Optimal ensemble construction improves prediction accuracy for multi-study tasks, especially in pandemic scenarios.
problem Poor out-of-study prediction performance due to heterogeneous datasets.
method Optimal ensemble construction using a two-stage stacking strategy that jointly estimates ensemble weights and study-specific model parameters.
result Our method outperforms multi-study stacking and other standard methods in predicting excess mortality during the pandemic.
A new method estimates treatment effects across multiple studies considering differences.
problem Estimating treatment effects across multiple studies with varying conditions.
method The multi-study R-learner framework that accounts for between-study heterogeneity.
result The multi-study R-learner is more efficient and normal than existing methods in the presence of heterogeneity.
Method learns shared and specific factors in multi-study gene expression data.
problem Understanding shared and specific factors in high-dimensional multi-study data.
method Nonlinear multi-study factor model with sparse variational autoencoder.
result Method recovers meaningful shared and specific factors in platelet gene expression data.
Boosting strategies for merging vs. ensembling studies analyzed.
problem Deciding between merging and ensembling studies for boosting.
method Analytical transition point and bias-variance decomposition for boosting with linear learners.
result Theoretical guidelines for merging vs. ensembling studies.
A critical decision point when training predictors using multiple studies is whether studies should be combined or treated separately. We compare two multi-study prediction approaches in the presence of potential heterogeneity in predictor-outcome relationships across datasets: 1) merging all of the datasets and traini…
Method estimates shared and study-specific factors for multi-study data.
problem Covariance estimation for multi-study data with shared and study-specific components.
method Spectral decomposition for latent factors, surrogate Bayesian regressions for loadings and variances.
result Strong frequentist guarantees and superior performance in simulations and real data.
New approach estimates treatment effects from decentralized data.
problem Estimating treatment effects from multiple studies with limited data.
method Three classes of ATE estimators derived from Plug-in G-Formula.
result Asymptotic variance of estimators for linear models derived.
bioLeak addresses data leakage in biomedical machine learning studies.
problem Data leakage causes optimistic bias in machine learning models for biomedical studies.
method bioLeak provides leakage-aware resampling workflows and model audits in R.
result The package supports various machine learning tasks and can detect leakage mechanisms.
Cognitive brain imaging is accumulating datasets about the neural substrate of many different mental processes. Yet, most studies are based on few subjects and have low statistical power. Analyzing data across studies could bring more statistical power; yet the current brain-imaging analytic framework cannot be used at…
Hippo optimizes deep learning hyper-parameters by reducing redundant trials.
problem Redundant hyper-parameter trials in hyper-parameter optimization.
method Hippo breaks down hyper-parameter sequences into stages and executes them in a tree structure.
result Hippo reduces GPU-hours and training time significantly compared to existing methods.
Bayesian optimization improves classifier selection for acute infection and mortality.
problem Improving accuracy of acute infection and mortality prediction.
method Comparison of hyperparameter optimization methods (grid search, random sampling, Bayesian optimization).
result Bayesian optimization outperforms grid search or random sampling for in-hospital mortality classifiers.