The use of drug combinations, termed polypharmacy, is common to treat patients with complex diseases and co-existing conditions. However, a major consequence of polypharmacy is a much higher risk of adverse side effects for the patient. Polypharmacy side effects emerge because of drug-drug interactions, in which activi…
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48 results for “side effects”
The polypharmacy side effect prediction problem considers cases in which two drugs taken individually do not result in a particular side effect; however, when the two drugs are taken in combination, the side effect manifests. In this work, we demonstrate that multi-relational knowledge graph completion achieves state-o…
Deep learning predicts drug side-effects from molecular graphs.
problem Predicting drug side-effects from molecular structures.
method Recurrent Graph Neural Networks for multi-class multi-label graph-focused classification.
result Improved classification capability compared to previous methods.
In modern recommender systems, both users and items are associated with rich side information, which can help understand users and items. Such information is typically heterogeneous and can be roughly categorized into flat and hierarchical side information. While side information has been proved to be valuable, the maj…
This paper improves sample efficiency in noisy inductive matrix completion with side-information.
problem Improving sample efficiency in noisy inductive matrix completion with side-information.
method Nonconvex projected gradient descent algorithm with spectral initialization.
result Achieves linear convergence and stable recovery at a sample complexity governed by the effective side-information dimension.
AdaDPS uses side information to improve private adaptive optimization.
problem Private adaptive optimization methods degrade when training with differential privacy.
method AdaDPS uses non-sensitive side information to precondition gradients.
result AdaDPS reduces the amount of noise needed for similar privacy guarantees, improving optimization performance.
Generalization Bounds for Learning with Linear, Polygonal, Quadratic and Conic Side Knowledgestat.ML
In this paper, we consider a supervised learning setting where side knowledge is provided about the labels of unlabeled examples. The side knowledge has the effect of reducing the hypothesis space, leading to tighter generalization bounds, and thus possibly better generalization. We consider several types of side knowl…
Complex or co-existing diseases are commonly treated using drug combinations, which can lead to higher risk of adverse side effects. The detection of polypharmacy side effects is usually done in Phase IV clinical trials, but there are still plenty which remain undiscovered when the drugs are put on the market. Such acc…
Framework for robust matrix estimation with side information.
problem High-dimensional matrix estimation with restrictive structure.
method Flexible framework decomposing matrix into four components: interaction, row, column, and residual.
result Improved imputation accuracy and treatment-effect estimation with side information.
This paper employs the extrinsic information transfer (EXIT) method, a technique imported from the analysis of the iterative decoding of error control codes, to study the performance of belief propagation in community detection in the presence of side information. We consider both the detection of a single (hidden) com…
Proposes a new IPW-based ranking metric for two-sided markets.
problem Addressing bias in implicit user feedback in two-sided markets.
method Extends IPW estimator to two-sided markets, addressing position bias.
result Proposed estimator is unbiased for ground-truth ranking metric.
How can we design safe reinforcement learning agents that avoid unnecessary disruptions to their environment? We show that current approaches to penalizing side effects can introduce bad incentives, e.g. to prevent any irreversible changes in the environment, including the actions of other agents. To isolate the source…
The paper analyzes side effects of learning from low-dimensional data embedded in a Euclidean space.
problem Learning from data distributed in a linear subspace of high-dimensional space.
method Derives estimates on the variation of the learning function and studies regularization effects.
result Potential regularization effects associated with network depth and noise in codimension of data manifold.
Study proposes method to estimate causal effects from noisy treatment data.
problem Estimating causal effects from noisy treatment data without side information.
method Deep latent variable model with neural network parameterization and amortized importance-weighted variational objective.
result Causal effect estimates are identifiable without side information and measurement error variance knowledge.
We propose a tensor-based model that fuses a more granular representation of user preferences with the ability to take additional side information into account. The model relies on the concept of ordinal nature of utility, which better corresponds to actual user perception. In addition to that, unlike the majority of h…
Catastrophic forgetting is a critical challenge in training deep neural networks. Although continual learning has been investigated as a countermeasure to the problem, it often suffers from the requirements of additional network components and the limited scalability to a large number of tasks. We propose a novel appro…
Optimizing Portfolio with Two-Sided Transactions and Lending: A Reinforcement Learning Frameworkq-fin.PM
Study uses RL to optimize crypto portfolios with two-sided transactions and lending.
problem Managing downside risk and capital optimization in high-risk crypto markets.
method Integrates RL with a new environmental formulation and PnL-based reward function, using SAC agent with CNN-MHA.
result Significantly outperforms benchmarks, especially in high-volatility scenarios.
Mining discriminative subgraph patterns from graph data has attracted great interest in recent years. It has a wide variety of applications in disease diagnosis, neuroimaging, etc. Most research on subgraph mining focuses on the graph representation alone. However, in many real-world applications, the side information …
Since governments give stimulus to firms and expect the spillover effect by fiscal policies, it is important to know the effectiveness that they can control the economy. To clarify the controllability of the economy, we investigate a firm production network observed exhaustively in Japan and what firms should be direct…
The use of drug combinations often leads to polypharmacy side effects (POSE). A recent method formulates POSE prediction as a link prediction problem on a graph of drugs and proteins, and solves it with Graph Convolutional Networks (GCNs). However, due to the complex relationships in POSE, this method has high computat…
Many immunization strategies have been proposed to prevent infectious viruses from spreading through a network. In this study, we propose efficient immunization strategies to prevent a default contagion that might occur in a financial network. An essential difference from the previous studies on immunization strategy i…
By restricting the iterate on a nonlinear manifold, the recently proposed Riemannian optimization methods prove to be both efficient and effective in low rank tensor completion problems. However, existing methods fail to exploit the easily accessible side information, due to their format mismatch. Consequently, there i…
We study the effect of the quality and quantity of side information on the recovery of a hidden community of size in a graph of size . Side information for each node in the graph is modeled by a random vector with the following features: either the dimension of the vector is allowed to vary with , while …
Zero-Liquidation loans protect ETH borrowers from liquidation risks.
problem Risk of liquidation in DeFi lending protocols.
method Allows borrowers to repay in either USDC or pledged ETH, compensating liquidity providers with higher yield.
result More robust and less contagion-prone lending compared to traditional protocols.
CREAM models enable concept-grounded predictions and interpretability.
problem Designing models that can encode and extend prior knowledge about concept-concept and concept-task relationships.
method Proposes a flexible and efficient framework (CREAMs) that encodes arbitrary and relationships, incorporating a side-channel for incomplete concept sets.
result CREAM models achieve competitive task performance while encouraging concept-grounded predictions, avoiding concept leakage and achieving black-box-level performance.
New method learns from biased data, outperforming existing approaches.
problem Learning from one-sided feedback in machine learning.
method Adaptive approach using variance estimation to mitigate sampling bias.
result Empirically outperforms existing methods for generalized linear models.
New estimator reduces bias in interference studies on content marketplaces.
problem Interference bias in experiments on content marketplaces like Douyin.
method Developed a Monte-Carlo estimator based on DQ techniques.
result Achieved bias second-order in treatment effect with low variance.
We define a notion of Hempel distance for one-sided Heegaard splittings and show that the existence of alternate surfaces restricts distance for one-sided splittings in a manner similar to Hartshorn's and Scharlemann-Tomova's results for two-sided splittings. We also show that every geometrically compressible one-sided…
A Multi-Agent Reinforcement Learning Framework for Off-Policy Evaluation in Two-sided Marketsstat.ML
A new framework uses multi-agent reinforcement learning for evaluating policies in two-sided markets.
problem Evaluating the effects of different policies in two-sided markets with spatial and temporal interference.
method Introduces a multi-agent reinforcement learning (MARL) framework to address policy evaluation challenges in large-scale fleet management.
result Proposes novel estimators for mean outcomes under different products that are consistent despite high-dimensionality.
There has been a recent interest in understanding the power of local algorithms for optimization and inference problems on sparse graphs. Gamarnik and Sudan (2014) showed that local algorithms are weaker than global algorithms for finding large independent sets in sparse random regular graphs. Montanari (2015) showed t…
New heat trace coefficients reveal curvature effects in polygonal domains.
problem Understanding heat trace behavior in polygonal domains with curved corners.
method Local heat trace expansion through order , analyzing both Dirichlet and Neumann boundary conditions.
result Sharp sign law for the Dirichlet angular factor of the first corner-curvature heat invariant.
Neural network training relies on our ability to find "good" minimizers of highly non-convex loss functions. It is well-known that certain network architecture designs (e.g., skip connections) produce loss functions that train easier, and well-chosen training parameters (batch size, learning rate, optimizer) produce mi…
Online health communities are a valuable source of information for patients and physicians. However, such user-generated resources are often plagued by inaccuracies and misinformation. In this work we propose a method for automatically establishing the credibility of user-generated medical statements and the trustworth…
New method for inference on covariates in NMF with random effects.
problem Formal inference for covariate effects in NMF with non-negativity constraints.
method NMF-RE model with random effects, ridge updates, df-based cap, asymptotic linearization, wild bootstrap.
result Valid inference on covariates with non-negativity constraint, avoiding degeneracy.
LASLA improves multiple testing accuracy with network-structured data.
problem Efficiently incorporating complex side information into multiple testing.
method Locally adaptive structure learning algorithm (LASLA) integrating auxiliary information.
result LASLA asymptotically controls FDR and enhances power with side information.
New method for estimating heterogeneous treatment effects in panel data.
problem Estimating heterogeneous treatment effects in non-stationary, temporally dependent panel data.
method Proposes H1SL and H2SL, synthetic learners for panel data, based on existing non-panel data estimators.
result Established convergence rates for proposed estimators and demonstrated superior performance.
In many applications of network analysis, it is important to distinguish between observed and unobserved factors affecting network structure. To this end, we develop spectral estimators for both unobserved blocks and the effect of covariates in stochastic blockmodels. On the theoretical side, we establish asymptotic no…
Algorithm solves two-sided matching markets with unknown preferences and constraints.
problem Two-sided online matching markets with complementary preferences and quota constraints.
method Formulated as a bandit learning problem, proposed MMTS algorithm combining Thompson Sampling and double matching.
result MMTS achieves stability and linear Bayesian regret with respect to quota and time horizon.
In addition to constraining bilateral exposures of financial institutions, there are essentially two options for future financial regulation of systemic risk (SR): First, financial regulation could attempt to reduce the financial fragility of global or domestic systemically important financial institutions (G-SIBs or D…
Estimates treatment effects in bipartite systems with partial eligibility and interference.
problem Randomized experiments in bipartite systems with partial treatment eligibility and interference.
method Formalizes eligibility-constrained bipartite experiments, defines PTTE and STTE, identifies conditions, develops ensemble estimators, introduces projection.
result Proposed estimators recover PTTE and STTE with low bias and variance, corrects interference bias in field experiments.
Behavioural effects on XVAq-fin.PR
Bank behaviour is important for pricing XVA because it links different counterparties and thus breaks the usual XVA pricing assumption of counterparty independence. Consider a typical case of a bank hedging a client trade via a CCP. On client default the hedge (effects) will be removed (rebalanced). On the other hand, …
A new SOHP filter improves trend estimation in economic time series.
problem Improving trend estimation in nonlinear economic time series.
method Recursive application of one-sided HP filter on updated cyclical components, combined with an incremental HP filtering algorithm.
result Better performance of SOHP filter compared to other HP-type filters on real economic data.
The area of constrained clustering has been extensively explored by researchers and used by practitioners. Constrained clustering formulations exist for popular algorithms such as k-means, mixture models, and spectral clustering but have several limitations. A fundamental strength of deep learning is its flexibility, a…
We prove that the cotangent of a double Lie groupoid S has itself a double groupoid structure with sides the duals of associated Lie algebroids, and double base the dual of the Lie algebroid of the core of S. Using this, we prove a result outlined by Weinstein in 1988, that the side groupoids of a general symplectic do…
This paper is a follow-up to our joint paper with I. Agol, P. Storm and K. Whyte "Finiteness of arithmetic hyperbolic reflection groups". The main purpose is to investigate the effective side of the method developed there and its possible application to the problem of classification of arithmetic hyperbolic reflection …
A new drug embedding method using hierarchical drug relations and chemical structures.
problem Learning accurate drug representations from chemical structures and hierarchies.
method Semi-supervised drug embedding using VAE in hyperbolic space.
result The method accurately places drugs in a hierarchy and predicts side-effects.
DGC clusters data with side-information for better prediction.
problem Improving clustering strategies through better prediction performance.
method Deep Goal-Oriented Clustering (DGC) framework that clusters data using supervision and unsupervised modeling.
result Achieves prediction accuracies comparable to state-of-the-art, while learning congruent clustering strategies.
In order-driven markets, limit-order book (LOB) resiliency is an important microscopic indicator of market quality when the order book is hit by a liquidity shock and plays an essential role in the design of optimal submission strategies of large orders. However, the evolutionary behavior of LOB resilience around liqui…