Develops a method to estimate personalized treatment regimes from summary statistics.
problem Estimating optimal treatment regimes for a target population when individual-level data is unavailable.
method A weighting framework that tailors a treatment regime for the target population using summary statistics.
result Consistent and asymptotically normal estimator for optimal treatment regimes.
This paper addresses external validity bias in causal inference.
problem Estimating causal effects in a target population.
method Synthesis of approaches for generalizability and transportability, including tests for heterogeneity of treatment effects and differences between study and target populations.
result Framework for addressing external validity bias in causal inference.
Framework improves policy generalizability under biased training data.
problem Learning policies that generalize to a target population from biased training data.
method Characterizes sample selection bias using a selection variable, optimizes minimax value over uncertainty set, derives efficient algorithm.
result Policies generalize to target population, outperform standard methods.
Develops a weighting framework to generalize ITRs from source to target populations.
problem Challenges in generalizing ITRs from a source population to a target population with differing characteristics.
method A robust sample weighting framework using a reproducing kernel Hilbert space to balance covariates and improve ITR learning methods.
result Improves ITR estimation for the target population compared to other weighting methods.
LEARNER improves low-rank matrix estimation using source population data.
problem Improving low-rank matrix estimation in target populations with diverse data sources.
method LEARNER uses similarity in latent spaces between source and target populations to enhance estimation.
result LEARNER often outperforms benchmark methods, especially with higher signal-to-noise ratios in the source population.
Estimates personalized policies robust to shifts in target populations.
problem Estimating policies that perform well in diverse target populations.
method Develops methods for estimating robust policies considering shifts in outcomes and characteristics.
result Welfare-maximizing policies are robust to certain shifts in potential outcomes.
Participants enrolled into randomized controlled trials (RCTs) often do not reflect real-world populations. Previous research in how best to translate RCT results to target populations has focused on weighting RCT data to look like the target data. Simulation work, however, has suggested that an outcome model approach …
ScoreFusion fuses multiple diffusion models to enhance generative modeling of a target population.
problem Enhancing generative modeling of a target population with limited data.
method ScoreFusion uses KL barycenters of auxiliary populations and recasts the learning problem as score matching in denoising diffusion.
result ScoreFusion achieves a dimension-free sample complexity bound in total variation distance.
Proposes CRA framework for certifying fair predictive models.
problem Certifying fairness of predictive models trained on biased data.
method Formulates CRA for fairness queries, uses background knowledge and limited target population stats.
result Builds certifiably fair predictive models on target population.
Copula-based method generates synthetic populations from marginal distributions.
problem Generating realistic synthetic populations from limited data.
method Copula-based framework for population synthesis.
result Copula framework enhances transferability and realism of synthetic populations.
New method for valid prediction intervals in counterfactual outcomes with runtime confounding.
problem Valid prediction intervals for counterfactual outcomes under runtime confounding.
method Debiased machine learning framework grounded in semiparametric efficiency theory.
result Prediction intervals achieve desired coverage rates with faster convergence compared to standard methods.
The quantification problem consists of determining the prevalence of a given label in a target population. However, one often has access to the labels in a sample from the training population but not in the target population. A common assumption in this situation is that of prior probability shift, that is, once the la…
Paper tackles efficient risk estimation under dataset shift conditions.
problem Limited data from target population; auxiliary data available.
method Semiparametric efficiency theory; efficient and multiply robust estimators.
result Developed estimators for various dataset shift conditions.
Estimates causal effect of managed care plans on NYC Medicaid spending.
problem Generalizing causal estimates to a target population not well-represented by randomized studies.
method Conditional cross-design synthesis estimators combining randomized and observational data.
result Estimates causal effect of managed care plans on health care spending.
New method constructs synthetic treatment groups without mean exchangeability assumption.
problem Violations of mean exchangeability assumption in randomized controlled trials.
method Weighted mixture of treatment groups from source populations, minimizing conditional maximum mean discrepancy.
result Asymptotic normality of synthetic treatment group estimator established.
Combines trial and observational data to improve policy evaluation.
problem External validity of randomized trial results in target populations.
method Uses covariate data to model trial sampling and certifies policy evaluations.
result Valid trial-based policy evaluations under model miscalibration.
New methods resolve conflicting treatment effect estimates in health tech assessments.
problem Conflicting conclusions from different sponsors analyzing the same data.
method Arbitrated indirect treatment comparisons (ArMAIC) targeting a common target population.
result Estimates treatment effects in a common target population, resolving the MAIC paradox.
TMLE improves IPM estimation for ecological population dynamics.
problem Estimating key demographic properties from IPM data.
method Targeted Maximum Likelihood Estimation (TMLE) for IPMs.
result Robust and efficient estimators for IPM properties.
TILT improves target domain performance by penalizing an auxiliary component on unlabeled target inputs.
problem Improving performance on target domain under covariate shift.
method TILT uses a novel objective function to decompose the source predictor and penalize an auxiliary component on unlabeled target inputs.
result TILT improves target domain performance over source-only training and other baselines.
Method tackles missing covariates in large-scale datasets.
problem Cross-population missing data problem in large-scale datasets.
method Augmented transfer regression learning method combining importance-weighted estimating equations and imputation terms.
result Estimator is n1/2-consistent and asymptotically normal, attaining semiparametric efficiency bound under correct specification. RECaST calibrates source models for target populations with uncertainty quantification.
problem Uncertainty in transfer learning predictions.
method Random effect calibration of source to target models.
result Nominal coverage of prediction sets in linear models, robust to nonlinear approximations.
Estimates population size using capture-recapture designs with binary indicators.
problem Estimating population size from capture-recapture data with binary indicators.
method Proposes a modern method using undersmoothed lasso model to estimate the target parameter of interest.
result The choice of constraint on the K-dimensional distribution significantly impacts the value of the estimand.
Study optimizes data collection from biased, costly sources to minimize risk.
problem Estimating population means and group-conditional means from multiple sources with varying costs and biases.
method Develops a sampling plan that maximizes effective sample size, paired with a post-stratification estimator.
result Achieves budgeted minimax optimal risk for estimating population means and group-conditional means.
Framework generates precise synthetic populations for scalable modeling.
problem Generating accurate synthetic populations without personal data.
method Constraint-programming framework encoding aggregated statistics and structural relations.
result Exact control of demographic profiles without requiring microdata.
New method predicts model performance under selection bias in healthcare.
problem Selection bias limits model generalizability in healthcare.
method Proposes a novel upper bound method for estimating model performance.
result Validates and demonstrates the practical utility of the method.
Proposes a method to correct for covariate shift in meta-analysis of randomized trials.
problem Invalidation of standard IPD meta-analysis due to covariate shift across studies.
method Placebo-anchored transport framework that treats source-trial outcomes as proxy signals and target-trial placebo outcomes as gold labels.
result Yields target-identified effect estimates in connected targets and a principled screen--then--transport procedure in disconnected targets.
DM improves self-supervised transfer learning by matching target distributions.
problem Improving self-supervised transfer learning performance.
method Distribution Matching (DM) method that drives representation distribution towards a predefined reference distribution.
result DM outperforms existing methods on target classification tasks.
Proposes a federated transfer learning method to improve precision medicine models for underrepresented populations.
problem Underrepresentation of minorities in precision medicine research leads to underperforming risk prediction models.
method Two-way federated transfer learning strategy integrating diverse populations and healthcare institutions.
result Improves risk prediction models for underrepresented populations, reducing performance gaps.
SDRF estimates complex survey designs for conditional distributions.
problem Estimating conditional distributions under complex survey designs.
method Survey-calibrated distributional random forest (SDRF) with pseudo-population bootstrap and MMD split criterion.
result Established design consistency and model consistency for survey designs.
We provide non-asymptotic excess risk guarantees for statistical learning in a setting where the population risk with respect to which we evaluate the target parameter depends on an unknown nuisance parameter that must be estimated from data. We analyze a two-stage sample splitting meta-algorithm that takes as input ar…
Population attributes are essential in health for understanding who the data represents and precision medicine efforts. Even within disease infection labels, patients can exhibit significant variability; "fever" may mean something different when reported in a doctor's office versus from an online app, precluding direct…
U-aggregation combines multiple models without labels for better risk prediction.
problem Challenges in selecting best model for new populations due to limited data and lack of true labels.
method U-aggregation, an unsupervised model aggregation method that integrates pre-trained models without observed labels.
result U-aggregation improves genetic risk prediction of complex traits using publicly available models.
The paper develops methods to identify stable associations across multiple studies.
problem Identifying stable associations across multiple studies with possible distributional shifts.
method Modeling heterogeneous multi-source data with multiple high-dimensional regressions and devising a novel sampling method for valid confidence intervals of maximin effects.
result Significant maximin effects indicate stable associations that can be generalized to target populations.
New federated method preserves privacy and estimates treatment effects.
problem Privacy-preserving causal inference for multi-site studies.
method Multiply robust nuisance function estimation, transfer learning.
result Efficient and optimal treatment effect estimation under different scenarios.
Gradient descent struggles with high-dimensional data fitting.
problem Gradient descent struggles with high-dimensional data fitting.
method Gradient descent training of a two-layer neural network on empirical or population risk.
result Gradient descent training may not decrease population risk faster than t−4/(d−2) under mean field scaling. New methods improve causal inference generalization using trial and observational data.
problem Limited trial data makes generalizing causal inferences to target populations statistically infeasible.
method Develops algorithms that combine trial and observational data to estimate complex nuisance functions.
result Improves generalization of causal inferences when the additional observational study is high-quality.
Objective: Predict patient-specific vitals deemed medically acceptable for discharge from a pediatric intensive care unit (ICU). Design: The means of each patient's hr, sbp and dbp measurements between their medical and physical discharge from the ICU were computed as a proxy for their physiologically acceptable state …
Method improves robustness and generalizability of CATE estimation.
problem Lack of external validity in site-specific models for diverse populations.
method Minimax-regret framework with robust optimization.
result Interpretable closed-form solution for generalizable CATE model.
Parallel recordings of neural spike counts have revealed the existence of context-dependent noise correlations in neural populations. Theories of population coding have also shown that such correlations can impact the information encoded by neural populations about external stimuli. Although studies have shown that the…
New models extrapolate false alarms in ASV without new data.
problem Reliable extrapolation of false alarm rates in ASV without new speaker data.
method Generative models in ASV score space for arbitrary systems.
result Models accurately extrapolate false alarm rates for large speaker populations.
The paper develops a minimax optimal method for high-dimensional regression using auxiliary data.
problem High-dimensional additive regression with heavy-tailed errors and transfer learning.
method Smooth backfitting estimator with local linear smoothing, followed by a two-stage estimation method.
result The method achieves the minimax optimal rate under certain conditions.
Generalizing empirical findings to new environments, settings, or populations is essential in most scientific explorations. This article treats a particular problem of generalizability, called "transportability", defined as a license to transfer information learned in experimental studies to a different population, on …
This paper introduces Tree-Pyramidal Adaptive Importance Sampling (TP-AIS), a novel iterated sampling method that outperforms state-of-the-art approaches like deterministic mixture population Monte Carlo (DM-PMC), mixture population Monte Carlo (M-PMC) and layered adaptive importance sampling (LAIS). TP-AIS iteratively…
New method estimates optimal personalized treatment rules from mixed data sources.
problem Combining RCT and observational data for personalized treatment rules.
method Doubly robust estimator for value function, maximizing within pre-specified ITR class.
result Consistent and asymptotically normal optimal value estimator with N−1/3 rate of convergence. We study ranking quantilized mean-field games to select top-performing agents.
problem Selecting top-performing agents in competitive scenarios.
method Developed two formulations: target-based and threshold-based, and provided analytic and semi-explicit solutions.
result Analytic and semi-explicit solutions for quantilized mean-field consistency conditions.
Method leverages data transfer for estimating CATE with KRR.
problem Leveraging findings from one study to estimate CATE in a different population.
method Overlap-adaptive transfer learning of CATE using kernel ridge regression.
result The method achieves superior efficiency and adaptability in estimating CATE.
While machine learning is rapidly being developed and deployed in health settings such as influenza prediction, there are critical challenges in using data from one environment in another due to variability in features; even within disease labels there can be differences (e.g. "fever" may mean something different repor…
Study on model accuracy when human subjects adapt to predictions.
problem Model accuracy on human-adaptive data.
method Formalized transferability study with upper and lower bounds.
result Performance gap between source and induced target distributions.