Paper derives policy rules from observational data for hepatitis C treatment.
problem Improving treatment guidelines for HIV/HCV co-infected patients.
method Weighted K-means algorithm for estimating CATEs, decision tree implementation.
result Identifies a subgroup with high spontaneous HCV clearance rate.
The dearth of prescribing guidelines for physicians is one key driver of the current opioid epidemic in the United States. In this work, we analyze medical and pharmaceutical claims data to draw insights on characteristics of patients who are more prone to adverse outcomes after an initial synthetic opioid prescription…
Improving cancer treatment decisions requires considering causal effects, not just model accuracy.
problem Cancer outcome prediction models may cause harm when used for treatment decisions.
method Explains the importance of considering causal effects in model validation and provides guidelines.
result Building and validating models that are useful for decision making requires considering causal effects.
The paper learns personalized treatment rules from observational data.
problem Developing effective treatment policies for individual patients.
method Contextual bandit approach to minimize expected risk of treatment policies.
result The proposed method outperforms physicians and baseline approaches in IV and VP administration.
Unified survey of treatment effect heterogeneity and uplift modeling methods.
problem Estimating heterogeneous treatment effects and uplift modeling.
method Unified survey of treatment effect heterogeneity and uplift modeling approaches.
result Unified notations for comparing methods and applications in personalized marketing, medicine, and social studies.
New method for finding optimal treatment regimes in medical settings with time-varying unobserved factors.
problem Finding optimal treatment regimes in medical settings with time-varying unobserved factors.
method Extend Dynamic Treatment Regimes (DTRs) to Ambiguous Dynamic Treatment Regimes (ADTRs), connect to Ambiguous Partially Observable Mark Decision Processes (APOMDPs), and develop Reinforcement Learning methods.
result Established theoretical results for learning methods, including consistency and asymptotic normality.
A new method improves treatment effect inferences in RCTs by adjusting for covariates and heteroskedasticity.
problem Improving treatment effect inferences in RCTs with efficient and powerful methods.
method Weighted Prognostic Covariate Adjustment Method (Weighted PROCOVA) for heteroskedasticity.
result The method reduces variance, maintains Type I error rate, and increases test power for treatment effect.
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
problem Suboptimal management and poor prognosis due to low incidence and heterogeneity of rare gynecological tumors.
method Developed a digital twin system using LLMs to integrate clinical and biomarker data.
result LLM-enabled digital twins efficiently model individual patient trajectories and identify potential treatment options.
The paper integrates AI and expert knowledge to optimize radiotherapy decisions.
problem Optimizing radiation dose planning considering patient-specific information.
method Integrating Gaussian process models with deep neural networks to quantify uncertainty.
result Improves AI model performance and guides clinical decision making.
A new metric for stable model selection in CATE prediction.
problem Model selection in conditional average treatment effect (CATE) prediction.
method Analysis of model performance ranking and formulation of a novel metric.
result Our metric outperforms existing metrics in model selection and hyperparameter tuning.
Background. Real-world data show that approximately 50% of psoriasis patients treated with a biologic agent will discontinue the drug because of loss of efficacy. History of previous therapy with another biologic, female sex and obesity were identified as predictors of drug discontinuations, but their individual predic…
Codebook for Institutional Grammar 2.0 simplifies policy encoding.
problem Facilitating consistent policy encoding for diverse analytical needs.
method Revised Institutional Grammar with multiple levels of expressiveness.
result Enhanced flexibility and specificity in policy encoding.
Current advances in research, development and application of artificial intelligence (AI) systems have yielded a far-reaching discourse on AI ethics. In consequence, a number of ethics guidelines have been released in recent years. These guidelines comprise normative principles and recommendations aimed to harness the …
Review of machine learning methods for detecting depression from resting EEG.
problem Detecting depression from resting-state EEG recordings.
method Machine learning combined with nonlinear analysis on EEG data.
result Improved reliability of depression detection models.
This work simplifies choosing reinforcement-learning algorithms.
problem Challenging selection of reinforcement-learning algorithms.
method Structured overview and guidelines for choosing methods.
result Provides structured guidelines for algorithm selection.
Machine learning improves CAD management outcomes.
problem Current CAD guidelines do not account for patient-specific characteristics.
method Developed binary classifiers and regression models using patient data.
result Improved health outcomes by 24.11% compared to standard care.
Annotation guidelines used to guide the annotation of training and evaluation datasets can have a considerable impact on the quality of machine learning models. In this study, we explore the effects of annotation guidelines on the quality of app feature extraction models. As a main result, we propose several changes to…
Framework for applying GPs to real-world data with scalability guidelines.
problem Deployment of Gaussian Processes (GPs) is hindered by computational costs and lack of guidelines.
method Proposed a framework for identifying GP suitability and setting up robust models, formalizing decisions of experienced practitioners.
result More accurate results at test time for glacier elevation change case study.
In this paper, we aimed at reviewing several different approaches present today in the search for more accurate diagnostic and treatment management in mental healthcare. Our focus is on mood disorders, and in particular on the major depressive disorder (MDD). We are reviewing and discussing findings based on neuroimagi…
Concave regularization methods provide natural procedures for sparse recovery. However, they are difficult to analyze in the high dimensional setting. Only recently a few sparse recovery results have been established for some specific local solutions obtained via specialized numerical procedures. Still, the fundamental…
Treatment recommendations within Clinical Practice Guidelines (CPGs) are largely based on findings from clinical trials and case studies, referred to here as research studies, that are often based on highly selective clinical populations, referred to here as study cohorts. When medical practitioners apply CPG recommend…
Deep learning clusters patient time-series data for better prognosis.
problem Clustering time-series data for patient phenotyping and prognosis.
method Deep predictive clustering with novel loss functions for future outcome distribution.
result Model achieves superior clustering performance and identifies meaningful patient subgroups.
Proposes guidelines for developing medical AI products.
problem Lack of clear pathways for regulating medical AI.
method Statistical risk perspective and deep understanding of machine learning methodologies.
result Enhanced development of medical AI products and regulations.
Excessively changing policies in many real world scenarios is difficult, unethical, or expensive. After all, doctor guidelines, tax codes, and price lists can only be reprinted so often. We may thus want to only change a policy when it is probable that the change is beneficial. In cases that a policy is a threshold on …
Bayesian optimisation has gained great popularity as a tool for optimising the parameters of machine learning algorithms and models. Somewhat ironically, setting up the hyper-parameters of Bayesian optimisation methods is notoriously hard. While reasonable practical solutions have been advanced, they can often fail to …
Consistently checking the statistical significance of experimental results is one of the mandatory methodological steps to address the so-called "reproducibility crisis" in deep reinforcement learning. In this tutorial paper, we explain how the number of random seeds relates to the probabilities of statistical errors. …
Scale of data and scale of computation infrastructures together enable the current deep learning renaissance. However, training large-scale deep architectures demands both algorithmic improvement and careful system configuration. In this paper, we focus on employing the system approach to speed up large-scale training.…
Sherpa.ai framework combines federated learning and differential privacy for edge AI services.
problem Protecting data privacy in edge AI services.
method Holistic federated learning and differential privacy approach with methodological guidelines.
result Demonstrated through classification and regression use cases.
Deep neural networks (DNNs) have been proven to have many redundancies. Hence, many efforts have been made to compress DNNs. However, the existing model compression methods treat all the input samples equally while ignoring the fact that the difficulties of various input samples being correctly classified are different…
The study analyzes convergence rates for sparse pivotal estimators in high-dimensional regression.
problem Sparse pivotal estimation in high-dimensional regression problems.
method Theoretical analysis and comparison of non-smooth + non-smooth optimization problems, including smoothing techniques.
result Minimax sup-norm convergence rates for square-root Lasso-type estimators are derived.
State-of-the-art machine learning frameworks support a wide variety of design features to enable a flexible machine learning programming interface and to ease the programmability burden on machine learning developers. Identifying and using a performance-optimal setting in feature-rich frameworks, however, involves a no…
Electronic health records (EHR) data provide a cost and time-effective opportunity to conduct cohort studies of the effects of multiple time-point interventions in the diverse patient population found in real-world clinical settings. Because the computational cost of analyzing EHR data at daily (or more granular) scale…
This chapter introduces reproducibility in machine learning for medical imaging.
problem Lack of reproducibility in machine learning for medical imaging.
method Distinguishes and defines types of reproducibility, outlines requirements, and discusses utility.
result Discussion on benefits and a plea for a non-dogmatic approach to reproducibility.
A framework for causal classification using uplift and causal heterogeneity methods.
problem Predicting the effect of interventions on different individuals from data.
method Causal classification framework using off-the-shelf supervised methods.
result Framework works for causal classification and uplift modelling, competitive with other methods.
Survival analysis models predict economic convergence across Americas.
problem Analyzing GDP per capita trajectories and convergence across the Americas.
method Survival analysis, machine learning, economic interpretation.
result DeepSurv captures non-linear interactions in GDP per capita trajectories.
GraphITE estimates individual effects of graph-structured treatments.
problem Estimating individual effects of complex treatment structures.
method Graph neural networks and Hilbert-Schmidt Independence Criterion regularization.
result GraphITE outperforms baselines in estimating treatment effects for large numbers of treatments.
M3E2 neural network estimates multiple treatment effects.
problem Estimating effects of multiple treatments simultaneously.
method Multi-task learning neural network model for multiple treatments, continuous and binary.
result M3E2 outperforms baselines in synthetic datasets.
The paper analyzes SMOTE for imbalanced classification, providing theoretical bounds and guidelines.
problem The challenge of imbalanced classification problems, especially with minority classes.
method Theoretical analysis of SMOTE and related oversampling techniques for minority classes.
result Derives concentration and excess risk bounds for SMOTE and kernel-based classifiers.
Robust low-rank matrix estimation is a topic of increasing interest, with promising applications in a variety of fields, from computer vision to data mining and recommender systems. Recent theoretical results establish the ability of such data models to recover the true underlying low-rank matrix when a large portion o…
Proposes a new method to estimate continuous treatment policies and match treatments effectively.
problem Current methods struggle with continuous treatment policies and complex matching.
method Formulates treatment effectiveness as a parametrizable model, using deep learning for optimization.
result Significant improvement in treatment effectiveness and matching efficiency.
Explainable machine learning (ML) enables human learning from ML, human appeal of automated model decisions, regulatory compliance, and security audits of ML models. Explainable ML (i.e. explainable artificial intelligence or XAI) has been implemented in numerous open source and commercial packages and explainable ML i…
The paper provides guidelines for choosing between SBI methods in complex biological models.
problem Choosing appropriate SBI methods for real-world biological data.
method Comprehensive guidelines and application to agent-based models.
result Statistical SBI methods outperform neural SBI methods with sufficient computational resources.
Framework generates personalized insulin treatment strategies using deep models.
problem Developing optimal personalized treatment strategies for diabetes patients.
method Combines deep generative time series models with decision theory.
result Demonstrated improved personalized insulin treatment strategies for diabetes patients.
Unified theory explains two failure modes of deep transformers and provides initialisation guidelines.
problem Two failure modes (rank collapse and entropy collapse) of self-attention layers in deep transformers.
method Analytical theory of signal propagation through deep transformers, using the Random Energy Model analogy.
result Simple algorithm to compute trainability diagrams for correct initialisation hyper-parameters.
New framework quantifies and reduces concept-based models' leakage.
problem Information leakage in concept-based models reduces interpretability.
method Information-theoretic framework with CTL and ICL measures.
result Measures predict model behaviour and identify leakage causes.
Develops deep jump learning for continuous treatment OPE.
problem Estimating mean outcomes under new treatment rules using historical data from different rules.
method Adaptive deep discretization of continuous treatment space using deep learning and multi-scale change point detection.
result Validated method through theoretical results, simulations, and real application to Warfarin Dosing.
SaML guides ML models to avoid survey biases.
problem ML models trained on survey data often ignore survey design metadata.
method Nine-step guideline for incorporating survey design metadata in ML lifecycle.
result SaML provides valid population inference from survey data.
Method controls treatment risk in learning beneficial allocations.
problem Learning beneficial treatment allocations with risk control in precision medicine.
method Proposes a certifiable learning method that controls treatment risk with finite samples in the partially identified setting.
result Illustrates method using both simulated and real data.