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0111 · Mar 201519922001200920172026
2 results for toxicophore

Interprets deep learning models in drug discovery to reveal hidden pharmacophores.

problem Neural networks in drug discovery are opaque; lack of interpretability limits their use.
method Identifies key components (pharmacophores/toxicophores) that influence model predictions.
result Extracted pharmacophores are consistent with literature findings and provide new insights.

Everyday we are exposed to various chemicals via food additives, cleaning and cosmetic products and medicines -- and some of them might be toxic. However testing the toxicity of all existing compounds by biological experiments is neither financially nor logistically feasible. Therefore the government agencies NIH, EPA …

2015-03-04abs ↗pdf ↗