Study of red blood cells using elastic surface theory.
problem Understanding the shape of red blood cells.
method Used Helfrich-Canham functional to model red blood cells as elastic surfaces.
result Cassinian ovals, except for the round sphere, do not solve the shape equation.
Mathematical model describes how red blood cells return to equilibrium.
problem How red blood cells regain equilibrium after deformation.
method Gradient flow of the Canham-Helfrich functional, proving global existence and convergence for spheres and axisymmetric tori.
result Global existence and convergence of smooth solutions for spheres and axisymmetric tori under specific energy conditions.
New method classifies reticulocytes from red blood cells without labels.
problem Classifying reticulocytes from mature red blood cells without fluorescent labels.
method Unsupervised machine learning on morpho-rheological markers.
result Promising results in classifying reticulocytes from mature red blood cells.
Malaria is a female anopheles mosquito-bite inflicted life-threatening disease which is considered endemic in many parts of the world. This article focuses on improving malaria detection from patches segmented from microscopic images of red blood cell smears by introducing a deep convolutional neural network. Compared …
Cell detection and cell type classification from biomedical images play an important role for high-throughput imaging and various clinical application. While classification of single cell sample can be performed with standard computer vision and machine learning methods, analysis of multi-label samples (region containi…
DISPR uses diffusion models to predict 3D cell shapes from 2D images.
problem Predicting 3D cell shapes from 2D microscopy images.
method Diffusion model trained to predict 3D shapes from 2D microscopy images as a prior.
result Adding DISPR predictions to minority cell classes improves classification accuracy.
This study automates blood cell classification using computer vision.
problem Automated detection and classification of white blood cells.
method Color-based segmentation, morphological processing, feature extraction, PCA, Unsupervised and Supervised learning algorithms, Deep Convolutional Neural Networks.
result Identification of robust algorithms for automated blood cell classification.
CST-YOLO improves blood cell detection with YOLOv7 and CNN-Swin Transformer.
problem Small-scale object detection in blood cells.
method YOLOv7 architecture enhanced with CNN-Swin Transformer, W-ELAN, MCS, CatConv.
result CST-YOLO achieves 92.7%, 95.6%, and 91.1% mAP@0.5 on three blood cell datasets.
Novel framework for whole-slide blood cell segmentation.
problem Semantic segmentation of whole-slide blood cell images.
method Convolutional encoder-decoder framework with VGG-16 feature extraction.
result Outstanding accuracy (97.18% global accuracy) in classwise segmentation.
TIMELY improves consistency in labeling blood cell images.
problem Inconsistent labeling of blood cells in microscopy images leads to unreliable diagnoses.
method TIMELY combines pseudotime inference and hidden Markov trees to correct labeling mistakes.
result TIMELY outperforms baseline methods in identifying and correcting inconsistent labels.
Counting and classifying blood cells is an important diagnostic tool in medicine. Support Vector Machines are increasingly popular and efficient and could replace artificial neural network systems. Here a method to classify blood cells is proposed using SVM. A set of statistics on images are implemented in C++. The MPE…
In this paper, we are interested in shape optimization problems involving the ge ometry (normal, curvatures) of the surfaces. We consider a class of hypersurface s in Rn satisfying a uniform ball condition and we prove the exist ence of a C1,1-regular minimizer for general geometric functionals and c…
The Helfrich functional, denoted by H^{c_0}, is a mathematical expression proposed by Helfrich (1973) for the natural free energy carried by an elastic phospholipid bilayer. Helfrich theorises that idealised elastic phospholipid bilayers minimise H^{c_0} among all possible configurations. The functional integrates a sp…
DCENWCNet improves WBC classification with LIME-based explainability.
problem Classifying white blood cells from blood images with high accuracy and interpretability.
method Integrates three CNN architectures with different settings to balance feature learning and performance.
result Achieves highest mean accuracy on the Rabbin-WBC dataset, outperforming state-of-the-art networks.
A low-cost, robust, and simple mechanism to measure hemoglobin would play a critical role in the modern health infrastructure. Consistent sample acquisition has been a long-standing technical hurdle for photometer-based portable hemoglobin detectors which rely on micro cuvettes and dry chemistry. Any particulates (e.g.…
We present a Bayesian hierarchical multi-view mixture model termed Symphony that simultaneously learns clusters of cells representing cell types and their underlying gene regulatory networks by integrating data from two views: single-cell gene expression data and paired epigenetic data, which is informative of gene-gen…
We preset a computational study of bending models for the curvature elasticity of lipid bilayer membranes that are relevant for simulations of vesicles and red blood cells. We compute bending energy and forces on triangulated meshes and evaluate and extend four well established schemes for their approximation: Kantor a…
The study compares different scRNA sequencing methods using a high-dimensional dataset.
problem To identify unique characteristics of different scRNA sequencing methods.
method Quantitative comparison through clustering analysis of a high-dimensional dataset.
result Identifies unique characteristics associated with different scRNA sequencing methods.
Detecting aggressive cancer tumors using ctDNA dynamics from few blood samples.
problem Early multi-cancer detection using circulating tumor DNA (ctDNA) levels.
method Combines continuous time Markov modelling and Signature theory for efficient testing procedures.
result Correctly addresses the challenge of data scarcity in cancer monitoring.
scICML integrates multi-omics data from single cells using co-clustering.
problem High noise and sparsity in multi-omics data from single cells.
method Information-theoretic co-clustering-based multi-view learning.
result Improves clustering performance and provides biological insights.
Using the mechanics of creep in material sciences as a metaphor, we present a general framework to understand the evolution of financial, economic and social systems and to construct scenarios for the future. In a nutshell, highly non-linear out-of-equilibrium systems subjected to exogenous perturbations tend to exhibi…
Model predicts HU response for sickle cell patients.
problem Predicting which sickle cell patients will respond to Hydroxyurea.
method Developed Deep Artificial Neural Network models.
result 92.6% accuracy in predicting HbF response.
Graph Attention Networks predict disease state from single-cell data.
problem Predicting disease state from single-cell data.
method Graph Attention Networks (GAT) for learning from both features and graph structures.
result Achieved 92% accuracy in predicting MS from single-cell data.
Tree-SNE combines t-SNE and hierarchical clustering for data visualization.
problem Data visualization and clustering in complex datasets.
method Stacked one-dimensional t-SNE embeddings and alpha-clustering.
result Effective hierarchical clustering and visualization of various datasets.
Flow cytometry is a high-throughput technology used to quantify multiple surface and intracellular markers at the level of a single cell. This enables to identify cell sub-types, and to determine their relative proportions. Improvements of this technology allow to describe millions of individual cells from a blood samp…
KOOW method provides optimal covariate balance for continuous treatments.
problem Estimating effects of continuous treatments with robustness to model misspecification and extreme weights.
method Kernel Optimal Orthogonality Weighting (KOOW) using convex optimization.
result KOOW provides optimal covariate balance and controls for extreme weights.
This paper presents the recurrent estimation of distributions (RED) for modeling real-valued data in a semiparametric fashion. RED models make two novel uses of recurrent neural networks (RNNs) for density estimation of general real-valued data. First, RNNs are used to transform input covariates into a latent space to …
ReD improves LLM inference efficiency at fixed budget, reducing attempts and cost.
problem Improving LLM inference efficiency at a fixed budget.
method Reset-and-Discard (ReD) query method.
result ReD increases coverage@cost for a given budget, reducing attempts and cost.
Blood glucose value prediction is an important task in diabetes management. While it is reported that glucose concentration is sensitive to social context such as mood, physical activity, stress, diet, alongside the influence of diabetes pathologies, we need more research on data and methodologies to incorporate and ev…
Generative ML learns optimal pursuit trajectories in pursuit-evasion games.
problem Optimizing Blue's pursuit trajectory to intercept Red in a game of pursuit-evasion.
method Applying generative machine learning to learn optimal action policies for Blue.
result Generative ML models can learn relevant representations for pursuit-evasion dynamics.
RED CoMETS improves multivariate time series classification accuracy.
problem Complexity of multivariate time series classification.
method Ensemble classifier RED CoMETS for symbolically represented multivariate time series.
result RED CoMETS achieves highest reported accuracy on 'HandMovementDirection' dataset.
Unified framework for semi-supervised learning reduces annotation needs.
problem Sparse annotations and large amounts of unlabeled data in computational pathology.
method S5CL integrates fully-supervised, self-supervised, and semi-supervised learning through hierarchical contrastive losses.
result S5CL improves accuracy and F1-score in histopathological datasets with sparse labels.
SPT predicts age and mass of red giants from spectra.
problem Challenges in age and mass estimation of red giants using traditional methods.
method SPT framework with Multi-head Hadamard Self-Attention and Mahalanobis distance-based loss function.
result Remarkable age and mass estimations with low errors and uncertainties.
Machine learning model diagnoses COVID-19 from routine blood tests.
problem Difficulty in diagnosing COVID-19 due to inconsistent blood parameter changes.
method Constructed a machine learning model using 5,333 patients with various infections and 160 COVID-19-positive patients.
result Cross-validated AUC of 0.97, sensitivity of 81.9%, specificity of 97.9%.
Quantization and reduction for coisotropic A-branes on Hamiltonian manifolds.
problem Quantization and reduction of coisotropic A-branes.
method Definition and construction of coisotropic A-branes, and a fibration over reduced spaces.
result Quantization commutes with reduction for coisotropic A-branes.
This study uses deep learning to infer stellar parameters from short TESS and K2 observations.
problem Inferring precise stellar parameters from short-duration TESS and K2 observations.
method Developed a machine learning algorithm to infer asteroseismic parameters from one-month-long TESS observations of red giants.
result The algorithm can accurately infer Δν and νmax for approximately 50% of TESS samples and ΔΠ1 for about 200 young red-giants from K2. Proposes RPG-RT for red-teaming T2I models without internal access.
problem Evaluating T2I models' security through red-teaming is challenging due to their closed-source nature and unknown defense mechanisms.
method Integrates LLM and rule-based preference modeling to dynamically adapt to unknown defense mechanisms.
result Demonstrates superior and practical approach for red-teaming T2I models.
Develops a tool to identify abnormal blood smear results based on CBC tests.
problem Manual review of blood smears by technologists is time-consuming and inconsistent.
method Cost-sensitive Lasso-penalized additive logistic regression combined with stability selection.
result The tool correctly identifies true cutoff values for abnormal smear results.
A deep learning network was used to predict future blood glucose levels, as this can permit diabetes patients to take action before imminent hyperglycaemia and hypoglycaemia. A sequential model with one long-short-term memory (LSTM) layer, one bidirectional LSTM layer and several fully connected layers was used to pred…
New framework assesses LLM security risks in BFSI.
problem Lack of domain-specific security evaluation for LLMs in BFSI.
method Risk-aware evaluation framework combining taxonomy, automated red-teaming, and ensemble judging.
result Higher decoding stochasticity and adaptive interaction lead to more severe disclosures.
In this paper, we introduce an insurance ruin model with adaptive premium rate, thereafter refered to as restructuring/refraction, in which classical ruin and bankruptcy are distinguished. In this model, the premium rate is increased as soon as the wealth process falls into the red zone and is brought back to its regul…
New method estimates effects of multiple nutrients on blood glucose.
problem Estimating physiological response to multiple nutrient treatments.
method Convolution-based multi-output Gaussian process model.
result Improved prediction accuracy and better interpretation of individual nutrient effects.
Study discovers patterns in insulin needs for T1D patients.
problem Finding the right insulin dose and time for T1D patients is challenging.
method Used OpenAPS Data Commons dataset and time series techniques like matrix profile and multi-variate clustering.
result Identified temporal patterns in insulin needs driven by factors like carbohydrates and possibly others.
We use a deep learning model trained only on a patient's blood oxygenation data (measurable with an inexpensive fingertip sensor) to predict impending hypoxemia (low blood oxygen) more accurately than trained anesthesiologists with access to all the data recorded in a modern operating room. We also provide a simple way…
RED-2400 is a public benchmark of trading events from a Solana exchange, labeled by algorithmic rejection.
problem Analyzing algorithmically-rejected trading events for insights into market dynamics.
method Public dataset of 6,660 algorithmically-rejected trading events, linked to post-rejection price and liquidity trajectories.
result First window of a planned series of datasets extending the time horizon and enabling regime-stratified analysis.
Deep RL improves blood glucose control for T1D patients.
problem Managing blood glucose levels for people with type 1 diabetes.
method Developed deep reinforcement learning techniques for automated blood glucose control.
result Deep RL approach outperforms baseline control algorithms, reducing glycemic risk and hypoglycemia.
Computational Drug Repositioning (CDR) is the task of discovering potential new indications for existing drugs by mining large-scale heterogeneous drug-related data sources. Leveraging the patient-level temporal ordering information between numeric physiological measurements and various drug prescriptions provided in E…
AI tool automates blood segmentation from head CT scans after SAH.
problem Accurate volumetric assessment of SAH patients for clinical and prognostic implications.
method Transformer-based Swin UNETR architecture for noncontrast CT scans.
result High accuracy and robust performance across internal and external validation cohorts.