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0111 · Sep 201819922001200920172026
3 results for Pharmacogenetics

This study uses bandit algorithms to predict Warfarin dosages more accurately.

problem Determining the correct initial Warfarin dosage is challenging due to patient variability and adverse effects.
method Developed and evaluated linear bandit algorithms on real data from PharmGKB.
result Proposed algorithms outperformed fixed-dose and clinical algorithms.

Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based warfarin dosing algorithms incorporating clinical factors and genetic va…

2018-09-10abs ↗pdf ↗

Determining the optimal initial dose for warfarin is a critically important task. Several factors have an impact on the therapeutic dose for individual patients, such as patients' physical attributes (Age, Height, etc.), medication profile, co-morbidities, and metabolic genotypes (CYP2C9 and VKORC1). These wide range f…

2019-03-21abs ↗pdf ↗