Optimizes treatment duration to maximize quality-adjusted lifetime.
problem Balancing risks and benefits in clinical decision making.
method Proposes a weighted estimating equation to adjust for confounding and informative censoring, and a nonparametric estimator for mean counterfactual quality-adjusted lifetime.
result Shows the optimal time for percutaneous endoscopic gastrostomy insertion in ALS patients.
We present a fundamental theory of curves in the affine plane and the affine space, equipped with the general-affine groups GA(2)=GL(2,R)⋉R2 and GA(3)=GL(3,R)⋉R3, respectively. We define general-affine length parameter and curvatures and show how such …
Study curves evolving on hypersurfaces with free boundaries, preserving length.
problem Evolution of curves on hypersurfaces with free boundaries.
method Nonlocal evolution equation with nonlinear boundary conditions, short-time existence, uniqueness, and parabolic energy estimates.
result Global existence and convergence to critical points proved.
Estimates individualized treatment effects using shared RBF-net neurons.
problem Identifying differential treatment effects based on covariates.
method Non-parametric radial basis function (RBF)-nets with shared hidden neurons in a Bayesian framework.
result Demonstrated through simulations and real data, the method identifies interesting treatment effects.
We present the first treatment of the arc length of the Gaussian Process (GP) with more than a single output dimension. GPs are commonly used for tasks such as trajectory modelling, where path length is a crucial quantity of interest. Previously, only paths in one dimension have been considered, with no theoretical con…
Background. Real-world data show that approximately 50% of psoriasis patients treated with a biologic agent will discontinue the drug because of loss of efficacy. History of previous therapy with another biologic, female sex and obesity were identified as predictors of drug discontinuations, but their individual predic…
Proposes a new Alzheimer's disease simulator for causal effect estimation.
problem Lack of suitable benchmarks for evaluating causal effect estimators in real-world healthcare data.
method Developed a simulator of Alzheimer's disease using ADNI dataset, incorporating various parameters to model complexities.
result Compared estimators of average and conditional treatment effects using the new simulator.
The paper explores conjugate points in Lorentzian spaces, comparing different definitions and proving related theorems.
problem Understanding conjugate points in Lorentzian geometry.
method Introducing and comparing different definitions of conjugate points in synthetic Lorentzian length spaces.
result All defined notions of conjugate points are compatible with the smooth spacetime setting.
Bayesian method for estimating ATE with robustness to model misspecification.
problem Estimating average treatment effects under unconfoundedness.
method Double robust Bayesian inference using adjusted prior and posterior distributions.
result Bayesian credible sets form asymptotically exact confidence intervals.
Inpatient care is a large share of total health care spending, making analysis of inpatient utilization patterns an important part of understanding what drives health care spending growth. Common features of inpatient utilization measures include zero inflation, over-dispersion, and skewness, all of which complicate st…
Recently, a framework for application-oriented optimal experiment design has been introduced. In this context, the distance of the estimated system from the true one is measured in terms of a particular end-performance metric. This treatment leads to superior unknown system estimates to classical experiment designs bas…
The study optimizes free trial lengths to boost subscriptions and consumer loyalty.
problem Optimizing free trial lengths to maximize customer acquisition and retention.
method A large-scale field experiment with personalized policy design and evaluation.
result Personalized free trial policies outperform uniform trial lengths.
GraphITE estimates individual effects of graph-structured treatments.
problem Estimating individual effects of complex treatment structures.
method Graph neural networks and Hilbert-Schmidt Independence Criterion regularization.
result GraphITE outperforms baselines in estimating treatment effects for large numbers of treatments.
M3E2 neural network estimates multiple treatment effects.
problem Estimating effects of multiple treatments simultaneously.
method Multi-task learning neural network model for multiple treatments, continuous and binary.
result M3E2 outperforms baselines in synthetic datasets.
Suppose (X,ω) is a compact Kähler manifold. Following Mabuchi, the space of smooth Kähler potentials H can be endowed with a Riemannian structure, which induces an infinite dimensional path length metric space (H,d). We prove that the metric completion of (H,d) can be identified with …
Proposes a new method to estimate continuous treatment policies and match treatments effectively.
problem Current methods struggle with continuous treatment policies and complex matching.
method Formulates treatment effectiveness as a parametrizable model, using deep learning for optimization.
result Significant improvement in treatment effectiveness and matching efficiency.
Framework generates personalized insulin treatment strategies using deep models.
problem Developing optimal personalized treatment strategies for diabetes patients.
method Combines deep generative time series models with decision theory.
result Demonstrated improved personalized insulin treatment strategies for diabetes patients.
Develops deep jump learning for continuous treatment OPE.
problem Estimating mean outcomes under new treatment rules using historical data from different rules.
method Adaptive deep discretization of continuous treatment space using deep learning and multi-scale change point detection.
result Validated method through theoretical results, simulations, and real application to Warfarin Dosing.
We combine and extend the work of Alexander & Antman \cite{alexander.82} and Fuller \cite{fuller.71,fuller.78} to give a framework within which precise definitions can be given of topological and geometrical quantities characterising the contortion of open rods undergoing large deformations under end loading. We use th…
Method controls treatment risk in learning beneficial allocations.
problem Learning beneficial treatment allocations with risk control in precision medicine.
method Proposes a certifiable learning method that controls treatment risk with finite samples in the partially identified setting.
result Illustrates method using both simulated and real data.
Optimal adaptive experiment for choosing best treatment with binary outcomes.
problem Choosing the best treatment from binary options in an adaptive experiment.
method Adaptive experiment with two phases: treatment allocation and choice. Neyman allocation method used.
result Neyman allocation is minimax and Bayes optimal, matching lower bounds for regret.
Proposes a fusion method for many treatment groups in ITRs.
problem Challenges in handling many treatment groups with data sparsity and covariate imbalance.
method Calibration-weighted treatment fusion procedure that balances covariates and fuses similar treatments.
result Ensures robust treatment group recovery and policy value compared to existing methods.
Dynamic treatment effects estimated over time using covariate balancing.
problem Estimating treatment effects in panel data with dynamic treatments.
method Dynamic covariate balancing with potential local projections.
result Established inferential guarantees for the proposed method.
CRN model estimates treatment effects over time using adversarial balancing.
problem Estimating treatment effects over time in medical settings.
method Adversarial domain balancing to remove time-varying confounders.
result CRN achieves lower error in estimating counterfactuals and treatment timing.
Heteroskedasticity biases uplift model rankings, leading to inefficient treatment allocation.
problem Bias in uplift model rankings due to heteroskedasticity.
method Theoretical analysis and simulation on real-world data.
result Heteroskedasticity can cause individuals with high treatment effects to be ranked at the bottom, leading to inefficient treatment allocation.
Estimates heterogeneous treatment effects in panel data with a new method.
problem Estimating heterogeneous treatment effects in panel data with general treatment patterns.
method Partition observations into clusters with similar treatment effects using a regression tree, then estimate average treatment effects for each cluster.
result Our method achieves superior accuracy compared to alternative approaches.
In treatment allocation problems the individuals to be treated often arrive sequentially. We study a problem in which the policy maker is not only interested in the expected cumulative welfare but is also concerned about the uncertainty/risk of the treatment outcomes. At the outset, the total number of treatment assign…
NICE model estimates causal effects for image treatments.
problem Challenges in causal effect estimation for multi-dimensional treatments.
method Proposes NICE model for image treatments, incorporating rich multidimensional information.
result NICE significantly outperforms existing models in estimating causal effects for image treatments.
XTNet estimates complex cross-treatment effects in multi-category, multi-valued settings.
problem Challenges in estimating causal effects for multi-category, multi-valued treatments.
method Dynamic Neural Masking for capturing treatment interactions without restrictive assumptions.
result XTNet consistently outperforms state-of-the-art baselines in multi-category, multi-valued treatment effect estimation.
Personalized medicine aims at identifying best treatments for a patient with given characteristics. It has been shown in the literature that these methods can lead to great improvements in medicine compared to traditional methods prescribing the same treatment to all patients. Subgroup identification is a branch of per…
The paper proposes a method to precisely decompose confounders and estimate treatment effects.
problem Estimating treatment effects from observational data with confounder identification and balancing.
method Learning decomposed representations to identify and balance confounders and non-confounders.
result The method achieves more precise treatment effect estimation than existing methods.
RATE metrics evaluate treatment prioritization rules, subsuming existing methods.
problem Comparing and testing the quality of treatment prioritization rules.
method Rank-weighted average treatment effect (RATE) metrics.
result RATE metrics enable asymptotically exact inference in various study settings.
Selective imputation improves treatment effect estimation from missing data.
problem Missing data complicates treatment effect estimation, especially with treatment variables.
method Introduced mixed confounded missingness (MCM) and selective imputation.
result Selective imputation provides unbiased treatment effect estimates.
TV-SurvCaus improves causal inference for dynamic treatments in survival analysis.
problem Estimating causal effects of time-varying treatments on survival outcomes.
method Representation balancing techniques extended to time-varying treatment regimes with survival outcomes.
result TV-SurvCaus outperforms existing methods in estimating individualized treatment effects with time-varying covariates and treatments.
Develops methods for near-optimal personalized treatment recommendations.
problem Assigning optimal treatments to patients based on individual characteristics.
method Outcome weighted learning framework to estimate near-optimal alternative individualized treatment recommendations (A-ITR).
result Consistency of proposed methods and upper bound for risk between optimal and estimated recommendations.
Given two possible treatments, there may exist subgroups who benefit greater from one treatment than the other. This problem is relevant to the field of marketing, where treatments may correspond to different ways of selling a product. It is similarly relevant to the field of public policy, where treatments may corresp…
Optimizes treatment allocation in networks considering indirect effects.
problem Finding optimal treatment allocation in network settings with interference.
method OTAPI: Optimizing Treatment Allocation in the Presence of Interference, integrating causal estimators into IM algorithms.
result OTAPI outperforms classic IM and UM approaches on synthetic and semi-synthetic datasets.
New test for binary treatment effects using kernel methods.
problem Testing distributional effects of binary treatments.
method Kernel-based doubly-robust test, avoiding permutations.
result Valid type-I error with computational efficiency.
LI-ITR combines flexible ML with interpretable approximations for personalized treatment rules.
problem Combining flexibility and interpretability in personalized treatment rules.
method Uses variational autoencoders and a mixture of interpretable experts.
result Accurately recovers true local coefficients and optimal treatment strategies.
Paper tackles CATE estimation with missing treatment info.
problem Challenges in estimating CATE with missing treatment information.
method Developed MTRNet, a novel CATE estimation algorithm using domain adaptation.
result Improves CATE estimation over state-of-the-art methods.
Paper tackles treatment leakage in text-based causal inference, proposing methods to mitigate bias.
problem Treatment leakage in text-as-confounder applications introduces bias in causal estimates.
method Formal definitions, four text distillation methods (passage removal, classification, salient feature removal, nullspace projection).
result Moderate distillation optimally balances bias reduction against confounder retention.
The causal effect of a treatment can vary from person to person based on their individual characteristics and predispositions. Mining for patterns of individual-level effect differences, a problem known as heterogeneous treatment effect estimation, has many important applications, from precision medicine to recommender…
A novel framework synthesizes treatment data across sites using optimal transport.
problem Estimating treatment effects across different sites with varying conditions.
method Distributional causal inference, Optimal Transport for alignment of control group distributions.
result Synthetic treatment group data aligns with true target distribution under general conditions.
DONUT improves treatment effect estimation by enforcing orthogonality constraints.
problem Estimating treatment effects from observational data is challenging due to unobserved outcomes.
method DONUT uses a regularization framework that formalizes unconfoundedness as orthogonality, leading to deep orthogonal networks.
result DONUT outperforms state-of-the-art methods in estimating average treatment effects.
Estimating the effect of a treatment on a given outcome, conditioned on a vector of covariates, is central in many applications. However, learning the impact of a treatment on a continuous temporal response, when the covariates suffer extensively from measurement error and even the timing of the treatments is uncertain…
Proposes a generalized causal tree for handling multiple treatments in uplift modeling.
problem Handling multiple treatments in uplift modeling.
method Generalizes causal tree algorithm to handle multiple discrete and continuous-valued treatments.
result Demonstrates improved performance over existing methods in experiments and real data examples.
Framework integrates mental disorder measurements for personalized treatment.
problem Optimizing treatment for mental disorders with latent mental states and heterogeneity.
method Measurement theory and multi-layer neural network for complex treatment effects.
result Learned treatment policies outperform alternatives on heterogeneous treatment effects.
New method learns unbiased treatment representations from structured high-dimensional data.
problem Estimating causal effects from high-dimensional, structured treatments.
method Contrastive learning approach to learn unbiased treatment representations.
result The method identifies causal factors and discards non-causal ones, leading to unbiased causal effect estimates.