Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, …
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48 results for “Alzheimer's disease detection”
On the design of convolutional neural networks for automatic detection of Alzheimer's diseaseeess.IV
Improved CNNs detect Alzheimer's with 14% accuracy boost.
problem Early detection of Alzheimer's Disease using MRI scans.
method Optimized 3D CNNs with instance normalization, spatial downsampling, model widening, and age information.
result 14% increase in test accuracy distinguishing AD, MCI, and controls.
Alzheimer's disease is the most common dementia leading to an irreversible neurodegenerative process. To date, subject revealed advanced brain structural alterations when the diagnosis is established. Therefore, an earlier diagnosis of this dementia is crucial although it is a challenging task. Recently, many studies h…
The paper generates future brain imaging sequences for Alzheimer's disease detection.
problem Understanding brain aging and neurodegenerative diseases through sequential image data.
method Formulated a min-max problem based on -divergence to learn a time series generator using a deep neural network.
result Generated image sequences converge to the latent truth under specific conditions, enhancing downstream tasks like Alzheimer's disease detection.
System diagnoses Alzheimer's disease from spoken language using multi-modal features.
problem Early diagnosis of Alzheimer's disease from spoken language.
method Classification system based on spoken language using three approaches (N-gram, i-vector, x-vector).
result Accuracy of 83.6% on the cookie picture description task from Pitt Corpus dementia bank.
Multimodal Inductive Transfer Learning for Detection of Alzheimer's Dementia and its Severityeess.AS
New model detects Alzheimer's and severity from speech, cognitive, and language data.
problem Detecting Alzheimer's disease and its severity from multimodal data.
method Multimodal ensemble system using acoustic, cognitive, and linguistic features.
result State-of-the-art accuracy and robustness in AD detection and MMSE score regression.
Novel approach combines local and global brain changes for AD prediction.
problem Detecting Alzheimer's disease through local and global brain changes.
method Patch-based 3D-CNNs combined with global topological features for multi-scale brain tissue connectivity.
result Average precision score of 0.95 for classifying cognitively normal subjects and AD patients (prevalence ~55%).
QC-SPHARM detects Alzheimer's Disease early using hippocampal surface geometry.
problem Early detection of Alzheimer's Disease (AD) using hippocampal surface geometry.
method Spherical harmonics registration, conformality and curvature distortions quantification, t-test feature selection, SVM classification.
result 85.2% testing accuracy on ADNI data, 81.2% on aMCI progression data.
Paper introduces a framework for diagnosing Alzheimer's disease using higher-order topological features from fMRI.
problem Diagnosing Alzheimer's disease using brain network topology.
method Persistent homology to extract higher-order features (cycles, cavities) from fMRI data.
result Framework significantly outperforms existing methods in AD classification.
Novel method identifies proteomic risk markers for Alzheimer disease.
problem Lack of comprehensive proteomic risk markers for Alzheimer disease diagnosis.
method Deep belief network-based feature selection method using proteomic and clinical data.
result Identified an optimal subset of proteins achieving 90% accuracy in Alzheimer disease diagnosis.
New method predicts AD progression using MEG brain networks.
problem Early diagnosis and prediction of Alzheimer's disease progression.
method MG2G, a deep learning method that maps brain networks into a latent space.
result MG2G detects subtle brain connectivity patterns and predicts AD progression.
Bayesian meta-learning predicts Alzheimer's disease progression.
problem Predicting individual Alzheimer's disease progression from limited data.
method Bayesian meta-learning approach that dynamically predicts disease score distributions.
result Bayesian meta-learner outperforms single-task models and deterministic meta-learners, especially for long-term predictions.
Deep learning ensemble improves Alzheimer vs. Mild Cognitive Impairment diagnosis.
problem Differentiating Alzheimer Disease from Mild Cognitive Impairment.
method Hybrid deep learning ensemble framework using MRI slices, pretrained models, and stacked ensemble learning.
result State-of-the-art accuracy (99.21%) for Alzheimer vs. Mild Cognitive Impairment classification.
ADCB: An Alzheimer's disease benchmark for evaluating observational estimators of causal effectscs.LG
Proposes a new Alzheimer's disease simulator for causal effect estimation.
problem Lack of suitable benchmarks for evaluating causal effect estimators in real-world healthcare data.
method Developed a simulator of Alzheimer's disease using ADNI dataset, incorporating various parameters to model complexities.
result Compared estimators of average and conditional treatment effects using the new simulator.
We develop three efficient approaches for generating visual explanations from 3D convolutional neural networks (3D-CNNs) for Alzheimer's disease classification. One approach conducts sensitivity analysis on hierarchical 3D image segmentation, and the other two visualize network activations on a spatial map. Visual chec…
Arguably, unsupervised learning plays a crucial role in the majority of algorithms for processing brain imaging. A recently introduced unsupervised approach Deep InfoMax (DIM) is a promising tool for exploring brain structure in a flexible non-linear way. In this paper, we investigate the use of variants of DIM in a se…
HMRNN combines HMMs and neural networks for Alzheimer's disease forecasting.
problem Improving disease progression modeling with hidden states not fully known.
method Developed HMRNN combining HMMs and recurrent neural networks.
result HMRNN improves disease forecasting and offers novel clinical interpretation.
Sparse symmetric tensor regression reduces brain connectivity complexity.
problem Complex brain connectivity analysis in neuroimaging.
method Sparse symmetric tensor regression model for functional connectivity.
result Superior performance in Alzheimer's disease detection.
Transformer model pretrains on synthetic graphs for AD detection.
problem Limited labeled data and class imbalance in AD diagnosis.
method Diffusion-generated synthetic graphs, Graph Transformers, transfer learning.
result Framework outperforms baselines in AD diagnosis metrics.
Speech datasets for identifying Alzheimer's disease (AD) are generally restricted to participants performing a single task, e.g. describing an image shown to them. As a result, models trained on linguistic features derived from such datasets may not be generalizable across tasks. Building on prior work demonstrating th…
Paper proposes machine learning model for early Alzheimer's diagnosis.
problem Early and accurate diagnosis of Alzheimer's Disease.
method Machine learning models, demographic, biomarker, and cognitive test data.
result 90% accuracy and 87% accuracy in predicting Alzheimer's development.
Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to have great efficacy in this domain. These algorithms often use neurological ima…
This paper considers the problem of brain disease classification based on connectome data. A connectome is a network representation of a human brain. The typical connectome classification problem is very challenging because of the small sample size and high dimensionality of the data. We propose to use simultaneous app…
Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in which biomarkers for a disease become abnormal based on cross-sectional data. It can…
StaPLR improves Alzheimer's disease classification by identifying important MRI scan types and measures.
problem Classifying Alzheimer's disease using multi-source MRI data.
method Stacked penalized logistic regression (StaPLR) with hierarchical multi-view structure and new view importance measure.
result StaPLR identifies the most important MRI scan types and measures for Alzheimer's disease classification.
Genome-wide association studies (GWAS) have achieved great success in the genetic study of Alzheimer's disease (AD). Collaborative imaging genetics studies across different research institutions show the effectiveness of detecting genetic risk factors. However, the high dimensionality of GWAS data poses significant cha…
Most approaches to machine learning from electronic health data can only predict a single endpoint. Here, we present an alternative that uses unsupervised deep learning to simulate detailed patient trajectories. We use data comprising 18-month trajectories of 44 clinical variables from 1908 patients with Mild Cognitive…
Joint models for longitudinal and time-to-event data are commonly used in longitudinal studies to forecast disease trajectories over time. Despite the many advantages of joint modeling, the standard forms suffer from limitations that arise from a fixed model specification and computational difficulties when applied to …
Transformers improve Alzheimer's disease progression prediction by accounting for irregular biomarker histories.
problem Difficult prediction of medium-horizon Alzheimer's disease progression due to tied clinical scores and irregular biomarker observations.
method Developed a residual gap-aware transformer that combines statistical reference with transformer-based residual learning.
result The proposed model reduces mean error and improves prediction-observation correlation compared to baseline models.
Study examines APOE's impact on AD progression using a novel DEBM approach.
problem Understanding APOE's role in AD progression and developing targeted clinical trials.
method Developed a discriminative event-based model (DEBM) and proposed a stratified approach to improve model accuracy.
result Identified APOE carriers' impact on AD progression timeline, aiding clinical trial selection.
Bayesian approach models neurodegenerative diseases without clinical labels.
problem Personalized, predictive modeling of neurodegenerative diseases.
method Probabilistic programmed deep kernel learning combining Gaussian processes and neural networks.
result Surpasses deep learning in accuracy and timeliness of predicting neurodegeneration.
Meta Fusion integrates various multimodal data fusion strategies into a unified framework.
problem Improving predictive power of machine learning methods across diverse applications.
method Meta Fusion constructs a cohort of models based on latent representations across modalities, sharing soft information to boost performance.
result Meta Fusion consistently outperforms conventional fusion strategies in simulation and real-world applications.
Accurate diagnosis of Alzheimer's Disease (AD) entails clinical evaluation of multiple cognition metrics and biomarkers. Metrics such as the Alzheimer's Disease Assessment Scale - Cognitive test (ADAS-cog) comprise multiple subscores that quantify different aspects of a patient's cognitive state such as learning, memor…
Ensemble model predicts AD progression from CN status with high accuracy.
problem Early prediction of clinical progression from cognitively normal to mild cognitive impairment or Alzheimer's disease.
method Ensemble survival analysis combining penalized Cox regression, advanced survival models, and aggregation techniques.
result Ensemble model achieved peak C-index of 0.907 and integrated time-dependent AUC of 0.904, outperforming baseline models.
PETNet improves AD diagnosis using graph-based CNN on PET images.
problem Early diagnosis of Alzheimer's Disease using PET imaging.
method PETNet, a graph-based CNN architecture for 3D PET image analysis.
result PETNet shows improved performance over deep learning and other methods on ADNI dataset.
Study identifies five AD subtypes using graph diffusion and similarity learning.
problem Identifying homogeneous AD subtypes to improve diagnosis and treatment.
method Unsupervised clustering with graph diffusion and similarity learning.
result Five distinct AD subtypes identified with significant differences in biomarkers and clinical features.
Improves disease progression prediction using auxiliary surrogate labels and health markers.
problem Challenges in predicting disease progression due to unknown true disease states.
method Integrates hidden Markov model with time-varying discriminative classification model.
result Significant improvement in distinguishing LBD from AD using objective markers.
NEURO-DRAM: a 3D recurrent visual attention model for interpretable neuroimaging classificationcs.LG
NEURO-DRAM improves neuroimaging classification accuracy.
problem Improper use of traditional computer vision models in neuroimaging.
method 3D recurrent visual attention model trained with reinforcement learning.
result NEURO-DRAM achieves state-of-the-art accuracy in Alzheimer's disease prediction.
Wavelets model complex interactions in spatial transcriptomics.
problem Capturing higher-order relationships in spatial transcriptomics data.
method Hypergraph diffusion wavelets for representing hyperedges.
result Wavelets effectively represent disease-relevant cellular niches in Alzheimer's disease.
THS-GAN uses tensorizing and high-order pooling for AD diagnosis.
problem Early diagnosis of Alzheimer's Disease (AD) using MRI images.
method Tensorizing a three-player cooperative game framework with high-order pooling for MRI images.
result THS-GAN achieves superior performance in AD diagnosis compared to existing methods.
Pattern recognition methods using neuroimaging data for the diagnosis of Alzheimer's disease have been the subject of extensive research in recent years. In this paper, we use deep learning methods, and in particular sparse autoencoders and 3D convolutional neural networks, to build an algorithm that can predict the di…
For precision medicine and personalized treatment, we need to identify predictive markers of disease. We focus on Alzheimer's disease (AD), where magnetic resonance imaging scans provide information about the disease status. By combining imaging with genome sequencing, we aim at identifying rare genetic markers associa…
Paper characterizes early-stage dementia signatures from sensor data.
problem Detecting early-stage dementia from sensor data.
method Developed bespoke behavioural models from longitudinal sensor data.
result Found subtle differences in sleep quality and wandering between dementia patients and controls.
SVEHNN explains DNN diagnoses of Alzheimer's disease from neuroanatomy and biomarkers.
problem Interpreting deep neural networks for medical diagnosis, especially in the clinic.
method Shapley Value Explanation of Heterogeneous Neural Networks (SVEHNN) for local explanations.
result SVEHNN provides interpretable explanations for DNN diagnoses with reduced runtime.
A Wide and Deep Neural Network for Survival Analysis from Anatomical Shape and Tabular Clinical Datacs.LG
We introduce a wide and deep neural network for prediction of progression from patients with mild cognitive impairment to Alzheimer's disease. Information from anatomical shape and tabular clinical data (demographics, biomarkers) are fused in a single neural network. The network is invariant to shape transformations an…
A new mathematical approach detects frequency-based alterations in brain networks.
problem Understanding disease-relevant brain alterations through network analysis.
method Proposes a novel connectome harmonic analysis framework using common harmonic waves learned from Stiefel manifolds.
result Identifies more significant and reproducible network dysfunction patterns in Alzheimer's disease.
Early detection of Alzheimer's disease (AD) and identification of potential risk/beneficial factors are important for planning and administering timely interventions or preventive measures. In this paper, we learn a disease model for AD that combines genotypic and phenotypic profiles, and cognitive health metrics of pa…
Genome-wide association studies (GWAS) offer new opportunities to identify genetic risk factors for Alzheimer's disease (AD). Recently, collaborative efforts across different institutions emerged that enhance the power of many existing techniques on individual institution data. However, a major barrier to collaborative…