A Pathology report is arguably one of the most important documents in medicine containing interpretive information about the visual findings from the patient's biopsy sample. Each pathology report has a retention period of up to 20 years after the treatment of a patient. Cancer registries process and encode high volume…
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48 results for “pathology reports”
Paper develops a BERT-based classifier to reduce pathology report annotation workload.
problem Manual annotation of pathology reports is labor-intensive and time-consuming.
method Developed an automatic text classifier using BERT and introduced a human-centric metric to identify low-confidence cases.
result The model reduces manual annotation workload by 80% to 98%.
Decision support tools that rely on supervised learning require large amounts of expert annotations. Using past radiological reports obtained from hospital archiving systems has many advantages as training data above manual single-class labels: they are expert annotations available in large quantities, covering a popul…
Deep learning improves cancer report classification accuracy.
problem Automatically assigning ICD-O3 codes to cancer reports.
method State-of-the-art deep learning techniques, including hierarchical and flat models, with attention mechanisms.
result Best model achieves 90.3% accuracy on topography site assignment and 84.8% on morphology type assignment.
This study investigates how much knowledge from natural images can be transferred to pathology images.
problem Quantifying how much knowledge from natural images can be transferred to pathology images.
method Proposes a framework to quantify knowledge gain by a particular layer, conducts empirical investigation in pathology image centered transfer learning.
result Early layers of deep models can transfer knowledge to pathology image classification tasks.
New analysis explains pathology of deep Gaussian processes.
problem Pathology of deep Gaussian processes reduces learning capacities with increased layers.
method Study nonlinear dynamic systems corresponding to DGPs, derive recurrence relations.
result Provide tighter bounds and rate of convergence for dynamic systems.
Generative Synthetic Augmentation using Label-to-Image Translation for Nuclei Image Segmentationcs.LG
This paper proposes synthetic augmentation for nuclei image segmentation in medical pathology.
problem Rare and time-consuming labeling of tumor nuclei images for semantic segmentation.
method Label-to-image translation to generate synthetic images.
result Synthetic augmentation improves segmentation accuracy.
Deep learning with convolutional neural networks for decoding and visualization of EEG pathologycs.LG
We apply convolutional neural networks (ConvNets) to the task of distinguishing pathological from normal EEG recordings in the Temple University Hospital EEG Abnormal Corpus. We use two basic, shallow and deep ConvNet architectures recently shown to decode task-related information from EEG at least as well as establish…
This short note has been written as an Oberwolfach report for the workshop "Differentialgeometrie im Grossen". We discuss properties of metric spaces that at almost all points admit a tangent metric space. We explain why, under some mild assumptions, the tangents are almost surely subFinsler Carnot groups. We mention s…
Much recent research aims to identify evidence for Drug-Drug Interactions (DDI) and Adverse Drug reactions (ADR) from the biomedical scientific literature. In addition to this "Bibliome", the universe of social media provides a very promising source of large-scale data that can help identify DDI and ADR in ways that ha…
Semi-supervised learning chain boosts histology image accuracy with minimal labeled data.
problem Expensive annotation of large histology image databases.
method Teacher-student knowledge distillation chain approach.
result Accuracy matches 100% labeled data with only 0.5% labeled data.
The chest X-ray (CXR) is by far the most commonly performed radiological examination for screening and diagnosis of many cardiac and pulmonary diseases. There is an immense world-wide shortage of physicians capable of providing rapid and accurate interpretation of this study. A radiologist-driven analysis of over two m…
On the Existence of Synchrostates in Multichannel EEG Signals during Face-perception Tasksphysics.med-ph
Phase synchronisation in multichannel EEG is known as the manifestation of functional brain connectivity. Traditional phase synchronisation studies are mostly based on time average synchrony measures hence do not preserve the temporal evolution of the phase difference. Here we propose a new method to show the existence…
Localization of chest pathologies in chest X-ray images is a challenging task because of their varying sizes and appearances. We propose a novel weakly supervised method to localize chest pathologies using class aware deep multiscale feature learning. Our method leverages intermediate feature maps from CNN layers at di…
This paper characterizes VAE training pathologies and their effects on tasks.
problem Characterizing VAE training pathologies and their impact on downstream tasks.
method Concretely characterizing conditions for VAE training pathologies and their connection to specific downstream tasks.
result Connects VAE training pathologies to specific downstream tasks like learning compressed and disentangled representations, adversarial robustness, and semi-supervised learning.
Method predicts ODX scores for breast cancer patients based on clinical data.
problem Predicting ODX scores for breast cancer patients to aid decision-making.
method Distributional random forest approach using 9 clinico-pathological characteristics.
result Correctly predicted 92% of low risk and 40.2% of high risk patients.
The paper identifies conditions for trend reversal in classification tasks.
problem Trend reversal in classification scores and dataset values.
method Algebraic conditions and numerical results for ridge regression.
result Existence of pathological regularization regimes for certain dataset conditions.
KL-regularized RL from expert demos can lead to slow, unstable learning.
problem Pathological training dynamics in KL-regularized RL from expert demonstrations.
method Empirical analysis and non-parametric behavioral reference policies.
result KL-regularized RL can be significantly improved by using non-parametric behavioral policies.
This work examines robust MCMC for pathological distributions.
problem Pathological behavior in target distributions affects MCMC efficiency.
method Reviewing and proposing remedies for roughness and flatness in MCMC.
result Robust MCMC algorithms can perform well even in challenging conditions.
Normalization methods play an important role in enhancing the performance of deep learning while their theoretical understandings have been limited. To theoretically elucidate the effectiveness of normalization, we quantify the geometry of the parameter space determined by the Fisher information matrix (FIM), which als…
Chronic Pulmonary Aspergillosis (CPA) is a complex lung disease caused by infection with Aspergillus. Computed tomography (CT) images are frequently requested in patients with suspected and established disease, but the radiological signs on CT are difficult to quantify making accurate follow-up challenging. We propose …
We introduce a novel approach, requiring only mild assumptions, for the characterization of deep neural networks at initialization. Our approach applies both to fully-connected and convolutional networks and easily incorporates batch normalization and skip-connections. Our key insight is to consider the evolution with …
The paper presents algorithms for diagnosing Pathological Myopia and detecting retinal structures.
problem Diagnosing Pathological Myopia and detecting retinal structures in fundus images.
method The approach uses Deep Learning techniques, including transfer learning with Xception and YOLO architecture.
result The method has shown satisfactory results in the Pathologic Myopia Challenge.
Machine learning improves EEG pathology classification.
problem Automating clinical EEG analysis using machine learning.
method Developed a comprehensive feature-based framework and compared it to deep neural networks.
result Feature-based framework achieves accuracies similar to deep neural networks.
Blood glucose value prediction is an important task in diabetes management. While it is reported that glucose concentration is sensitive to social context such as mood, physical activity, stress, diet, alongside the influence of diabetes pathologies, we need more research on data and methodologies to incorporate and ev…
Glottal Closure Instants Detection From Pathological Acoustic Speech Signal Using Deep Learningcs.SD
In this paper, we propose a classification based glottal closure instants (GCI) detection from pathological acoustic speech signal, which finds many applications in vocal disorder analysis. Till date, GCI for pathological disorder is extracted from laryngeal (glottal source) signal recorded from Electroglottograph, a d…
Causal methods for GRN inference from single-cell data often fail in real-world benchmarks.
problem Understanding when and why causal methods for GRN inference from single-cell data fail in real-world benchmarks.
method Introduced a controlled diagnostic framework to isolate and measure seven pathologies.
result Causal methods dominate in clean and structurally favorable regimes but fail in specific pathologies.
Regularized Stein thinning improves MCMC output approximations.
problem Pathologies in Stein thinning leading to poor approximations.
method Theoretical analysis and regularization to improve KSD.
result Regularized Stein thinning alleviates pathologies and improves efficiency.
We propose a method to classify cardiac pathology based on a novel approach to extract image derived features to characterize the shape and motion of the heart. An original semi-supervised learning procedure, which makes efficient use of a large amount of non-segmented images and a small amount of images segmented manu…
For test configurations, the Donaldson-Futaki invariant F_1 is well-known. In this note, its refinement will be discussed. Then we see that Li-Xu's pathology doesn't occur, since their example of a non-normal test configuration, with trivial normalization, actually has non-vanishing F_1 in this refined sense.
New test identifies specific biological parameters for personalized CVD detection.
problem Ineffectual pathology tests fail to consider platelet activation and inter-individual variability.
method Stochastic platelet deposition model and approximate Bayesian computation with discriminative summary statistics.
result Inferred parameters help identify specific biological parameters for personalized CVD detection.
Proposes isotonic regression for calibrating Deep Cox models' survival probabilities.
problem Poor calibration of Deep Cox models' survival probabilities.
method Isotonic regression for post hoc calibration of Deep Cox models.
result Establishes favorable theoretical guarantees and demonstrates empirical effectiveness.
Pathological spectra of the Fisher information metric and its variants in deep neural networksstat.ML
Study reveals pathological eigenvalue spectra in FIM and its variants of DNNs.
problem Understanding sharp local shapes in DNN loss landscapes.
method Analysis of FIM and its variants in regression and classification DNNs.
result Pathological eigenvalue spectra appear in FIM and its variants, indicating sharp local shapes in specific directions.
Automatic Chemical Design is a framework for generating novel molecules with optimized properties. The original scheme, featuring Bayesian optimization over the latent space of a variational autoencoder, suffers from the pathology that it tends to produce invalid molecular structures. First, we demonstrate empirically …
Optimal prototypes found for challenging pathological geometries.
problem Finding optimal prototypes for pathological geometries is challenging.
method Analytical and heuristic algorithms for finding nearly-optimal prototypes.
result Optimal prototypes can be found analytically for challenging geometries.
A crucial challenge in image-based modeling of biomedical data is to identify trends and features that separate normality and pathology. In many cases, the morphology of the imaged object exhibits continuous change as it deviates from normality, and thus a generative model can be trained to model this morphological con…
Study uses image analysis to predict MSI status in tumors.
problem Challenges in distinguishing MSI from its counterpart.
method Interpretable pathological image analysis strategies using Haematoxylin and eosin-stained images.
result Strategies achieve decent performance in MSI prediction.
Pseudo healthy synthesis, i.e. the creation of a subject-specific `healthy' image from a pathological one, could be helpful in tasks such as anomaly detection, understanding changes induced by pathology and disease or even as data augmentation. We treat this task as a factor decomposition problem: we aim to separate wh…
Many people are suffering from voice disorders, which can adversely affect the quality of their lives. In response, some researchers have proposed algorithms for automatic assessment of these disorders, based on voice signals. However, these signals can be sensitive to the recording devices. Indeed, the channel effect …
We propose a new model for digital pathology segmentation, based on the observation that histopathology images are inherently symmetric under rotation and reflection. Utilizing recent findings on rotation equivariant CNNs, the proposed model leverages these symmetries in a principled manner. We present a visual analysi…
Boosted additive models reveal new insights and potential pathologies.
problem Theoretical understanding of boosted additive models (BAMs) and their convergence behavior.
method Study of solution paths of BAMs and derivation of convergence results.
result Uncovering pathologies of boosting for certain additive model classes.
Here we present DIVE: Data-driven Inference of Vertexwise Evolution. DIVE is an image-based disease progression model with single-vertex resolution, designed to reconstruct long-term patterns of brain pathology from short-term longitudinal data sets. DIVE clusters vertex-wise biomarker measurements on the cortical surf…
Dropout, a stochastic regularisation technique for training of neural networks, has recently been reinterpreted as a specific type of approximate inference algorithm for Bayesian neural networks. The main contribution of the reinterpretation is in providing a theoretical framework useful for analysing and extending the…
New GP kernels avoid mean reversion without losing smoothness.
problem Pathological behavior in stationary GP regression.
method Improper Gaussian processes with non-positive kernels.
result Stationary, non-reverting covariance functions.
Machine learning identifies potential drugs for COVID-19.
problem Finding effective treatments for COVID-19.
method Trained neural network models on virus protein sequences and antiviral drugs.
result Identified potential drug candidates for treating COVID-19.
Bayesian neural networks ignore data in infinite units limit.
problem Pathological behavior of posterior in over-parameterized networks.
method Mean-field variational inference in infinite hidden units limit.
result Posterior mean converges to zero, ignoring data.
We give examples of open 3-manifolds and 3-orbifolds that exhibit pathological behavior with respect to splitting along surfaces (2-suborbifolds) with nonnegative Euler characteristic.
Choosing appropriate architectures and regularization strategies for deep networks is crucial to good predictive performance. To shed light on this problem, we analyze the analogous problem of constructing useful priors on compositions of functions. Specifically, we study the deep Gaussian process, a type of infinitely…