Given the crucial role of microtubules for cell survival, many researchers have found success using microtubule-targeting agents in the search for effective cancer therapeutics. Understanding microtubule responses to targeted interventions requires that the microtubule network within cells can be consistently observed …
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4 results for “microtubules”
Two-sample tests improve on existing methods for microtubule data.
problem Testing differences between two groups of filament data.
method Optimal lifts and manifold stability theorem applied to microtubule data.
result New tests outperform existing methods on simulated and real data.
Graph Prolongation Convolutional Networks improve model performance in microtubule bending simulations.
problem Improving prediction accuracy in coarse-grained mechanochemical simulations of microtubule bending.
method Defines a novel ensemble Graph Convolutional Network model using optimized linear projection operators to map between graph scales.
result Graph Prolongation-Convolutional Network outperforms other GCN ensemble models in predicting microtubule bending potential energy.
Sparse GFA identifies disease factors in FTD subgroups.
problem Heterogeneity in neurological disorders hinders understanding and treatment.
method Sparse Group Factor Analysis (GFA) with regularised horseshoe priors.
result Identified latent disease factors differentially expressed in FTD subgroups.