A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
AdaCare learns health status from biomarkers across multiple time scales.
Paper uses RL to optimize daily step distribution for better health biomarkers.
Study uses machine learning to predict future health from various health data types.
Maintaining good cardiac function for as long as possible is a major concern for healthcare systems worldwide and there is much interest in learning more about the impact of different risk factors on cardiac health. The aim of this study is to analyze the impact of systolic blood pressure (SBP) on cardiac function whil…
Imaging fluorescent disease biomarkers in tissues and skin is a non-invasive method to screen for health conditions. We report an automated process that combines intraoral fluorescent porphyrin biomarker imaging, clinical examinations and machine learning for correlation of systemic health conditions with periodontal d…
Prediction of the future trajectory of a disease is an important challenge for personalized medicine and population health management. However, many complex chronic diseases exhibit large degrees of heterogeneity, and furthermore there is not always a single readily available biomarker to quantify disease severity. Eve…
Study finds PLI functional connectivity feature superior for depression recognition.
Finite mixture model is an important branch of clustering methods and can be applied on data sets with mixed types of variables. However, challenges exist in its applications. First, it typically relies on the EM algorithm which could be sensitive to the choice of initial values. Second, biomarkers subject to limits of…
CovidCare uses EMR data to predict patient outcomes in emerging epidemics.
VBphenoR uses variational Bayes for EHR-based patient phenotyping.
Machine learning analysis of neuroimaging data can accurately predict chronological age in healthy people and deviations from healthy brain ageing have been associated with cognitive impairment and disease. Here we sought to further establish the credentials of "brain-predicted age" as a biomarker of individual differe…
We study information theoretic methods for ranking biomarkers. In clinical trials there are two, closely related, types of biomarkers: predictive and prognostic, and disentangling them is a key challenge. Our first step is to phrase biomarker ranking in terms of optimizing an information theoretic quantity. This formal…
New method detects biomarker-treatment interactions in clinical trials.
A method to explain disease transformation using biomarker covariance matrices.
Develops a method to denoise and analyze wearable ECGs.
The method integrates survival constraints into NMF for identifying survival-associated gene clusters.
Neural network models improve ROC curve evaluation of biomarkers, focusing on age's role in physical activity-mortality association.
Predicts clinical events using a landmark approach with machine learning for large biomarker histories.
New biomarker predicts MRgFUS treatment outcome without contrast agents.
RIF prioritizes predictive biomarkers for precision medicine.
A method models continuous-time glucose distributions in children with diabetes.
Stein-Encoder isolates genetic signals in multi-modal biomedical data.
Optimal biomarker combinations for treatment-selection can be derived by minimizing total burden to the population caused by the targeted disease and its treatment. However, when multiple biomarkers are present, including all in the model can be expensive and hurt model performance. To remedy this, we consider feature …
New methods for selecting variables in complex biomedical data.
Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.
Proposes ConRad model for lung cancer classification using radiomics and interpretable machine learning.
Finding the biomarkers associated with ASD is helpful for understanding the underlying roots of the disorder and can lead to earlier diagnosis and more targeted treatment. A promising approach to identify biomarkers is using Graph Neural Networks (GNNs), which can be used to analyze graph structured data, i.e. brain ne…
Study identifies biomarkers for lung cancer in female non-smokers.
Study highlights robustness issues in healthcare diagnostic models due to distribution shifts.
We introduce Disease Knowledge Transfer (DKT), a novel technique for transferring biomarker information between related neurodegenerative diseases. DKT infers robust multimodal biomarker trajectories in rare neurodegenerative diseases even when only limited, unimodal data is available, by transferring information from …
With the increasing availability of wearable devices, continuous monitoring of individuals' physiological and behavioral patterns has become significantly more accessible. Access to these continuous patterns about individuals' statuses offers an unprecedented opportunity for studying complex diseases and health conditi…
Novel framework predicts brain biomarker trajectories with superior performance.
Obtaining magnetic resonance images (MRI) with high resolution and generating quantitative image-based biomarkers for assessing tissue biochemistry is crucial in clinical and research applications. How- ever, acquiring quantitative biomarkers requires high signal-to-noise ratio (SNR), which is at odds with high-resolut…
Discovering imaging biomarkers for autism spectrum disorder (ASD) is critical to help explain ASD and predict or monitor treatment outcomes. Toward this end, deep learning classifiers have recently been used for identifying ASD from functional magnetic resonance imaging (fMRI) with higher accuracy than traditional lear…
Event-based models (EBM) are a class of disease progression models that can be used to estimate temporal ordering of neuropathological changes from cross-sectional data. Current EBMs only handle scalar biomarkers, such as regional volumes, as inputs. However, regional aggregates are a crude summary of the underlying hi…
Paper proposes machine learning model for early Alzheimer's diagnosis.
PR-GNN identifies salient brain regions for ASD biomarkers.
A broad spectrum of data from different modalities are generated in the healthcare domain every day, including scalar data (e.g., clinical measures collected at hospitals), tensor data (e.g., neuroimages analyzed by research institutes), graph data (e.g., brain connectivity networks), and sequence data (e.g., digital f…
Univariate and multivariate feature selection methods can be used for biomarker discovery in analysis of toxicant exposure. Among the univariate methods, differential expression analysis (DEA) is often applied for its simplicity and interpretability. A characteristic of methods for DEA is that they treat genes individu…
New method uses SHAP for biomarker identification in CATE models.
We introduce a wide and deep neural network for prediction of progression from patients with mild cognitive impairment to Alzheimer's disease. Information from anatomical shape and tabular clinical data (demographics, biomarkers) are fused in a single neural network. The network is invariant to shape transformations an…
The identification of predictive biomarkers from a large scale of covariates for subgroup analysis has attracted fundamental attention in medical research. In this article, we propose a generalized penalized regression method with a novel penalty function, for enforcing the hierarchy structure between the prognostic an…
Identifying measurable genetic indicators (or biomarkers) of a specific condition of a biological system is a key element of precision medicine. Indeed it allows to tailor diagnostic, prognostic and treatment choice to individual characteristics of a patient. In machine learning terms, biomarker discovery can be framed…
AFTNet uses a network-constrained Weibull model for biomarker discovery.
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
Transformers improve Alzheimer's disease progression prediction by accounting for irregular biomarker histories.
A new framework models multi-state events and biomarkers.
This study interprets machine learning models to identify biomarkers for severe COVID-19 infection.