The regulatory process of Drosophila is thoroughly studied for understanding a great variety of biological principles. While pattern-forming gene networks are analysed in the transcription step, post-transcriptional events (e.g. translation, protein processing) play an important role in establishing protein expression …
arXiv research
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siRF identifies transcription factor binding near enhancers in flies.
Study proposes curvature flow model for Drosophila dorsal closure.
We present semiparametric spectral modeling of the complete larval Drosophila mushroom body connectome. Motivated by a thorough exploratory data analysis of the network via Gaussian mixture modeling (GMM) in the adjacency spectral embedding (ASE) representation space, we introduce the latent structure model (LSM) for n…
Due to the dynamic nature of biological systems, biological networks underlying temporal process such as the development of {\it Drosophila melanogaster} can exhibit significant topological changes to facilitate dynamic regulatory functions. Thus it is essential to develop methodologies that capture the temporal evolut…
The paper predicts responses on out-of-sample nodes using latent positions on unknown curves.
Genomics has revolutionized biology, enabling the interrogation of whole transcriptomes, genome-wide binding sites for proteins, and many other molecular processes. However, individual genomic assays measure elements that interact in vivo as components of larger molecular machines. Understanding how these high-order in…
New method uses manifold learning to infer latent positions of 1D submanifolds in random dot product graphs.
We propose a robust, scalable, integrated methodology for community detection and community comparison in graphs. In our procedure, we first embed a graph into an appropriate Euclidean space to obtain a low-dimensional representation, and then cluster the vertices into communities. We next employ nonparametric graph in…
Estimates effect sizes and power from a pilot experiment.
Stochastic networks are a plausible representation of the relational information among entities in dynamic systems such as living cells or social communities. While there is a rich literature in estimating a static or temporally invariant network from observation data, little has been done toward estimating time-varyin…
The problem of finding the vertex correspondence between two noisy graphs with different number of vertices where the smaller graph is still large has many applications in social networks, neuroscience, and computer vision. We propose a solution to this problem via a graph matching matched filter: centering and padding…
Proposes CVKT to complete missing kernel matrices across multiple views.
The random dot product graph (RDPG) is an independent-edge random graph that is analytically tractable and, simultaneously, either encompasses or can successfully approximate a wide range of random graphs, from relatively simple stochastic block models to complex latent position graphs. In this survey paper, we describ…
Random forest improves nearest neighbor estimation of information-theoretic quantities.
Develops statistical guarantees for image-to-image regression models.
Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis can be highly time consuming. In motor control studies, humans or other …
Quantitatively predicting phenotype variables by the expression changes in a set of candidate genes is of great interest in molecular biology but it is also a challenging task for several reasons. First, the collected biological observations might be heterogeneous and correspond to different biological mechanisms. Seco…
BioHash improves similarity search performance using sparse high-dimensional hash codes.
A novel algorithm optimizes sparsity in reservoir computing inspired by insect brain.
New model uncovers non-Euclidean neural representations.
Controller-Augmented Hidden Markov Models (CHMMs) are a framework for constrained sequential inference.
Many applications donot have the benefit of the laws of physics to derive succinct descriptive models for observed data. In alternative, interdependencies among time series are nowadays often captured by a graph or network that in practice may be very large. The network itself may …
New sparse CCA method finds interpretable associations in multi-view data.