Approach for training deep nets with unlabeled patches.
problem Training deep neural networks with detailed expert annotations.
method Cluster-based learning from weakly labeled bags in latent space.
result Improved performance on Camelyon dataset.
We propose a new model for digital pathology segmentation, based on the observation that histopathology images are inherently symmetric under rotation and reflection. Utilizing recent findings on rotation equivariant CNNs, the proposed model leverages these symmetries in a principled manner. We present a visual analysi…
Digital pathology is not only one of the most promising fields of diagnostic medicine, but at the same time a hot topic for fundamental research. Digital pathology is not just the transfer of histopathological slides into digital representations. The combination of different data sources (images, patient records, and *…
Semi-supervised learning chain boosts histology image accuracy with minimal labeled data.
problem Expensive annotation of large histology image databases.
method Teacher-student knowledge distillation chain approach.
result Accuracy matches 100% labeled data with only 0.5% labeled data.
Deep Learning model diagnoses four lymphoma categories with high accuracy.
problem Automated detection of lymphoma categories using digital pathology images.
method Convolutional neural network algorithm trained on 128 cases of lymph node images.
result Excellent diagnostic accuracy (95% image-by-image, 10% set-by-set).
Model learns cancer tissue images onto a low-dimensional space revealing tissue characteristics.
problem Improving cancer diagnosis through high-fidelity digital pathology.
method Deep generative model using PathologyGAN to map real images onto a latent space.
result Latent space encodes morphological characteristics and reveals distinct tissue clusters.
This paper proposes synthetic augmentation for nuclei image segmentation in medical pathology.
problem Rare and time-consuming labeling of tumor nuclei images for semantic segmentation.
method Label-to-image translation to generate synthetic images.
result Synthetic augmentation improves segmentation accuracy.
New strategies help CNNs recognize tissue features across different stains.
problem Training deep learning models for images with multiple stains is challenging and expensive.
method Presented unsupervised training strategies that leverage one staining modality to improve performance on images with multiple stains.
result CNNs trained with these strategies outperform standard training methods on images with multiple stains.
A Convolutional Neural Network was used to predict kidney function in patients with chronic kidney disease from high-resolution digital pathology scans of their kidney biopsies. Kidney biopsies were taken from participants of the NEPTUNE study, a longitudinal cohort study whose goal is to set up infrastructure for obse…
This paper studies the performance of a recently proposed preconditioned stochastic gradient descent (PSGD) algorithm on recurrent neural network (RNN) training. PSGD adaptively estimates a preconditioner to accelerate gradient descent, and is designed to be simple, general and easy to use, as stochastic gradient desce…
Novel fusion network combines polarization and radiomics features for liver cancer classification.
problem Challenges in histopathological diagnosis of HCC and ICC.
method Two-tier fusion approach: feature-level and classification-level.
result Significantly enhances classification accuracy, even at reduced resolutions.
Probabilistic method identifies Purkinje network from ECG data.
problem Challenging task of identifying Purkinje conduction system in heart.
method Bayesian optimization and approximate Bayesian computation for probabilistic identification.
result Generates a population of plausible Purkinje networks fitting ECG within tolerance.
Accurate and robust cell nuclei classification is the cornerstone for a wider range of tasks in digital and Computational Pathology. However, most machine learning systems require extensive labeling from expert pathologists for each individual problem at hand, with no or limited abilities for knowledge transfer between…
Localization of chest pathologies in chest X-ray images is a challenging task because of their varying sizes and appearances. We propose a novel weakly supervised method to localize chest pathologies using class aware deep multiscale feature learning. Our method leverages intermediate feature maps from CNN layers at di…
Aims to integrate AI and modelling for patient health forecasting.
problem Personalized, precise treatment plans for patients.
method Graph neural network (GNNs) and generative adversarial network (GANs) for probabilistic simulations.
result Demonstrated integration of molecular data for predicting physiological state evolution.
This study investigates how much knowledge from natural images can be transferred to pathology images.
problem Quantifying how much knowledge from natural images can be transferred to pathology images.
method Proposes a framework to quantify knowledge gain by a particular layer, conducts empirical investigation in pathology image centered transfer learning.
result Early layers of deep models can transfer knowledge to pathology image classification tasks.
Study classifies pathology reports using TF-IDF features and machine learning.
problem Classifying pathology reports for cancer surveillance and diagnostic workflow.
method Extracted TF-IDF features from pathology reports and classified them using SVM, XGBoost, and Logistic Regression.
result XGBoost achieved 92% accuracy in classifying pathology reports.
Transfer learning from breast histopathology improves prostate cancer detection.
problem Insufficient prostate histopathology datasets for training.
method Transfer learning from breast histopathology images.
result Proposed approach outperforms transfer learning from ImageNet dataset.
This paper characterizes VAE training pathologies and their effects on tasks.
problem Characterizing VAE training pathologies and their impact on downstream tasks.
method Concretely characterizing conditions for VAE training pathologies and their connection to specific downstream tasks.
result Connects VAE training pathologies to specific downstream tasks like learning compressed and disentangled representations, adversarial robustness, and semi-supervised learning.
Proposes deep learning method for GCI detection from pathological speech.
problem Detecting glottal closure instants (GCI) in pathological acoustic speech.
method Convolutional neural network with fused deep acoustic speech and linear prediction residual features.
result Significantly better than state-of-the-art methods in GCI detection.
Semi-supervised learning classifies cardiac pathology using motion features from cine MRI.
problem Classifying cardiac pathology based on motion features from cine MRI.
method Semi-supervised learning of apparent flow to generate motion features from non-segmented images.
result The model achieves 95% classification accuracy on ACDC test set.
Novel approach characterizes deep neural networks at initialization.
problem Characterizing the behavior of deep neural networks at initialization.
method A novel approach considering the evolution of statistical moments of signal and noise.
result Established that skip-connections in residual networks lead to well-behaved moments and no pathology.
Batch normalization in the last layer reduces sharpness in wide neural networks.
problem Pathological sharpness in wide neural networks.
method Quantifying the geometry of the parameter space using Fisher information matrix and analyzing deep neural networks with random initialization.
result Batch normalization in the last layer significantly decreases pathological sharpness under specific conditions.
The paper identifies conditions for trend reversal in classification tasks.
problem Trend reversal in classification scores and dataset values.
method Algebraic conditions and numerical results for ridge regression.
result Existence of pathological regularization regimes for certain dataset conditions.
SAPSAM trains CNNs on lung CTs with binary labels, improving CPA detection and localization.
problem Chronic Pulmonary Aspergillosis (CPA) detection and localization on CT scans using binary labels.
method Binary labels, average intensity projections, 2D RGB-like images, hierarchical CNN architectures.
result High classification accuracy, precise localization, predictive power of 2-year survival.
KL-regularized RL from expert demos can lead to slow, unstable learning.
problem Pathological training dynamics in KL-regularized RL from expert demonstrations.
method Empirical analysis and non-parametric behavioral reference policies.
result KL-regularized RL can be significantly improved by using non-parametric behavioral policies.
This work examines robust MCMC for pathological distributions.
problem Pathological behavior in target distributions affects MCMC efficiency.
method Reviewing and proposing remedies for roughness and flatness in MCMC.
result Robust MCMC algorithms can perform well even in challenging conditions.
Paper develops a BERT-based classifier to reduce pathology report annotation workload.
problem Manual annotation of pathology reports is labor-intensive and time-consuming.
method Developed an automatic text classifier using BERT and introduced a human-centric metric to identify low-confidence cases.
result The model reduces manual annotation workload by 80% to 98%.
Generative model for morphological continuum of normal and pathological states.
problem Identifying trends and features that separate normality and pathology in biomedical images.
method Wasserstein Auto-encoder with HSIC regularization for latent features.
result Model generates a continuum of morphological changes corresponding to side information.
The paper presents algorithms for diagnosing Pathological Myopia and detecting retinal structures.
problem Diagnosing Pathological Myopia and detecting retinal structures in fundus images.
method The approach uses Deep Learning techniques, including transfer learning with Xception and YOLO architecture.
result The method has shown satisfactory results in the Pathologic Myopia Challenge.
The computer-aided analysis of medical scans is a longstanding goal in the medical imaging field. Currently, deep learning has became a dominant methodology for supporting pathologists and radiologist. Deep learning algorithms have been successfully applied to digital pathology and radiology, nevertheless, there are st…
A DenseNet model classifies metastatic cancer in medical images.
problem Classifying metastatic cancer in medical images efficiently and accurately.
method Proposes a DenseNet-based model for metastatic cancer classification on medical images.
result The proposed model outperformed other classical methods like Resnet34, Vgg19.
New analysis explains pathology of deep Gaussian processes.
problem Pathology of deep Gaussian processes reduces learning capacities with increased layers.
method Study nonlinear dynamic systems corresponding to DGPs, derive recurrence relations.
result Provide tighter bounds and rate of convergence for dynamic systems.
Machine learning improves EEG pathology classification.
problem Automating clinical EEG analysis using machine learning.
method Developed a comprehensive feature-based framework and compared it to deep neural networks.
result Feature-based framework achieves accuracies similar to deep neural networks.
Causal methods for GRN inference from single-cell data often fail in real-world benchmarks.
problem Understanding when and why causal methods for GRN inference from single-cell data fail in real-world benchmarks.
method Introduced a controlled diagnostic framework to isolate and measure seven pathologies.
result Causal methods dominate in clean and structurally favorable regimes but fail in specific pathologies.
Regularized Stein thinning improves MCMC output approximations.
problem Pathologies in Stein thinning leading to poor approximations.
method Theoretical analysis and regularization to improve KSD.
result Regularized Stein thinning alleviates pathologies and improves efficiency.
For test configurations, the Donaldson-Futaki invariant F_1 is well-known. In this note, its refinement will be discussed. Then we see that Li-Xu's pathology doesn't occur, since their example of a non-normal test configuration, with trivial normalization, actually has non-vanishing F_1 in this refined sense.
New test identifies specific biological parameters for personalized CVD detection.
problem Ineffectual pathology tests fail to consider platelet activation and inter-individual variability.
method Stochastic platelet deposition model and approximate Bayesian computation with discriminative summary statistics.
result Inferred parameters help identify specific biological parameters for personalized CVD detection.
Method treats pseudo healthy synthesis as a factor decomposition problem.
problem Creating a healthy-looking image from a pathological one.
method Adversarial training with paired or unpaired settings, combining two factors (healthy and disease) to reconstruct the input.
result Method outperforms conditional GAN and CycleGAN in generating pseudo healthy images.
Study reveals pathological eigenvalue spectra in FIM and its variants of DNNs.
problem Understanding sharp local shapes in DNN loss landscapes.
method Analysis of FIM and its variants in regression and classification DNNs.
result Pathological eigenvalue spectra appear in FIM and its variants, indicating sharp local shapes in specific directions.
Automatic Chemical Design is a framework for generating novel molecules with optimized properties. The original scheme, featuring Bayesian optimization over the latent space of a variational autoencoder, suffers from the pathology that it tends to produce invalid molecular structures. First, we demonstrate empirically …
Study improves voice disorder detection system robust to channel effects.
problem Voice signals are sensitive to recording devices.
method Bidirectional LSTM network with domain adversarial training (DAT).
result Increased PR-AUC from 0.8448 to 0.9455 (and 0.9522 with labels).
Digital money could reduce germ spread during coronavirus.
problem Spreading of germs via paper money during coronavirus.
method Policy recommendations for mobile wallets, digital currencies, and data protection.
result Adopting digital money can help reduce germ spread.
Optimal prototypes found for challenging pathological geometries.
problem Finding optimal prototypes for pathological geometries is challenging.
method Analytical and heuristic algorithms for finding nearly-optimal prototypes.
result Optimal prototypes can be found analytically for challenging geometries.
Study of digital topology concepts like hyperspaces and function graphs.
problem Adapting classical topology concepts to digital topology.
method Define digital hyperspaces and function graphs, study their properties.
result Some relationships and graphical properties of digital hyperspaces and function graphs.
Study uses image analysis to predict MSI status in tumors.
problem Challenges in distinguishing MSI from its counterpart.
method Interpretable pathological image analysis strategies using Haematoxylin and eosin-stained images.
result Strategies achieve decent performance in MSI prediction.
Corrects a false claim about a digital sphere model's contractibility.
problem Incorrect claim about MSS_18's 18-contractibility.
method Analyzes digital image MSS_18 as a digital model of S^2.
result Shows MSS_18 is 18-contractible.
The paper highlights issues with fixed point claims in digital images.
problem Flaws in published assertions about fixed points in digital images.
method Continues a series of studies examining digital topology.
result Identifies and discusses problems with fixed point claims.