In this paper, we seek a clinically-relevant latent code for representing the spectrum of macular disease. Towards this end, we construct retina-VAE, a variational autoencoder-based model that accepts a patient profile vector (pVec) as input. The pVec components include clinical exam findings and demographic informatio…
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New mechanisms from primate vision improve neural network robustness.
problem Demonstrating robust neural networks to small adversarial perturbations.
method Investigated two biologically plausible mechanisms: non-uniform retina sampling and receptive field diversity.
result Non-uniform retina sampling and receptive field diversity improve adversarial robustness.
RETINA Benchmark evaluates Bayesian deep learning on diabetic retinopathy detection.
problem Reliable uncertainty quantification for deep learning models in medical applications.
method Design and evaluation of a real-world diabetic retinopathy dataset and tasks.
result Benchmarking of Bayesian deep learning methods on diabetic retinopathy detection tasks.
The design of robotic systems is largely dictated by our purely human intuition about how we perceive the world. This intuition has been proven incorrect with regard to a number of critical issues, such as visual change blindness. In order to develop truly autonomous robots, we must step away from this intuition and le…
Deep convolutional neural networks (CNNs) have demonstrated impressive performance on visual object classification tasks. In addition, it is a useful model for predication of neuronal responses recorded in visual system. However, there is still no clear understanding of what CNNs learn in terms of visual neuronal circu…
A new method tracks retinal vessels more accurately than existing methods.
problem Tracking retinal vessels accurately in spherical images.
method Computing cusp-free, crossing-preserving geodesics on spherical positions and orientations.
result Crossing-preserving tracking shows clear advantages over non-crossing-preserving tracking.
Identification of patterns from discrete data time-series for statistical inference, threat detection, social opinion dynamics, brain activity prediction has received recent momentum. In addition to the huge data size, the associated challenges are, for example, (i) missing data to construct a closed time-varying compl…
Adds a precortical module to CNNs for improved robustness to light variations.
problem Robustness of CNNs to global light intensity and contrast variations.
method Developed a mathematical model of the mammalian visual pathway, inspired by CNNs, and added a preliminary convolutional module.
result Significantly more robust CNNs achieved with added module on MNIST, FashionMNIST, and SVHN databases.
Optical Coherence Tomography allows ophthalmologist to obtain cross-section imaging of eye retina. Assisted with digital image analysis methods, effective disease detection could be performed. Various methods exist to extract feature from OCT images. The proposed study aims to compare the effectiveness of handcrafted a…
Vision impairment due to pathological damage of the retina can largely be prevented through periodic screening using fundus color imaging. However the challenge with large scale screening is the inability to exhaustively detect fine blood vessels crucial to disease diagnosis. In this work we present a computational ima…
Neural connectomics has begun producing massive amounts of data, necessitating new analysis methods to discover the biological and computational structure. It has long been assumed that discovering neuron types and their relation to microcircuitry is crucial to understanding neural function. Here we developed a nonpara…
A fundamental challenge in calcium imaging has been to infer the timing of action potentials from the measured noisy calcium fluorescence traces. We systematically evaluate a range of spike inference algorithms on a large benchmark dataset recorded from varying neural tissue (V1 and retina) using different calcium indi…
Artificial perception is traditionally handled by hand-designing task specific algorithms. However, a truly autonomous robot should develop perceptive abilities on its own, by interacting with its environment, and adapting to new situations. The sensorimotor contingencies theory proposes to ground the development of th…
Convolutional neural network localizes OD and fovea in UWFoV-SLO images.
problem Localizing optic disc and fovea centers in ultra-widefield retinal images.
method Convolutional neural network trained on reflectance and autofluorescence images.
result 99.4% OD localisation accuracy and 99.1% fovea localisation accuracy.
Diabetes is a globally prevalent disease that can cause visible microvascular complications such as diabetic retinopathy and macular edema in the human eye retina, the images of which are today used for manual disease screening. This labor-intensive task could greatly benefit from automatic detection using deep learnin…
The retinal vascular condition is a reliable biomarker of several ophthalmologic and cardiovascular diseases, so automatic vessel segmentation may be crucial to diagnose and monitor them. In this paper, we propose a novel method that combines the multiscale analysis provided by the Stationary Wavelet Transform with a m…
Neural circuits contain heterogeneous groups of neurons that differ in type, location, connectivity, and basic response properties. However, traditional methods for dimensionality reduction and clustering are ill-suited to recovering the structure underlying the organization of neural circuits. In particular, they do n…
Neuronal circuits formed in the brain are complex with intricate connection patterns. Such complexity is also observed in the retina as a relatively simple neuronal circuit. A retinal ganglion cell receives excitatory inputs from neurons in previous layers as driving forces to fire spikes. Analytical methods are requir…
We present two Bayesian procedures to infer the interactions and external currents in an assembly of stochastic integrate-and-fire neurons from the recording of their spiking activity. The first procedure is based on the exact calculation of the most likely time courses of the neuron membrane potentials conditioned by …
Modeling curvature-sensitive cells in visual cortex with geometric structures.
problem Understanding the functional architecture of curvature-sensitive cells in the visual cortex.
method Geometric model based on Engel structure and SIM(2) symmetry.
result Identified SIM(2) as the natural symmetry group for curvature-sensitive cells.
Despite significant advances in artificial intelligence (AI) for computer vision, its application in medical imaging has been limited by the burden and limits of expert-generated labels. We used images from optical coherence tomography angiography (OCTA), a relatively new imaging modality that measures perfusion of the…
Study limits of circadian synchronization under different light signals.
problem Disruption of circadian rhythms due to misalignment with external light signals.
method Matrix-free approach for locating periodic steady states, numerical continuation, bifurcation diagrams, unsupervised learning.
result Limits of circadian synchronization to external light signals of different frequency and duty cycle.
POSCMs extend SCMs for causal modeling with latent contexts.
problem Causal modeling with latent contexts and endogenous mechanisms.
method Kolmogorov-Arnold-Sprecher edge-functional decomposition for explicit parametrization.
result Identifiability of structure and mechanisms under latent context.
Evaluation of Bayesian deep learning (BDL) methods is challenging. We often seek to evaluate the methods' robustness and scalability, assessing whether new tools give `better' uncertainty estimates than old ones. These evaluations are paramount for practitioners when choosing BDL tools on-top of which they build their …
Paper uses deep Q-network to correct eye movement artifacts in OCT volumes.
problem Unsupervised correction of inter-frame misalignments in OCT volumes due to eye movement artifacts.
method Dueling deep Q-network trained to maximize reward signals based on intensity-based image similarity metrics.
result Average normalized mutual information and correlation coefficient of 0.985 and 0.914, respectively.