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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,695 papers · 148 categories

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0111 · Apr 201919922001200920172026
8 results for immunotherapy

MSB framework improves survival prediction in immunotherapy patients with missing data.

problem High dimensionality and blockwise missingness in multimodal clinical data.
method MSB is a late-fusion framework that independently models modality-specific features before aggregating predictions via cross-validated stacking.
result MSB outperformed baseline algorithms in predicting progression-free survival in lung cancer patients.

New method estimates treatment effects over time for survival data, improving accuracy and smoothness.

problem Estimating treatment effects over time for survival data with left truncation and right censoring.
method surv-iTMLE, a targeted learning procedure for estimating conditional survival probabilities.
result surv-iTMLE outperforms existing methods in bias and smoothness of time-varying effect estimates.

Personalized cancer vaccines are envisioned as the next generation rational cancer immunotherapy. The key step in developing personalized therapeutic cancer vaccines is to identify tumor-specific neoantigens that are on the surface of tumor cells. A promising method for this is through de novo peptide sequencing from m…

2019-04-17abs ↗pdf ↗

KM-GPT automates IPD reconstruction from KM plots with high accuracy and scalability.

problem Manual digitization of IPD from KM plots is error-prone and lacks scalability.
method KM-GPT integrates advanced image preprocessing, multi-modal reasoning, and iterative reconstruction algorithms.
result KM-GPT generates high-quality IPD without manual input or intervention, achieving superior accuracy.

Develops a method to estimate average hazard under non-proportional hazards without relying on proportional hazards assumption.

problem Estimation of treatment effects when hazards are non-proportional, leading to unstable hazard ratios.
method Semiparametric, doubly robust framework for covariate-adjusted average hazard estimation.
result Valid sqrt{n} inference with small bias and near-nominal confidence-interval coverage across proportional and non-proportional hazards settings.

ROOFS helps researchers select robust biomarker features from complex data.

problem Challenges in feature selection for biomarker discovery and clinical models.
method ROOFS is a Python package that benchmarks multiple feature selection methods on user data.
result ROOFS identifies a filter method as optimal for identifying predictors of lung cancer resistance.