Traditional medicine typically applies one-size-fits-all treatment for the entire patient population whereas precision medicine develops tailored treatment schemes for different patient subgroups. The fact that some factors may be more significant for a specific patient subgroup motivates clinicians and medical researc…
On-device research index
arXiv research
A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
169,051 papers · 148 categories
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48 results for “patient variability”
Enhances causal estimation using unlabeled offline ICU data.
problem Assessing unmeasured physiological variables in new ICU patients.
method Three-stage approach: non-causal and causal estimators, causal filter, and prediction for new patients.
result Enhanced causal estimation for new ICU patients using offline data.
Improved aggregation methods learn from all ICU events without preprocessing for better patient risk analysis.
problem Lack of efficient methods to dynamically assess patient status in ICU.
method Improved aggregation methods for a deep learning architecture that learns from all events without preprocessing.
result Models achieve strong performance (AUROC 0.87) in patient mortality classification.
Identifies patient-specific root causes of disease using structural equation models.
problem Detecting significant variables in complex diseases that differ between patients.
method Defining patient-specific root causes as exogenous errors in a structural equation model, quantifying predictivity using Shapley values, and developing a fast algorithm called Root Causal Inference.
result Significant improvements in accuracy by uncovering root causes with large effect sizes at the individual level but clinically insignificant effect sizes at the group level.
New method uses latent variables to estimate treatment effects from single-arm trials.
problem Estimating treatment effects from single-arm trials due to lack of external control groups.
method Latent-variable modeling with amortized variational inference for patient matching and direct effect estimation.
result Improved performance in direct treatment effect estimation and effect estimation via patient matching compared to previous methods.
Many in-hospital mortality risk prediction scores dichotomize predictive variables to simplify the score calculation. However, hard thresholding in these additive stepwise scores of the form "add x points if variable v is above/below threshold t" may lead to critical failures. In this paper, we seek to develop risk pre…
RL model improves sepsis treatment strategies.
problem Treating sepsis is challenging due to patient variability.
method Model-based reinforcement learning for continuous state-space.
result Improved treatment policies discovered through RL.
Deep learning predicts SAH patient mortality from initial CT scans.
problem High mortality rates in SAH patients.
method CNN-based algorithm using transfer learning on CT scans.
result Model accurately predicts mortality (74% accuracy, 82% AUC).
A novel approach for augmenting histopathological images by blending Gaussian-Laplacian pyramids.
problem Data imbalance and inter-patient variability in histopathological images.
method Image blending using Gaussian-Laplacian pyramids to distribute inter-patient variability.
result Promising gains in performance compared to existing data augmentation techniques.
MuVI models multi-view data with structured sparsity, integrating domain knowledge.
problem Disentangling variation across multiple data views in complex systems.
method Multi-view latent variable model with structured sparsity using a modified horseshoe prior.
result MuVI outperforms state-of-the-art methods in structured sparsity modeling and integrates noisy domain expertise.
Bayesian model predicts patient survival from sparse EHR data.
problem Analyzing EHR data with few samples and diverse information.
method Nonparametric probabilistic model using Bayesian trees.
result Improved survival trajectory predictions on patient data.
We present a personalized and reliable prediction model for healthcare, which can provide individually tailored medical services such as diagnosis, disease treatment, and prevention. Our proposed framework targets at making personalized and reliable predictions from time-series data, such as Electronic Health Records (…
Objectives: Electronic health records (EHRs) are only a first step in capturing and utilizing health-related data - the challenge is turning that data into useful information. Furthermore, EHRs are increasingly likely to include data relating to patient outcomes, functionality such as clinical decision support, and gen…
In this work, we consider the problem of predicting the course of a progressive disease, such as cancer or Alzheimer's. Progressive diseases often start with mild symptoms that might precede a diagnosis, and each patient follows their own trajectory. Patient trajectories exhibit wild variability, which can be associate…
Advance Prediction of Ventricular Tachyarrhythmias using Patient Metadata and Multi-Task Networkscs.LG
Model predicts ventricular tachyarrhythmias with high accuracy.
problem Predicting ventricular tachyarrhythmias for patient care.
method Multi-task neural network architecture with patient metadata.
result 74.02% prediction accuracy 60 seconds in advance.
Precision disease networks (PDN)q-bio.QM
The paper introduces Precision Disease Networks (PDN) for predicting medical outcomes.
problem Predicting medical outcomes for patients with diseases.
method Building patient-specific disease networks, clustering, and data visualization.
result PDN improves prediction of patient outcomes compared to standard statistical analysis.
New test identifies specific biological parameters for personalized CVD detection.
problem Ineffectual pathology tests fail to consider platelet activation and inter-individual variability.
method Stochastic platelet deposition model and approximate Bayesian computation with discriminative summary statistics.
result Inferred parameters help identify specific biological parameters for personalized CVD detection.
New definition of patient-specific root causes of disease using counterfactuals.
problem Lack of rigorous mathematical formulation for automatic detection of root causes.
method Proposes a counterfactual definition matching clinical intuition and uses Shapley values for causal contribution scores.
result Adapts to disease prevalence, accounts for noisy labels, and admits fast computation.
Study develops electronic phenotypes of ICU patient acuity.
problem Limited time for patient acuity assessments and imprecise clinical trajectory prediction.
method Developed electronic phenotypes using automated variable retrieval in electronic health records.
result Identified three phenotypes: persistently stable, persistently unstable, and transitioning from unstable to stable.
Study uses machine learning to predict heart failure in cancer patients.
problem Early detection of cancer patients at risk for cardiotoxicity.
method Examined four machine learning algorithms on 143,199 cancer patients.
result Gradient boosting model achieved best AUC score of 0.9077.
Most approaches to machine learning from electronic health data can only predict a single endpoint. Here, we present an alternative that uses unsupervised deep learning to simulate detailed patient trajectories. We use data comprising 18-month trajectories of 44 clinical variables from 1908 patients with Mild Cognitive…
Machine learning predicts biologic therapy outcomes in psoriasis patients.
problem Predicting long-term biologic therapy outcomes in psoriasis patients.
method Machine learning algorithms were used to predict drug discontinuation and treatment duration.
result Machine learning models accurately predict outcomes with high diagnostic accuracy and low MAE.
Deep learning predicts ICD codes with high accuracy for patient phenotyping.
problem Variability in ICD code assignment by coders.
method Deep learning model trained on demographics, lab results, and medications.
result Model predictions outperform coder assigned ICD codes in accuracy.
FalconBC improves patient-specific cardiovascular modeling by estimating boundary conditions efficiently.
problem Efficiently estimating boundary conditions in patient-specific cardiovascular models, especially in open-loop models and anatomies with lesions.
method A general amortized inference framework based on probabilistic flow that treats clinical targets and anatomies as conditioning variables.
result Demonstrated on two patient-specific models, FalconBC improves efficiency and accuracy in estimating boundary conditions.
Study predicts colorectal polyp recurrence using medical records and statistical models.
problem Identifying patient characteristics influencing colorectal polyp recurrence.
method Natural language processing for extracting polyp characteristics, Kaplan-Meier curves, Cox proportional hazards modeling, random survival forest models.
result Polyp size, number, location, and patient smoking status significantly influence recurrence risk.
Standard models assign disease progression to discrete categories or stages based on well-characterized clinical markers. However, such a system is potentially at odds with our understanding of the underlying biology, which in highly complex systems may support a (near-)continuous evolution of disease from inception to…
Deep learning classifies keratoconus patients with high accuracy.
problem Accurately identifying keratoconus patients for early intervention.
method Unsupervised and semi-supervised machine learning models using corneal topography and clinical data.
result Unsupervised method with 29 variables shows better classification accuracy.
Paper proposes a deep learning method for automatic seizure detection.
problem Manual seizure identification is time-consuming, labor-intensive, and error-prone.
method Leverages attention mechanism and BiLSTM to capture spatial and temporal features.
result Average sensitivity, specificity, and precision of 87.00%, 88.60%, and 88.63% respectively.
Study shows model uncertainty is crucial for medical predictions, especially for individual patients.
problem Uncertainty in medical predictions, especially for individual patients.
method Used RNN ensembles and various Bayesian RNNs to analyze model uncertainty.
result RNNs with only Bayesian embeddings are more efficient for capturing model uncertainty.
A large fraction of the electronic health records consists of clinical measurements collected over time, such as blood tests, which provide important information about the health status of a patient. These sequences of clinical measurements are naturally represented as time series, characterized by multiple variables a…
A novel continual prediction model outperforms traditional one-time models in predicting AKI.
problem Optimally predicting AKI before it develops during a hospital stay.
method A novel continual prediction model that predicts AKI every time a patient's AKI-relevant variable changes in the EHR.
result The continual prediction model outperformed traditional one-time models, achieving a higher AUC of 0.724 compared to 0.653.
Study uses ML to predict cancer patient mortality from FN onset.
problem Predicting mortality in cancer patients with FN to improve survival.
method Multi-domain machine learning models using HCUP data.
result Clinical diagnoses have highest predictive power for FN mortality.
ICU mortality scoring systems attempt to predict patient mortality using predictive models with various clinical predictors. Examples of such systems are APACHE, SAPS and MPM. However, most such scoring systems do not actively look for and include interaction terms, despite physicians intuitively taking such interactio…
Simulates sepsis treatment decisions using a world model approach.
problem Predicting optimal sepsis treatment actions based on noisy EHR data.
method Uses a Variational Auto-Encoder and Mixture Density Network (MDN-RNN) to model sepsis patient trajectories.
result Simulator learns from MIMIC dataset to predict patient states.
Machine learning models fail due to concept and data drift during pandemic.
problem Machine learning models trained before the pandemic are unreliable during the pandemic.
method Detect and diagnose concept and data drift in models.
result Model resilience and robustness are crucial for future predictions.
ConBO optimizes multiple objectives conditional on state variables.
problem Optimizing multiple objectives with conditional state variables.
method Conditional Bayesian Optimization (ConBO) framework.
result Significantly better performance on various problems.
Feature Engineering Combined with 1 D Convolutional Neural Network for Improved Mortality Predictioncs.LG
Study improves mortality prediction in ICU patients using feature engineering and 1D CNN.
problem Improving mortality prediction in ICU patients with high-dimensional, imbalanced, and missing data.
method Feature engineering, 1D Convolutional Neural Network (1D CNN), traditional machine learning algorithms.
result Best AUC of 0.848 achieved with 1D CNN model.
Objective: Predict patient-specific vitals deemed medically acceptable for discharge from a pediatric intensive care unit (ICU). Design: The means of each patient's hr, sbp and dbp measurements between their medical and physical discharge from the ICU were computed as a proxy for their physiologically acceptable state …
Though suicide is a major public health problem in the US, machine learning methods are not commonly used to predict an individual's risk of attempting/committing suicide. In the present work, starting with an anonymized collection of electronic health records for 522,056 unique, California-resident adolescents, we dev…
New method uses probabilistic independence to discover disease signatures from medical records.
problem Insufficiently precise diagnosis of clinical disease leading to treatment failures.
method Unsupervised machine learning using probabilistic independence to disentangle disease patterns.
result Inferred 2000 clinical disease signatures from medical records, improving cancer prediction.
RNN models perform similarly with or without extraneous variables.
problem Impact of extraneous variables on RNN performance in clinical tasks.
method Investigated the effect of extraneous input variables on RNN predictive performance using EMR and randomly drawn variables.
result Degradations in RNN's predictive performance with extraneous variables were negligible.
Model estimates lung well-aerated volume from CT images, independent of patient and imaging parameters.
problem Lack of clear connection between quantitative metrics in lung CT images and physiology.
method Patient-independent model using Gaussian fit to lower CT histogram data points.
result Model estimates well-aerated volume (WAVE) independent of CT reconstruction parameters and respiratory cycle.
Bayesian networks and ML improve COVID-19 symptom classification and severity analysis.
problem Understanding the relationship between COVID-19 symptoms and demographic variables.
method Bayesian network structure learning followed by unsupervised clustering and demographic symptom identification.
result 99.99% testing accuracy compared to 41.15% for a heuristic method.
Model learns low-dimensional representation from heterogeneous data with missing values.
problem Handling high-dimensional, noisy, and missing data from clinical records.
method Latent Gaussian process with composite likelihoods and numerical quadrature.
result Improves upon existing GPLVM methods for heterogeneous data.
This research improves transparency in RNN predictions of ICU mortality risk.
problem Lack of transparency in RNNs' healthcare predictions.
method Introduced Learned Binary Masks (LBM) and KernelSHAP for identifying EMR variables' contributions to RNN risk of mortality predictions.
result Attribution matrices show each input feature's contribution to RNN predictions, facilitating analysis of the model and its predictions.
This study improves early prediction of CPAP therapy compliance.
problem Predicting early compliance with CPAP therapy to improve patient outcomes.
method Built classifiers for compliance at three CPAP therapy follow-up points.
result Month 3 classifier achieved highest f1-score of 87% in cross-validation and test.
Penalized Deep Partially Linear Cox Models with Application to CT Scans of Lung Cancer Patientsstat.ML
Proposes a new model to analyze CT scans for lung cancer patients.
problem Analyzing survival risks of lung cancer patients using CT scans.
method Penalized Deep Partially Linear Cox Model (Penalized DPLC) incorporating SCAD penalty and deep neural network.
result The model effectively selects important texture features and estimates nonparametric components.
Framework identifies brain connectivity alterations for MDD patients using limited rs-fMRI data.
problem Difficult to analyze brain connectivity alterations from limited rs-fMRI data.
method Proposed a multitask Gaussian Bayesian network (MTGBN) framework to learn individual disease-induced alterations.
result Framework efficiently learns Bayesian network structures from limited data, showing improved performance.