Context-aware CNN improves cancer grading accuracy.
problem Grading colorectal cancer histology images accurately.
method Proposes a context-aware neural network for 1,792x1,792 pixel images.
result Outperforms traditional methods by 3.61%.
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30 results for “histology”
Efficient and precise classification of histological cell nuclei is of utmost importance due to its potential applications in the field of medical image analysis. It would facilitate the medical practitioners to better understand and explore various factors for cancer treatment. The classification of histological cell …
Monte-Carlo Sampling applied to Multiple Instance Learning for Histological Image Classificationcs.CV
We propose a patch sampling strategy based on a sequential Monte-Carlo method for high resolution image classification in the context of Multiple Instance Learning. When compared with grid sampling and uniform sampling techniques, it achieves higher generalization performance. We validate the strategy on two artificial…
Diffusion Generative Modeling for Spatially Resolved Gene Expression Inference from Histology Imagescs.CV
Stem uses diffusion models to infer gene expression from H&E images.
problem Inference of gene expression from H&E stained images is time-consuming and expensive.
method Conditional diffusion generative model to infer gene expression.
result Stem achieves state-of-the-art performance in spatial gene expression prediction.
Semi-supervised learning chain boosts histology image accuracy with minimal labeled data.
problem Expensive annotation of large histology image databases.
method Teacher-student knowledge distillation chain approach.
result Accuracy matches 100% labeled data with only 0.5% labeled data.
Deep learning model diagnoses celiac disease severity from intestinal biopsy images.
problem Diagnosing celiac disease severity from biopsy images, especially mild cases.
method Deep residual networks trained on a modified Marsh score histological scoring system.
result Model achieved AUC > 0.96 in all classes for CD severity classification.
Automatization of the diagnosis of any kind of disease is of great importance and it's gaining speed as more and more deep learning solutions are applied to different problems. One of such computer aided systems could be a decision support too able to accurately differentiate between different types of breast cancer hi…
Study uses deep learning to detect BCCs in high-res histopathological images.
problem Detecting BCCs in high-resolution, weakly labeled histopathological images.
method Attention-based deep learning models to process ultra-high resolution images with weak labels.
result Attention-based models achieve almost perfect classification performance (AUC of 0.99).
A deep learning framework separates overlapping nuclei in histology images.
problem Challenges in nuclear segmentation due to overlapping nuclei.
method Proposal-free spatially-aware deep learning framework with multi-scale spatial information.
result State-of-the-art performance in nuclear segmentation on a multi-organ data set.
Colon Cancer is one of the most common types of cancer. The treatment is planned to depend on the grade or stage of cancer. One of the preconditions for grading of colon cancer is to segment the glandular structures of tissues. Manual segmentation method is very time-consuming, and it leads to life risk for the patient…
This paper benchmarks OoDD methods for medical imaging.
problem Medical models trained for one domain may fail on images from a different domain.
method Defined 3 categories of OoD examples and benchmarked methods in 3 medical imaging domains.
result Simple binary classifier on feature representation yields best accuracy and AUPRC.
Histopathology tissue samples are widely available in two states: paraffin-embedded unstained and non-paraffin-embedded stained whole slide RGB images (WSRI). Hematoxylin and eosin stain (H&E) is one of the principal stains in histology but suffers from several shortcomings related to tissue preparation, staining proto…
Dropout improves MIL performance on noisy WSI classification.
problem Noisy feature embeddings and weak supervision in MIL for WSI classification.
method Empirical exploration of dropout in MIL, proposing MIL-Dropout.
result MIL-Dropout boosts MIL performance with minimal computational cost.
Towards Unsupervised Cancer Subtyping: Predicting Prognosis Using A Histologic Visual Dictionarycs.CV
Unlike common cancers, such as those of the prostate and breast, tumor grading in rare cancers is difficult and largely undefined because of small sample sizes, the sheer volume of time needed to undertake on such a task, and the inherent difficulty of extracting human-observed patterns. One of the most challenging exa…
Universally valid ground truth is almost impossible to obtain or would come at a very high cost. For supervised learning without universally valid ground truth, a recommended approach is applying crowdsourcing: Gathering a large data set annotated by multiple individuals of varying possibly expertise levels and inferri…
A deep learning approach classifies medical images hierarchically.
problem Limitations of traditional supervised classifiers in medical image classification.
method Hierarchical Medical Image Classification (HMIC) using deep learning models.
result HMIC achieved better performance in classifying medical images hierarchically.
A new method for deep multiple instance learning using self-attention.
problem Classifying bags of instances with dependencies.
method Introducing Self-Attention-based aggregation operation for bags of instances.
result SA-AbMILP outperforms other models in various datasets.
Neural networks promise to bring robust, quantitative analysis to medical fields, but adoption is limited by the technicalities of training these networks. To address this translation gap between medical researchers and neural networks in the field of pathology, we have created an intuitive interface which utilizes the…
Automated Prostate Cancer Diagnosis Based on Gleason Grading Using Convolutional Neural Networkeess.IV
CNN-based prostate cancer grading improves accuracy and efficiency.
problem Manual Gleason grading by pathologists is time-consuming and prone to errors.
method Patch-Based Image Reconstruction (PBIR), Distribution Correction (DC), Quadratic Weighted Mean Square Error (QWMSE).
result Achieved superior expert-level performance (0.8885 quadratic-weighted kappa coefficient).
Unified framework for linear attribution methods in deep learning.
problem Separate theoretical foundations of XAI attribution methods.
method GRALIS (Gradient-Riesz Averaged Locally-Integrated Shapley) framework.
result Unified representation theory for linear attribution methods.
EAGLE-Net enhances foundation models by integrating patch-level features for better tissue understanding.
problem Foundation models lack mechanisms for global tissue structure and local context in computational pathology.
method EAGLE-Net combines multi-scale spatial encoding, attention-guided loss functions, and background suppression to aggregate patch-level features into slide-level predictions.
result EAGLE-Net improves classification accuracy and concordance indices across multiple cancer types, producing biologically coherent attention maps.
Due to advances in sensors, growing large and complex medical image data have the ability to visualize the pathological change in the cellular or even the molecular level or anatomical changes in tissues and organs. As a consequence, the medical images have the potential to enhance diagnosis of disease, prediction of c…
WILDS 2.0 expands benchmark datasets for unsupervised adaptation.
problem Leveraging unlabeled data for distribution shifts in real-world applications.
method Curated unlabeled data across various applications, tasks, and modalities.
result State-of-the-art methods perform poorly on WILDS datasets.
Spectral decoupling improves neural network generalization in medical imaging.
problem Poor generalization of neural networks trained on medical imaging data.
method Spectral decoupling, a regularization technique that encourages learning more features.
result Spectral decoupling increases network robustness and performance on external datasets.
A clinical Meta-Dataset from TCGA for multi-task learning.
problem Clinical decision making requires considering multiple factors; current benchmarks lack consistency and variety.
method Developed a Meta-Dataset with 174 tasks from TCGA, using regression and neural networks.
result Demonstrated the feasibility of predicting multiple clinical variables from gene expression data.
Machine learning improves glioma diagnosis and prognosis.
problem Improving glioma diagnosis and prognosis using imaging biomarkers.
method Search PubMed and MEDLINE for articles applying machine learning to high-grade glioma biomarkers.
result Machine learning enables accurate classification of glioma biomarkers.
Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and non-enhancing core. This intrinsic heterogeneity is also portrayed in their radio-p…
Method predicts ODX scores for breast cancer patients based on clinical data.
problem Predicting ODX scores for breast cancer patients to aid decision-making.
method Distributional random forest approach using 9 clinico-pathological characteristics.
result Correctly predicted 92% of low risk and 40.2% of high risk patients.
A benchmark evaluates ioUS-to-MR synthesis methods for brain tumor surgery.
problem Difficult interpretation of ioUS images for brain tumor surgery.
method Six generators trained under four inference regimes and two targets on public data.
result SynDiff-2.5D best preserved downstream segmentation (U_Dice=0.55).
MRI method predicts glioma features, survival, and endothelial proliferation.
problem Invasive biopsy limits detection of glioma features due to tumor heterogeneity.
method Voxel-wise, multiparametric MRI radiomics with k-NN classifier.
result Model accurately predicts disease compositions, survival, and endothelial proliferation.