siRF identifies transcription factor binding near enhancers in flies.
problem Identifying functional transcription factor binding near enhancers.
method Signed iterative random forests (siRF) for machine learning.
result Infers regulatory interactions among transcription factors and enhancers.
Dilated convolutions model long-distance genomic dependencies effectively.
problem Detecting regulatory elements from raw DNA with long-distance dependencies.
method Developed and used a novel dataset for dilated convolutional neural networks.
result Dilated convolutions are effective at modeling regulatory elements in the human genome.
This research assesses uncertainty quantification and sensitivity analysis for DTs in nuclear fuel performance.
problem Understanding the reliability and performance of advanced nuclear fuels using DTs.
method Introduces ML-based uncertainty quantification and sensitivity analysis methods applied to BISON fuel performance code.
result Demonstrates the effectiveness of DTs in multi-criteria decision-making for nuclear fuel performance.
Within the Own Risk and Solvency Assessment framework, the Solvency II directive introduces the need for insurance undertakings to have efficient tools enabling the companies to assess the continuous compliance with regulatory solvency requirements. Because of the great operational complexity resulting from each comple…
RECON reconstructs regulatory networks from time-course data, reducing spurious edges and preserving true regulatory edges.
problem Reconstructing regulatory networks from time-course data with minimal spurious edges and preserving true regulatory relationships.
method RECON uses an integral-based additive nonparametric ODE model with five methodological advances to reconstruct regulatory networks.
result RECON consistently outperforms existing methods, reducing spurious edges and preserving true regulatory edges across various scenarios.
Over the last 23 years, the U.S. Securities and Exchange Commission has required over 34,000 companies to file over 165,000 annual reports. These reports, the so-called "Form 10-Ks," contain a characterization of a company's financial performance and its risks, including the regulatory environment in which a company op…
This paper examines market misconduct in DeFi and proposes regulatory solutions.
problem Novel forms of market misconduct in DeFi.
method Comprehensive analysis, comparative study, empirical measurements, and tailored regulatory framework investigation.
result Identification of key areas for regulatory enhancement in DeFi.
Paper develops a framework to discover bioprocessing regulatory mechanisms using symbolic and statistical learning.
problem Challenges in modeling complex intracellular regulation, stochastic system behavior, and limited experimental data.
method Symbolic and statistical learning framework based on stochastic differential equations and Bayesian learning.
result Improved sample efficiency and robust model selection compared to state-of-the-art approaches.
regvis.net offers a visual survey of regulatory visualization.
problem Lack of a comprehensive resource for regulatory visualization.
method Collection and manual tagging of 80+ publications, creation of a searchable webpage.
result First publication set tailored for regulatory visualization.
Optimizes insurance profits under regulatory constraints.
problem Maximizing profits while adhering to regulatory and risk policies.
method Developed a formalism for in-force business profit optimisation.
result Identified optimal asset allocation and annual opportunity cost.
Bayesian method infers gene regulatory network structure from data.
problem Discovering local causal relationships in gene regulatory networks.
method Bayesian approach scoring covariance patterns with background priors.
result Stable and conservative posterior estimates of regulatory relationships.
TNDE quantifies dynamic gene drivers from single-cell snapshots.
problem Reconstructing time-resolved regulatory effects in biological processes.
method Time-varying Network Driver Estimation (TNDE) using shared graph attention encoder and partial optimal transport.
result TNDE identifies stage-specific driver genes in mouse erythropoiesis.
LexNLP processes legal and regulatory texts for structured information.
problem Processing structured information from legal and regulatory texts.
method Natural language processing and machine learning for legal and regulatory text.
result LexNLP extracts over eighteen types of structured information from legal and regulatory texts.
In a market system, regulations are designed to prevent or rectify market failures that inhibit fair exchange, such as monopoly or transactions with hidden costs. Because regulations reduce profits to those possessing unfair advantage, these advantaged corporations (whether individuals, companies, or other collective o…
System tracks regulatory changes for compliance officers.
problem Struggling to keep up with regulatory changes.
method Fetch announcements, classify importance and applicability.
result Simple hierarchical classification works best.
Bayesian method discovers local causal relationships among genes from gene expression data.
problem Discovering gene regulatory relationships from gene expression data.
method Bayesian approach scoring covariance structures for triplets of normally distributed variables, incorporating background knowledge as priors.
result Stable and conservative posterior probability estimates of local causal structures.
Paper constructs a CRRIX index to assess cryptocurrency market risks from regulatory changes.
problem Lack of indices quantifying regulatory risks in cryptocurrencies.
method CRRIX index based on news coverage frequency, using Latent Dirichlet Allocation and Hellinger distance.
result CRRIX successfully captures major policy-changing moments and synchronizes with market volatility.
InfoSEM infers gene regulatory networks without GT labels, improving performance.
problem Inferring GRNs from gene expression data with high accuracy and avoiding biases.
method InfoSEM uses deep generative models with informative priors (textual gene embeddings).
result InfoSEM outperforms existing models by 38.5% across four datasets.
New method constructs confidence bands for ODE models with unknown regulatory effects.
problem Building confidence bands for ODE models with unknown regulatory relations is challenging.
method Localized kernel learning approach combined with de-biasing method.
result The constructed confidence band has the desired asymptotic coverage probability and accurately recovers the regulatory network.
Proposes a new method for determining LGD discount rates based on cost of capital.
problem Determining an appropriate discount rate for LGD estimation.
method Market-consistent pricing of defaulted loan portfolios to infer discount rates.
result Discount rates reflect both undiversifiable risk and time value of money.
Develops a haircut model for non-cash collateral.
problem Addressing the need for accurate non-cash collateral valuation in shadow banking and OTC derivatives markets.
method Expands haircut definitions, uses a double-exponential jump-diffusion model, and solves for credit risk measurements.
result Computational results show potential for collateral agreements and regulatory capital calculations.
Funding is a cost to trading desks that they see as an input. Current FVA-related literature reflects this by also taking funding costs as an input, usually constant, and always risk-neutral. However, this funding curve is the output from a Treasury point of view. Treasury must consider Regulatory-required liquidity bu…
NO-BEARS algorithm speeds up gene network inference from transcriptomic data.
problem Constructing accurate gene regulatory networks from transcriptomic data.
method NO-BEARS algorithm, based on NOTEARS, with new constraint and polynomial regression loss.
result Significantly reduced computational time and improved accuracy in inferring gene regulatory networks.
Optimal trading and liquidation strategies with signals and regulatory constraints.
problem Optimal trading and liquidation in models with price predictions and regulatory limits.
method Almgren-Chriss model with general signals, target zone models, and lookback option analysis.
result Explicit formulas for optimal liquidation rates in Bachelier and Black-Scholes dynamics.
Simple method calculates WWR for regulatory and accounting purposes.
problem Estimating WWR for regulatory and accounting capital requirements.
method Model-independent approach using integral expressions and component calibration.
result WWR effects for FVA are significantly more material than for CVA.
DASH simplifies neural networks for gene regulatory dynamics using domain knowledge.
problem Pruning neural networks for gene regulatory dynamics lacks biologically meaningful structure learning.
method DASH uses domain-specific structural information to guide network pruning, leading to sparser, better interpretable models.
result DASH outperforms general pruning methods in gene regulatory network inference, yielding deeper insights.
Bayesian model learns cell types and gene networks from two data views.
problem Estimating cell types and their regulatory networks from single-cell gene expression and epigenetic data.
method Symphony Bayesian hierarchical multi-view mixture model with Variational EM inference.
result Symphony outperforms other methods in learning cell types and regulatory networks.
Cryptocurrency markets show similar returns but different volatility responses to infrastructure and regulatory shocks.
problem Understanding how cryptocurrency markets differentiate between infrastructure and regulatory shocks.
method Event-level block bootstrap inference on 31 cryptocurrency events across Bitcoin, Ethereum, Solana, and Cardano (2019-2025).
result No statistically significant difference in cumulative abnormal returns between infrastructure failures and regulatory enforcement.
New framework for adaptive clinical trials to address real-world challenges.
problem Real-world challenges in post-regulatory clinical trials.
method RFAN framework integrating regulatory constraints and treatment policy value.
result Empirical evaluation of RFAN's performance.
Efficiently infers gene regulatory networks from spatial data.
problem Inferring spatially-varying gene regulatory networks.
method Proposed an efficient optimization problem for SV-GMRFs.
result Solves large-scale SV-GMRF problems in minutes.
SHARC explains machine learning risk models for regulatory capital, linking outputs to scenarios.
problem Inability to explain machine learning model outputs to regulatory bodies.
method SHAP-based explainability framework for Hybrid GPR-HS architecture and SVaR stress-testing.
result SHARC links SVaR outputs to scenario inputs, providing auditable traceability.
Robust machine learning models improve DNA regulatory sequence prediction under various shifts.
problem Real-world applications of DNA regulatory sequence prediction involve shifts not captured by standard i.i.d. assumptions.
method Introduces a robustness framework combining simulation benchmarks and real data analysis.
result Models remain accurate and calibrated under mild shifts but show higher error and miscalibration under strong shifts.
Develops probabilistic models for gene regulatory network inference.
problem Challenges in reconstructing gene regulatory networks from genome-wide data.
method Two complementary frameworks: PMF-GRN and GLM-Prior.
result Probabilistic inference refines regulatory estimates with quantified uncertainty.
Study examines how business units can benefit from group cohesion under regulatory constraints.
problem Regulatory constraints limit business units' ability to form a single cohesive group.
method Defined and analyzed cohesive risk measures to minimize capital costs.
result Cohesive risk measures allow groups to achieve minimal capital costs without altering individual liabilities.
Study analyzes FIT schemes under market and regulatory uncertainty.
problem Tackles uncertainty in feed-in tariffs and their impact on investment thresholds.
method Uses semi-analytical real options framework to model and compare FIT schemes.
result Increasing regulatory uncertainty lowers investment thresholds for FIT schemes.
The DAO Report led to a significant shift of ICO activity to Europe.
problem The impact of U.S. regulatory changes on global ICO activity.
method Analysis of a global dataset of ICOs from 2014 to 2021, focusing on the DAO Report's effects.
result A substantial and persistent reallocation of ICO activity to Europe following the DAO Report.
Machine learning identifies key metabolic control circuits in bacterial pathways.
problem Identifying regulated metabolic pathways in bacteria.
method Machine learning approach analyzing multi-omics data.
result Identification of E. coli Glycolysis regulatory circuits.
Study improves detection of accounting fraud using machine learning.
problem Global concern of accounting fraud threatening financial stability.
method Machine learning methods to differentiate between fraud and non-fraud companies.
result Out-of-sample results suggest great potential in detecting falsified financial statements.
Study analyzes climate-tech investments across 14 sectors.
problem Accelerating climate-tech innovation in nascent value chains.
method Analysis of 4,172 firms and 12,929 investments over 15 years.
result Only 15% of firms develop end products, 59% support them, and 26% develop services.
Enhances systemic risk analysis by incorporating debt valuation factors.
problem Systemic risk in financial networks due to bank failures.
method Incorporates debt valuation factors into existing risk analysis frameworks.
result Additional debt valuation factors substantially influence risk assessment outcomes.
Reconstructing transcriptional regulatory networks is an important task in functional genomics. Data obtained from experiments that perturb genes by knockouts or RNA interference contain useful information for addressing this reconstruction problem. However, such data can be limited in size and/or are expensive to acqu…
Model predicts trade volume changes from financial filings.
problem Improving financial market understanding through machine learning.
method Hierarchical Reformer model trained on SEDAR filings.
result Model can predict trade volume changes without explicit training.
Regulations impose idiosyncratic capital and funding costs for holding derivatives. Capital requirements are costly because derivatives desks are risky businesses; funding is costly in part because regulations increase the minimum funding tenor. Idiosyncratic costs mean no single measure makes derivatives martingales f…
FinDiff generates synthetic financial data for regulatory tasks.
problem Sharing microdata for research due to privacy regulations.
method Diffusion model using embedding encodings for mixed modality financial data.
result FinDiff excels in generating high-fidelity, privacy-preserving synthetic financial data.
New framework makes ML methods compliant with regulations.
problem Ensuring ML methods meet regulatory standards.
method InfoGram and Admissible Machine Learning framework.
result Redesigns ML methods for regulatory compliance.
In 1999 Robert Fernholz observed an inconsistency between the normative assumption of existence of an equivalent martingale measure (EMM) and the empirical reality of diversity in equity markets. We explore a method of imposing diversity on market models by a type of antitrust regulation that is compatible with EMMs. T…
RSI uses Bayesian inference to monitor compliance in rule-governed domains.
problem Structural obstacles in compliance monitoring, including unlabeled outcomes and selective withholding of evidence.
method Rule-State Inference (RSI) treats formalized rules as Bayesian priors and infers compliance states through mean-field variational inference.
result RSI delivers formal guarantees of adaptability, consistency, and convergence, validated on a synthetic enterprise benchmark.
Regshock visualizes financial risks to help regulators manage systemic shocks.
problem Managing systemic risks in financial networks.
method Risk-island visualization algorithm and regshock visual exploration approach.
result Demonstrated improved risk management and control capabilities.