Model predicts patient trajectories and interventions from EMR data.
problem Forecasting patient outcomes from EMR data.
method Deep state space generative model capturing latent state dynamics.
result Model outperforms state-of-the-art methods on real EMR data.
RL model improves sepsis treatment strategies.
problem Treating sepsis is challenging due to patient variability.
method Model-based reinforcement learning for continuous state-space.
result Improved treatment policies discovered through RL.
Personalized predictive medicine necessitates the modeling of patient illness and care processes, which inherently have long-term temporal dependencies. Healthcare observations, recorded in electronic medical records, are episodic and irregular in time. We introduce DeepCare, an end-to-end deep dynamic neural network t…
New monitoring method detects ML risk models' performance changes in medical interventions.
problem Monitoring ML risk models in healthcare is complicated by confounding medical interventions.
method Developed a new score-based CUSUM monitoring procedure with dynamic control limits.
result Valid inference is possible if conditional exchangeability or time-constant selection bias hold.
A new model uses GPs and latent force models to predict patient responses to drugs.
problem Challenges in modeling short-term effects of drugs on patient physiology.
method Hybrid Gaussian process with latent force model for joint modeling of patient physiology and drug effects.
result The model accurately predicts patient responses to three common drugs, showing competitive performance.
Develops a personalized reinforcement learning algorithm for dyadic health interventions.
problem Personalizing health interventions for dyadic relationships in mobile health.
method Dyadic Reinforcement Learning (dyadic RL), a Bayesian and hierarchical online algorithm.
result Established a regret bound and demonstrated empirical performance through simulations and real data.
PLIs improve classifier performance by fine-tuning latent representations.
problem Difficult interpretation of high-dimensional latent representations in neural networks.
method Back-propagation of manual changes to low-dimensional embeddings using t-distributed stochastic neighbourhood embeddings.
result Manual separation of class clusters in latent space enhances classifier performance.
New method estimates treatment effects from high dimensional data.
problem Estimating treatment effects from high dimensional data with confounders.
method Generative modeling approach to backdoor adjustment in variational inference.
result Empirically, estimates interventional likelihood in high dimensional settings.
This study applies neural models to automatically recognize medical entities from natural language.
problem Automated recognition of medical entities from natural language is complex and time-consuming.
method Utilizes deep neural sequence models trained on a large dataset of death certificates.
result Deep neural models can efficiently recognize medical entities from natural language.
Deep learning improves medical ultrasound image segmentation accuracy.
problem Improving accuracy in medical ultrasound image segmentation.
method Categorizes deep learning methods into six groups and analyzes current representative algorithms.
result Current methods show significant improvement in image segmentation accuracy.
CPP improves predictive model outputs for better intervention decisions.
problem Predictive models often misguide resource allocation.
method Causal post-processing techniques using limited experimental data.
result CPP can improve intervention decisions, especially with imperfect causal signals.
Feature engineering remains a major bottleneck when creating predictive systems from electronic medical records. At present, an important missing element is detecting predictive regular clinical motifs from irregular episodic records. We present Deepr (short for Deep record), a new end-to-end deep learning system that …
Paper models Alzheimer's disease using genotypic, phenotypic, and cognitive data.
problem Early detection and risk factor identification for Alzheimer's disease.
method Probabilistic generative subspace learning from multi-view medical data.
result Proposes a method to model Alzheimer's disease that combines genotypic, phenotypic, and cognitive data.
Stability in clinical prediction models is crucial for transferability between studies, yet has received little attention. The problem is paramount in high dimensional data which invites sparse models with feature selection capability. We introduce an effective method to stabilize sparse Cox model of time-to-events usi…
New framework for managing medical risks using convex responses.
problem Medical risk management and dosing optimization.
method Analyzes convex and concave dose-response functions, defines antifragility.
result Proposes a mathematical framework for integrating nonlinearities in oncology.
Objective: Predict patient-specific vitals deemed medically acceptable for discharge from a pediatric intensive care unit (ICU). Design: The means of each patient's hr, sbp and dbp measurements between their medical and physical discharge from the ICU were computed as a proxy for their physiologically acceptable state …
Meta-learning method for estimating time-varying mHealth intervention effects.
problem Complex mHealth data and uncertain randomization probabilities.
method DR-WCLS meta-learning procedure for causal excursion effects.
result More efficient and consistent estimates of causal excursion effects.
Deep learning predicts opioid use disorder risk in patients.
problem Identifying patients at high risk of opioid use disorder.
method Applied LSTM models to analyze electronic health records of opioid users.
result LSTM model outperformed other methods with F1 score of 0.8023 and AUCROC of 0.9369.
New findings show single-treatment effects are unidentifiable in factorial experiments.
problem Identifying the effect of a single intervention in factorial experiments.
method Formalized sufficient conditions for the identifiability of single-treatment effects and developed nonparametric sharp bounds.
result Researchers must justify assumptions for extrapolating single-treatment effects.
New bandit model for healthcare intervention planning.
problem Maximizing patient health with limited monitoring resources.
method Developed Collapsing Bandits model and derived optimal policies.
result 3-order-of-magnitude speedup in algorithm performance.
Smart bin monitors predict medication adherence with high accuracy.
problem Predicting chronic medication adherence to improve healthcare efficiency.
method Machine learning models trained on IoT device data.
result High predictive performance (ROC AUC 0.86).
Segmentation is essential for medical image analysis tasks such as intervention planning, therapy guidance, diagnosis, treatment decisions. Deep learning is becoming increasingly prominent for segmentation, where the lack of annotations, however, often becomes the main limitation. Due to privacy concerns and ethical co…
CovidCare uses EMR data to predict patient outcomes in emerging epidemics.
problem Intelligent prognosis for patients with emerging infectious diseases during rapid epidemics.
method Transfer learning and knowledge distillation from existing EMR data.
result CovidCare outperforms baseline methods in predicting patient length of stay.
Study identifies diverse health states of opioid users to improve policy.
problem Diverse health states of opioid users lead to ineffective policy interventions.
method Probabilistic topic modeling of medical histories.
result Learned phenotypes predict future opioid use and prescription variability.
Framework for deferring decisions to experts in sequential medical settings.
problem Myopic and non-adaptive decision-making by ML models in sequential medical contexts.
method Sequential Learning-to-Defer (SLTD) framework using model-based reinforcement learning.
result Adaptive deferral policy improves trade-off between long-term outcomes and deferral frequency.
Method learns optimal treatment sequences from observational data.
problem Optimal dynamic treatment regimes for public policies and medical interventions.
method Doubly robust classification-based approach via backward induction.
result Achieves optimal convergence rate of n^(-1/2) for welfare regret.
The paper explains how data augmentation can improve domain generalization by weakening spurious correlations.
problem Machine learning models trained with observational data fail to generalize to unseen domains due to spurious correlations.
method Developed a causal perspective to explain the success of data augmentation and derived an algorithm to select effective augmentation techniques.
result Data augmentation can be used to simulate interventional data, leading to better domain generalization.
System predicts HIV patients at risk of dropping out of care.
problem High non-adherence and dropout rates among HIV patients.
method Predictive machine learning model based on resource constraints, stability, and fairness.
result Model performs 3x better than baseline for clinical use and 2.3x better for city-wide use.
This work abstracts deep neural networks into concept graphs for better interpretability in medical tasks.
problem Lack of interpretability in deep learning models, especially in medical domains.
method Developed a graphical representation of medical image processing models to understand concept-based reasoning.
result Extracted a concept-level graph that reveals the decision-making process of deep learning models.
Zero-Shot Learning helps learn new concepts without examples, useful for COVID-19 diagnosis.
problem Learning new concepts without examples, especially in medical imaging.
method Uses existing knowledge and auxiliary information to predict unknown concepts.
result Effective in diagnosing COVID-19 from chest X-rays.
Study estimates treatment effect on survival outcomes using targeted maximum likelihood estimation.
problem Estimating treatment effect on time-to-event outcomes in clinical settings.
method Divided into three phases: estimation, feature selection, and targeted maximum likelihood estimation.
result Method performs well in high sample size or event rate conditions.
Although there are millions of transgender people in the world, a lack of information exists about their health issues. This issue has consequences for the medical field, which only has a nascent understanding of how to identify and meet this population's health-related needs. Social media sites like Twitter provide ne…
Viewing the trajectory of a patient as a dynamical system, a recurrent neural network was developed to learn the course of patient encounters in the Pediatric Intensive Care Unit (PICU) of a major tertiary care center. Data extracted from Electronic Medical Records (EMR) of about 12000 patients who were admitted to the…
In the scenario of real-time monitoring of hospital patients, high-quality inference of patients' health status using all information available from clinical covariates and lab tests is essential to enable successful medical interventions and improve patient outcomes. Developing a computational framework that can learn…
Proposes DR-ME test for interpretable distributional treatment effects.
problem Detects invisible differences in treatment effects on distributional outcomes.
method Semiparametrically efficient finite-location test using kernel witnesses and orthogonal features.
result DR-ME reveals causal-discrepancy coordinates and has noncentral chi-square local power.
Proposes pT-Learning for optimal dynamic treatment regimes in mHealth.
problem Challenges in learning optimal dynamic treatment regimes with large intervention options and infinite time horizon.
method Proximal Temporal consistency Learning (pT-Learning) framework for adaptively adjusting between deterministic and stochastic policies.
result Minimax estimator avoids double sampling issue and can incorporate off-policy data.
IML methods improve survival analysis transparency.
problem Limited interpretability in survival analysis models.
method Adapting IML techniques to survival analysis.
result Enhanced understanding of model predictions and risks.
This paper reviews causal inference methods for time series data.
problem Estimating treatment effects and identifying causal relations from time series data.
method Comprehensive review of approaches for treatment effect estimation and causal discovery.
result Provides a list of evaluation metrics and datasets for time series causal inference.
Improved assessment of knee osteoarthritis using geodesic B-score.
problem Need for automatic, reader-independent measures of osteoarthritis clinical outcomes.
method Derive a geodesic B-score for Riemannian shape spaces, develop efficient algorithm for large shape populations.
result Geodesic B-score exhibits improved discrimination ability over Euclidean B-score.
Estimates joint causal effects using single-variable interventions on nonlinear models.
problem Estimating joint causal effects from single-variable interventions.
method Identifiability result and practical estimator for decomposing causal effects.
result Joint effects can be inferred without joint interventional data for nonlinear additive models.
Introduces info intervention to handle causal questions and check counterfactual variables.
problem Controversial interpretation of causal questions for non-manipulable variables and lack of power to check counterfactual variables.
method Intervenes input/output information of causal mechanisms, providing causal diagrams for communication and theoretical focus.
result Causal diagrams based on info intervention provide a new perspective on information transfer as causality.
This paper tackles CRL for multi-node interventions, achieving identifiability guarantees.
problem CRL under unknown multi-node interventions, focusing on single-node assumptions.
method Establishes identifiability results for general latent causal models under stochastic interventions.
result Identifiability up to ancestors using soft interventions, perfect identifiability using hard interventions.
New algorithm improves efficiency of Bayesian Causal Forest for subgroup analysis.
problem Estimating heterogeneous effects in subgroup analysis.
method Developed a novel algorithm for fitting Bayesian Causal Forest (BCF) model, more efficient than Gibbs sampler.
result New algorithm improves posterior exploration and coverage of interval estimates.
This work tackles causal graph discovery with stochastic interventions to minimize the number of interventions.
problem Discovering the true causal graph from observational data with limited interventions.
method Proposes a stochastic intervention model and studies verification and search problems with approximation algorithms.
result Provides approximation algorithms with competitive ratios for verification and search problems.
Developed a new algorithm to improve dynamic treatment regimens.
problem Non-convergence of Q-learning-based Q-shared algorithm in dynamic treatment regimens.
method Penalized Q-shared algorithm to address convergence issues.
result The penalized Q-shared algorithm converges and outperforms the original in various settings.
Model predicts missed doses and targets TB patients more effectively.
problem Improving adherence to TB treatment using digital data.
method Deep learning model trained on 17k TB patients' adherence data.
result Model predicts 21% more patients at risk of missing doses.
Our goal is to identify beneficial interventions from observational data. We consider interventions that are narrowly focused (impacting few covariates) and may be tailored to each individual or globally enacted over a population. For applications where harmful intervention is drastically worse than proposing no change…
Paper proposes scalable algorithm to estimate intervention targets in linear models.
problem Estimating intervention targets in linear models from observational and interventional data.
method The paper proposes a scalable algorithm that estimates intervention sites from the difference between precision matrices of observational and interventional datasets.
result The algorithm consistently identifies all intervention targets and updates observational Markov equivalence classes to interventional ones.