Generative models create H&E-stained and destained prostate biopsy images.
problem Lack of H&E-stained prostate biopsy images.
method Conditional GAN for H&E staining, destaining model learning from stained to non-stained images.
result Generated images maintain structural similarity to non-stained biopsy.
Convolutional neural networks improve biopsy image classification for diagnosing Celiac Disease and Environmental Enteropathy.
problem Diagnosing Celiac Disease and Environmental Enteropathy from biopsy images due to histopathologic overlap.
method Proposed a convolutional neural network (CNN) to classify duodenal biopsy images.
result The proposed model achieves high accuracy in classifying biopsy images for CD, EE, and healthy controls.
Transfer learning from breast histopathology improves prostate cancer detection.
problem Insufficient prostate histopathology datasets for training.
method Transfer learning from breast histopathology images.
result Proposed approach outperforms transfer learning from ImageNet dataset.
A Convolutional Neural Network was used to predict kidney function in patients with chronic kidney disease from high-resolution digital pathology scans of their kidney biopsies. Kidney biopsies were taken from participants of the NEPTUNE study, a longitudinal cohort study whose goal is to set up infrastructure for obse…
Deep CNNs segment prostate from MRI images.
problem Variability and scarcity of annotated prostate MRI data.
method Two-step CNN approach: global bounding box, local delineation; data augmentation.
result State-of-the-art Dice scores (90.6) on PROMISE12 dataset.
Study proposes deep learning techniques to diagnose and differentiate Celiac Disease and Environmental Enteropathy from biopsy images.
problem Challenging histopathologic overlap between Celiac Disease and Environmental Enteropathy in biopsy images.
method Color balancing and Random Multimodel Deep Learning (RMDL) architecture to address staining variability.
result Proposed deep learning techniques improve diagnosis accuracy of Celiac Disease and Environmental Enteropathy.
In order to investigate the breast cancer prediction problem on the aging population with the grades of DCIS, we conduct a tree augmented naive Bayesian network experiment trained and tested on a large clinical dataset including consecutive diagnostic mammography examinations, consequent biopsy outcomes and related can…
Study evaluates data augmentation methods for prostate cancer detection in MRI.
problem Limited data for prostate cancer detection in MRI.
method Static application of five augmentation techniques (rotation, flip, crop, translation) to MRI dataset.
result Rotation method improved 2D slice-based AUC to 0.85.
Radiological imaging of the prostate is becoming more popular among researchers and clinicians in searching for diseases, primarily cancer. Scans might be acquired with different equipment or at different times for prognosis monitoring, with patient movement between scans, resulting in multiple datasets that need to be…
Proposes using MR images to create synthetic CT images for prostate segmentation.
problem Creating high-quality annotations for prostate segmentation in CT scans.
method CycleGAN algorithm to create synthetic CT images from MR images, using a 2.5D Residual U-Net for segmentation.
result Automatic delineation of prostate from real CT scans achieved with comparable results to radiologist annotations.
Deep learning model diagnoses celiac disease severity from intestinal biopsy images.
problem Diagnosing celiac disease severity from biopsy images, especially mild cases.
method Deep residual networks trained on a modified Marsh score histological scoring system.
result Model achieved AUC > 0.96 in all classes for CD severity classification.
Capsule network improves polyp diagnosis accuracy.
problem Low accuracy of optical biopsy methods for polyps.
method D-Caps architecture with CAP method.
result 43% improvement over previous state-of-the-art.
Deep neural networks predict prostate motion from MR images.
problem Predicting prostate motion during ultrasound-guided interventions.
method Biomechanically-trained deep neural networks on unstructured nodes.
result Trained networks yield near real-time inference with 0.017 mm error.
Mammography is the most effective and available tool for breast cancer screening. However, the low positive predictive value of breast biopsy resulting from mammogram interpretation leads to approximately 70% unnecessary biopsies with benign outcomes. Data mining algorithms could be used to help physicians in their dec…
Study compares DL models for medical image segmentation, finds synergistic ensemble strategies improve performance.
problem Improving DL models for specialized medical image segmentation using transfer learning.
method Detailed comparisons of TII and LMI models for binary segmentation of medical images.
result Ensemble strategies improve performance by 10% in certain scenarios.
PersonalizedUS assesses breast cancer risk with local coverage guarantees.
problem Manual BI-RADS scoring leads to unnecessary biopsies and mental health burden.
method Conformal prediction for precise, personalized risk estimates.
result Local coverage guarantees with high sensitivity and specificity.
Proposes a multi-resolution model for prostate cancer classification using mpMRI.
problem Improving voxel-wise classification of prostate cancer using multi-parametric MRI data.
method Multi-resolution Super Learner framework combining local base learners at multiple resolutions and spatial Gaussian kernel smoothing.
result Enhanced voxel-wise classification of prostate cancer status and clinical significance.
Machine learning classifies colorectal tissue using photoacoustic microscopy.
problem Traditional diagnostic methods for colorectal cancer are limited in detail and painful.
method Machine learning applied to acoustic resolution photoacoustic microscopy.
result Machine learning accurately classified benign and malignant tissue.
CNN-based prostate cancer grading improves accuracy and efficiency.
problem Manual Gleason grading by pathologists is time-consuming and prone to errors.
method Patch-Based Image Reconstruction (PBIR), Distribution Correction (DC), Quadratic Weighted Mean Square Error (QWMSE).
result Achieved superior expert-level performance (0.8885 quadratic-weighted kappa coefficient).
Spatially-aware metrics improve uncertainty evaluation in segmentation.
problem Uncertainty evaluation metrics treat voxels independently, ignoring spatial context.
method Proposed three spatially aware metrics incorporating structural and boundary information.
result Improved alignment with clinically important factors and better discrimination between uncertainty patterns.
A novel deep learning architecture (XmasNet) based on convolutional neural networks was developed for the classification of prostate cancer lesions, using the 3D multiparametric MRI data provided by the PROSTATEx challenge. End-to-end training was performed for XmasNet, with data augmentation done through 3D rotation a…
Study builds tools to detect misinformation in online medical videos.
problem Misleading information in online medical videos.
method Manual annotation of a dataset, use of linguistic, acoustic, and user engagement features for classification models.
result Automatic models can identify misinformation with up to 74% accuracy.
A deep learning approach classifies medical images hierarchically.
problem Limitations of traditional supervised classifiers in medical image classification.
method Hierarchical Medical Image Classification (HMIC) using deep learning models.
result HMIC achieved better performance in classifying medical images hierarchically.
New method for causal inference in survival outcomes using RDD.
problem Censoring in time-to-event analyses.
method Nonparametric approach with doubly robust censoring corrections.
result Higher efficiency and robustness to misspecification.
Survival analysis has been developed and applied in the number of areas including manufacturing, finance, economics and healthcare. In healthcare domain, usually clinical data are high-dimensional, sparse and complex and sometimes there exists few amount of time-to-event (labeled) instances. Therefore building an accur…
This paper synthesizes mp-MRI data for prostate cancer detection.
problem Synthesizing clinically significant prostate cancer MRI data.
method Semi-supervised adversarial learning with StitchLayer and auxiliary distance maximization.
result Synthesizes high-quality mp-MRI images with distinguishable prostate cancer lesions.
Develops platforms to analyze social media data for human behavior and emotions.
problem Understanding human behavior and emotions from social media data.
method Self-structuring incremental machine learning, event detection, natural language processing.
result Captured salient topics and events from social media data, validated against news.
Deep object detection improves mitotic nucleus detection in breast cancer biopsies.
problem Challenges in automated mitotic nucleus detection in breast cancer histopathological images.
method Adapted Mask R-CNN for deep object detection, initially selects candidate regions with maximum recall, refines them with multi-object loss function.
result Improved discrimination ability (F-score of 0.86) and significant precision (0.86) for mitotic nuclei compared to two-stage models.
Optimal cutoff interval for risk scores improves binary classification accuracy.
problem Improving binary classification accuracy with abstention.
method Determines optimal cutoff interval for risk scores, refraining from decisions outside this interval.
result Minimizes classification margin and maximizes accuracy within the interval.
Hierarchical CNNs improve diagnosis of GI diseases from histopathological images.
problem Diagnosing GI diseases from histopathological images is challenging due to heterogeneity and shared features.
method Embedded a class hierarchy into a VGGNet to address the hierarchical structure of GI diseases.
result The hierarchical model achieved better results than a flat model for multi-category diagnosis of GI disorders.
We propose a Bayesian model that predicts recovery curves based on information available before the disruptive event. A recovery curve of interest is the quantified sexual function of prostate cancer patients after prostatectomy surgery. We illustrate the utility of our model as a pre-treatment medical decision aid, pr…
Robust cancer screening model using pre-trained ensembles for biomarkers.
problem Detecting early-stage cancer, especially in hard-to-diagnose cases like pancreatic cancer.
method Meta-trained Hyperfast model for robust classification, combined with ensembling of XGBoost and LightGBM.
result Achieved highest AUC of 0.9929 and robust performance on imbalanced datasets.
The paper develops a method to learn cost-optimal sequential testing policies from retrospective data.
problem Learning cost-optimal sequential decision policies from retrospective data with missing test results.
method Doubly robust Q-learning framework with path-specific inverse probability weights.
result The method reduces testing cost without compromising predictive accuracy.
The incidence of malignant melanoma continues to increase worldwide. This cancer can strike at any age; it is one of the leading causes of loss of life in young persons. Since this cancer is visible on the skin, it is potentially detectable at a very early stage when it is curable. New developments have converged to ma…
Automatization of the diagnosis of any kind of disease is of great importance and it's gaining speed as more and more deep learning solutions are applied to different problems. One of such computer aided systems could be a decision support too able to accurately differentiate between different types of breast cancer hi…
Study improves machine learning for estimating survival treatment effects.
problem Estimating heterogeneous survival treatment effects in observational data.
method Flexible machine learning methods in the counterfactual framework, including AFT-BART-NP.
result AFT-BART-NP consistently yields best performance in terms of bias, precision, and frequentist coverage.
We describe an adversarial learning approach to constrain convolutional neural network training for image registration, replacing heuristic smoothness measures of displacement fields often used in these tasks. Using minimally-invasive prostate cancer intervention as an example application, we demonstrate the feasibilit…
We estimate treatment cost-savings from early cancer diagnosis. For breast, lung, prostate and colorectal cancers and melanoma, which account for more than 50% of new incidences projected in 2017, we combine published cancer treatment cost estimates by stage with incidence rates by stage at diagnosis. We extrapolate to…
New method groups genetic data into coherent topics for disease insights.
problem Analyzing large, multi-dimensional genetic data sets.
method Conditional Hierarchical Bayesian Tucker Decomposition for genetic data analysis.
result Our models are more coherent than baseline models.
Accurate and robust cell nuclei classification is the cornerstone for a wider range of tasks in digital and Computational Pathology. However, most machine learning systems require extensive labeling from expert pathologists for each individual problem at hand, with no or limited abilities for knowledge transfer between…
DP synthetic data may inflate statistical test results, caution advised.
problem Inflated Type I errors in statistical tests on DP-synthetic data.
method Evaluation of Mann-Whitney U test, t-test, chi-squared test, and median test on DP-synthetic data generated from real-world and simulated datasets using various DP-synthetic data generation methods.
result A large portion of evaluation results showed inflated Type I errors, especially at low privacy levels.
The outcome of a functional genomics pipeline is usually a partial list of genomic features, ranked by their relevance in modelling biological phenotype in terms of a classification or regression model. Due to resampling protocols or just within a meta-analysis comparison, instead of one list it is often the case that …
Develops CSI for predicting disease progression from sparse data.
problem Lack of frequent clinical metrics for disease progression.
method Machine learning framework (CSI) for analyzing disease progression from sparse observations.
result CSI effectively predicts disease progression from sparse data.
Improves uncertainty estimates in lung node segmentation.
problem Inaccurate uncertainty estimates in medical segmentation.
method Supervised learning using multi-grader annotation variability.
result Improves predictive uncertainty estimates and sample diversity.
Penalized regression models are popularly used in high-dimensional data analysis to conduct variable selection and model fitting simultaneously. Whereas success has been widely reported in literature, their performances largely depend on the tuning parameters that balance the trade-off between model fitting and model s…
Modified AUC improves CNN training by considering model confidence.
problem Improving binary classifier performance metrics.
method Proposes a modified AUC metric that incorporates model confidence into BCE loss for CNN training.
result Demonstrates improved performance on three datasets: MNIST, prostate MRI, and brain MRI.
Proposes efficient data acquisition for personalized treatment effects from observational data.
problem Efficiently acquiring outcomes for personalized treatment effects in observational studies.
method Introduces causal, Bayesian acquisition functions to select points with overlapping support.
result Demonstrates improved sample efficiency and accuracy in learning personalized treatment effects.
Study uses NMF to reduce cancer microarray data dimensions.
problem High dimensionality of cancer microarray data hinders understanding.
method Used Non-negative Matrix Factorization (NMF) for dimensionality reduction.
result NMF achieves 98% classification accuracy.