New method classifies reticulocytes from red blood cells without labels.
arXiv research
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Improves disease progression prediction using auxiliary surrogate labels and health markers.
Novel method identifies proteomic risk markers for Alzheimer disease.
AR app visualizes Quranic Surah al-Fil for Islamic education.
Microbial clades modeling is a challenging problem in biology based on microarray genome sequences, especially in new species gene isolates discovery and category. Marker family genome sequences play important roles in describing specific microbial clades within species, a framework of support vector machine (SVM) base…
MarkerMap selects key genes for cell type analysis in single-cell RNA-seq.
Predicts clinical events using a landmark approach with machine learning for large biomarker histories.
This paper introduces the factorial marked temporal point process model and presents efficient learning methods. In conventional (multi-dimensional) marked temporal point process models, event is often encoded by a single discrete variable i.e. a marker. In this paper, we describe the factorial marked point processes w…
We target modeling latent dynamics in high-dimension marked event sequences without any prior knowledge about marker relations. Such problem has been rarely studied by previous works which would have fundamental difficulty to handle the arisen challenges: 1) the high-dimensional markers and unknown relation network amo…
CNMs detect tipping points in complex systems using causal network markers.
The diagnosis of Alzheimer's disease (AD) in routine clinical practice is most commonly based on subjective clinical interpretations. Quantitative electroencephalography (QEEG) measures have been shown to reflect neurodegenerative processes in AD and might qualify as affordable and thereby widely available markers to f…
Preterm birth is the most common cause of neonatal death. Current diagnostic methods that assess the risk of preterm birth involve the collection of maternal characteristics and transvaginal ultrasound imaging conducted in the first and second trimester of pregnancy. Analysis of the ultrasound data is based on visual i…
fiBAG integrates multiplatform genomic data to identify disease markers.
Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis can be highly time consuming. In motor control studies, humans or other …
For precision medicine and personalized treatment, we need to identify predictive markers of disease. We focus on Alzheimer's disease (AD), where magnetic resonance imaging scans provide information about the disease status. By combining imaging with genome sequencing, we aim at identifying rare genetic markers associa…
We describe a method that infers whether statistical dependences between two observed variables X and Y are due to a "direct" causal link or only due to a connecting causal path that contains an unobserved variable of low complexity, e.g., a binary variable. This problem is motivated by statistical genetics. Given a ge…
Study uses DNM theory to detect early warning signals of market instability.
The paper proposes a method to integrate prior information into penalized regression.
Proposes a two-stage method for estimating heterogeneous treatment effects using gradient boosting trees.
The paper proposes a method to assess surrogate heterogeneity in non-randomized data.
The paper analyzes the observability of relative pose estimation using dual quaternions.
Many complex disease syndromes such as asthma consist of a large number of highly related, rather than independent, clinical phenotypes, raising a new technical challenge in identifying genetic variations associated simultaneously with correlated traits. In this study, we propose a new statistical framework called grap…
Feature selection predicts immune state changes in RA mouse model.
Neural network training entails heavy computation with obvious bottlenecks. The Compute Unified Device Architecture (CUDA) programming model allows us to accelerate computation by passing the processing workload from the CPU to the graphics processing unit (GPU). In this paper, we leveraged the power of Nvidia GPUs to …
As societies around the world are ageing, the number of Alzheimer's disease (AD) patients is rapidly increasing. To date, no low-cost, non-invasive biomarkers have been established to advance the objectivization of AD diagnosis and progression assessment. Here, we utilize Bayesian neural networks to develop a multivari…
AR app enhances young children's understanding of Wudhu.
In this paper we extend the market-making models with inventory constraints of Avellaneda and Stoikov ("High-frequency trading in a limit-order book", Quantitative Finance Vol.8 No.3 2008) and Gueant, Lehalle and Fernandez-Tapia ("Dealing with inventory risk", Preprint 2011) to the case of a rather general class of mid…
Let R be an o-minimal expansion of the real field. We introduce a class of Hausdorff limits, the T-infinity limits over R, that do not in general fall under the scope of Marker and Steinhorn's definability-of-types theorem. We prove that if R admits analytic cell decomposition, then every T-infinity limit over R is def…
Flow cytometry is often used to characterize the malignant cells in leukemia and lymphoma patients, traced to the level of the individual cell. Typically, flow cytometric data analysis is performed through a series of 2-dimensional projections onto the axes of the data set. Through the years, clinicians have determined…
In many data exploration tasks it is meaningful to identify groups of attribute interactions that are specific to a variable of interest. For instance, in a dataset where the attributes are medical markers and the variable of interest (class variable) is binary indicating presence/absence of disease, we would like to k…
In this work we perform a study of various unsupervised methods to identify mental stress in firefighter trainees based on unlabeled heart rate variability data. We collect RR interval time series data from nearly 100 firefighter trainees that participated in a drill. We explore and compare three methods in order to pe…
The development of molecular signatures for the prediction of time-to-event outcomes is a methodologically challenging task in bioinformatics and biostatistics. Although there are numerous approaches for the derivation of marker combinations and their evaluation, the underlying methodology often suffers from the proble…
We propose using canonical correlation analysis (CCA) to generate features from sequences of medical billing codes. Applying this novel use of CCA to a database of medical billing codes for patients with diverticulitis, we first demonstrate that the CCA embeddings capture meaningful relationships among the codes. We th…
Model uses smartphone data to assess MS trajectories.
In this article, we have proposed several approaches for post processing a large ensemble of prediction models or rules. The results from our simulations show that the post processing methods we have considered here are promising. We have used the techniques developed here for estimation of quantitative traits from mar…
Associating genetic markers with a multidimensional phenotype is an important yet challenging problem. In this work, we establish the equivalence between two popular methods: kernel-machine regression (KMR), and kernel distance covariance (KDC). KMR is a semiparametric regression frameworks that models the covariate ef…
Estimates vaccine effectiveness and immune correlates in TND studies with missing data.
Understanding cell identity is an important task in many biomedical areas. Expression patterns of specific marker genes have been used to characterize some limited cell types, but exclusive markers are not available for many cell types. A second approach is to use machine learning to discriminate cell types based on th…
Falls prevention, especially in older people, becomes an increasingly important topic in the times of aging societies. In this work, we present Gated Recurrent Unit-based neural networks models designed for predicting falls (syncope). The cardiovascular systems signals used in the study come from Gravitational Physiolo…
While the prevalence of Autism Spectrum Disorder (ASD) is increasing, research continues in an effort to identify common etiological and pathophysiological bases. In this regard, modern machine learning and network science pave the way for a better understanding of the neuropathology and the development of diagnosis ai…
Estimation of facial expressions, as spatio-temporal processes, can take advantage of kernel methods if one considers facial landmark positions and their motion in 3D space. We applied support vector classification with kernels derived from dynamic time-warping similarity measures. We achieved over 99% accuracy - measu…
Flow cytometry is a high-throughput technology used to quantify multiple surface and intracellular markers at the level of a single cell. This enables to identify cell sub-types, and to determine their relative proportions. Improvements of this technology allow to describe millions of individual cells from a blood samp…
SDSR reconstructs species trees from genetic markers efficiently.
Unified method visualizes curvature on curves and surfaces.
This paper examines the quantitative finance aspects of AMMs in decentralized finance.
Optimal biomarker combinations for treatment-selection can be derived by minimizing total burden to the population caused by the targeted disease and its treatment. However, when multiple biomarkers are present, including all in the model can be expensive and hurt model performance. To remedy this, we consider feature …
We study the calibration of several state of the art neural machine translation(NMT) systems built on attention-based encoder-decoder models. For structured outputs like in NMT, calibration is important not just for reliable confidence with predictions, but also for proper functioning of beam-search inference. We show …
By using the cohomology theory of quandles, quandle cocycle invariants and shadow quandle cocycle invariants are defined for oriented links and surface-links via broken surface diagrams. By using symmetric quandles, symmetric quandle cocycle invariants are also defined for unoriented links and surface-links via broken …