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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,657 papers · 148 categories

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24497397 · Jun 202019922001200920172026
48 results for Cellular Perturbations

ChemCPA predicts cellular responses to novel drugs using transfer learning.

problem Scaling high-throughput screens to measure cellular responses for many drugs is costly and challenging.
method ChemCPA, a new encoder-decoder architecture combined with transfer learning.
result Training on existing bulk RNA HTS datasets improves generalization performance, reducing the need for extensive single-cell screens.

PerturBench benchmarks ML models for cellular perturbation analysis.

problem Standardizing benchmarking in modeling single cell transcriptomic responses to perturbations.
method Modular platform, diverse datasets, metrics, extensive evaluation, rank metrics.
result Simpler models are competitive and scale well with larger datasets.

Novel framework predicts cell responses to perturbations using GRNs.

problem Predicting cellular responses to perturbations for drug discovery and personalized therapeutics.
method Graph variational Bayesian causal inference framework with refined GRNs and robust estimator.
result Enhanced model performance and robust estimation of perturbation effects.

SAMS-VAE models cellular perturbations using sparse additive mechanisms.

problem Modeling effects of diverse interventions on cells.
method Sparse Additive Mechanism Shift Variational Autoencoder (SAMS-VAE).
result SAMS-VAE identifies disentangled, perturbation-specific latent subspaces.

New method learns cell trajectories and network interactions from single-cell data.

problem Network inference in systems biology from steady-state data.
method Min-entropy estimation for stochastic dynamics, leveraging both temporal and perturbational data.
result Jointly learns cellular trajectories and network interactions.

In this paper we generalize cellular algebras by allowing different partial orderings relative to fixed idempotents. For these relative cellular algebras we classify and construct simple modules, and we obtain other characterizations in analogy to cellular algebras. We also give several examples of algebras that are re…

2017-10-08abs ↗pdf ↗

This article introduces descriptive cellular homology on cell complexes, which is an extension of J.H.C. Whitehead's CW topology. A main result is that a descriptive cellular complex is a topology on fibres in a fibre bundle. An application of two forms of cellular homology is given in terms of the persistence of shape…

2018-01-05abs ↗pdf ↗

This study benchmarks transcriptomics models for perturbation analysis, finding scVI and PCA superior.

problem Limited evaluation of transcriptomics foundation models for perturbation analysis.
method Developed a novel evaluation framework using diverse public datasets from different sequencing techniques and cell lines.
result scVI and PCA identified as superior models for understanding biological perturbations.

We present a construction of cellular BF theory (in both abelian and non-abelian variants) on cobordisms equipped with cellular decompositions. Partition functions of this theory are invariant under subdivisions, satisfy a version of the quantum master equation, and satisfy Atiyah-Segal-type gluing formula with respect…

2017-01-20abs ↗pdf ↗

Optimizes natural frequencies of cellular composites with various microstructures.

problem Designing cellular composites with diverse microstructures for maximizing natural frequencies.
method Data-driven topology optimization with a latent-variable Gaussian process model.
result Cellular designs with multiclass microstructures achieve higher natural frequencies.

For leveled spatial graphs, we find a surface embedding that allows cellular embedding.

problem Finding a surface embedding for general spatial graphs is not always possible.
method Define leveled property, decompose graph into subgraphs, and construct surface.
result For leveled spatial graphs with a small number of levels, a surface can always be found.

The notion of cellular stratified spaces was introduced in a joint work of the author with Basabe, González, and Rudyak [1009.1851] with the aim of constructing a cellular model of the configuration space of a sphere. In particular, it was shown that the classifying space (order complex) of the face poset of a totally …

2011-06-19abs ↗pdf ↗

New findings on hyperbolicity of augmented links in thickened surfaces.

problem Proving hyperbolicity of links in thickened surfaces.
method Extending hyperbolicity results to generalized augmented cellular alternating links.
result Generalized augmented cellular alternating links in thickened surfaces are hyperbolic.

CURIE uses cellular automata to detect concept drift in data streams.

problem Detecting changes in data distribution (concept drift) in data streams.
method CURIE represents data stream distribution in a cellular automata grid and uses its neighborhood rule to detect changes.
result CURIE, when hybridized with base learners, performs competitively in detection metrics and classification accuracy.

The paper optimizes UAV path and power for QoS in cellular networks.

problem Optimizing UAV path and power for QoS in cellular networks.
method Apprenticeship learning via deep inverse reinforcement learning (IRL) combined with Q-learning and DRL.
result The proposed method achieves expert-level performance and maintains performance in unseen situations.

Motivation: Understanding functions of proteins in specific human tissues is essential for insights into disease diagnostics and therapeutics, yet prediction of tissue-specific cellular function remains a critical challenge for biomedicine. Results: Here we present OhmNet, a hierarchy-aware unsupervised node feature le…

2017-07-14abs ↗pdf ↗

We show that tree almost automorphism groups, including Neretin groups, satisfy the analogue of the FF_\infty-finiteness condition in the world of totally disconnected groups: They possess a cellular action on a contractible cellular complex such that the stabilizers are open and compact and the restriction of the act…

2015-10-19abs ↗pdf ↗

In this brief sequel to a previous article, we recall the notion of a cut cellular surface (CCS), being a surface with boundary, which is cut in a specified way to be represented in the plane, and is composed of 0-, 1- and 2-cells. We obtain invariants of CCS's under Pachner-like moves on the cellular structure, by cou…

2017-10-04abs ↗pdf ↗

Recently V. Krushkal and D. Renardy generalized the Tutte polynomial from graphs to cell complexes. We show that evaluating this polynomial at the origin gives the number of cellular spanning trees in the sense of A. Duval, C. Klivans, and J. Martin. Moreover, after a slight modification, the Tutte-Krushkal-Renardy pol…

2012-04-16abs ↗pdf ↗

We introduce the notion of a cut cellular surface (CCS), being a surface with boundary, which is cut in a specified way to be represented in the plane, and is composed of 0-, 1- and 2-cells. We obtain invariants of CCS's under Pachner-like moves on the cellular structure, by counting colourings of the 1-cells with elem…

2015-12-22abs ↗pdf ↗

The paper solves curvature problems on infinite hyperbolic surfaces.

problem Prescribed curvature flow on hyperbolic surfaces with infinite topological type.
method Introduced a prescribed curvature flow adapted to infinite cellular decompositions.
result Established well-posedness of the flow and proved convergence under certain conditions.

Let FΘ=G/PΘ\mathbb{F}_{Θ}=G/P_{Θ} be a generalized flag manifold, where GG is a real noncompact semi-simple Lie group and PΘP_{Θ} a parabolic subgroup. A classical result says the Schubert cells, which are the closure of the Bruhat cells, endow FΘ\mathbb{F}_Θ with a cellular CW structure. In this paper we exhibit explicit …

2018-10-01abs ↗pdf ↗

SENA-discrepancy-VAE interprets latent causal factors in biological pathways.

problem Interpreting latent causal factors in biological pathways.
method SENA-discrepancy-VAE, a model based on discrepancy-VAE, that produces interpretable latent causal factors.
result Sena-discrepancy-VAE achieves comparable predictive performance with non-interpretable counterparts while providing biologically meaningful causal factors.

New stability theorem for nonorientable surfaces mapping class groups.

problem Stability of homology groups of mapping class groups of nonorientable surfaces.
method Galatius--Kupers--Randal-Williams framework of cellular E2E_2-algebras.
result New best known stability range for homology of nonorientable surfaces.

Optimizes antenna tilt for better QoS in cellular networks.

problem Hard to learn optimal antenna tilt policies in real networks due to risk and simulation gap.
method Uses off-policy Contextual Multi-Armed-Bandit (CMAB) techniques to learn from existing data.
result Trained policies show consistent improvements over existing logging policies.

IH-GAN models cellular structures accurately and improves structural performance.

problem Optimizing variable-density cellular structures with multiscale design challenges.
method Conditional deep generative model (IH-GAN) for property-to-geometry mapping using implicit function parameterization.
result Generates unit cells with high accuracy and improves structural performance.

The main results of this paper are: (1) If a space XX can be embedded as a cellular subspace of Rn\mathbb{R}^n then XX admits arbitrary fine open coverings whose nerves are homeomorphic to the nn-dimensional cube Dn\mathbb{D}^n; (2) Every nn-dimensional cell-like compactum can be embedded into (2n+1)(2n+1)-dimensional …

2015-02-07abs ↗pdf ↗