-score of 0.86) and significant precision (0.86) for mitotic nuclei compared to two-stage models.
CN-SBM clusters cancer samples and regions based on copy number variants.
problem Clonal evolution in cancer monitored by noisy copy number variants.
method Probabilistic framework using bipartite categorical block model.
result Improved model fit and clinically relevant subtypes identified.
Deep feature fusion improves mitosis counting accuracy.
problem Manual mitosis counting by pathologists is time-consuming and inconsistent.
method Combines Faster R-CNN for object detection with UNet segmentation features and RGB image features.
result Achieved an F-score of 0.508 on mitosis counting challenge dataset, outperforming state-of-the-art methods.
Model predicts anti-cancer drug responses using gene and molecular data.
problem Expensive and time-consuming cancer drug discovery and tailoring.
method Uses variational autoencoders and multi-layer perceptrons to encode gene expression and drug data.
result High average R2 of 0.83 and 0.845 in predicting drug responses for breast and pan-cancer cell lines, respectively. Study uses machine learning to predict heart failure in cancer patients.
problem Early detection of cancer patients at risk for cardiotoxicity.
method Examined four machine learning algorithms on 143,199 cancer patients.
result Gradient boosting model achieved best AUC score of 0.9077.
System accurately detects lung cancer from CT images.
problem Early and accurate detection of lung cancer.
method Developed algorithms using a dataset of CT images.
result Accuracy of 72.2% on test dataset.
We estimate treatment cost-savings from early cancer diagnosis. For breast, lung, prostate and colorectal cancers and melanoma, which account for more than 50% of new incidences projected in 2017, we combine published cancer treatment cost estimates by stage with incidence rates by stage at diagnosis. We extrapolate to…
Deep learning models improve cancer detection and typing classification from gene expression data.
problem Challenges in establishing specificity for cancer diagnosis using gene expression data.
method Developed deep learning models using mRNA datasets for cancer detection and typing classification.
result Achieved 98% accuracy in cancer detection and 18 out of 32 cancer-typing classifications over 90% accuracy.
We present a novel method for extracting cancer signatures by applying statistical risk models (http://ssrn.com/abstract=2732453) from quantitative finance to cancer genome data. Using 1389 whole genome sequenced samples from 14 cancers, we identify an "overall" mode of somatic mutational noise. We give a prescription …
Study predicts 10-year survival rates for breast cancer patients.
problem Predicting long-term survival of breast cancer patients.
method Machine learning approaches to assess survival rates.
result Improved accuracy in predicting 10-year survival.
Study uses Apple ML to accurately detect and classify lung cancer.
problem Accurate diagnosis and sub-classification of non-small cell lung cancer.
method Evaluation of Apple Create ML module on histopathological images.
result 100% detection and successful subclassification of non-small cell lung cancer.
Cancer patients admitted to ICU had improved survival over 10 years.
problem To assess changes in survival of cancer patients admitted to ICU over 10 years.
method Retrospective analysis of MIMIC-III database, adjusted for confounders using logistic regression.
result Cancer patients had significantly lower 28-day and 1-year mortality rates over 10 years.
Paper identifies key CpG methylation sites for breast cancer.
problem Early detection and treatment of breast cancer.
method Used machine learning on TCGA dataset to classify cancer vs. non-cancer samples.
result Reduced model with 25 key CpG sites achieves over 94% accuracy.
Data mining techniques predict breast cancer types with high accuracy.
problem Early detection of breast cancer to reduce mortality rates.
method Twelve classification algorithms applied to the Breast Cancer Wisconsin dataset.
result High accuracy in predicting malignant and benign breast cancer.
Study examines perceptions and attitudes about breast cancer on Twitter.
problem Understanding public perceptions and attitudes towards breast cancer on social media.
method Identified and collected tweets, used topic modeling and sentiment analysis.
result Identified themes and quantified users' perceptions and emotions about breast cancer.
Deep learning predicts breast cancer with high accuracy from patient data.
problem Early detection of breast cancer from patient data.
method Feature selection and k-fold Monte Carlo cross-validation using deep learning.
result Deep learning model effectively distinguishes between cancer and healthy patients.
Machine learning accurately diagnoses cancer from whole genome sequencing data.
problem Accurate cancer diagnosis at all stages.
method Novel MLAC (Machine Learning Against Cancer) method using next-gen RNA sequencing.
result Perfect precision, sensitivity, and specificity achieved for most tumor types.
Neural networks improve cancer risk prediction from family history data.
problem Improving cancer risk prediction from family history data using machine learning.
method Developed and trained neural network models on large pedigrees to predict hereditary cancers.
result Neural networks can achieve nearly optimal prediction performance and outperform traditional models in misreported data.
Machine learning detects metastatic breast cancer cases from linked EMR and cancer registry data.
problem Lack of metastatic recurrence data in cancer registries and EMRs.
method Semi-supervised machine learning on linked EMR and CCR data.
result Model achieved high accuracy in detecting metastatic breast cancer cases.
L-Perceptron improves breast cancer diagnosis and survival prediction.
problem Improving early prognosis and survival prediction rates for breast cancer.
method Proposes a novel type of perceptron (L-Perceptron) for better accuracy and sensitivity.
result Achieves 97.42% and 98.73% accuracy and sensitivity in Wisconsin Breast Cancer dataset.
We present *K-means clustering algorithm and source code by expanding statistical clustering methods applied in https://ssrn.com/abstract=2802753 to quantitative finance. *K-means is statistically deterministic without specifying initial centers, etc. We apply *K-means to extracting cancer signatures from genome data w…
Accurately predicting drug responses to cancer is an important problem hindering oncologists' efforts to find the most effective drugs to treat cancer, which is a core goal in precision medicine. The scientific community has focused on improving this prediction based on genomic, epigenomic, and proteomic datasets measu…
System automates identification of cancer drug repurposing from PubMed.
problem Manual extraction of cancer drug repurposing evidence from scientific publications is infeasible.
method NLP pipeline including querying, filtering, entity extraction, classification, and study type classification.
result Automated system extracts cancer drug repurposing evidence from PubMed abstracts.
Study identifies biomarkers for lung cancer in female non-smokers.
problem Identifying prognostic biomarkers for stage III NSCLC in non-smoking females.
method Gene expression profiling and XGBoost machine learning algorithm.
result Top biomarkers validated in literature, with AUC score of 0.835.
PathologyGAN learns deep representations of cancer tissue images.
problem Limited high-quality labels for cancer tissue images.
method Developed a GAN framework for unsupervised learning of cancer tissue phenotypes.
result Generated high-quality images with interpretable latent space.
Deep autoencoder predicts cancer types from DNA methylation patterns.
problem Differentiating cancer types based on DNA methylation states.
method Deep learning system with CpG island state classification and statistical methods.
result Overall Sensitivity of 88.24%, Specificity of 83.33%, Accuracy of 84.75%.
Deep CNN model improves breast cancer screening exam classification.
problem Improving accuracy in breast cancer screening exam classification.
method Localization-based deep CNN trained on 200,000 exams.
result AUC of 0.919 in predicting malignancy, reducing error rate by 23%.
We apply our statistically deterministic machine learning/clustering algorithm *K-means (recently developed in https://ssrn.com/abstract=2908286) to 10,656 published exome samples for 32 cancer types. A majority of cancer types exhibit mutation clustering structure. Our results are in-sample stable. They are also out-o…
Modeling correlated mutations in cancer for personalized treatment.
problem Identifying mutations for personalized cancer therapy in heterogeneous profiles.
method Proposed correlated zero-inflated negative binomial process with mixed beta-Bernoulli and variational inference.
result Identified biologically relevant correlations between somatic mutations.
Network Elastic Net identifies smoking-specific gene expression for lung cancer prognosis.
problem Identifying smoking-specific gene expression biomarkers in lung cancer prognosis.
method Introduces Network Elastic Net, a method that clusters and regresses on graphs based on smoking behavior.
result Shows efficacy of clusters in identifying cancer stages using gene expression and smoking behavior.
The study improves colorectal cancer survivability prediction by considering ethnicity.
problem Improving colorectal cancer survivability prediction using machine learning.
method Machine learning techniques applied to SEER cancer incidence database, comparing different ethnicities.
result Models perform better on single-ethnicity populations and provide different feature importance rankings.
Automates deep learning model development for cancer data.
problem Manual design of high-performing deep learning models for cancer data is time-consuming and requires expertise.
method Reinforcement-learning-based neural architecture search with custom building blocks.
result Automated discovery of deep neural network architectures with similar or higher accuracy.
BIDIFAC+ factorizes linked matrices for cancer studies.
problem Integrating multiple omics platforms across various cancer types.
method Flexible approach to simultaneous factorization and decomposition of linked matrices using BIDIFAC+.
result Identifies shared and specific modes of variability across multiple omics platforms and cancer types.
Paper proposes scalable method for analyzing multi-omic data.
problem Integrating high-dimensional multi-omic data for cancer subtyping.
method Mixed graphical model approach using Birth-Death MCMC algorithm.
result Our method outperforms LASSO and standard BDMCMC in computational efficiency and model selection accuracy.
Model learns cancer tissue images onto a low-dimensional space revealing tissue characteristics.
problem Improving cancer diagnosis through high-fidelity digital pathology.
method Deep generative model using PathologyGAN to map real images onto a latent space.
result Latent space encodes morphological characteristics and reveals distinct tissue clusters.
Machine learning can predict cancer with 100% accuracy on a dataset.
problem Accuracy of cancer predictions using machine learning.
method Extensive experiments on the Wisconsin Diagnostic Breast Cancer dataset.
result Machine learning algorithms can be easily misled to achieve 100% accuracy.
Transfer learning from breast histopathology improves prostate cancer detection.
problem Insufficient prostate histopathology datasets for training.
method Transfer learning from breast histopathology images.
result Proposed approach outperforms transfer learning from ImageNet dataset.
Deep neural networks infer multiple cancer properties from transcriptome data.
problem Limited use of biomarkers in molecular cancer pathology due to computational challenges.
method Multi-task and transfer learning architecture encoding whole transcriptome into a latent vector.
result Significantly better at predicting tissue-of-origin, disease state, and cancer type.