Dynamic treatment regimes are of growing interest across the clinical sciences as these regimes provide one way to operationalize and thus inform sequential personalized clinical decision making. A dynamic treatment regime is a sequence of decision rules, with a decision rule per stage of clinical intervention; each de…
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48 results for “dynamic treatment rules”
The paper develops methods to estimate optimal treatment sequences under policy constraints.
problem Estimating the best sequence of treatments over multiple stages for individuals.
method Empirical welfare maximization approach, solving treatment assignment sequentially or simultaneously.
result Established convergence rates and upper bounds for estimation methods.
Bayesian model estimates ACT impact on pediatric AML survival.
problem Estimating ACT impact on survival in AML patients with treatment timing issues.
method Generative Bayesian semi-parametric model with Gamma Process priors.
result Posterior inference for ACT efficacy under dynamic rules.
Medical Knowledge Integration into Reinforcement Learning Algorithms for Dynamic Treatment Regimesstat.ME
RL algorithms with medical integration improve personalized treatment recommendations.
problem Developing effective personalized treatment strategies for chronic diseases.
method Integrating medical knowledge into RL algorithms for DTR.
result Enhanced treatment recommendations with increased confidence.
Developed a new algorithm to improve dynamic treatment regimens.
problem Non-convergence of Q-learning-based Q-shared algorithm in dynamic treatment regimens.
method Penalized Q-shared algorithm to address convergence issues.
result The penalized Q-shared algorithm converges and outperforms the original in various settings.
Proposes a new decision rule for continuous treatments.
problem Developing personalized treatment recommendations for continuous treatments.
method Jump interval-learning method to estimate conditional mean of outcomes.
result Optimal interval-valued decision rule (I2DR) for continuous treatments.
Proposes methods for learning optimal dynamic treatment regimes robust to unconfoundedness violations.
problem Estimating optimal dynamic treatment regimes using historical observational data when unconfoundedness is violated.
method Utilizes proximal causal inference framework to propose three nonparametric identification methods, a (K+1)-robust method, and establish a semiparametric efficiency bound.
result Establishes the (K+1)-robust method for learning optimal dynamic treatment regimes, validating its efficiency and multiple robustness through numerical experiments.
LI-ITR combines flexible ML with interpretable approximations for personalized treatment rules.
problem Combining flexibility and interpretability in personalized treatment rules.
method Uses variational autoencoders and a mixture of interpretable experts.
result Accurately recovers true local coefficients and optimal treatment strategies.
Dynamic CBDT improves treatment effect estimation in clinical data.
problem Estimating heterogeneous treatment effects in observational data with high accuracy and interpretability.
method Dynamic Regularized Causal Boosted Decision Trees (CBDT) integrating variance regularization and calibration.
result Significantly improved estimation accuracy and reliable coverage of true treatment effects.
Paper proposes robust methods for estimating optimal treatment rules with censored survival data.
problem Estimating optimal treatment rules for censored survival data.
method Developed two robust criteria and a sampling-based difference-of-convex algorithm for learning optimal treatment rules.
result Proposed methods show improved performance compared to existing methods in simulations and real data.
Many applied decision-making problems have a dynamic component: The policymaker needs not only to choose whom to treat, but also when to start which treatment. For example, a medical doctor may choose between postponing treatment (watchful waiting) and prescribing one of several available treatments during the many vis…
An optimal dynamic treatment regime (DTR) consists of a sequence of decision rules in maximizing long-term benefits, which is applicable for chronic diseases such as HIV infection or cancer. In this paper, we develop a novel angle-based approach to search the optimal DTR under a multicategory treatment framework for su…
A New Causal Rule Learning Approach to Interpretable Estimation of Heterogeneous Treatment Effectcs.LG
CRL approach improves understanding of heterogeneous treatment effects in complex diseases.
problem Estimating heterogeneous treatment effects in complex diseases.
method Causal rule learning (CRL) workflow consisting of rule discovery, selection, and analysis.
result CRL outperforms other methods in providing interpretable estimates of HTE.
The vision for precision medicine is to use individual patient characteristics to inform a personalized treatment plan that leads to the best healthcare possible for each patient. Mobile technologies have an important role to play in this vision as they offer a means to monitor a patient's health status in real-time an…
RATE metrics evaluate treatment prioritization rules, subsuming existing methods.
problem Comparing and testing the quality of treatment prioritization rules.
method Rank-weighted average treatment effect (RATE) metrics.
result RATE metrics enable asymptotically exact inference in various study settings.
The paper develops deep learning models for personalized treatment rules in survival analysis.
problem Deriving optimal treatment rules for bivariate survival outcomes in randomized trials.
method Adaptive prediction-powered learning using deep neural networks and stochastic policies.
result Maximizes joint survival probability beyond fixed time points .
Comment on entropy learning for dynamic treatment regimes.
problem Evaluating dynamic treatment regimes using entropy loss.
method Optimization-based alternative to IPW estimate.
result Suggests optimization-based approach for evaluation.
Q-learning adapted to find near-equivalent treatment strategies.
problem Finding optimal treatment sequences in dynamic treatment regimes.
method Introducing a worst-value tolerance criterion to find sets of near-equivalent policies.
result Constructs families of near-equivalent treatment strategies.
Paper extends transfer learning for decision rules, improving treatment rule estimation.
problem Estimating optimal individualized treatment rules under changing conditions.
method Bayes decision rules and low-dimensional empirical risk minimization.
result Consistent estimators and risk bounds established under mild conditions.
The paper learns personalized treatment rules from observational data.
problem Developing effective treatment policies for individual patients.
method Contextual bandit approach to minimize expected risk of treatment policies.
result The proposed method outperforms physicians and baseline approaches in IV and VP administration.
Nonparametric estimation of a covariate-adjusted counterfactual treatment regimen response curvemath.ST
Estimates personalized treatment response curves using covariates.
problem Flexible estimation of personalized treatment response curves.
method Sieve based nonparametric estimator of smoothed regimen-response curve function.
result Asymptotic linearity and undersmoothing criteria for efficient estimation.
A new method improves efficiency in finding optimal personalized treatment rules.
problem Heteroscedasticity and misspecified treatment-free effect models affect optimal ITR estimation.
method E-Learning framework that accounts for covariate-treatment dependent variance of residuals.
result E-Learning framework improves efficiency of optimal ITR estimation.
Paper derives policy rules from observational data for hepatitis C treatment.
problem Improving treatment guidelines for HIV/HCV co-infected patients.
method Weighted K-means algorithm for estimating CATEs, decision tree implementation.
result Identifies a subgroup with high spontaneous HCV clearance rate.
Algorithm identifies interpretable subgroups with elevated treatment effects.
problem Estimating high-dimensional, uninterpretable CATE results.
method Rule sets summarizing CATE estimates, optimizing subgroup size and effect size.
result Frontier of Pareto optimal rule sets for subgroup identification.
Develops deep jump learning for continuous treatment OPE.
problem Estimating mean outcomes under new treatment rules using historical data from different rules.
method Adaptive deep discretization of continuous treatment space using deep learning and multi-scale change point detection.
result Validated method through theoretical results, simulations, and real application to Warfarin Dosing.
The paper uses machine learning to find causal rules from business process logs.
problem Discovering causal relationships in business process logs.
method Action rule mining followed by causal machine learning (uplift trees).
result Identifies treatments with high causal effect on outcomes.
Meta-analysis improves personalized treatment rules across multiple sites.
problem Lack of generalizability in learning individualized treatment rules across different medical sites.
method Developed a method for individual-level meta-analysis of ITRs, borrowing sign-coherency information between sites.
result Jointly learned site-specific ITRs with improved generalizability.
We present nonparametric algorithms for estimating optimal individualized treatment rules. The proposed algorithms are based on the XGBoost algorithm, which is known as one of the most powerful algorithms in the machine learning literature. Our main idea is to model the conditional mean of clinical outcome or the decis…
Optimal biomarker combinations for treatment-selection can be derived by minimizing total burden to the population caused by the targeted disease and its treatment. However, when multiple biomarkers are present, including all in the model can be expensive and hurt model performance. To remedy this, we consider feature …
Fuses ITRs for primary and secondary outcomes to minimize harm.
problem Learn an ITR maximizing primary outcome while minimizing harm to secondary outcomes.
method Introduces fusion penalty to encourage similar recommendations for different outcomes. Two algorithms estimate the ITR using surrogate loss functions.
result Agreement rate between primary and secondary optimal ITRs converges faster than ignoring secondary outcomes.
Neyman Meets Causal Machine Learning: Experimental Evaluation of Individualized Treatment Rulesstat.ME
Neyman's framework evaluates personalized treatment rules using experiments.
problem Evaluating the efficacy of individualized treatment rules derived by machine learning.
method Neyman's repeated sampling framework applied to cross-fitted ITRs.
result Ex-post evaluation of ITRs can be more efficient than random assignment.
Paper proposes a new framework for individualized treatment rules that generalize better across different distributions.
problem Existing individualized treatment rules may not generalize well when training and testing distributions differ.
method Distributionally robust individualized treatment rules (DR-ITR) framework that maximizes worst-case value function across close distributions.
result Calibrated DR-ITR outperforms standard ITR in generalizability.
Proposes an interpretable machine learning framework for multi-arm HTE estimation.
problem Challenges in estimating heterogeneous treatment effects in multi-arm settings.
method Rule-based ensemble approach for HTE estimation in multi-arm trials.
result Achieved lower bias and higher estimation accuracy compared to existing methods.
The paper develops a method to optimize individualized treatment rules for cost-effectiveness.
problem Developing cost-effective individualized treatment rules for healthcare policy.
method Using conditional random forest and net-monetary-benefit (NMB) to estimate optimal CE-ITR.
result The approach optimizes healthcare resource allocation by maximizing health gains and minimizing costs.
There is tremendous interest in precision medicine as a means to improve patient outcomes by tailoring treatment to individual characteristics. An individualized treatment rule formalizes precision medicine as a map from patient information to a recommended treatment. A treatment rule is defined to be optimal if it max…
Differentially private method for estimating individualized treatment rules.
problem Estimating individualized treatment rules while preserving privacy.
method Differentially private two-stage empirical risk minimization (DP-2ERM).
result Improved privacy-utility trade-off demonstrated through simulations and applications.
Causal Rule Ensemble: Interpretable Discovery and Inference of Heterogeneous Treatment Effectsstat.ME
CRE discovers interpretable subgroups with heterogeneous treatment effects.
problem Identifying subgroups with notable treatment effect heterogeneity.
method Causal Rule Ensemble (CRE) using an ensemble-of-trees approach.
result CRE offers interpretable decision rules and high stability in subgroup discovery.
Dynamic covariate balancing: estimating treatment effects over time with potential local projectionsecon.EM
Dynamic treatment effects estimated over time using covariate balancing.
problem Estimating treatment effects in panel data with dynamic treatments.
method Dynamic covariate balancing with potential local projections.
result Established inferential guarantees for the proposed method.
Resampling-based Confidence Intervals for Model-free Robust Inference on Optimal Treatment Regimesstat.ME
We propose a new procedure for inference on optimal treatment regimes in the model-free setting, which does not require to specify an outcome regression model. Existing model-free estimators for optimal treatment regimes are usually not suitable for the purpose of inference, because they either have nonstandard asympto…
Mining relationships between treatment(s) and medical problem(s) is vital in the biomedical domain. This helps in various applications, such as decision support system, safety surveillance, and new treatment discovery. We propose a deep learning approach that utilizes both word level and sentence-level representations …
Robust Sample Weighting to Facilitate Individualized Treatment Rule Learning for a Target Populationstat.ML
Develops a weighting framework to generalize ITRs from source to target populations.
problem Challenges in generalizing ITRs from a source population to a target population with differing characteristics.
method A robust sample weighting framework using a reproducing kernel Hilbert space to balance covariates and improve ITR learning methods.
result Improves ITR estimation for the target population compared to other weighting methods.
TV-SurvCaus improves causal inference for dynamic treatments in survival analysis.
problem Estimating causal effects of time-varying treatments on survival outcomes.
method Representation balancing techniques extended to time-varying treatment regimes with survival outcomes.
result TV-SurvCaus outperforms existing methods in estimating individualized treatment effects with time-varying covariates and treatments.
A Disease Diagnosis and Treatment Recommendation System Based on Big Data Mining and Cloud Computingcs.LG
It is crucial to provide compatible treatment schemes for a disease according to various symptoms at different stages. However, most classification methods might be ineffective in accurately classifying a disease that holds the characteristics of multiple treatment stages, various symptoms, and multi-pathogenesis. More…
Dynamic treatment strategies on networks amplify policy impact through spillovers.
problem Effective dynamic treatment allocation in network settings.
method Q-Ising, a three-stage pipeline integrating Bayesian dynamic Ising model, treatment adoption histories, and offline reinforcement learning.
result Adaptive targeting outperforms static centrality benchmarks in Indian village microfinance networks and synthetic data.
The paper uses double machine learning to estimate dynamic treatment effects robustly.
problem Estimating causal effects of dynamic treatments with time-varying covariates.
method Double machine learning with Neyman-orthogonal score functions for robustness.
result Asymptotic normality and -consistency of the estimators under specific conditions.
We propose a heterogeneous agent market model (HAM) in continuous time. The market is populated by fundamental traders and chartists, who both use simple linear trading rules. Most of the related literature explores stability, price dynamics and profitability either within deterministic models or by simulation. Our nov…
Paper uses stats to predict treatment choice based on illness probability.
problem Improving treatment decision-making in personalized medicine.
method Statistical decision theory with maximum regret evaluation.
result Estimates illness probability for better treatment choice.
Proposes robust ITRs integrating multiple datasets to handle posterior shift.
problem Posterior shift in conditional outcome distributions between source and target populations.
method Distributionally robust approach with closed-form solution and adaptive uncertainty tuning.
result Achieves superior performance compared to existing methods in simulations and real-data applications.