Frengression models causal data flexibly and faithfully.
problem Challenges in robust benchmarking and evaluation of causal inference with real-world data.
method Introduces frengression, a deep generative model for joint distribution of covariates, treatments, and outcomes.
result Frengression provides accurate estimation and flexible simulation of multivariate, time-varying data.
Deep neural networks for ordinal outcomes combining image and tabular data.
problem Lack of interpretable models for ordinal outcomes in mixed data types.
method Ordinal Neural Network Transformation Models (ONTRAMs) integrating DL and classical ordinal regression.
result ONTRAMs achieve performance equivalent to standard multi-class DL models but are faster and more interpretable.
Many estimators of the average effect of a treatment on an outcome require estimation of the propensity score, the outcome regression, or both. It is often beneficial to utilize flexible techniques such as semiparametric regression or machine learning to estimate these quantities. However, optimal estimation of these r…
CPME embeds counterfactual outcomes in RKHS for flexible policy evaluation.
problem Estimating counterfactual policy outcomes for decision-making.
method Counterfactual Policy Mean Embedding (CPME) framework in RKHS, plug-in and doubly robust estimators, kernel test statistic.
result Doubly robust estimator improves convergence rates and asymptotic normality.
Treatment effects can be estimated from observational data as the difference in potential outcomes. In this paper, we address the challenge of estimating the potential outcome when treatment-dose levels can vary continuously over time. Further, the outcome variable may not be measured at a regular frequency. Our propos…
New framework estimates treatment effects based on preferences.
problem Estimating treatment effects with flexible outcomes.
method Preference-based Conditional Treatment Effect (CPTE) framework.
result CPTE provides interpretable targets and new identifiability conditions.
Learning algorithms need bias to generalize and perform better than random guessing. We examine the flexibility (expressivity) of biased algorithms. An expressive algorithm can adapt to changing training data, altering its outcome based on changes in its input. We measure expressivity by using an information-theoretic …
A method corrects bias in estimating a high-dimensional classification rule using auxiliary outcomes.
problem Bias in estimating a high-dimensional classification rule using only one outcome.
method Robust transfer learning approach combining MTL and calibration steps.
result Final estimator achieves lower error than using only the target outcome.
The paper discusses selecting predictive models for causal inference, highlighting the challenges and proposing a solution.
problem Selecting the best predictive models for causal inference from a variety of machine learning models.
method The paper proposes using R e x t − r i s k R ext{-risk} R e x t − r i s k , flexible estimators, and splitting data to compute risks for model selection. result The proposed method controls both outcome errors for treated and non-treated individuals, addressing the issue of model selection for causal inference.
WDL models density curves using Wasserstein distance and flexible mixture models.
problem Modeling entire distribution and non-negativity constraints.
method Wasserstein distance, Semi-parametric Conditional Gaussian Mixture Models (SCGMM), Majorization-Minimization optimization.
result WDL better characterizes nonlinear dependence of conditional densities.
This chapter covers different approaches to policy evaluation for assessing the causal effect of a treatment or intervention on an outcome of interest. As an introduction to causal inference, the discussion starts with the experimental evaluation of a randomized treatment. It then reviews evaluation methods based on se…
Causal ML predicts treatment outcomes, aiding personalized medicine.
problem Predicting individualized treatment effects for personalized medicine.
method Flexible, data-driven methods using causal inference with clinical trial and real-world data.
result Causal ML allows for estimating individualized treatment effects.
New method combines randomization tests and flexible models for valid inference without splitting data.
problem Valid inference in randomized panel experiments with complex effect heterogeneity.
method Model-assisted randomization tests that estimate unsigned CATE from residualized outcomes.
result CATE-assisted tests control Type I error and achieve higher power than alternatives.
New algorithm for nonparametric IV regression using stochastic gradients.
problem Identifying causal effects in the presence of unobservable confounders.
method Functional stochastic gradient descent for NPIV regression.
result Superior stability and competitive performance compared to existing methods.
Clinical decision making is challenging because of pathological complexity, as well as large amounts of heterogeneous data generated as part of routine clinical care. In recent years, machine learning tools have been developed to aid this process. Intensive care unit (ICU) admissions represent the most data dense and t…
A new model uses neural networks for consistent discrete choice analysis.
problem Difficulties in specifying utility functions in RUM models.
method Alternative-Specific and Shared weights Neural Network (ASS-NN) model.
result ASS-NN provides consistent outcomes without specifying utility form.
InVA models image outcomes from multiple modalities, outperforming standard VAEs.
problem Understanding relationships across multiple imaging modalities in neuroimaging.
method Integrative Variational Autoencoder (InVA) framework for image-on-image regression.
result InVA accurately predicts PET scans from structural MRI, outperforming conventional models.
LUQ-Learning adapts Q-learning for healthcare decisions considering patient preferences.
problem Optimizing treatment decisions for multivariate outcomes based on individual preferences.
method Latent Utility Q-Learning (LUQ-Learning) framework that adapts Q-learning for composite outcomes.
result LUQ-Learning achieves highly competitive performance compared to alternative methods in simulations.
Study tackles variable selection with missing covariates and outcomes using machine learning and imputation.
problem Missing data in both covariates and outcomes complicates variable selection in health studies.
method Exploits machine learning flexibility and bootstrap imputation for variable selection, comparing multiple methods.
result XGBoost and BART perform best in variable selection with bootstrap imputation, achieving high F 1 F_1 F 1 scores and low Type I errors. New method uses AI predictions as cheaper alternatives to expensive outcomes.
problem Using expensive outcomes for statistical inference.
method Recalibrated prediction-powered inference using machine learning techniques.
result Significant gains in effective sample size over existing PPI proposals.
We introduce a Bayesian nonparametric regression model for data with multiway (tensor) structure, motivated by an application to periodontal disease (PD) data. Our outcome is the number of diseased sites measured over four different tooth types for each subject, with subject-specific covariates available as predictors.…
Paper introduces GDR-learners for estimating potential outcomes from observational data.
problem Lack of theoretical property of general Neyman-orthogonality in deep generative models.
method Develops flexible GDR-learners based on various deep generative models.
result GDR-learners possess quasi-oracle efficiency and rate double robustness, asymptotically optimal.
DFL framework improves action and outcome fairness in policy learning.
problem Fairness in policy learning, especially action and outcome fairness.
method Integrates action and outcome fairness into a multi-objective optimization problem using a lexicographic weighted Tchebyshev method.
result DFL framework improves both action and outcome fairness with minimal value reduction.
DynForest R package predicts outcomes with time-dependent predictors.
problem Handling time-dependent predictors in random forest models.
method Random forests with time-dependent predictors summarized using flexible linear mixed models.
result DynForest can predict continuous, categorical, and survival outcomes.
Optimal treatment regimes (OTR) are individualised treatment assignment strategies that identify a medical treatment as optimal given all background information available on the individual. We discuss Bayes optimal treatment regimes estimated using a loss function defined on the bivariate distribution of dichotomous po…
A new uplift modeling approach uses binary treatment indicators more efficiently.
problem Lack of full value utilization in binary uplift modeling.
method Design a novel transformed outcome for binary target variables.
result Our new approach outperforms traditional methods in synthetic and real-world datasets.
CDM models counterfactual outcomes in longitudinal data with improved accuracy.
problem Predicting counterfactual outcomes in longitudinal data with complex time-dependent confounding.
method Causal Diffusion Model (CDM) using denoising diffusion architecture with relational self-attention.
result CDM outperforms state-of-the-art methods in generating full probabilistic distributions of counterfactual outcomes.
We study notions of fairness in decision-making systems when individuals have diverse preferences over the possible outcomes of the decisions. Our starting point is the seminal work of Dwork et al. which introduced a notion of individual fairness (IF): given a task-specific similarity metric, every pair of individuals …
Proposes a new Q-learning method for survival outcomes in clinical trials.
problem Incomplete follow-up data and nonlinear covariate effects in clinical trials.
method Combines Buckley-James boosting with flexible base learners for estimating optimal treatment regimes.
result Improves treatment decision accuracy and stability in longitudinal clinical trials.
CCN estimates full potential outcome distributions without restrictive assumptions.
problem Estimating CATE is insufficient; full potential outcome distributions provide greater insights.
method Collaborating Causal Networks (CCN) learns full potential outcome distributions without restrictive assumptions.
result CCN learns distributions that asymptotically capture true potential outcome distributions.
Three approaches learn personalized treatment policies for UTI patients.
problem Learning optimal treatment policies in multiobjective settings with fully observed outcomes.
method Indirect and direct approaches using predictive models and without intermediate models.
result All approaches outperform clinicians in achieving better performance on all outcomes and trade-offs.
Combines MCTM and NF for flexible multivariate density regression with interpretable marginals.
problem Difficult interpretation of flexible NF models and limitations of MCTM in flexibility.
method Hybrid approach combining MCTM for interpretable marginals and NF for complex joint distributions.
result Demonstrates versatility and improved performance compared to MCTM and other NF models.
FIDDLE uses deep learning to estimate ATE from complex data.
problem Estimating ATE from high-dimensional, correlated covariates with sparse nonlinear effects.
method Factor-augmented deep learning for propensity and outcome models.
result FIDDLE consistently estimates ATE under model misspecification and is semiparametrically efficient.
Estimates outcomes under hypothetical scenarios using a flexible framework.
problem Adapting to sudden shifts in treatment patterns.
method Doubly robust estimator using incremental interventions.
result Achieves n \sqrt{n} n -consistency and asymptotic normality. New scalable method balances hospital profit status and heart attack outcomes.
problem Balancing covariate distributions and minimizing weight dispersion in large datasets.
method Combines kernel basis expansion and convex optimization for efficient and flexible weighting.
result For-profit hospitals use interventional cardiology similarly to other hospitals but have higher mortality and readmission rates.
Paper proposes Bayesian TMLE methods for causal effect uncertainty quantification.
problem Quantifying uncertainty in causal effect estimation.
method Three Bayesian TMLE approaches for binary and continuous outcomes.
result BN-TMLE outperforms classical implementations in small data regimes.
We propose a method to learn causal response representations through direct effect analysis.
problem Uncovering direct causal effects in complex, multivariate settings.
method Our method bridges conditional independence testing with causal representation learning, formulating an optimisation problem to maximise evidence against conditional independence.
result The largest eigenvalue distribution can be bounded by an F F F -distribution, providing testable conditional independence. Proposes a new decision rule for continuous treatments.
problem Developing personalized treatment recommendations for continuous treatments.
method Jump interval-learning method to estimate conditional mean of outcomes.
result Optimal interval-valued decision rule (I2DR) for continuous treatments.
Proposes a framework for causal inference with processed outcomes in biomedical research.
problem Impact of intra-subject processing on inter-subject statistical inference in biomedical research.
method Semiparametric framework with multiply robust estimators and step-down procedure for high-dimensional inference.
result Superior performance of the proposed approach demonstrated through simulations and application to autism research.
BCF models estimate causal effects on multiple outcomes in TIMSS data.
problem Estimating causal effects on multiple outcomes in educational data.
method Bayesian Additive Regression Trees (BART) for multivariate causal inference.
result Positive and negative effects of home study conditions and school absence on student achievement.
Develops a new multivariate regression model for complex outcomes.
problem Flexible, heterogeneous, and residual-dependent multivariate regression problems.
method MultiVCBART framework with Graphical Horseshoe priors.
result Empirically outperforms existing models on sparse, high-dimensional datasets.
Study efficient inference for network quantile causal effects with partial interference.
problem Estimating network causal effects on outcome quantiles with partial interference.
method Developed a nonparametric efficiency theory and a nonparametrically efficient estimator using a three-way cross-fitting procedure.
result Proposed estimator is consistent, asymptotically normal, and allows flexible estimation of nuisance functions.
LI-ITR combines flexible ML with interpretable approximations for personalized treatment rules.
problem Combining flexibility and interpretability in personalized treatment rules.
method Uses variational autoencoders and a mixture of interpretable experts.
result Accurately recovers true local coefficients and optimal treatment strategies.
Method estimates joint distribution of bivariate outcomes.
problem Modeling dependence between bivariate outcomes.
method Semiparametric distribution regression.
result Method performs similarly or better than alternatives in finite samples.
pmsims R package uses Gaussian process for flexible sample size estimation in clinical models.
problem Determining adequate sample size for clinical prediction models.
method Simulation-based Gaussian process search for flexible sample size estimation.
result Gaussian process-based method produces more stable sample size estimates, especially in challenging settings.
A new meta-learner improves prediction of individualized outcomes in sequential decisions.
problem Predicting individualized outcomes over long horizons in sequential decision-making.
method Developed a novel meta-learner called DRQ-learner with theoretical guarantees of orthogonality and quasi-oracle efficiency.
result DRQ-learner achieves quasi-oracle efficiency, doubly robustness, and Neyman-orthogonality.
Study uses exchangeable GPs for staggered-adoption policy evaluation in panel data.
problem Evaluating the impact of staggered treatments in panel data settings.
method Exchangeable multi-task Gaussian processes (GPs) with flexible kernels.
result Flexible tool for policy evaluation in panel data settings.
DFIV uses deep neural nets to learn nonlinear features in IV regression.
problem Learning causal relationships from observational data with nonlinear interactions.
method DFIV trains deep neural nets to define nonlinear features on instruments and treatments, alternating training to compose stages 1 and 2.
result DFIV outperforms state-of-the-art methods on IV benchmarks and off-policy policy evaluation.