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168,695 papers · 148 categories

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0111 · Oct 200719922001200920172026
18 results for knockout

The paper tackles extrapolation of gene knockouts effects on RNA counts.

problem Modeling effects of gene knockouts on RNA counts for new perturbations.
method Formulated as a latent variable model with additive perturbation effects, proved identifiability, proposed PDAE for estimation.
result PDAE can accurately predict effects of unseen but identifiable perturbations.

We consider the pricing and hedging of exotic options in a model-independent set-up using \emph{shortfall risk and quantiles}. We assume that the marginal distributions at certain times are given. This is tantamount to calibrating the model to call options with discrete set of maturities but a continuum of strikes. In …

2013-07-09abs ↗pdf ↗

We study the problem of estimating the distribution of effect sizes (the mean of the test statistic under the alternate hypothesis) in a multiple testing setting. Knowing this distribution allows us to calculate the power (type II error) of any experimental design. We show that it is possible to estimate this distribut…

2020-02-17abs ↗pdf ↗

The latest generation of volatility derivatives goes beyond variance and volatility swaps and probes our ability to price realized variance and sojourn times along bridges for the underlying stock price process. In this paper, we give an operator algebraic treatment of this problem based on Dyson expansions and moment …

2007-10-16abs ↗pdf ↗

This work tackles causal graph discovery with stochastic interventions to minimize the number of interventions.

problem Discovering the true causal graph from observational data with limited interventions.
method Proposes a stochastic intervention model and studies verification and search problems with approximation algorithms.
result Provides approximation algorithms with competitive ratios for verification and search problems.

Fan tokens surged before World Cup matches, but declined during them, revealing cognitive biases.

problem Analyzing the impact of FIFA World Cup matches on fan tokens.
method Event study and intraday analysis of blockchain-based fan tokens.
result Fan tokens experienced a surge in returns six months before the World Cup, followed by a decline during the matches, revealing asymmetries in performance.

Study identifies components of unknown interventions in a mixture.

problem Identify components of a mixture of unknown interventions on a causal Bayesian Network.
method Construct example showing components not identifiable. Prove identifiability under mild conditions. Develop efficient algorithm for recovery. Analyze performance in simulation.
result Components of a mixture of unknown interventions can be uniquely identified under certain conditions.

ODBAE detects complex phenotypes in biological data.

problem Challenges in identifying complex phenotypes from high-dimensional biological data.
method ODBAE (Outlier Detection using Balanced Autoencoders) identifies influential and high leverage points in latent relationships among multiple physiological parameters.
result ODBAE reveals novel metabolism-related genes and uncovers coordinated abnormalities across metabolic indicators.

Many tasks require finding groups of elements in a matrix of numbers, symbols or class likelihoods. One approach is to use efficient bi- or tri-linear factorization techniques including PCA, ICA, sparse matrix factorization and plaid analysis. These techniques are not appropriate when addition and multiplication of mat…

2012-06-27abs ↗pdf ↗

A new model adds stochastic spot/volatility correlation to Heston model for better exotic pricing.

problem Improving exotic option pricing in foreign exchange markets.
method Developed a Double Heston model with stochastic spot/volatility correlation, an affine model.
result The new model increases prices of out-of-the-money knockout options and one touch options.

New causal models perform poorly when evaluated on biased training sets.

problem Sample selection bias affects the evaluation of causal models' prediction performance.
method Re-evaluated prediction performance of causal models on a genetic perturbation data set, proposing a less-biased evaluation set.
result Causal models have similar or worse performance when evaluated on a less-biased set compared to standard association-based estimators.

Typically options with a path dependent payoff, such as Target Accumulation Redemption Note (TARN), are evaluated by a Monte Carlo method. This paper describes a finite difference scheme for pricing a TARN option. Key steps in the proposed scheme involve tracking of multiple one-dimensional finite difference solutions,…

2013-04-29abs ↗pdf ↗

Automated tests detect interactions in unstructured data.

problem Detecting interactions between latent variables in low-dimensional systems.
method Derive two interaction tests based on pairwise interventions and integrate them into an active learning pipeline.
result Tests can identify more known biological interactions than random search and standard active learning baselines.

The World Trade Web (WTW) is a weighted network whose nodes correspond to countries with edge weights reflecting the value of imports and/or exports between countries. In this paper we introduce to this macroeconomic system the notion of extinction analysis, a technique often used in the analysis of ecosystems, for the…

2011-04-22abs ↗pdf ↗