MDCN improves treatment effect estimation in multicenter observational studies.
problem Incongruities in multicenter observational studies due to center-specific protocols and treatment reactions.
method MDCN learns a new feature embedding to address selection bias and strengthen information sharing between similar centers.
result MDCN provides more accurate treatment insights for new, unobserved centers compared to existing methods.
Bayesian Federated Inference improves statistical model estimation from multicenter data.
problem Combining data from different medical centers is challenging due to regulatory and logistic issues.
method Bayesian Federated Inference (BFI) framework for multicenter data.
result BFI framework infers additional features of the posterior parameter distribution, capturing more information than Federated Learning.
PersonalizedUS assesses breast cancer risk with local coverage guarantees.
problem Manual BI-RADS scoring leads to unnecessary biopsies and mental health burden.
method Conformal prediction for precise, personalized risk estimates.
result Local coverage guarantees with high sensitivity and specificity.
EHR-MPC optimizes sepsis treatment using digital twins and inference-time control.
problem Optimal sepsis treatment policies are contested and difficult to adapt during inference.
method EHR-MPC decouples learning patient dynamics from treatment optimization, enabling inference-time control over learned digital twins.
result EHR-MPC achieves comparable off-policy performance and improved simulation performance compared to RL baselines.
Study addresses covariate mismatch in federated learning, improving model accuracy.
problem Learning from clients with different feature sets in federated learning.
method Developed two approaches for linear prediction under covariate mismatch: plug-in estimator and impute-then-regress strategy.
result Proposed methods provide asymptotic and finite-sample learning rates, improving model accuracy.
Causal graph aids observational study insights in aSAH patients.
problem Lack of clear objectives and tools for identifying necessary adjustments in observational studies.
method Uses causal directed acyclic graphs (DAGs) to provide insights mid-study and identify necessary data enhancements.
result Midway insights and necessary data enhancements identified for meaningful causal questions.
Bayesian Federated Inference combines local data analyses to estimate regression models.
problem Estimating accurate parameters with limited data from different centers.
method Bayesian Federated Inference (BFI) for pooling local data analyses.
result Excellent performance of BFI methodology shown in real-life examples.
Method predicts NAFLD risk with high accuracy and distribution-free coverage guarantees.
problem Insufficient population-level screening tools for NAFLD.
method Gradient-boosted decision trees with conformal prediction.
result Method achieves AUROC of 0.912 internally and 0.891 externally, superior to other models.
Deep learning based task systems normally rely on a large amount of manually labeled training data, which is expensive to obtain and subject to operator variations. Moreover, it does not always hold that the manually labeled data and the unlabeled data are sitting in the same distribution. In this paper, we alleviate t…
Background: Cardiac MRI derived biventricular mass and function parameters, such as end-systolic volume (ESV), end-diastolic volume (EDV), ejection fraction (EF), stroke volume (SV), and ventricular mass (VM) are clinically well established. Image segmentation can be challenging and time-consuming, due to the complex a…
The timeliness of detection of a sepsis event in progress is a crucial factor in the outcome for the patient. Machine learning models built from data in electronic health records can be used as an effective tool for improving this timeliness, but so far the potential for clinical implementations has been largely limite…
Predicting response to neoadjuvant therapy is a vexing challenge in breast cancer. In this study, we evaluate the ability of deep learning to predict response to HER2-targeted neo-adjuvant chemotherapy (NAC) from pre-treatment dynamic contrast-enhanced (DCE) MRI acquired prior to treatment. In a retrospective study enc…
Machine learning improves early detection of patient deterioration in Brazilian hospitals.
problem Challenges in recognizing clinical deterioration in hospital settings.
method Application of machine learning to analyze EHR data from multiple hospitals.
result Machine learning models outperformed traditional protocols by 25 percentage points in AUC.
GOPSA optimizes EEG data for cross-site age prediction, improving performance on multiple metrics.
problem Predictive shifts in EEG data from different sites and participants.
method Geodesic Optimization for Predictive Shift Adaptation (GOPSA) on the SPD manifold.
result Significantly higher performance on age prediction metrics compared to state-of-the-art methods.
Background: Elderly patients with MODS have high risk of death and poor prognosis. The performance of current scoring systems assessing the severity of MODS and its mortality remains unsatisfactory. This study aims to develop an interpretable and generalizable model for early mortality prediction in elderly patients wi…