New research finds uncertainty estimation techniques fail to reliably detect abnormal medical cases.
problem Uncertainty estimation does not reliably detect out-of-distribution patients in medical tabular data.
method A series of tests on various uncertainty estimation techniques on real-world medical data.
result Almost all techniques fail to identify out-of-distribution patients, contradicting earlier findings.
Automatic representation learning of key entities in electronic health record (EHR) data is a critical step for healthcare informatics that turns heterogeneous medical records into structured and actionable information. Here we propose ME2Vec, an algorithmic framework for learning low-dimensional vectors of the most co…
Representation learning (RL) plays an important role in extracting proper representations from complex medical data for various analyzing tasks, such as patient grouping, clinical endpoint prediction and medication recommendation. Medical data can be divided into two typical categories, outpatient and inpatient, that h…
Framework harmonizes EHR data across institutions for better analysis.
problem Heterogeneity of medical codes and terminologies hinder EHR data analysis.
method MASH (Multi-source Automated Structured Hierarchy) uses neural optimal transport and learned hyperbolic embeddings to align and structure EHR data.
result MASH generates interpretable hierarchical graphs for unstructured local laboratory codes.
Study introduces a new method for multiple parameter regularization in polynomial functional regression.
problem Handling varying regularization parameters in polynomial functional regression.
method Developed a theoretically grounded algorithm for multiple parameter regularization and model aggregation.
result Promising results from evaluations on synthetic and real-world data.
Rough Transformers improve efficiency for medical time-series data.
problem Efficiently modeling irregularly sampled, long-range time-series data.
method Introducing Rough Transformers, a Transformer variant with continuous-time representations and multi-view signature attention.
result Rough Transformers outperform vanilla Transformers while using less computational resources.
With the expeditious advancement of information technologies, health-related data presented unprecedented potentials for medical and health discoveries but at the same time significant challenges for machine learning techniques both in terms of size and complexity. Those challenges include: the structured data with var…
In medical real-world study (RWS), how to fully utilize the fragmentary and scarce information in model training to generate the solid diagnosis results is a challenging task. In this work, we introduce a novel multi-instance neural network, AMI-Net+, to train and predict from the incomplete and extremely imbalanced da…
This paper benchmarks privacy-preserving machine learning on medical images.
problem Ensuring privacy in medical image analysis while maintaining model accuracy.
method Comparing Local-DP and DP-SGD for differential privacy in medical imagery.
result Theoretical privacy guarantees do not fully align with real-world performance.
A method for data encryption makes data look identical to humans but misleading to machine learning.
problem Data leakage in data sharing for medical purposes.
method Proposes a method inspired by adversarial attacks for data encryption.
result Encrypted data look identical to humans but misleading to machine learning methods.
Proposes online learning for Hawkes processes with network structure and event interaction.
problem Modeling complex interactions and latent structures in network events.
method Online learning approach for mixture of multivariate Hawkes processes.
result Efficacy demonstrated on synthetic and real-world data.
Paper detects biases in medical imaging ML models using counterfactual analysis.
problem Bias in medical imaging ML models negatively impacts generalization performance.
method Counterfactual invariance framework combining conditional latent diffusion models and statistical hypothesis testing.
result The method identifies and quantifies biases without direct access to counterfactual data.
Paper harmonizes medical data using flow-based causal inference.
problem Heterogeneity in medical data from different sites and protocols.
method Flow-based normalizing method for counterfactual inference on structural causal models.
result Better cross-domain generalization compared to state-of-the-art algorithms.
Paper proposes a graph network for EHR data that learns robust representations.
problem Learning robust representations for EHR data with implicit connections.
method Variationally regularized encoder-decoder graph network.
result Model outperforms existing methods in various EHR predictive tasks.
FLBench automates federated learning benchmarking.
problem Manual dataset partitioning fails to simulate real-world isolated data islands.
method Develops a federated learning benchmark suite with three domains.
result Automates evaluation of federated learning systems and algorithms.
This research improves uncertainty estimation for medical predictions, enhancing model trust and decision support.
problem Improving model uncertainty estimation for rare medical conditions.
method Developed and refined heuristics for selecting uncertainty estimation techniques, distinguishing them by clinical use-case. Also, compared ensembles vs. auto-encoders for detecting out-of-domain examples.
result Auto-encoders outperform ensembles in detecting out-of-domain examples, highlighting their importance for medical tabular data.
We present an operational component of a real-world patient triage system. Given a specific patient presentation, the system is able to assess the level of medical urgency and issue the most appropriate recommendation in terms of best point of care and time to treat. We use an attention-based convolutional neural netwo…
The study compares Euclidean and cosine distances in medical drug prescription prediction.
problem Comparing Euclidean and cosine distances in medical drug prescription prediction.
method Established geometric properties and compared distances in real-world medical data.
result Different distances lead to different optimizing nonlinear kernel embedding frameworks.
Sparse learning has been shown to be effective in solving many real-world problems. Finding sparse representations is a fundamentally important topic in many fields of science including signal processing, computer vision, genome study and medical imaging. One important issue in applying sparse representation is to find…
Efficiently find near-optimal medical treatments with less trial and error.
problem Finding effective medical treatments through trial and error.
method Formalizes the problem, uses a causal inference framework, and proposes model-based dynamic programming and greedy algorithms.
result Our methods compare favorably to model-free reinforcement learning, offering a more transparent trade-off between search time and treatment efficacy.
The paper investigates deep neural networks for medical imaging applications, providing interpretable results.
problem Uninterpretable decisions made by deep neural networks in medical imaging applications.
method Investigation of deep neural networks for malaria, diabetic retinopathy, brain tumor, and tuberculosis detection in various imaging modalities. Visualization of class activation mappings provided.
result Visualization of class activation mappings enhances understanding of deep neural networks and aids doctors in decision-making.
Evaluating the clinical similarities between pairwise patients is a fundamental problem in healthcare informatics. A proper patient similarity measure enables various downstream applications, such as cohort study and treatment comparative effectiveness research. One major carrier for conducting patient similarity resea…
Deep tabular models outperform GBDT in medical diagnosis tasks.
problem Transfer learning for tabular data in medical diagnosis.
method Proposes a pseudo-feature method for transfer learning between different feature sets.
result Tabular neural networks outperform GBDT in medical diagnosis tasks.
Visual analytics system for comparing medical records using sequence embeddings.
problem Challenges in analyzing medical records due to high dimensionality, irregularity, and sparsity.
method Event and sequence embeddings using autoencoder and self-attention mechanism, with sequence alignment for comparison.
result Demonstrated effectiveness with real-world neonatal ICU dataset.
Study on how imprecise medical data affects predictions in hyperthyroidism.
problem Impact of imprecise medical data on prediction results.
method Formulated a model for data imprecisions, generated imprecise samples, defined measures to evaluate impacts, and performed experiments.
result Small imprecisions can lead to large ranges of predicted results, potentially causing mis-labeling and inappropriate actions.
CovidCare uses EMR data to predict patient outcomes in emerging epidemics.
problem Intelligent prognosis for patients with emerging infectious diseases during rapid epidemics.
method Transfer learning and knowledge distillation from existing EMR data.
result CovidCare outperforms baseline methods in predicting patient length of stay.
Deep learning models for survival analysis have gained significant attention in the literature, but they suffer from severe performance deficits when the dataset contains many irrelevant features. We give empirical evidence for this problem in real-world medical settings using the state-of-the-art model DeepHit. Furthe…
DiffDenoise preserves fine structures in medical images using conditional diffusion models.
problem Medical image denoising often results in loss of fine structures.
method Conditional diffusion model with stabilized reverse sampling and supervised training.
result DiffDenoise outperforms state-of-the-art methods in medical image denoising.
Laboratory testing and medication prescription are two of the most important routines in daily clinical practice. Developing an artificial intelligence system that can automatically make lab test imputations and medication recommendations can save costs on potentially redundant lab tests and inform physicians of a more…
Learning from electronic medical records (EMR) is challenging due to their relational nature and the uncertain dependence between a patient's past and future health status. Statistical relational learning is a natural fit for analyzing EMRs but is less adept at handling their inherent latent structure, such as connecti…
Paper tackles label noise in large datasets, purifying noisy data with a nonparametric framework.
problem Label noise in large-scale datasets with coarse labels.
method Develops a model-agnostic nonparametric framework for classification.
result Framework purifies noisy data using a small clean dataset and manages ambiguous samples.
TAnoGan detects anomalies in time series data using GANs.
problem Anomaly detection in time series data.
method Generative Adversarial Networks (GAN) for unsupervised anomaly detection.
result TAnoGan outperforms traditional and neural network models in anomaly detection.
Background: The problem of predicting whether a drug combination of arbitrary orders is likely to induce adverse drug reactions is considered in this manuscript. Methods: Novel kernels over drug combinations of arbitrary orders are developed within support vector machines for the prediction. Graph matching methods are …
ConCare personalizes healthcare predictions by capturing EMR features.
problem Predicting patient outcomes from EMR data with personalization.
method Captures personal characteristics and time-aware distribution in EMR data.
result Improves healthcare prediction accuracy through personalized health context.
A neural network method tackles high-dimensional diffeomorphic mapping problems.
problem High-dimensional diffeomorphic mapping struggles with the curse of dimensionality.
method Combines variational principles with quasi-conformal theory for accurate, bijective mappings.
result Validated accuracy, robustness, and effectiveness in complex registration scenarios.
Gaussian process variational autoencoders improve disentanglement in time series data.
problem Learning disentangled representations from multivariate time series data.
method Model each latent channel with a Gaussian process prior and a structured variational distribution to capture temporal dependencies.
result Competitive performance on benchmark and real-world medical time series data.
The paper investigates interpretability techniques for deep learning models in medical data.
problem Understanding the logic behind predictions of black-box models in medical decision-making.
method Applied deep neural networks and random forests to a medical dataset. Used autoencoders and local interpretable models to provide insights.
result Local interpretable models and autoencoders provide meaningful insights into cancer predictions, identifying distinct and non-generalizable features.
Enhances understanding of patient healthcare journeys using self-attention.
problem Capturing hidden dependencies in multi-level patient journey data.
method Proposes a multi-level self-attention network (MusaNet) for encoding patient journeys.
result MusaNet produces higher-quality representations than state-of-the-art methods.
New benchmark evaluates BDL methods in medical retinopathy diagnosis.
problem Evaluate robustness and scalability of BDL methods in medical applications.
method Developed a new benchmark with real-world diabetic retinopathy tasks.
result Some BDL techniques overfit uncertainty to datasets, underperforming on new benchmark.
DDGroup identifies subgroups with uniform linear relationships.
problem Heterogeneous effects of covariates in linear models.
method Data-driven method to identify subgroups with uniform linear relationships.
result DDGroup can discover subgroups with improved performance.
Automated system extracts medication regimens from medical conversations.
problem Extract relevant medication information from medical conversations.
method QA task approach, combined QA and Information Extraction, data augmentation, public embeddings, pretraining.
result Improved accuracy in extracting dosage and frequency from 54.28 and 37.13 to 89.57 and 45.94.
Privacy-preserving deep learning for medical data across distributed platforms.
problem Data leakage in medical platforms.
method Separates hidden layers; first layer local, others centralized for training.
result Improved learning performance with all data used during training.
Rate-In dynamically adjusts dropout rates during inference to improve uncertainty estimation in neural networks.
problem Static dropout rates lead to suboptimal uncertainty estimates in neural networks.
method Rate-In dynamically adjusts dropout rates using information-theoretic principles.
result Rate-In improves calibration and sharpens uncertainty estimates compared to fixed or heuristic dropout rates.
Underspecified ML models can behave unpredictably in real-world use.
problem ML models can fail in real-world deployment due to ambiguous predictors.
method Identified underspecification as the cause, showing it affects various ML domains.
result Underspecified models can behave differently in deployment domains.
Develops a new RL algorithm for medical treatment regimes.
problem Optimal dose determination in continuous action environments.
method Quasi-optimal learning algorithm for near-optimal actions.
result Guaranteed convergence and effectiveness in real applications.
Zero-Shot Learning helps learn new concepts without examples, useful for COVID-19 diagnosis.
problem Learning new concepts without examples, especially in medical imaging.
method Uses existing knowledge and auxiliary information to predict unknown concepts.
result Effective in diagnosing COVID-19 from chest X-rays.
Develops ML-DQA for healthcare data quality assurance.
problem Inconsistent use of real-world data in machine learning projects.
method Develops ML-DQA framework based on RWD best practices.
result Five generalizable practices emerge from ML-DQA implementation.
CP-ROC bands improve graph classification accuracy and uncertainty quantification.
problem Uncertainty quantification and robustness to distributional shifts in graph classification.
method Conditional Prediction ROC (CP-ROC) bands for graph classification, developed for TGNNs and adaptable to GNNs.
result Statistically guaranteed coverage for CP-ROC under local exchangeability condition, improving prediction reliability.