Deep learning system tracks stool consistency for GI disease assessment.
problem Lack of objective stool consistency measurements in chronic GI disease.
method Computer vision and deep convolutional neural networks (CNN).
result Developed a stool detection and tracking system.
A new method tracks retinal vessels more accurately than existing methods.
problem Tracking retinal vessels accurately in spherical images.
method Computing cusp-free, crossing-preserving geodesics on spherical positions and orientations.
result Crossing-preserving tracking shows clear advantages over non-crossing-preserving tracking.
Improved bio-surveillance through automated document classification.
problem Tracking infectious diseases across global news alerts.
method Recurrent neural networks, TF-IDF, Naive Bayes, logistic regression.
result 97% recall and 93.3% accuracy in bio-surveillance event classification.
Machine learning improves CHD screening accuracy from 70% to 87.7%.
problem Predicting coronary heart disease using echocardiography and clinical features.
method Ensemble machine learning approach with model stacking and two-step stacking.
result Improved CHD classification accuracy from 70% to 87.7%.
BoXHED boosts hazard estimation for dynamic health risk scores.
problem Analyzing time-varying health vitals for disease onset prediction.
method Gradient boosting for nonparametric hazard function estimation with time-dependent covariates.
result Novel interaction effects among risk factors identified in cardiovascular disease onset data.
Method predicts disease outbreaks using search logs, overcoming instability.
problem Predicting disease outbreaks from search logs is challenging due to short-term and long-term instability.
method Seasonal-adjustment method decomposes logs into seasonal, trend, and irregular components; feature selection method selects relevant search terms.
result Proposed method outperforms comparative methods in prediction accuracy for seven of ten diseases.
Contagions such as the spread of popular news stories, or infectious diseases, propagate in cascades over dynamic networks with unobservable topologies. However, "social signals" such as product purchase time, or blog entry timestamps are measurable, and implicitly depend on the underlying topology, making it possible …
New model maps malaria prevalence across Kenya's changing administrative boundaries.
problem Mapping disease prevalence with changing administrative boundaries.
method Combines deep learning and MCMC with aggVAE for disease mapping.
result Solves the change-of-support problem in disease surveillance.
Hidden Markov Model helps track asymptomatic carriers in pandemic.
problem Tracking spread of asymptomatic carriers (super-spreaders) during pandemic.
method Applied Hidden Markov Model to analyze COVID-19 data.
result Better assessment of spread extent for calibrated interventions.
Paper models COVID-19 spread as spatio-temporal point processes.
problem Understanding complex spacetime propagation of COVID-19.
method Generative and intensity-free model using adversarial imitation learning.
result Imitation learning framework for scalable model inference.
Deep learning maps tongue movements to speech sounds for voiceless individuals.
problem Developing silent speech interfaces for individuals without a larynx.
method Hybrid spatio-temporal 3D convolutions and feature shuffling for formant estimation and tracking from ultrasound tongue images.
result Best model achieves R-squared of 99.96% for vowel formant regression.
Social dynamics is concerned primarily with interactions among individuals and the resulting group behaviors, modeling the temporal evolution of social systems via the interactions of individuals within these systems. In particular, the availability of large-scale data from social networks and sensor networks offers an…
Motion Code models time series dynamics with sparse approximations.
problem Challenges in time series classification and forecasting on noisy data.
method Motion Code views time series as stochastic processes, assigning unique signatures to distinct dynamics.
result Motion Code outperforms benchmarks in noisy datasets, including real-world Parkinson's disease tracking.
DPVis integrates HMMs into visualizations for disease progression analysis.
problem Challenges in interpreting HMMs for disease progression modeling.
method Design study with clinical experts, visualizations of HMM parameters and outcomes.
result DPVis successfully evaluates and summarizes disease progression models.
Bayesian hypergraph inference models disease pathways from EHR data.
problem Modeling rare diseases influenced by shared risk factors.
method Bayesian hypergraph inference framework reframing multi-disease modeling.
result Interpretable disease pathways and well-calibrated uncertainty quantification.
Paper develops fine-grain spatiotemporal risk scores using high-resolution mobility data.
problem Developing reliable spatiotemporal risk scores for safe economic reopening.
method Hawkes process-based technique leveraging high-resolution cell-phone location signals.
result Fine-grain spatiotemporal risk scores based on high-resolution mobility data provide useful insights for safe re-opening.
Model learns disease self-representations for drug repositioning.
problem Drug repositioning for disease treatment.
method Enforces proximity in disease self-representations to preserve human phenome network structure.
result Method outperforms state-of-the-art approaches and produces biologically interpretable disease self-representations.
Bayesian model identifies health disparities in disease progression.
problem Health disparities bias disease progression models.
method Interpretable Bayesian model accounting for three disparities.
result Model identifies and corrects for health disparities.
Disease phenotyping algorithms process observational clinical data to identify patients with specific diseases. Supervised phenotyping methods require significant quantities of expert-labeled data, while unsupervised methods may learn non-disease phenotypes. To address these limitations, we propose the Semi-Supervised …
Bayesian meta-learning predicts Alzheimer's disease progression.
problem Predicting individual Alzheimer's disease progression from limited data.
method Bayesian meta-learning approach that dynamically predicts disease score distributions.
result Bayesian meta-learner outperforms single-task models and deterministic meta-learners, especially for long-term predictions.
VGAE learns gene-disease associations from networks, predicting disease-genes.
problem Predicting gene-disease associations from disease-gene networks.
method Introducing VGAE, a variational graph auto-encoder for disease-gene prediction.
result VGAE and C-VGAE outperform baseline methods in disease-gene prediction.
It is crucial to provide compatible treatment schemes for a disease according to various symptoms at different stages. However, most classification methods might be ineffective in accurately classifying a disease that holds the characteristics of multiple treatment stages, various symptoms, and multi-pathogenesis. More…
Elucidating the genetic basis of human diseases is a central goal of genetics and molecular biology. While traditional linkage analysis and modern high-throughput techniques often provide long lists of tens or hundreds of disease gene candidates, the identification of disease genes among the candidates remains time-con…
Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, …
Deep Belief Network predicts lncRNA-disease associations with high accuracy.
problem Accurately identifying lncRNA-disease associations to understand lncRNA functionality and disease mechanism.
method Proposes a DBN-based model using heterogeneous networks and DBN for feature learning.
result Obtained AUC of 0.96 and AUPR of 0.967 on standard dataset.
Enhances disease progression modeling using LLMs for complex brain connectivity.
problem Inaccurate predictions of disease spread due to oversimplified brain connectivity models.
method Uses LLMs to synthesize multi-modal relationships and learn disease trajectories from longitudinal data.
result Superior prediction accuracy and interpretability compared to traditional methods.
For many complex diseases, there is a wide variety of ways in which an individual can manifest the disease. The challenge of personalized medicine is to develop tools that can accurately predict the trajectory of an individual's disease, which can in turn enable clinicians to optimize treatments. We represent an indivi…
A method to explain disease transformation using biomarker covariance matrices.
problem Understanding disease transformation from a healthy baseline.
method Modeling healthy and disease states of biomarker covariance matrices to characterize perturbations.
result Disease perturbs the biomarker covariance structure, allowing for mechanistic explanations and individual patient prognosis.
We introduce Disease Knowledge Transfer (DKT), a novel technique for transferring biomarker information between related neurodegenerative diseases. DKT infers robust multimodal biomarker trajectories in rare neurodegenerative diseases even when only limited, unimodal data is available, by transferring information from …
Paper predicts multiple types of miRNA-disease associations using tensor decomposition.
problem Predicting miRNA-disease associations, especially multi-type ones.
method Represented miRNA-disease-type triplets as a tensor and used Tensor Decomposition methods.
result Tensor Decomposition methods improve a recent baseline by up to 38% in top-1 F1.
The technique of Formal Concept Analysis is applied to a dataset describing the traits of rodents, with the goal of identifying zoonotic disease carriers,or those species carrying infections that can spillover to cause human disease. The concepts identified among these species together provide rules-of-thumb about the …
Paper uses TDA for automated Parkinson's disease classification and severity assessment.
problem Manual diagnosis of neurological diseases is time-consuming and inaccurate.
method Combines Topological Data Analysis (TDA) with machine learning on postural shift data.
result Proposes a stable and accurate method for classifying Parkinson's disease.
Proposes Ada-Sit method for mortality prediction of rare diseases.
problem Data insufficiency and clinical diversity of rare diseases make mortality prediction hard.
method Initialization-sharing multi-task learning method (Ada-Sit) for fast adaptation to similar tasks.
result Experimental results show the proposed model is effective for mortality prediction of diverse rare diseases.
Rare diseases affect a relatively small number of people, which limits investment in research for treatments and cures. Developing an efficient method for rare disease detection is a crucial first step towards subsequent clinical research. In this paper, we present a semi-supervised learning framework for rare disease …
Graph network predicts circRNA-disease associations using multi-source similarity features.
problem Identifying circRNA-disease associations is challenging and time-consuming.
method Proposes a graph convolution network framework using multi-source similarity information.
result Framework predicts circRNA-disease associations with promising results and outperforms existing methods.
RL approach for target tracking with unknown dynamics and sensor control.
problem Tracking an unknown target with sensor control.
method Track-MDP formulation for RL, compared with POMDP.
result Optimal RL policy tracks all target paths with certainty.
Deep learning detects Crohn's disease in MRI images.
problem Detecting Crohn's disease in MRI images.
method Residual Networks for feature extraction and soft attention mechanisms for interpretability.
result Deep learning algorithms perform comparably to clinical standards with faster inference.
Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in which biomarkers for a disease become abnormal based on cross-sectional data. It can…
This work uses SVM to identify track component failures in AC Track Circuits.
problem Detecting and identifying specific track component failures in AC Track Circuits.
method Applied SVM classifier to STDS track circuit data.
result Successfully classified 15 different track component failures.
Deep learning boosts rare disease detection from medical claims.
problem Improving diagnosis and treatment of rare diseases.
method Generative adversarial networks (GANs) and recurrent neural networks for sequence modeling.
result Accurate prediction with 0.56 PR-AUC, outperforming benchmarks.
New train tracks for complex homeomorphisms found.
problem Existence of irreducible train tracks for pseudo-Anosov homeomorphisms.
method Starting from a veering triangulation, identify and modify branches to bypass obstructions.
result Construction of invariant train tracks with irreducible transition matrix.
Study compares machine learning and process-based models for predicting rice blast disease.
problem Predicting rice blast disease to support rice growers in controlling the disease.
method Compared four models: two process-based (Yoshino and WARM) and two machine learning (M5Rules and RNN).
result Machine learning models outperformed process-based models in predicting rice blast disease.
New method uses cluster shapes to improve track finding in particle collisions.
problem Combining timing and additional detector information for efficient track finding.
method Neural networks to analyze cluster shapes for track seeding.
result Cluster shapes reduce fake combinatorial backgrounds while maintaining high track efficiency.
Model shows screening for infectious disease is hard but Thompson sampling works well.
problem Optimal screening policy for infectious diseases is hard to find.
method Stochastic-control model with Thompson sampling for optimal performance.
result Thompson sampling provides optimal performance guarantees in screening for infectious diseases.
Value-tracking in financial markets breaks down when non-valuation-based traders dominate.
problem Understanding the threshold for value-tracking in financial markets.
method Simple discrete-time model to show how non-valuation-based traders can cause tracking errors.
result A threshold above which value-tracking breaks down without changes in asset value.
WEST uses EHRs and expert cases to improve rare disease phenotyping.
problem Limited labeled data for rare diseases.
method Weakly supervised transformer model trained on probabilistic silver-standard labels.
result WEST outperforms existing methods in phenotype classification and subphenotyping.
Traditional disease surveillance can be augmented with a wide variety of real-time sources such as, news and social media. However, these sources are in general unstructured and, construction of surveillance tools such as taxonomical correlations and trace mapping involves considerable human supervision. In this paper,…
Imaging fluorescent disease biomarkers in tissues and skin is a non-invasive method to screen for health conditions. We report an automated process that combines intraoral fluorescent porphyrin biomarker imaging, clinical examinations and machine learning for correlation of systemic health conditions with periodontal d…