Generative AI models improve clinical trial data by generating survival outcomes.
problem Generating valid survival outcomes for clinical trials with synthetic data.
method A variational autoencoder (VAE) that jointly generates mixed-type covariates and survival outcomes.
result The method outperforms GAN baselines on fidelity, utility, and privacy metrics.
New method combines regional HIV prevention trial data without sharing individual patient info.
problem Regional differences in HIV prevention efficacy, privacy concerns, and data sharing limitations.
method Federated learning approach that combines site-specific estimators via L1-regularization.
result Improved precision in estimating region-specific survival curves.
Proposes a new Q-learning method for survival outcomes in clinical trials.
problem Incomplete follow-up data and nonlinear covariate effects in clinical trials.
method Combines Buckley-James boosting with flexible base learners for estimating optimal treatment regimes.
result Improves treatment decision accuracy and stability in longitudinal clinical trials.
Develops a TL framework for estimating RMST difference in clinical trials.
problem Estimating RMST difference in clinical trials with time-to-event outcomes.
method Targeted learning (TL) framework using pseudo-observations and copy reference (CR) approach for sensitivity analysis.
result Demonstrated the effectiveness of the TL framework using real data.
Privacy-preserving inference for clinical trials using differential privacy.
problem Balancing knowledge sharing and privacy in healthcare data.
method Differential privacy (DP) applied to log-linear belief updates in distributed settings.
result Differentially private, distributed inference methods outperform existing techniques.
A new method boosts survival analysis by stratifying patients and removing noise covariates.
problem Weak detection of treatment differences in randomized clinical trials due to patient heterogeneity.
method 5-Step Stratified Testing and Amalgamation Routine (5-STAR) using elastic net Cox regression and conditional inference trees.
result The 5-STAR routine significantly improves power in detecting treatment effects compared to traditional methods.
MEC-Cox: A Machine-Learning-Assisted Generalized Entropy Calibration Method for Estimating ATT Marginal Hazard-Ratio
problem Estimating ATT marginal hazard-ratio in externally controlled survival trials
method Machine-learning-assisted generalized entropy calibration for IPW Cox regression
result Reduces bias, increases efficiency, and improves coverage
Study compares Cox model and RSF for predicting patient survival, finding RSF superior in certain scenarios.
problem Comparing predictive accuracy of Cox proportional hazards model and Random Survival Forest for patient-specific survival probabilities.
method Conducted a comprehensive comparison study using simulation scenarios and real-world datasets.
result RSF outperforms Cox model in nonproportional hazards settings and with treatment-covariate interactions.
Bayesian model improves cure fraction estimation in survival analysis.
problem Estimating cure fraction in survival analysis.
method Hierarchical Bayesian framework for semiparametric mixture cure model.
result Improved accuracy in capturing unobserved heterogeneity.
New method for causal inference in survival outcomes using RDD.
problem Censoring in time-to-event analyses.
method Nonparametric approach with doubly robust censoring corrections.
result Higher efficiency and robustness to misspecification.
The paper develops deep learning models for personalized treatment rules in survival analysis.
problem Deriving optimal treatment rules for bivariate survival outcomes in randomized trials.
method Adaptive prediction-powered learning using deep neural networks and stochastic policies.
result Maximizes joint survival probability beyond fixed time points (t1,t2). Bayesian model estimates ACT impact on pediatric AML survival.
problem Estimating ACT impact on survival in AML patients with treatment timing issues.
method Generative Bayesian semi-parametric model with Gamma Process priors.
result Posterior inference for ACT efficacy under dynamic rules.
Paper proposes robust methods for estimating optimal treatment rules with censored survival data.
problem Estimating optimal treatment rules for censored survival data.
method Developed two robust criteria and a sampling-based difference-of-convex algorithm for learning optimal treatment rules.
result Proposed methods show improved performance compared to existing methods in simulations and real data.
Unified framework for counterfactual survival analysis improves treatment effect estimation.
problem Limited methods for counterfactual inference with survival outcomes.
method Unified framework for survival outcomes, nonparametric hazard ratio metric.
result Significantly outperforms alternatives in survival-outcome prediction and treatment-effect estimation.
SurvHTE-Bench benchmarks HTE estimation in survival analysis with diverse datasets.
problem Challenges in estimating HTEs from right-censored survival data.
method Modular synthetic datasets, semi-synthetic datasets, and real-world datasets.
result First rigorous comparison of survival HTE methods under diverse conditions.
SurvTRACE uses transformers to analyze survival times with competing events.
problem Analyzing survival times with multiple competing events and confounders.
method Transformer-based model for survival analysis, handling competing events and confounders.
result SurvTRACE outperforms existing methods in multi-event scenarios.
Develops adaptive framework for estimating survival effects with censoring.
problem Estimating causal effects in survival data with censoring.
method Derives semiparametric efficiency bound, proposes efficiency-optimal allocation policy, and develops Adaptive Survival Estimator (ASE).
result ASE achieves asymptotic normality via martingale central limit theorem and demonstrates efficiency gains over uniform randomization.
In this manuscript we analyze a data set containing information on children with Hodgkin Lymphoma (HL) enrolled on a clinical trial. Treatments received and survival status were collected together with other covariates such as demographics and clinical measurements. Our main task is to explore the potential of machine …
Test for quasi-independence in ordered time data.
problem Determining dependence beyond temporal ordering.
method Nonparametric statistical test considering infinite alternatives.
result Better power and computational efficiency compared to existing methods.
New method calibrates heterogeneous treatment effect models.
problem Difficulty in estimating and calibrating heterogeneous treatment effects.
method Defined and proposed a robust estimator for HTE calibration, based on doubly robust treatment effect estimators.
result Proposed method evaluates calibration of learned HTE models, addressing overfitting and high-dimensionality.
MISTR improves HTE estimation in survival data with heavy censoring and instrumental variables.
problem Estimating HTE in survival data with censoring and unobserved confounders.
method MISTR uses recursively imputed survival trees to handle censoring and instrumental variables.
result MISTR outperforms existing methods under heavy censoring and instrumental variable settings.
Participants enrolled into randomized controlled trials (RCTs) often do not reflect real-world populations. Previous research in how best to translate RCT results to target populations has focused on weighting RCT data to look like the target data. Simulation work, however, has suggested that an outcome model approach …
Paper models treatment effects by clustering patients with distinct survival characteristics.
problem Estimating treatment efficacy in clinical settings with censored outcomes.
method Latent variable approach to model heterogeneous treatment effects.
result The latent structure can mediate base survival rates and reveal actionable phenotypes.
New method estimates optimal personalized treatment rules from mixed data sources.
problem Combining RCT and observational data for personalized treatment rules.
method Doubly robust estimator for value function, maximizing within pre-specified ITR class.
result Consistent and asymptotically normal optimal value estimator with N−1/3 rate of convergence. Random forest (Leo Breiman 2001a) (RF) is a non-parametric statistical method requiring no distributional assumptions on covariate relation to the response. RF is a robust, nonlinear technique that optimizes predictive accuracy by fitting an ensemble of trees to stabilize model estimates. Random survival forests (RSF) …
The change of two orders of magnitude in the 'new DCF' of NIST's SRE'10, relative to the 'old DCF' evaluation criterion, posed a difficult challenge for participants and evaluator alike. Initially, participants were at a loss as to how to calibrate their systems, while the evaluator underestimated the required number o…
Develops a machine learning model to predict ALS progression and assistive device use.
problem Challenges in predicting clinically meaningful milestones in ALS.
method Integrates longitudinal ALSFRS-R trajectories with survival modeling.
result Generates individualized survival curves and predicts wheelchair-free survival.
In both the fields of computer science and medicine there is very strong interest in developing personalized treatment policies for patients who have variable responses to treatments. In particular, I aim to find an optimal personalized treatment policy which is a non-deterministic function of the patient specific cova…
Proposes a new model to analyze CT scans for lung cancer patients.
problem Analyzing survival risks of lung cancer patients using CT scans.
method Penalized Deep Partially Linear Cox Model (Penalized DPLC) incorporating SCAD penalty and deep neural network.
result The model effectively selects important texture features and estimates nonparametric components.
Proposes modifications to model-based forests for HTE estimation in observational data.
problem Estimating heterogeneous treatment effects in observational studies with complex outcomes.
method Orthogonalization strategy from Robinson (1988) applied to model-based forests.
result The orthogonalization strategy reduces confounding effects in simulated studies.
The consistency of doubly robust estimators relies on consistent estimation of at least one of two nuisance regression parameters. In moderate to large dimensions, the use of flexible data-adaptive regression estimators may aid in achieving this consistency. However, n1/2-consistency of doubly robust estimators is…
SurvMixClust clusters survival data and predicts individual survival curves.
problem Integrating clustering into survival analysis for precision medicine.
method SurvMixClust learns latent representations for clustering and predicts survival functions using a mixture of non-parametric experts.
result SurvMixClust creates balanced clusters with distinct survival curves, outperforming clustering baselines and competing with non-clustering models in predictive accuracy.
Machine learning predicts patient recruitment for clinical trials.
problem Improving patient recruitment prediction for clinical trials.
method Machine learning methods applied to historical clinical trial data.
result Reduced prediction error compared to current industry standards.
The paper predicts survival functions using random survival trees and concordance maximization.
problem Predicting conditional survival functions in right-censored data.
method The approach combines regression strategies with random survival trees and maximizes concordance.
result The proposed weighted predictor outperforms the usual survival cobra in terms of concordance.
Survival kernets scale deep kernel survival analysis to large datasets with interpretability and theoretical guarantees.
problem Scalable and interpretable deep kernel survival analysis for large datasets.
method Survival kernets use kernel netting for training set compression and XGBoost for warm-starting neural architecture search.
result Survival kernets achieve optimal time-dependent concordance index on various survival analysis datasets.
Survival MDN uses invertible functions to speed up survival analysis models.
problem Training neural ODEs for survival analysis is computationally expensive.
method Survival MDN applies an invertible positive function to MDN outputs.
result Survival MDN outperforms or matches other models on concordance, Brier score, and log-likelihood.
RSM provides insights into deep survival models' decision-making.
problem Ensuring trust in deep survival models' predictions for healthcare applications.
method Reverse survival model (RSM) framework that explains deep survival models' decisions.
result RSM extracts relevant features for deep survival models' predictions.
Neural network learns kernel functions for survival analysis and prediction intervals.
problem Predicting survival times for individuals based on similar training subjects.
method Develops a neural network framework to learn kernel functions for kernel survival analysis and uses these to construct valid prediction intervals.
result Neural network survival estimators are competitive with existing methods and provide valid prediction intervals.
Reduces survival analysis to common regression tasks.
problem Applying standard machine learning tools to survival analysis.
method Various reduction techniques to simplify survival analysis.
result Benchmark analysis shows improved predictive performance.
A new method clusters survival data using deep variational models.
problem Clustering survival data, a challenging task.
method Semi-supervised probabilistic approach with deep generative model.
result The method outperforms previous models in clustering and predicting survival times.
We investigate the effect of the proportional hazards assumption on prognostic and predictive models of the survival time of patients suffering from amyotrophic lateral sclerosis (ALS). We theoretically compare the underlying model formulations of several variants of survival forests and implementations thereof, includ…
Optimal Survival Trees improve accuracy in medical data analysis.
problem Analyzing censored outcomes in medical data.
method Mixed-integer optimization and local search techniques.
result Improves accuracy in large datasets compared to existing methods.
RSF models censored functional data for better survival analysis.
problem Modeling survival trajectories with censored data.
method Random Survival Forest for Censored Functional Data (RSF).
result Good performance in predicting survival variables.
Improves survival analysis across multiple domains with machine learning.
problem Adapting survival analysis to new or rare illness types with limited labeled data.
method Introduces a new survival metric and discrepancy measure for censored data, enabling domain adaptation.
result Superb performance on target domains, better treatment recommendations, and interpretable weight matrix.
HACSurv models dependencies between competing risks and censoring for improved survival analysis.
problem Inaccurate survival predictions due to ignoring dependencies between competing risks and censoring.
method HACSurv uses hierarchical Archimedean copulas to model dependencies and cause-specific survival functions.
result HACSurv improves accuracy in survival predictions and captures complex risk interactions.
Optimal survival trees ensemble reduces tree count and improves predictive performance.
problem Improving predictive performance in survival analysis.
method Grows a forest of optimal survival trees by ranking and selecting the best trees based on out-of-bag error.
result Reduces the number of trees in the ensemble while improving predictive performance.
Combines trial and observational data to improve policy evaluation.
problem External validity of randomized trial results in target populations.
method Uses covariate data to model trial sampling and certifies policy evaluations.
result Valid trial-based policy evaluations under model miscalibration.
In this paper we utilize a survival analysis methodology incorporating Bayesian additive regression trees to account for nonlinear and additive covariate effects. We compare the performance of Bayesian additive regression trees, Cox proportional hazards and random survival forests models for censored survival data, usi…