TMLE improves unbiased estimation in public health studies.
problem Improving unbiased estimation in observational studies.
method Targeted Maximum Likelihood Estimation (TMLE) integrates machine learning and statistical theory.
result TMLE has been adopted by researchers worldwide, especially outside the US.
TMLE improves causal effect estimation in missing data scenarios with various positivity violations.
problem Estimating causal effects in studies with missing data and positivity violations.
method Targeted Maximum Likelihood Estimation (TMLE) with various missing data methods.
result Complete cases with TMLE incorporating an outcome-missingness model exhibit lower bias and greater robustness against positivity violations.
Paper proposes Bayesian TMLE methods for causal effect uncertainty quantification.
problem Quantifying uncertainty in causal effect estimation.
method Three Bayesian TMLE approaches for binary and continuous outcomes.
result BN-TMLE outperforms classical implementations in small data regimes.
A-TMLE estimates ATE from RCT and RWD, achieving super-efficiency.
problem Estimating ATE from RCT and RWD data.
method Adaptive-TMLE framework for decomposing and estimating ATE.
result A-TMLE is root-n consistent and asymptotically normal, achieving super-efficiency.
New methods improve subgroup analysis in trials with limited data.
problem Limited sample sizes in subgroup analyses of randomized controlled trials.
method Two TMLEs that borrow information from non-subgroup participants.
result Improved precision in subgroup-specific treatment effect estimates.
CVTMLE improves statistical inference in settings of positivity or Donsker class violations.
problem Inference issues in causal inference due to data sparsity or near-positivity violations.
method Cross-validation of TMLE (CVTMLE) to improve performance in settings of positivity or Donsker class violations.
result CVTMLE vastly improves confidence interval coverage without affecting bias, especially in small sample sizes and near-positivity violations.
We wish to infer the value of a parameter at a law from which we sample independent observations. The parameter is smooth and we can define two variation-independent features of the law, its Q- and G-components, such that estimating them consistently at a fast enough product of rates allows to build a confidence in…
New estimators improve efficiency in two-phase designs with coarsened data.
problem Efficient estimation in two-phase designs with incomplete data.
method Developed new estimators within the TMLE framework.
result New estimators are asymptotically equivalent and more efficient.
The positivity assumption, or the experimental treatment assignment (ETA) assumption, is important for identifiability in causal inference. Even if the positivity assumption holds, practical violations of this assumption may jeopardize the finite sample performance of the causal estimator. One of the consequences of pr…
Electronic health records (EHR) data provide a cost and time-effective opportunity to conduct cohort studies of the effects of multiple time-point interventions in the diverse patient population found in real-world clinical settings. Because the computational cost of analyzing EHR data at daily (or more granular) scale…
Paper introduces geometry-aware normalizing flows for improved causal inference.
problem Disparity between sample and population distributions in causal inference.
method Integrates continuous normalizing flows with parametric submodels, employing Wasserstein gradient flows and optimal transport.
result Significantly reduces parameter estimation bias and variance in finite-sample settings.
TMLE improves IPM estimation for ecological population dynamics.
problem Estimating key demographic properties from IPM data.
method Targeted Maximum Likelihood Estimation (TMLE) for IPMs.
result Robust and efficient estimators for IPM properties.
Two-stage TMLE reduces bias and improves efficiency in CRTs.
problem Differential outcome measurement and imbalance in baseline predictors in CRTs.
method Two-stage targeted minimum loss-based estimator (TMLE) to adjust for baseline covariates.
result Our approach nearly eliminates bias due to differential outcome measurement.
Machine learning improves official statistics but needs rigorous validation.
problem Lack of methodological robustness in machine learning for official statistics.
method Total Machine Learning Error (TMLE) framework to validate ML models.
result TMLE addresses representativeness and measurement errors in ML models.
Propensity score (PS) based estimators are increasingly used for causal inference in observational studies. However, model selection for PS estimation in high-dimensional data has received little attention. In these settings, PS models have traditionally been selected based on the goodness-of-fit for the treatment mech…
Unified theory for causal inference using various methods.
problem Estimating causal effects in ATE estimation.
method Riesz regression, covariate balancing, DRE, TMLE, matching estimator.
result Unified theory integrating multiple methods for ATE estimation.
Consider the case that one observes a single time-series, where at each time t one observes a data record O(t) involving treatment nodes A(t), possible covariates L(t) and an outcome node Y(t). The data record at time t carries information for an (potentially causal) effect of the treatment A(t) on the outcome Y(t), in…
Develops a direct debiased machine learning framework using Bregman divergence.
problem Reduces bias in machine learning estimates of causal effects or structural models.
method Neyman targeted estimation and generalized Riesz regression using Bregman divergence.
result Improves estimation of parameters of interest in causal models.
Develops a TL framework for estimating RMST difference in clinical trials.
problem Estimating RMST difference in clinical trials with time-to-event outcomes.
method Targeted learning (TL) framework using pseudo-observations and copy reference (CR) approach for sensitivity analysis.
result Demonstrated the effectiveness of the TL framework using real data.
Proposes Deep LTMLE for estimating dynamic treatment effects in longitudinal studies.
problem Estimating counterfactual mean outcomes under dynamic treatment policies in longitudinal settings.
method Uses a transformer architecture with temporal-difference learning for initial estimation, followed by TMLE correction and statistical inference.
result Demonstrates superior performance in complex, long-term scenarios compared to existing methods.
A new method debiases multiple target parameters without IFs.
problem Debiasing multiple target parameters in nonparametric models.
method Kernel Debiased Plug-in Estimation (KDPE) using TMLE and reproducing kernel Hilbert spaces.
result KDPE simultaneously debiases all pathwise differentiable target parameters.
Many questions in Data Science are fundamentally causal in that our objective is to learn the effect of some exposure, randomized or not, on an outcome interest. Even studies that are seemingly non-causal, such as those with the goal of prediction or prevalence estimation, have causal elements, including differential c…
Generative synthetic data can preserve predictive accuracy but distort causal inference.
problem Distortion of average treatment effect estimates in synthetic data.
method Hybrid synthetic-data framework that generates covariates while modeling treatment and outcome mechanisms separately.
result Hybrid synthesis improves causal fidelity compared to fully generative baselines.
Proposes a new method for estimating non-pathwise differentiable functional parameters.
problem Estimating dose-response curves for continuous exposure.
method Targeted Highly Adaptive Lasso (HAL) for non-pathwise differentiable functional parameters.
result The Targeted HAL-MLE achieves dimension-free rates up to log(n) factors and outperforms other methods in simulations.
Python package automates causal parameter estimation using Riesz regression.
problem Efficient estimation of causal and structural parameters.
method Automatic DML and generalized Riesz regression framework.
result Automatic construction of balancing link functions for generalized Riesz regression.
Unified framework for debiased machine learning using Riesz representer and Bregman divergence.
problem Estimating causal and structural parameters in machine learning.
method Generalized Riesz regression for fitting Riesz representer via Bregman divergence minimization.
result Automatic covariate balancing and Neyman orthogonality properties for debiased estimation.
Prediction-powered causal inference achieves smaller asymptotic variance than traditional methods.
problem Estimating causal and structural parameters in a semi-supervised setting.
method Combining efficient influence function with debiased machine learning and semi-supervised Riesz regression.
result Asymptotic variances of estimators match the derived efficiency bound.
Machine learning improves trial analysis precision by adjusting for prognostic variables.
problem Improving precision in randomized trial analyses using covariate adjustment.
method Targeted machine learning estimation (TMLE) with adaptive pre-specification.
result Maximized empirical efficiency through cross-validated variance minimization.
Adaptive Prespecification improves precision in randomized trials.
problem Selecting optimal covariates for precision in randomized trials.
method Adaptive Prespecification using V-fold cross-validation and influence curve-squared loss function.
result Substantial gains in precision, equivalent to 20-43% reductions in sample size for the same power.
Study evaluates how changes in mobility affect COVID-19 case rates.
problem Mixed evidence on mobility-COVID-19 case rate associations.
method Modified treatment policy (MTP) approach with TMLE and Super Learner ensemble.
result Shifts in mobility do not consistently affect subsequent case rates after adjusting for confounders.