Machine learning identifies key metabolic control circuits in bacterial pathways.
problem Identifying regulated metabolic pathways in bacteria.
method Machine learning approach analyzing multi-omics data.
result Identification of E. coli Glycolysis regulatory circuits.
This paper is concerned with the problem of stochastic control of gene regulatory networks (GRNs) observed indirectly through noisy measurements and with uncertainty in the intervention inputs. The partial observability of the gene states and uncertainty in the intervention process are accounted for by modeling GRNs us…
Gene regulatory networks play a crucial role in controlling an organism's biological processes, which is why there is significant interest in developing computational methods that are able to extract their structure from high-throughput genetic data. Many of these computational methods are designed to infer individual …
Research creates a taxonomy to bridge AI security and regulatory gaps.
problem Disciplinary disconnect between technical and legal teams in AI risk assessment.
method Developed an AI System Threat Vector Taxonomy with 9 domains and 53 sub-threats.
result Empirically validated and aligned with ISO/IEC 42001 controls and NIST AI RMF functions.
In a market system, regulations are designed to prevent or rectify market failures that inhibit fair exchange, such as monopoly or transactions with hidden costs. Because regulations reduce profits to those possessing unfair advantage, these advantaged corporations (whether individuals, companies, or other collective o…
Gene regulatory networks play a crucial role in controlling an organism's biological processes, which is why there is significant interest in developing computational methods that are able to extract their structure from high-throughput genetic data. A typical approach consists of a series of conditional independence t…
New framework for adaptive clinical trials to address real-world challenges.
problem Real-world challenges in post-regulatory clinical trials.
method RFAN framework integrating regulatory constraints and treatment policy value.
result Empirical evaluation of RFAN's performance.
Optimizes bank capital structure under Basel III constraints, simplifying complex dynamics.
problem Optimizing risky investments, dividends, and capital structure under Basel III constraints.
method Formulated as a stochastic control problem, reducing dynamics to a one-dimensional process in leverage ratio.
result Simple policy: pay dividends at an upper barrier and recapitalize at the distress boundary.
New risk measure improves creditor protection in financial regulation.
problem Current solvency requirements fail to control the size of recovery on creditors' claims.
method Developed Recovery Value at Risk (Recovery VaR) to control recovery on creditors' claims.
result Recovery VaR flexibly controls recovery on creditors' claims and integrates protection needs into management incentives.
Causal methods for GRN inference from single-cell data often fail in real-world benchmarks.
problem Understanding when and why causal methods for GRN inference from single-cell data fail in real-world benchmarks.
method Introduced a controlled diagnostic framework to isolate and measure seven pathologies.
result Causal methods dominate in clean and structurally favorable regimes but fail in specific pathologies.
New mechanism designs regulate herding in financial markets.
problem Herding causes irrational market decisions and volatility.
method A trilateral game framework based on optimal control theory.
result Effective mechanisms improve social welfare.
Regshock visualizes financial risks to help regulators manage systemic shocks.
problem Managing systemic risks in financial networks.
method Risk-island visualization algorithm and regshock visual exploration approach.
result Demonstrated improved risk management and control capabilities.
Study optimal incentives for cleaner energy production.
problem Accelerate transition to cleaner technologies in energy market.
method Stochastic control models for three scenarios: single firm, two firms, and two firms without incentives.
result Optimal strategies for investment and production emerge, highlighting firm interactions and incentive effects.
This research develops a new framework to measure AI investment returns considering both gains and risks.
problem Traditional ROI calculations fail to account for AI's dual impact on risk reduction and new exposures.
method Integrates ISO 42001 and regulatory exposure into a comprehensive financial framework using risk quantification methods.
result Accurate AI investment evaluation requires modeling both productivity gains and risk exposures.
Over the last 23 years, the U.S. Securities and Exchange Commission has required over 34,000 companies to file over 165,000 annual reports. These reports, the so-called "Form 10-Ks," contain a characterization of a company's financial performance and its risks, including the regulatory environment in which a company op…
In November, 2011, the Financial Stability Board, in collaboration with the International Monetary Fund, published a list of 29 "systemically important financial institutions" (SIFIs). This designation reflects a concern that the failure of any one of them could have dramatic negative consequences for the global econom…
This paper examines market misconduct in DeFi and proposes regulatory solutions.
problem Novel forms of market misconduct in DeFi.
method Comprehensive analysis, comparative study, empirical measurements, and tailored regulatory framework investigation.
result Identification of key areas for regulatory enhancement in DeFi.
Paper develops a framework to discover bioprocessing regulatory mechanisms using symbolic and statistical learning.
problem Challenges in modeling complex intracellular regulation, stochastic system behavior, and limited experimental data.
method Symbolic and statistical learning framework based on stochastic differential equations and Bayesian learning.
result Improved sample efficiency and robust model selection compared to state-of-the-art approaches.
In this paper we solve the dividend optimization problem for a corporation or a financial institution when the managers of the corporation are facing (regulatory) implementation delays. We consider several cash reservoir models for the firm including two mean-reverting processes, Ornstein-Uhlenbeck and square-root proc…
Study how firm liquidation regimes affect shareholder value and stability.
problem Balancing shareholder value and financial stability during firm liquidation.
method Modelled forced liquidation in reduced form, solved singular stochastic control problem.
result Combining distress regions below and above ruin threshold improves both shareholder value and firm survival.
regvis.net offers a visual survey of regulatory visualization.
problem Lack of a comprehensive resource for regulatory visualization.
method Collection and manual tagging of 80+ publications, creation of a searchable webpage.
result First publication set tailored for regulatory visualization.
Optimizes insurance profits under regulatory constraints.
problem Maximizing profits while adhering to regulatory and risk policies.
method Developed a formalism for in-force business profit optimisation.
result Identified optimal asset allocation and annual opportunity cost.
Framework audits synthetic datasets for trustworthiness across various use cases.
problem Assessing the trustworthiness of synthetic datasets and models.
method Holistic auditing framework focusing on bias, fidelity, utility, robustness, and privacy.
result Introduces a trustworthiness index and model selection process for controllable trade-offs.
TNDE quantifies dynamic gene drivers from single-cell snapshots.
problem Reconstructing time-resolved regulatory effects in biological processes.
method Time-varying Network Driver Estimation (TNDE) using shared graph attention encoder and partial optimal transport.
result TNDE identifies stage-specific driver genes in mouse erythropoiesis.
This paper tackles interpretability of LLMs in finance.
problem Complexity and lack of transparency of LLMs in finance.
method Mechanistic interpretability to understand LLM behavior.
result Demonstrates practical relevance of mechanistic interpretability in financial use cases.
Deep neural network learns optimal trading controls for high-frequency finance.
problem Optimal trading on high-frequency data with market impact and limited data.
method Deep neural network, Monte-Carlo initialization, transfer learning, explainable controls.
result Neural network learns optimal controls for trader preferences.
Paper constructs a CRRIX index to assess cryptocurrency market risks from regulatory changes.
problem Lack of indices quantifying regulatory risks in cryptocurrencies.
method CRRIX index based on news coverage frequency, using Latent Dirichlet Allocation and Hellinger distance.
result CRRIX successfully captures major policy-changing moments and synchronizes with market volatility.
CRC method provides tighter uncertainty intervals for CT images.
problem Expressing uncertainty in CT images in clinically meaningful terms.
method Semantically adaptive CRC procedure leveraging length minimization.
result Valid coverage of ground-truth images with tighter uncertainty intervals.
InfoSEM infers gene regulatory networks without GT labels, improving performance.
problem Inferring GRNs from gene expression data with high accuracy and avoiding biases.
method InfoSEM uses deep generative models with informative priors (textual gene embeddings).
result InfoSEM outperforms existing models by 38.5% across four datasets.
New method constructs confidence bands for ODE models with unknown regulatory effects.
problem Building confidence bands for ODE models with unknown regulatory relations is challenging.
method Localized kernel learning approach combined with de-biasing method.
result The constructed confidence band has the desired asymptotic coverage probability and accurately recovers the regulatory network.
Proposes a new method for determining LGD discount rates based on cost of capital.
problem Determining an appropriate discount rate for LGD estimation.
method Market-consistent pricing of defaulted loan portfolios to infer discount rates.
result Discount rates reflect both undiversifiable risk and time value of money.
To meet the Basel II regulatory requirements for the Advanced Measurement Approaches in operational risk, the bank's internal model should make use of the internal data, relevant external data, scenario analysis and factors reflecting the business environment and internal control systems. One of the unresolved challeng…
Funding is a cost to trading desks that they see as an input. Current FVA-related literature reflects this by also taking funding costs as an input, usually constant, and always risk-neutral. However, this funding curve is the output from a Treasury point of view. Treasury must consider Regulatory-required liquidity bu…
Simple method calculates WWR for regulatory and accounting purposes.
problem Estimating WWR for regulatory and accounting capital requirements.
method Model-independent approach using integral expressions and component calibration.
result WWR effects for FVA are significantly more material than for CVA.
Optimizes trading strategy for cointegrated assets with bounded risk.
problem Maximizing profit from cointegrated assets with risk constraints.
method Formulates as convex optimization problem, then generalizes to bounded risk.
result Optimal strategy remains efficiently solvable even with bounded risk.
Paper proposes a framework for token economy simulation and wealth distribution.
problem Simulation and regulation of token economies.
method Formal analysis framework for tokenomics, defining mechanisms for wealth distribution and stability.
result Algorithmic regulatory controls for token economies to achieve desired wealth distribution.
DASH simplifies neural networks for gene regulatory dynamics using domain knowledge.
problem Pruning neural networks for gene regulatory dynamics lacks biologically meaningful structure learning.
method DASH uses domain-specific structural information to guide network pruning, leading to sparser, better interpretable models.
result DASH outperforms general pruning methods in gene regulatory network inference, yielding deeper insights.
A great deal of academic and theoretical work has been dedicated to optimal liquidation of large orders these last twenty years. The optimal split of an order through time (`optimal trade scheduling') and space (`smart order routing') is of high interest \rred{to} practitioners because of the increasing complexity of t…
Cryptocurrency markets show similar returns but different volatility responses to infrastructure and regulatory shocks.
problem Understanding how cryptocurrency markets differentiate between infrastructure and regulatory shocks.
method Event-level block bootstrap inference on 31 cryptocurrency events across Bitcoin, Ethereum, Solana, and Cardano (2019-2025).
result No statistically significant difference in cumulative abnormal returns between infrastructure failures and regulatory enforcement.
Efficiently infers gene regulatory networks from spatial data.
problem Inferring spatially-varying gene regulatory networks.
method Proposed an efficient optimization problem for SV-GMRFs.
result Solves large-scale SV-GMRF problems in minutes.
Exchange uses incentives to optimize limit order book dynamics.
problem Optimizing market liquidity in fragmented electronic markets.
method Modeling limit order book as SPDE and using control theory to design incentives.
result Exchange can design incentives to modify order book shape and increase liquidity.
SHARC explains machine learning risk models for regulatory capital, linking outputs to scenarios.
problem Inability to explain machine learning model outputs to regulatory bodies.
method SHAP-based explainability framework for Hybrid GPR-HS architecture and SVaR stress-testing.
result SHARC links SVaR outputs to scenario inputs, providing auditable traceability.
The financial crisis clearly illustrated the importance of characterizing the level of 'systemic' risk associated with an entire credit network, rather than with single institutions. However, the interplay between financial distress and topological changes is still poorly understood. Here we analyze the quarterly inter…
Robust machine learning models improve DNA regulatory sequence prediction under various shifts.
problem Real-world applications of DNA regulatory sequence prediction involve shifts not captured by standard i.i.d. assumptions.
method Introduces a robustness framework combining simulation benchmarks and real data analysis.
result Models remain accurate and calibrated under mild shifts but show higher error and miscalibration under strong shifts.
Analysis of the 2007-8 credit crisis has concentrated on issues of relaxed lending standards, and the perception of irrational behaviour by speculative investors in real estate and other assets. Asset backed securities have been extensively criticised for creating a moral hazard in loan issuance and an associated incre…
Smart Close-out Netting aims to automate close-out netting processes.
problem Inefficiencies in close-out netting processes for financial institutions.
method Standardisation and automation of legal and regulatory processes using a data-driven framework and controlled natural language.
result Standardisation and automation can improve close-out netting processes for prudentially regulated financial institutions.
Develops probabilistic models for gene regulatory network inference.
problem Challenges in reconstructing gene regulatory networks from genome-wide data.
method Two complementary frameworks: PMF-GRN and GLM-Prior.
result Probabilistic inference refines regulatory estimates with quantified uncertainty.
Study examines how business units can benefit from group cohesion under regulatory constraints.
problem Regulatory constraints limit business units' ability to form a single cohesive group.
method Defined and analyzed cohesive risk measures to minimize capital costs.
result Cohesive risk measures allow groups to achieve minimal capital costs without altering individual liabilities.