Bayesian model predicts patient survival from sparse EHR data.
problem Analyzing EHR data with few samples and diverse information.
method Nonparametric probabilistic model using Bayesian trees.
result Improved survival trajectory predictions on patient data.
Develops algorithm to find subgroups with different treatment effects in HIV patients.
problem Estimating treatment effects in EHR data with challenges like time-varying confounding.
method SDLD algorithm combining generalized interaction tree and longitudinal targeted maximum likelihood estimation.
result Identifies subgroups of HIV patients at higher risk of weight gain with dolutegravir-containing ARTs.
The wide implementation of electronic health record (EHR) systems facilitates the collection of large-scale health data from real clinical settings. Despite the significant increase in adoption of EHR systems, this data remains largely unexplored, but presents a rich data source for knowledge discovery from patient hea…
Novel framework detects CKD in diabetic patients using sparse EHR representations.
problem Early detection of CKD in diabetic patients.
method Sparse longitudinal representations of EHR data.
result Proposed model achieves higher predictive performance than baselines.
Enhances generative model for clinical data privacy and accuracy.
problem Data privacy in electronic patient records.
method Improves a time-series generative model with privacy safeguards.
result DP-TimeGAN achieves a mean authenticity of 0.778 on the CKD dataset.
Patient journeys are compared to find clusters of similar disease trajectories.
problem Discovering shared health outcomes among patient journeys.
method Comparing longitudinal health data to identify clusters of similar patient trajectories.
result Clusters of patient journeys with similar health outcomes can be identified.
Machine learning constructs problem-based medical records from electronic health records.
problem Difficulty in finding relevant medical information for clinical questions.
method Knowledge base completion using machine learning on electronic health records.
result Automatic construction of problem-based groupings of medications, procedures, and lab tests.
TPSQRs model longitudinal event data, detecting ADRs from EHRs.
problem Detecting adverse drug reactions from longitudinal event data.
method Learned by estimating a collection of interrelated PSQRs, using Poisson pseudo-likelihood for estimation.
result TPSQRs effectively and efficiently recover ADR signals from EHRs.
Study proposes a model to improve patient subtyping from EHR data.
problem Challenges in subtyping temporal EHR datasets.
method Self-supervised Mamba-based model for learning EHR representations.
result Model outperforms baseline models in EHR data subtyping.
With the expeditious advancement of information technologies, health-related data presented unprecedented potentials for medical and health discoveries but at the same time significant challenges for machine learning techniques both in terms of size and complexity. Those challenges include: the structured data with var…
Neural network predicts cardiovascular events from EHRs with high accuracy.
problem Predicting onset of cardiovascular diseases from electronic health records.
method Multi-task gated recurrent units with attention mechanism.
result Model outperforms clinical risk scores in predicting stroke and myocardial infarction.
Proposes a new model for time-to-event prediction with uncertainty quantification.
problem Lack of uncertainty in time-to-event predictions using recurrent neural networks.
method Deep Kernel Accelerated Failure Time models combining RNN and sparse Gaussian Process.
result Model delivers better uncertainty estimates compared to related methods.
Prediction of the future trajectory of a disease is an important challenge for personalized medicine and population health management. However, many complex chronic diseases exhibit large degrees of heterogeneity, and furthermore there is not always a single readily available biomarker to quantify disease severity. Eve…
Developed a flexible Bayesian g-formula for causal survival analysis with time-dependent confounding.
problem Estimating causal survival curves in longitudinal observational studies with time-varying treatments and confounding.
method Incorporated Bayesian Additive Regression Trees (BART) into the g-formula to model time-evolving generative components and mitigate bias due to model misspecification.
result Demonstrated improved empirical performance and practical utility of the proposed method through simulations and real-world data analysis.
A Longitudinal Attribute-Conditioned Neural Network (LANTERN) framework for modeling health-state transition probabilities in irregular longitudinal data.
problem Estimating long-term care transition probabilities in irregular longitudinal health data.
method A neural network that learns from individual health history, incorporates time elapsed, and conditions on demographic and socioeconomic attributes.
result Improves severe disability discrimination and maintains strong calibration.
With the increased availability of large databases of electronic health records (EHRs) comes the chance of enhancing health risks screening. Most post-marketing detections of adverse drug reaction (ADR) rely on physicians' spontaneous reports, leading to under reporting. To take up this challenge, we develop a scalable…
Improved functional data modeling with modern imputation methods.
problem Estimating complex non-linear models with sparsely and irregularly sampled functional data.
method Modified multiple imputation methods combining MissForest and Local Linear Forest.
result New imputation methods produce better estimates than existing methods.
Evaluating the clinical similarities between pairwise patients is a fundamental problem in healthcare informatics. A proper patient similarity measure enables various downstream applications, such as cohort study and treatment comparative effectiveness research. One major carrier for conducting patient similarity resea…
TASTE combines static and temporal data for phenotyping EHRs.
problem Phenotyping EHRs with both static and temporal data.
method Jointly models static and temporal tensors using PARAFAC2 and non-negative matrix factorization, alternatingly solving sub-problems.
result TASTE outperforms existing methods in speed and clinical meaningfulness of phenotypes.
Recent progress in deep learning is revolutionizing the healthcare domain including providing solutions to medication recommendations, especially recommending medication combination for patients with complex health conditions. Existing approaches either do not customize based on patient health history, or ignore existi…
The occurrence of drug-drug-interactions (DDI) from multiple drug dispensations is a serious problem, both for individuals and health-care systems, since patients with complications due to DDI are likely to reenter the system at a costlier level. We present a large-scale longitudinal study (18 months) of the DDI phenom…
CPTD improves prediction intervals in time series regression with cross-sectional data.
problem Constructing valid prediction intervals in time series regression with a cross-section.
method Conformal Prediction with Temporal Dependence (CPTD) for post-hoc, light-weight approach.
result CPTD maintains cross-sectional validity while improving longitudinal coverage.
The widespread availability of electronic health records (EHRs) promises to usher in the era of personalized medicine. However, the problem of extracting useful clinical representations from longitudinal EHR data remains challenging. In this paper, we explore deep neural network models with learned medical feature embe…
New model captures patient-level EHR data efficiently.
problem Irregular EHR code timing and lack of temporal structure.
method Latent factor point process model with Fourier-Eigen embedding.
result Efficiently captures subgroup-specific temporal patterns.
Model identifies key problems in HIV patients' records.
problem Complex and time-consuming task of identifying patient problems from electronic health records.
method Unsupervised phenotyping approach that jointly learns phenotypes from structured and unstructured data.
result Learned phenotypes and their relatedness are clinically valid and surpass existing methods.
Missing data is a common problem in real-world settings and particularly relevant in healthcare applications where researchers use Electronic Health Records (EHR) and results of observational studies to apply analytics methods. This issue becomes even more prominent for longitudinal data sets, where multiple instances …
Generative models create personalized patient health simulations.
problem Creating accurate digital twins for personalized medicine.
method Neural network architecture for conditional generative models of clinical trajectories.
result Same architecture generates accurate twins across 13 indications.
Study uses machine learning to predict future health from various health data types.
problem Predicting future health using diverse health data types.
method Applied machine learning (neural networks and XGBoost) to longitudinal data from 6830 individuals.
result Health-related measures were the strongest predictors of future health status, while genetic data performed poorly.
SurvLatent ODE predicts VTE risk for cancer patients, outperforming current methods.
problem Predicting clinical outcomes from irregularly sampled EHR data with competing events.
method Neural ODE-based Recurrent Neural Networks (ODE-RNN) for flexible survival time estimation.
result SurvLatent ODE outperforms Khorana Risk scores for VTE risk prediction.
In recent years, increasingly augmentation of health data, such as patient Electronic Health Records (EHR), are becoming readily available. This provides an unprecedented opportunity for knowledge discovery and data mining algorithms to dig insights from them, which can, later on, be helpful to the improvement of the q…
Obesity is a serious public health concern world-wide, which increases the risk of many diseases, including hypertension, stroke, and type 2 diabetes. To tackle this problem, researchers across the health ecosystem are collecting diverse types of data, which includes biomedical, behavioral and activity, and utilizing m…
New method calibrates asynchronous, error-prone covariates for longitudinal data.
problem Estimation biases and slow convergence in analyzing time-varying covariates with measurement error.
method Functional calibration approach based on functional principal component analysis.
result Asymptotically unbiased and consistent estimators for time-invariant coefficients; optimal convergence rate for time-varying coefficients.
LHIEM model predicts health, income, and employment over years.
problem Lack of path dependency in health policy simulations.
method Discrete-time microsimulation with Markov chain modules.
result Validates health care financing proposal through detailed modeling.
Predicting an individual's risk of experiencing a future clinical outcome is a statistical task with important consequences for both practicing clinicians and public health experts. Modern observational databases such as electronic health records (EHRs) provide an alternative to the longitudinal cohort studies traditio…
We study regularized estimation in high-dimensional longitudinal classification problems, using the lasso and fused lasso regularizers. The constructed coefficient estimates are piecewise constant across the time dimension in the longitudinal problem, with adaptively selected change points (break points). We present an…
Dynamic topic model improves mental health note analysis for children.
problem Lack of longitudinal topic models for psychiatric clinical notes.
method Developed a dynamic topic model with consistent topics and individualized temporal dependencies.
result Achieved a 38% increase in topic coherence.
Proposes Ada-Sit method for mortality prediction of rare diseases.
problem Data insufficiency and clinical diversity of rare diseases make mortality prediction hard.
method Initialization-sharing multi-task learning method (Ada-Sit) for fast adaptation to similar tasks.
result Experimental results show the proposed model is effective for mortality prediction of diverse rare diseases.
Proposes a model to handle mobile health data with irregular measurements.
problem Handling heterogeneous, multi-resolution data in mobile health.
method Individualized dynamic latent factor model for irregular multi-resolution time series data.
result Superior performance compared to existing methods in simulation and smartwatch data applications.
Develops a method to denoise and analyze wearable ECGs.
problem Noisy ECGs from wearable devices.
method Statistical model, beat-to-beat representation, factor analysis.
result Upper bound on performance quantified and compared.
Accurate real-time monitoring systems of influenza outbreaks help public health officials make informed decisions that may help save lives. We show that information extracted from cloud-based electronic health records databases, in combination with machine learning techniques and historical epidemiological information,…
This paper presents an example of how demographical characteristics of patients influence their susceptibility to certain medical conditions. In this paper, we investigate the association of health conditions to age of patients in a heterogeneous population. We show that besides the symptoms a patients is having, the a…
Deep models predict suicidal ideation from EHR and EMA data.
problem Predicting suicidal ideation from mixed data sources.
method Deep sequential models using RNNs for EHR and EMA data, attention schemes, and temporal alignment.
result EMA data improves recall to 67.78% from 48.13% using EHR data alone.
XLabel tool reduces medical experts' workload by 40% and explains its decisions.
problem Efficiently labeling large electronic health records.
method Visual-interactive tool using Explainable Boosting Machine (EBM) for classification and explanation.
result EBM achieves high accuracy and explainability, even with mislabeled data.
Hidden Markov Models analyze mobile health data to identify APNS states.
problem Subjective self-report measures of APNS lead to errors and biases.
method Exploratory hidden Markov factor models and Stabilized Expectation-Maximization algorithm.
result Identified homogeneous APNS states and dynamic transitions.
Deep neural network predicts health costs better than traditional models.
problem Accurate prediction of healthcare costs for optimal cost management.
method Developed a deep neural network to predict future health care costs from health insurance claims records.
result Deep neural network outperformed ridge regression and Morbi-RSA models in cost prediction.
Deep learning predicts drug prescriptions across global health records.
problem Predicting drug prescriptions in chronic disease patients.
method Adaptive cross-global attention graph kernel network with support vector machine.
result Model outperforms current methods in accuracy and interpretability.
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of obser…
Language models improve clinical prediction models using EHR data.
problem Limited patient data for training clinical prediction models.
method Using patient representation schemes from natural language processing.
result 3.5% mean improvement in AUROC on five prediction tasks.