Model predicts VKA dosage for Indian patients, aiding in safe medication.
problem Safe and accurate dosing of VKA drugs for Indian patients.
method Support Vector Machine (SVM) Regression model trained on patient data.
result Predicted dosages closely match actual dosages.
This study uses bandit algorithms to predict Warfarin dosages more accurately.
problem Determining the correct initial Warfarin dosage is challenging due to patient variability and adverse effects.
method Developed and evaluated linear bandit algorithms on real data from PharmGKB.
result Proposed algorithms outperformed fixed-dose and clinical algorithms.
Estimating what would be an individual's potential response to varying levels of exposure to a treatment is of high practical relevance for several important fields, such as healthcare, economics and public policy. However, existing methods for learning to estimate counterfactual outcomes from observational data are ei…
Study uses Thompson Sampling to find optimal drug dosages in clinical trials.
problem Finding the best drug dosage in early-stage clinical trials.
method Adopted Thompson Sampling for dose-finding clinical trials, considering different monotonicity assumptions.
result Thompson Sampling variants outperform existing methods in various dose-finding scenarios.
A new experimental design method for combinatorial interventions reduces complexity and improves accuracy.
problem Efficiently conducting all possible combinatorial interventions with multiple treatments and potential interactions.
method Probabilistic factorial experimental design, applying random combinations of treatments and adapting over multiple rounds.
result Optimal dosage of 1/2 for each treatment yields near-optimal design for estimating any k-way interaction model.
C3T-Budget optimizes drug efficacy in dose-finding trials with budget and safety constraints.
problem Heterogeneous patient populations and budget constraints make dose-finding clinical trials challenging.
method Contextual constrained clinical trial algorithm that maximizes drug efficacy while learning subgroup responses.
result Demonstrates efficient budget usage and balanced learning-treatment trade-off in simulated trials.
Automated system extracts medication regimens from medical conversations.
problem Extract relevant medication information from medical conversations.
method QA task approach, combined QA and Information Extraction, data augmentation, public embeddings, pretraining.
result Improved accuracy in extracting dosage and frequency from 54.28 and 37.13 to 89.57 and 45.94.
The paper tackles sequential experimental design for transductive linear bandits.
problem Inferring the maximum of a target vector with limited noisy measurements.
method Introduces a new transductive linear bandit problem and provides instance-dependent lower bounds, an algorithm matching these bounds, and evaluation.
result First non-asymptotic algorithm for linear bandits nearly achieving information theoretic lower bound.
Study efficient policy value estimation with sublinear samples.
problem Estimating optimal policy value in stochastic disjoint linear bandits.
method Sublinear sample estimation of optimal policy value.
result Achieves near optimal estimation error with sublinear samples.
New framework for managing medical risks using convex responses.
problem Medical risk management and dosing optimization.
method Analyzes convex and concave dose-response functions, defines antifragility.
result Proposes a mathematical framework for integrating nonlinearities in oncology.
New method estimates effects of multiple nutrients on blood glucose.
problem Estimating physiological response to multiple nutrient treatments.
method Convolution-based multi-output Gaussian process model.
result Improved prediction accuracy and better interpretation of individual nutrient effects.
Develops a new RL algorithm for medical treatment regimes.
problem Optimal dose determination in continuous action environments.
method Quasi-optimal learning algorithm for near-optimal actions.
result Guaranteed convergence and effectiveness in real applications.
Gonogo offers tools for sensitivity experiments in R.
problem Conducting, analyzing, and simulating sensitivity experiments.
method Suite of R functions for various adaptive procedures.
result Achieving overlapping data and refining testing in distribution tails.
Develops algorithms to exploit historical and pre-clustered arm information in bandit problems.
problem Optimizing decision-making in multi-armed bandit and contextual bandit problems with historical observations and pre-clustered arms.
method META algorithm that combines historical observations and pre-clustering information, deriving regret bounds for various scenarios.
result META algorithm effectively balances between using historical observations and clustering, outperforming the other in different scenarios.
Study robust best-arm identification in linear bandits with lower bounds and algorithms.
problem Identify a near-optimal robust arm in linear bandits with adversarial actions.
method Propose instance-dependent lower bounds and both static and adaptive bandit algorithms.
result Sample complexity matches the lower bound and algorithms effectively identify robust arms.
Kernel method optimizes personalized dose rules for patients.
problem Finding optimal individualized dose rules for patients.
method Kernel assisted learning method for estimating optimal dose rules.
result The method identifies the optimal individualized dose rule and produces favorable outcomes.
Current pharmaceutical formulation development still strongly relies on the traditional trial-and-error approach by individual experiences of pharmaceutical scientists, which is laborious, time-consuming and costly. Recently, deep learning has been widely applied in many challenging domains because of its important cap…
Many scientific and engineering challenges -- ranging from pharmacokinetic drug dosage allocation and personalized medicine to marketing mix (4Ps) recommendations -- require an understanding of the unobserved heterogeneity in order to develop the best decision making-processes. In this paper, we develop a hypothesis te…
Research evaluates data poisoning attacks on regression learning and introduces a new defense strategy.
problem Data poisoning attacks on regression learning threaten model integrity in critical systems.
method Realistic scenarios, novel black-box attack, and evaluation on 26 datasets.
result Mean squared error (MSE) increases to 150% with only 2% poisoned samples.
The introduction of data analytics into medicine has changed the nature of patient treatment. In this, patients are asked to disclose personal information such as genetic markers, lifestyle habits, and clinical history. This data is then used by statistical models to predict personalized treatments. However, due to pri…
Paper uses GANs to estimate effects of continuous interventions.
problem Estimating effects of continuous interventions from observational data.
method SCIGAN model based on modified GAN framework.
result SCIGAN model estimates counterfactual outcomes for continuous interventions.
Deep RL controls anesthesia more accurately than traditional methods.
problem Controlling the level of unconsciousness during anesthesia.
method Deep Reinforcement Learning (DRL) to map patient state to propofol dosage.
result Deep RL model outperformed traditional controllers (1.7% vs 3.4% median absolute performance error).
Prototype controls stochastic drug resistance in cells.
problem Emergence of drug-resistant cells from random mutations.
method Deep reinforcement learning for adaptive drug dosing.
result 100% success rate in suppressing cell proliferation.
A model predicts which patients can safely use a warfarin dosing algorithm.
problem Determining the optimal initial dose for warfarin patients.
method Support Vector Machines with a polynomial kernel function.
result The model increases dosing accuracy by 15% in RMSE and 17% in MAE.
Oral Disintegrating Tablets (ODTs) is a novel dosage form that can be dissolved on the tongue within 3min or less especially for geriatric and pediatric patients. Current ODT formulation studies usually rely on the personal experience of pharmaceutical experts and trial-and-error in the laboratory, which is inefficient…
Bayesian framework for analyzing heterogeneous covariance data with a novel MoE-Wishart model.
problem Analyzing complex multivariate systems with varying covariance structures.
method Comprehensive Bayesian framework using mixture-of-experts Wishart model with predictor-dependent mixture weights.
result Accurate subpopulation recovery and estimation in heterogeneous covariance scenarios.
Simulates sepsis treatment decisions using a world model approach.
problem Predicting optimal sepsis treatment actions based on noisy EHR data.
method Uses a Variational Auto-Encoder and Mixture Density Network (MDN-RNN) to model sepsis patient trajectories.
result Simulator learns from MIMIC dataset to predict patient states.
New method predicts Alzheimer's risk with individual uncertainty estimates.
problem Predicting conversion from mild cognitive impairment to Alzheimer's disease.
method Persistent homology of clinical trajectories combined with stacking ensemble.
result Pipeline achieves high accuracy and individual-level uncertainty quantification.
The paper proves an obstruction to immersed curves with specific curvature.
problem Existence of immersed curves with prescribed curvature.
method Proofs and corrections of submitted manuscript.
result An obstruction to the existence of immersed curves of prescribed curvature.