A new model uses GPs and latent force models to predict patient responses to drugs.
problem Challenges in modeling short-term effects of drugs on patient physiology.
method Hybrid Gaussian process with latent force model for joint modeling of patient physiology and drug effects.
result The model accurately predicts patient responses to three common drugs, showing competitive performance.
Identifies patient-specific root causes of disease using structural equation models.
problem Detecting significant variables in complex diseases that differ between patients.
method Defining patient-specific root causes as exogenous errors in a structural equation model, quantifying predictivity using Shapley values, and developing a fast algorithm called Root Causal Inference.
result Significant improvements in accuracy by uncovering root causes with large effect sizes at the individual level but clinically insignificant effect sizes at the group level.
Personalized models explain TB treatment outcomes considering patient context.
problem Heterogeneity in TB treatment outcomes due to co-morbidities.
method Multi-task learning approach encoding patient context into personalized models.
result Identifies anemia, age of onset, and HIV as influential for treatment efficacy.
Efficiently fine-tunes patient-independent seizure detection models with tensor kernel machine.
problem Improving seizure detection accuracy for wearable devices.
method Transfer learning with tensor kernel machine using canonical polyadic decomposition.
result Patient fine-tuned model achieves high performance with smaller model size.
New model identifies patient-specific disease root causes.
problem Identifying root causes of complex diseases varying between patients.
method Generalized Root Causal Inference (GRCI) algorithm for heteroscedastic noise model.
result GRCI accurately extracts patient-specific root causes.
New definition of patient-specific root causes of disease using counterfactuals.
problem Lack of rigorous mathematical formulation for automatic detection of root causes.
method Proposes a counterfactual definition matching clinical intuition and uses Shapley values for causal contribution scores.
result Adapts to disease prevalence, accounts for noisy labels, and admits fast computation.
Paper develops methods for estimating patient-specific survival curve prediction intervals.
problem Lack of uncertainty quantification in ISD models.
method Adapted existing method for ISD survival curve analysis.
result New methods provide accurate simultaneous prediction intervals.
FalconBC improves patient-specific cardiovascular modeling by estimating boundary conditions efficiently.
problem Efficiently estimating boundary conditions in patient-specific cardiovascular models, especially in open-loop models and anatomies with lesions.
method A general amortized inference framework based on probabilistic flow that treats clinical targets and anatomies as conditioning variables.
result Demonstrated on two patient-specific models, FalconBC improves efficiency and accuracy in estimating boundary conditions.
Deep CNN-RNN model classifies breathing sounds for respiratory disease diagnosis.
problem Automated diagnosis of respiratory diseases using wearable devices.
method Patient-specific model tuning and local log quantization of weights.
result 71.81% accuracy on leave-one-out validation with patient-specific data.
Study finds RNNs predict STBG better than ARIMA, useful for diabetes patients.
problem Improving short-term blood glucose prediction for diabetes management.
method Investigated Recurrent Neural Networks (RNNs) and compared them to ARIMA for STBG prediction.
result Population-based RNN model outperforms ARIMA across various prediction horizons.
An accurate model of patient-specific kidney graft survival distributions can help to improve shared-decision making in the treatment and care of patients. In this paper, we propose a deep learning method that directly models the survival function instead of estimating the hazard function to predict survival times for …
Framework predicts clinical severity from rs-fMRI data using network optimization.
problem Predicting clinical severity from rs-fMRI data.
method Joint network optimization framework combining sparse subnetworks and linear regression.
result Framework outperforms standard methods and identifies clinically relevant ASD networks.
Hybrid pipeline detects spike-and-wave discharges in long-term EEG recordings.
problem Manual identification of spike-and-wave discharges in long-term EEG recordings is labour-intensive and error-prone.
method A hybrid pipeline that combines analytical features with a shallow ANN for SWD detection.
result The method correctly detected 384 out of 392 annotated SWD events, achieving high sensitivity and specificity.
Proposes a framework for personalized treatment recommendations using observational data.
problem Estimating patient-level treatment effects from observational data.
method Integrates existing methods for learning patient-level causal models.
result Improves patient outcomes in heart failure patients with acute kidney injury.
A deep learning framework segments deep cerebellar nuclei from 7T MRI, improving accuracy and consistency.
problem Challenging to accurately segment small deep cerebellar nuclei using standard MRI protocols.
method Proposes DCN-Net, a deep learning framework that encodes contextual information and handles imbalanced data.
result Improves segmentation accuracy and consistency compared to existing methods.
DDR estimates personalized treatment effects from clinical trials.
problem Estimating personalized treatment effects from clinical trials data.
method Transforms outcome into Dirac delta distributions and estimates density using non-linear regression.
result Identifies significant patient-specific outcomes even when no population-level effect exists.
New method learns DAG structure in clustered data, accounting for local variations.
problem Learning DAG structure in clustered data with varying effects.
method Extends mixed models to structure learning, using a differentiable graph coupling mechanism.
result Asymptotically recovers true structure, detecting dependencies missed by other methods.
LI-ITR combines flexible ML with interpretable approximations for personalized treatment rules.
problem Combining flexibility and interpretability in personalized treatment rules.
method Uses variational autoencoders and a mixture of interpretable experts.
result Accurately recovers true local coefficients and optimal treatment strategies.
The paper estimates personalized treatment effects in medical settings with competing risks.
problem Estimating treatment effectiveness for specific events in the presence of alternative event types.
method Meta-learners combining Cox regression or random survival forests for risk modeling and elastic net regression or random forests for direct CATE modeling.
result Compared meta-learners in multiple simulation settings, providing practical guidance for model selection.
We present a personalized and reliable prediction model for healthcare, which can provide individually tailored medical services such as diagnosis, disease treatment, and prevention. Our proposed framework targets at making personalized and reliable predictions from time-series data, such as Electronic Health Records (…
Deep model integrates MRI and DTI for autism severity prediction.
problem Predicting spectrum-level deficits in autism using multimodal brain imaging.
method Generative deep-learning framework combining rs-fMRI and DTI data.
result Hybrid model outperforms existing methods in predicting autism severity.
The paper integrates AI and expert knowledge to optimize radiotherapy decisions.
problem Optimizing radiation dose planning considering patient-specific information.
method Integrating Gaussian process models with deep neural networks to quantify uncertainty.
result Improves AI model performance and guides clinical decision making.
New methods use RL and DA to improve dosing precision and reduce side effects.
problem Improving precision and safety of anticancer drug dosing.
method Bayesian data assimilation and reinforcement learning.
result Significantly reduces incidence of severe side effects.
Proposes a method to estimate personalized treatments from high-dimensional data.
problem Estimating individualized treatment regimes (ITRs) from high-dimensional covariates.
method Directly targets the contrast between potential outcomes, using dimension-reduced outcome-weighted learning.
result Achieves universal consistency, converging to the Bayes risk under mild conditions.
Generative adversarial network system improves ECG arrhythmia classification.
problem Improving automatic ECG arrhythmia classification accuracy.
method Generative adversarial network with patient-specific normal beats and generated abnormal beats.
result Superior overall classification performance for SVEB and VEB on MIT-BIH arrhythmia database.
Machine learning builds personalized pediatric abdominal phantoms.
problem Lack of individualized phantoms for radiation therapy studies.
method Combining imaging and machine learning to automatically build phantoms.
result Automatically constructed phantoms more accurately represent patient anatomy.
Proposes a tool to contrast global vs personalized models in clinical prediction.
problem Balancing global vs personalized models in clinical prediction.
method Localized regression approach using autoencoder for dimension reduction.
result Identification of patient subgroups where global models fall short.
SepVAE separates patient-specific patterns from healthy ones using contrastive VAE.
problem Separating patient-specific patterns from healthy ones in medical datasets.
method SepVAE uses a contrastive VAE with disentangling and classification losses to differentiate between common and salient features.
result SepVAE outperforms previous methods in three medical applications and a CelebA dataset.
The field of precision medicine aims to tailor treatment based on patient-specific factors in a reproducible way. To this end, estimating an optimal individualized treatment regime (ITR) that recommends treatment decisions based on patient characteristics to maximize the mean of a pre-specified outcome is of particular…
Machine learning improves CAD management outcomes.
problem Current CAD guidelines do not account for patient-specific characteristics.
method Developed binary classifiers and regression models using patient data.
result Improved health outcomes by 24.11% compared to standard care.
New method detects spike-and-wave epileptiform discharges using Kendall's Tau-b.
problem Detecting spike-and-wave epileptiform discharges in EEG signals.
method Proposes a new method based on Kendall's Tau-b coefficient.
result High Specificity and rule in (SpPIn) for spike-and-wave discharge detection.
In both the fields of computer science and medicine there is very strong interest in developing personalized treatment policies for patients who have variable responses to treatments. In particular, I aim to find an optimal personalized treatment policy which is a non-deterministic function of the patient specific cova…
Proposes a new Q-learning method for survival outcomes in clinical trials.
problem Incomplete follow-up data and nonlinear covariate effects in clinical trials.
method Combines Buckley-James boosting with flexible base learners for estimating optimal treatment regimes.
result Improves treatment decision accuracy and stability in longitudinal clinical trials.
CLOCS uses contrastive learning to improve cardiac signal representations.
problem Lack of labelled data in cardiac signal analysis.
method Contrastive learning across space, time, and patients.
result CLOCS outperforms state-of-the-art methods and achieves strong generalization.
Simplifies decision-making during medical exams with cost-efficient feature acquisition.
problem Guiding physicians during examination acquisition for accurate and efficient diagnosis.
method Dropout at input layer and integrated gradients at test-time for dynamic feature importance.
result More cost- and feature-efficient than prior approaches, achieving higher overall accuracy.
In this work we propose a method to compute continuous embeddings for kmers from raw RNA-seq data, without the need for alignment to a reference genome. The approach uses an RNN to transform kmers of the RNA-seq reads into a 2 dimensional representation that is used to predict abundance of each kmer. We report that our…
New framework predicts arterial blood pressure from MRI data using physics-informed neural networks.
problem Clinical applicability of predictive cardiovascular flow models is hindered by computational cost and tedious pre-processing.
method Physics-informed neural networks constrained by conservation of mass and momentum principles.
result Deep neural networks provide physically consistent predictions for arterial blood pressure without conventional simulators.
Mathematical conditions and practical computations for adversarial robustness measures are established.
problem Existence, uniqueness, and scalability of adversarial robustness measures for AI classifiers.
method Formulated and proven mathematical conditions for existence, uniqueness, and explicit analytical computation of minimal adversarial paths and distances. Practical computation demonstrated on various AI tools and synthetic benchmarks.
result Explicit mathematical conditions and practical computations for adversarial robustness measures are established.
Missing data is a common problem in real-world settings and particularly relevant in healthcare applications where researchers use Electronic Health Records (EHR) and results of observational studies to apply analytics methods. This issue becomes even more prominent for longitudinal data sets, where multiple instances …
We present algorithms for the detection of a class of heart arrhythmias with the goal of eventual adoption by practicing cardiologists. In clinical practice, detection is based on a small number of meaningful features extracted from the heartbeat cycle. However, techniques proposed in the literature use high dimensiona…
Novel deep learning model improves AUC prediction for tacrolimus dosing.
problem Model misspecification in current pharmacokinetic models.
method Latent Neural-ODE for learning individualized pharmacokinetic dynamics.
result Latent ODE model outperforms standard methods in AUC prediction accuracy.
DeepCoDA provides personalized interpretability for complex health data.
problem Interpreting complex health data, especially compositional data, is challenging.
method DeepCoDA framework for high-dimensional compositional data, personalized interpretability through patient-specific weights.
result DeepCoDA maintains state-of-the-art performance and provides coherent, personalized interpretations.
Photoplethysmogram (PPG) is increasingly used to provide monitoring of the cardiovascular system under ambulatory conditions. Wearable devices like smartwatches use PPG to allow long term unobtrusive monitoring of heart rate in free living conditions. PPG based heart rate measurement is unfortunately highly susceptible…
A new algorithm uses concavity in Gaussian processes to optimize decisions in bandit problems.
problem Optimizing decisions in sequential problems with context-dependent rewards.
method Proposes a UCB algorithm using a shape-constrained reward function estimator based on a Gaussian Process model with concavity constraints.
result Derives regret bounds for the proposed UCB algorithm.
The distribution of absorbed dose in radionuclide therapy with Lu177 can be approximated by convolving an image of the time-integrated activity distribution with a dose voxel kernel representing different tissue types. This fast but inaccurate approximation is unsuitable for personalised dosimetry because it negle…
New algorithms improve vascular flow simulations in aortic aneurysms.
problem Limited accuracy of MRI in hemodynamics, patient-specific flow boundary conditions, and CFD's computational demands.
method Physics-Informed Neural Networks (PINNs) and Deep Operator Networks (DeepONets) integrated with 3D Navier-Stokes equations.
result Improved computational efficiency and good agreement with CFD simulations.
A new framework optimizes fMRI and behavioral data for better understanding of Autism.
problem Linking complex fMRI data to behavioral measures is challenging.
method Coupled manifold optimization framework projecting fMRI onto a shared manifold and mapping to behavioral measures.
result Framework outperforms traditional methods in predicting clinical severity of Autism.
Study shows model uncertainty is crucial for medical predictions, especially for individual patients.
problem Uncertainty in medical predictions, especially for individual patients.
method Used RNN ensembles and various Bayesian RNNs to analyze model uncertainty.
result RNNs with only Bayesian embeddings are more efficient for capturing model uncertainty.